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Aliases for KIAA0355 Gene

Aliases for KIAA0355 Gene

  • KIAA0355 2 3
  • Uncharacterized Protein KIAA0355 3 4

External Ids for KIAA0355 Gene

Previous GeneCards Identifiers for KIAA0355 Gene

  • GC19P035363
  • GC19P035194
  • GC19P039421
  • GC19P039437
  • GC19P039482
  • GC19P034745
  • GC19P031250

Summaries for KIAA0355 Gene

GeneCards Summary for KIAA0355 Gene

KIAA0355 (KIAA0355) is a Protein Coding gene.

Additional gene information for KIAA0355 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0355 Gene

Genomics for KIAA0355 Gene

GeneHancer (GH) Regulatory Elements for KIAA0355 Gene

Promoters and enhancers for KIAA0355 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J034253 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 606.8 +0.2 164 3.4 ZFX MNT NKRF POLR2A ZNF121 GTF2F1 ZBTB7A YY1 SP7 ELF1 KIAA0355 ZNF181 ZNF302 ZNF599 GC19M034255
GH19J034264 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 605.7 +11.5 11489 2.4 SP7 ZNF680 ZNF600 ZNF341 SCRT2 ZNF189 KLF1 KIAA0355 GC19P034265 GC19M034297
GH19J035246 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 67.8 +993.7 993717 4.1 ZNF473 MTA3 SP1 CTCF ZFX CC2D1A ELF3 MNT SIX5 CBFA2T2 LSR HAUS5 TMEM147-AS1 ZNF599 KMT2B RBM42 KIAA0355 ZNF792 ZNF30 ZNF302
GH19J033370 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 63.3 -879.8 -879838 8.7 ZNF473 SP1 ELF3 ZFX MNT NKRF POLR2A MLLT1 ZNF121 CEBPG CEBPG GPATCH1 LSM14A CEP89 KIAA0355 FAAP24 PDCD5 ENSG00000267219 WDR88 ANKRD27
GH19J034994 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 53.3 +746.4 746395 13.5 ZNF473 MTA3 SP1 ZNF652 ZFX ELF3 ZNF148 POLR2A MLLT1 ZNF121 GRAMD1A ENSG00000269303 TMEM147-AS1 ZNF599 HAUS5 LSM14A KMT2B ZNF792 KIAA0355 ZNF302
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KIAA0355 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIAA0355 gene promoter:
  • aMEF-2
  • c-Ets-1
  • c-Myc
  • Evi-1
  • FOXO1
  • FOXO1a
  • GATA-1
  • GATA-2
  • GATA-3
  • MEF-2A

Genomic Locations for KIAA0355 Gene

Genomic Locations for KIAA0355 Gene
chr19:34,254,537-34,355,586
(GRCh38/hg38)
Size:
101,050 bases
Orientation:
Plus strand
chr19:34,745,442-34,846,491
(GRCh37/hg19)
Size:
101,050 bases
Orientation:
Plus strand

Genomic View for KIAA0355 Gene

Genes around KIAA0355 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0355 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0355 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0355 Gene

Proteins for KIAA0355 Gene

  • Protein details for KIAA0355 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15063-K0355_HUMAN
    Recommended name:
    Uncharacterized protein KIAA0355
    Protein Accession:
    O15063
    Secondary Accessions:
    • Q2M3W4

    Protein attributes for KIAA0355 Gene

    Size:
    1070 amino acids
    Molecular mass:
    116020 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20812.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KIAA0355 Gene

Post-translational modifications for KIAA0355 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0355 Gene

No data available for DME Specific Peptides for KIAA0355 Gene

Domains & Families for KIAA0355 Gene

Gene Families for KIAA0355 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIAA0355 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KIAA0355 Gene

GenScript: Design optimal peptide antigens:
  • KIAA0355 protein (A1A512_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0355: view

No data available for UniProtKB/Swiss-Prot for KIAA0355 Gene

Function for KIAA0355 Gene

Molecular function for KIAA0355 Gene

GENATLAS Biochemistry:
cDNA sequence,expressed in brain,>100kDa

Phenotypes From GWAS Catalog for KIAA0355 Gene

genes like me logo Genes that share phenotypes with KIAA0355: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA0355

