Aliases for KHSRP Gene
External Ids for KHSRP Gene
Previous GeneCards Identifiers for KHSRP Gene
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]
GeneCards Summary for KHSRP Gene
KHSRP (KH-Type Splicing Regulatory Protein) is a Protein Coding gene. Diseases associated with KHSRP include Paralytic Poliomyelitis and Poliomyelitis. Among its related pathways are Preimplantation Embryo and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is FUBP1.
UniProtKB/Swiss-Prot Summary for KHSRP Gene
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.