Aliases for KIAA0754 Gene

Aliases for KIAA0754 Gene

  • KIAA0754 2 3
  • Uncharacterized Protein KIAA0754 3 4

External Ids for KIAA0754 Gene

Previous GeneCards Identifiers for KIAA0754 Gene

  • GC01U990245
  • GC01P039648
  • GC01P039875
  • GC01P039081

Summaries for KIAA0754 Gene

GeneCards Summary for KIAA0754 Gene

KIAA0754 (KIAA0754) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and calcium ion binding.

Additional gene information for KIAA0754 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KIAA0754 Gene

Genomics for KIAA0754 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KIAA0754 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J039404 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 604.3 -0.1 -147 8.2 ARHGAP35 GATAD2A CTCF PRDM10 REST TFE3 IKZF1 ZNF692 JUND ETV6 KIAA0754 OXCT2P1 ENSG00000226438 BMP8B MN308938 piR-53450 MACF1
GH01J039182 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 4.2 -218.6 -218571 15.7 SP1 CREB1 GATAD2A CTCF ZBTB33 ATF7 PRDM10 ZNF629 ZNF512 RFX1 MACF1 ENSG00000226438 PPIEL RNU6-608P OXCT2P1 TRIT1 PPIE PABPC4 BMP8B KIAA0754
GH01J039171 Enhancer 0.8 ENCODE dbSUPER 4.4 -235.2 -235181 3.8 CTCF ZNF512 SCRT2 CEBPB FOXA2 ATF3 SCRT1 ZFHX2 ZNF384 RXRA RNU6-608P ENSG00000226438 OXCT2P1 KIAA0754 lnc-NDUFS5-5 RNA5SP44 RF00001-002 RF00017-168 MACF1
GH01J039391 Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -12.7 -12703 10.5 GATAD2A PRDM10 ZNF629 REST ZNF512 LEF1 SOX13 IKZF1 JUND FOXA1 PPIEL PPIE PABPC4-AS1 SNORA55 PABPC4 OXCT2P1 MACF1 TRIT1 BMP8A BMP8B
GH01J039416 Promoter/Enhancer 0.7 Ensembl dbSUPER 0.7 +4.8 4828 0.2 HNRNPL GLIS2 ENSG00000226438 KIAA0754 MN308938 BMP8A MACF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIAA0754 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KIAA0754

Top Transcription factor binding sites by QIAGEN in the KIAA0754 gene promoter:
  • aMEF-2
  • AP-4
  • Chx10
  • Evi-1
  • FOXI1
  • HFH-3
  • HSF2
  • MEF-2
  • MEF-2A
  • RORalpha2

Genomic Locations for KIAA0754 Gene

Genomic Locations for KIAA0754 Gene
chr1:39,409,073-39,416,482
(GRCh38/hg38)
Size:
7,410 bases
Orientation:
Plus strand
chr1:39,875,176-39,882,154
(GRCh37/hg19)
Size:
6,979 bases
Orientation:
Plus strand

Genomic View for KIAA0754 Gene

Genes around KIAA0754 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0754 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0754 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0754 Gene

Proteins for KIAA0754 Gene

  • Protein details for KIAA0754 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94854-K0754_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0754
    Protein Accession:
    O94854
    Secondary Accessions:
    • E9PMC2
    • Q6ZSB2

    Protein attributes for KIAA0754 Gene

    Size:
    1291 amino acids
    Molecular mass:
    135148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KIAA0754 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KIAA0754 Gene

Post-translational modifications for KIAA0754 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0754 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for KIAA0754 Gene

Domains & Families for KIAA0754 Gene

Protein Domains for KIAA0754 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with KIAA0754: view

No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KIAA0754 Gene

Function for KIAA0754 Gene

Phenotypes From GWAS Catalog for KIAA0754 Gene

genes like me logo Genes that share phenotypes with KIAA0754: view

Animal Model Products

CRISPR Products

miRNA for KIAA0754 Gene

miRTarBase miRNAs that target KIAA0754

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA0754

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0754 Gene

Localization for KIAA0754 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for KIAA0754 Gene

Pathways & Interactions for KIAA0754 Gene

genes like me logo Genes that share pathways with KIAA0754: view

Pathways by source for KIAA0754 Gene

1 BioSystems pathway for KIAA0754 Gene

Interacting Proteins for KIAA0754 Gene

Gene Ontology (GO) - Biological Process for KIAA0754 Gene

None

No data available for SIGNOR curated interactions for KIAA0754 Gene

Drugs & Compounds for KIAA0754 Gene

No Compound Related Data Available

Transcripts for KIAA0754 Gene

mRNA/cDNA for KIAA0754 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA0754

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0754 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - - - - - - -
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ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^
SP1: - - -
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ExUns: 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^ 56 ^ 57 ^ 58 ^ 59 ^ 60 ^ 61 ^ 62a · 62b ^ 63 ^ 64 ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^ 70 ^
SP1: -
SP2: - - -
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ExUns: 71 ^ 72 ^ 73 ^ 74 ^ 75 ^ 76 ^ 77 ^ 78a · 78b ^ 79 ^ 80a · 80b ^ 81 ^ 82 ^ 83 ^ 84 ^ 85 ^ 86 ^ 87a · 87b ^ 88 ^ 89a · 89b ^ 90 ^ 91a · 91b ^
SP1: -
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ExUns: 92a · 92b ^ 93a · 93b ^ 94 ^ 95 ^ 96a · 96b ^ 97 ^ 98a · 98b · 98c · 98d ^ 99a · 99b · 99c ^ 100 ^ 101a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
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SP14: - - -
SP15: -
SP16: - -
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Relevant External Links for KIAA0754 Gene

GeneLoc Exon Structure for
KIAA0754

Expression for KIAA0754 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KIAA0754 Gene

Protein differential expression in normal tissues from HIPED for KIAA0754 Gene

This gene is overexpressed in Heart (41.1), Breast (13.3), and Plasma (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA0754 Gene



Protein tissue co-expression partners for KIAA0754 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KIAA0754

SOURCE GeneReport for Unigene cluster for KIAA0754 Gene:

Hs.658760
genes like me logo Genes that share expression patterns with KIAA0754: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0754 Gene

Orthologs for KIAA0754 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KIAA0754 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia KIAA0754 30
  • 80.99 (n)
Mouse
(Mus musculus)
Mammalia D830031N03Rik 30 17
  • 78.68 (n)
Species where no ortholog for KIAA0754 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

No data available for Evolution for KIAA0754 Gene

Paralogs for KIAA0754 Gene

No data available for Paralogs for KIAA0754 Gene

Variants for KIAA0754 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KIAA0754 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1746842 - p.Ile824Val
rs587523 - p.Glu1058Lys
rs783822 - p.Thr969Ala

Additional dbSNP identifiers (rs#s) for KIAA0754 Gene

Variation tolerance for KIAA0754 Gene

Gene Damage Index Score: 4.67; 65.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA0754 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0754

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KIAA0754 Gene

Disorders for KIAA0754 Gene

Additional Disease Information for KIAA0754

No disorders were found for KIAA0754 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0754 Gene

Publications for KIAA0754 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3

Products for KIAA0754 Gene

Sources for KIAA0754 Gene