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0355 Gene

Localization for KIAA0355 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA0355 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KIAA0355 Gene

Pathways & Interactions for KIAA0355 Gene

PathCards logo

SuperPathways for KIAA0355 Gene

No Data Available

Interacting Proteins for KIAA0355 Gene

Gene Ontology (GO) - Biological Process for KIAA0355 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KIAA0355 Gene

Drugs & Compounds for KIAA0355 Gene

No Compound Related Data Available

Transcripts for KIAA0355 Gene

mRNA/cDNA for KIAA0355 Gene

Unigene Clusters for KIAA0355 Gene

KIAA0355:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KIAA0355

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0355 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3: -
SP4: - - -
SP5:

Relevant External Links for KIAA0355 Gene

GeneLoc Exon Structure for
KIAA0355
ECgene alternative splicing isoforms for
KIAA0355

Expression for KIAA0355 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA0355 Gene

Protein differential expression in normal tissues from HIPED for KIAA0355 Gene

This gene is overexpressed in Placenta (40.0) and Testis (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KIAA0355 Gene



Protein tissue co-expression partners for KIAA0355 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA0355 Gene:

KIAA0355

SOURCE GeneReport for Unigene cluster for KIAA0355 Gene:

Hs.330073
genes like me logo Genes that share expression patterns with KIAA0355: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0355 Gene

Orthologs for KIAA0355 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0355 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0355 35 34
  • 99.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0355 35 34
  • 91.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0355 35 34
  • 91.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 4931406P16Rik 17 35 34
  • 89.89 (n)
rat
(Rattus norvegicus)
Mammalia RGD1308428 34
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA0355 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0355 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0355 35 34
  • 74.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0355 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0355 34
  • 70.81 (n)
Str.19353 34
zebrafish
(Danio rerio)
Actinopterygii KIAA0355 35
  • 64 (a)
OneToOne
Species where no ortholog for KIAA0355 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0355 Gene

ENSEMBL:
Gene Tree for KIAA0355 (if available)
TreeFam:
Gene Tree for KIAA0355 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KIAA0355: view image

Paralogs for KIAA0355 Gene

No data available for Paralogs for KIAA0355 Gene

Variants for KIAA0355 Gene

Sequence variations from dbSNP and Humsavar for KIAA0355 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000018510 -- 34,268,784(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000058391 -- 34,353,711(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000066670 -- 34,311,665(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000079598 -- 34,298,081(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000089909 -- 34,269,784(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0355 Gene

Variant ID Type Subtype PubMed ID
esv3644205 CNV loss 21293372
esv3644206 CNV loss 21293372
nsv1121979 CNV deletion 24896259
nsv1143915 CNV deletion 24896259
nsv2468 CNV insertion 18451855
nsv474884 CNV novel sequence insertion 20440878
nsv474905 CNV novel sequence insertion 20440878
nsv474923 CNV novel sequence insertion 20440878
nsv475034 CNV novel sequence insertion 20440878
nsv475206 CNV novel sequence insertion 20440878
nsv475303 CNV novel sequence insertion 20440878
nsv475634 CNV novel sequence insertion 20440878
nsv476189 CNV novel sequence insertion 20440878
nsv478015 CNV novel sequence insertion 20440878
nsv480065 CNV novel sequence insertion 20440878
nsv480180 CNV novel sequence insertion 20440878
nsv509737 CNV insertion 20534489
nsv509738 CNV insertion 20534489
nsv961210 CNV duplication 23825009

Variation tolerance for KIAA0355 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA0355 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KIAA0355

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0355 Gene

Disorders for KIAA0355 Gene

Additional Disease Information for KIAA0355

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KIAA0355 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0355 Gene

Publications for KIAA0355 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  2. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. (PMID: 29395067) Youn JY … Gingras AC (Molecular cell 2018) 2 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  4. A genome-wide association study of amygdala activation in youths with and without bipolar disorder. (PMID: 20215924) Liu X … McMahon FJ (Journal of the American Academy of Child and Adolescent Psychiatry 2010) 3 45 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for KIAA0355 Gene

Sources for KIAA0355 Gene

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