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Aliases for KIAA0141 Gene

Aliases for KIAA0141 Gene

  • KIAA0141 2 3
  • Death Ligand Signal Enhancer 2 3
  • DELE 3 4

External Ids for KIAA0141 Gene

Previous GeneCards Identifiers for KIAA0141 Gene

  • GC05P141124
  • GC05P141886
  • GC05P141286
  • GC05P141331
  • GC05P141283
  • GC05P136446
  • GC05P141323
  • GC05P141328
  • GC05P141401

Summaries for KIAA0141 Gene

GeneCards Summary for KIAA0141 Gene

KIAA0141 (KIAA0141) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA0141 Gene

  • Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Additional gene information for KIAA0141 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0141 Gene

Genomics for KIAA0141 Gene

GeneHancer (GH) Regulatory Elements for KIAA0141 Gene

Promoters and enhancers for KIAA0141 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I141922 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557.6 0.0 -16 2.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B KIAA0141 GC05M141922 LOC102723915 HDAC3 GC05M141915
GH05I141968 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.9 +45.8 45782 3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RNF14 PCDH12 PCDHB18P PCDHGA6 PCDHGA7 LOC102723915 HDAC3 KIAA0141 PCDHGA5 PCDHB12
GH05I141679 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 20.2 -242.0 -241974 4.7 HDGF ARNT SIN3A ZNF2 CBX5 ZNF213 FOS SP3 REST ZNF592 ARAP3 PCDHB19P HARS2 KIAA0141 PCDHB18P PCDHGA7 PCDH1 PCDH12 RNF14 HDAC3
GH05I141957 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 26.9 +35.6 35575 4.5 HDGF ARNT ARID4B ZNF2 ETS1 ZNF766 E2F8 ELK1 ARID2 ZNF143 RNF14 GC05M141957 PCDH12 LOC102723915 HDAC3 KIAA0141 FCHSD1 ARAP3 ENSG00000271871 PCDH1
GH05I142815 Enhancer 1.4 Ensembl ENCODE dbSUPER 24.5 +900.5 900493 17.2 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF548 FOS KIAA0141 ENSG00000271871 ARHGAP26-AS1 GC05P142827 GC05P142826 ARHGAP26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KIAA0141 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KIAA0141 gene promoter:

Genomic Locations for KIAA0141 Gene

Genomic Locations for KIAA0141 Gene
27,681 bases
Plus strand

Genomic View for KIAA0141 Gene

Genes around KIAA0141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KIAA0141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KIAA0141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0141 Gene

Proteins for KIAA0141 Gene

  • Protein details for KIAA0141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Death ligand signal enhancer
    Protein Accession:
    Secondary Accessions:
    • Q969R4
    • Q96EU9

    Protein attributes for KIAA0141 Gene

    515 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Interacts with DAP3.
    • Sequence=BAA09490.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for KIAA0141 Gene

Post-translational modifications for KIAA0141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KIAA0141 Gene

Domains & Families for KIAA0141 Gene

Gene Families for KIAA0141 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KIAA0141 Gene


Suggested Antigen Peptide Sequences for KIAA0141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KIAA0141: view

No data available for UniProtKB/Swiss-Prot for KIAA0141 Gene

Function for KIAA0141 Gene

Molecular function for KIAA0141 Gene

GENATLAS Biochemistry:
putative protein,expressed in fetal heart and kidney
UniProtKB/Swiss-Prot Function:
Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

Phenotypes From GWAS Catalog for KIAA0141 Gene

Gene Ontology (GO) - Molecular Function for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20563667
genes like me logo Genes that share ontologies with KIAA0141: view

Phenotypes for KIAA0141 Gene

genes like me logo Genes that share phenotypes with KIAA0141: view

Animal Model Products

CRISPR Products

miRNA for KIAA0141 Gene

miRTarBase miRNAs that target KIAA0141

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KIAA0141 Gene

Localization for KIAA0141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0141 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KIAA0141 gene
Compartment Confidence
mitochondrion 5
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 10942595
genes like me logo Genes that share ontologies with KIAA0141: view

Pathways & Interactions for KIAA0141 Gene

SuperPathways for KIAA0141 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA 20563667
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 20563667
genes like me logo Genes that share ontologies with KIAA0141: view

No data available for Pathways by source and SIGNOR curated interactions for KIAA0141 Gene

Drugs & Compounds for KIAA0141 Gene

No Compound Related Data Available

Transcripts for KIAA0141 Gene

Unigene Clusters for KIAA0141 Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0141 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: -
SP10: -

ExUns: 16b · 16c · 16d · 16e

Relevant External Links for KIAA0141 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KIAA0141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KIAA0141 Gene

Protein differential expression in normal tissues from HIPED for KIAA0141 Gene

This gene is overexpressed in Oral epithelium (8.6), Nasopharynx (7.8), and Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KIAA0141 Gene

Protein tissue co-expression partners for KIAA0141 Gene

NURSA nuclear receptor signaling pathways regulating expression of KIAA0141 Gene:


SOURCE GeneReport for Unigene cluster for KIAA0141 Gene:


mRNA Expression by UniProt/SwissProt for KIAA0141 Gene:

Tissue specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Evidence on tissue expression from TISSUES for KIAA0141 Gene

  • Nervous system(4.8)
  • Bone marrow(4.3)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with KIAA0141: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KIAA0141 Gene

Orthologs for KIAA0141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KIAA0141 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIAA0141 33 34
  • 99.35 (n)
(Bos Taurus)
Mammalia KIAA0141 33 34
  • 86.8 (n)
(Canis familiaris)
Mammalia KIAA0141 33 34
  • 84.92 (n)
(Mus musculus)
Mammalia 0610009O20Rik 33 16 34
  • 79.29 (n)
(Rattus norvegicus)
Mammalia RGD735029 33
  • 78.96 (n)
(Monodelphis domestica)
Mammalia KIAA0141 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia KIAA0141 34
  • 45 (a)
(Gallus gallus)
Aves KIAA0141 33
  • 67.05 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0141 33
  • 49.55 (n)
(Danio rerio)
Actinopterygii zgc:158257 33 34
  • 47.12 (n)
Species where no ortholog for KIAA0141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KIAA0141 Gene

Gene Tree for KIAA0141 (if available)
Gene Tree for KIAA0141 (if available)

Paralogs for KIAA0141 Gene

No data available for Paralogs for KIAA0141 Gene

Variants for KIAA0141 Gene

Sequence variations from dbSNP and Humsavar for KIAA0141 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000284609 -- 141,927,042(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000465484 -- 141,922,030(+) C/A upstream_transcript_variant
rs1000649715 -- 141,922,859(+) A/G upstream_transcript_variant
rs1000840304 -- 141,937,998(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000894208 -- 141,937,598(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0141 Gene

Variant ID Type Subtype PubMed ID
esv2667575 CNV deletion 23128226
nsv1117586 CNV deletion 24896259
nsv1154058 CNV deletion 26484159
nsv599924 CNV gain 21841781

Variation tolerance for KIAA0141 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.85; 89.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KIAA0141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KIAA0141 Gene

Disorders for KIAA0141 Gene

Additional Disease Information for KIAA0141

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KIAA0141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KIAA0141 Gene

Publications for KIAA0141 Gene

  1. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PMID: 20563667) Harada T … Miyazaki T (Apoptosis : an international journal on programmed cell death 2010) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for KIAA0141 Gene

Sources for KIAA0141 Gene

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