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This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic su... See more...
Aliases for KEAP1 Gene
Aliases for KEAP1 Gene
External Ids for KEAP1 Gene
- HGNC: 23177
- Entrez Gene: 9817
- Ensembl: ENSG00000079999
- OMIM: 606016
- UniProtKB: Q14145
Previous GeneCards Identifiers for KEAP1 Gene
- GC19M010727
- GC19M010819
- GC19M010442
- GC19M010457
- GC19M010596
- GC19M010176
Summaries for KEAP1 Gene
-
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KEAP1 Gene
KEAP1 (Kelch Like ECH Associated Protein 1) is a Protein Coding gene. Diseases associated with KEAP1 include Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors and Papillary Adenocarcinoma. Among its related pathways are Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is KLHL17.
UniProtKB/Swiss-Prot Summary for KEAP1 Gene
-
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835).
Additional gene information for KEAP1 Gene
- HGNC(23177)
- Entrez Gene(9817)
- Ensembl(ENSG00000079999)
- OMIM(606016)
- UniProtKB(Q14145)
- Open Targets Platform(ENSG00000079999)
- Monarch Initiative
- Search for KEAP1 at DataMed
- Search for KEAP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KEAP1 Gene
Genomics for KEAP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KEAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KEAP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KEAP1
- Top Transcription factor binding sites by QIAGEN in the KEAP1 gene promoter:
-
- AREB6
- c-Myc
- Egr-4
- Max
- Pax-4a
Genomic Locations for KEAP1 Gene
Genomic Locations for KEAP1 Gene
- chr19:10,486,125-10,503,558
- (GRCh38/hg38)
- Size:
- 17,434 bases
- Orientation:
- Minus strand
- chr19:10,596,796-10,614,417
- (GRCh37/hg19)
- Size:
- 17,622 bases
- Orientation:
- Minus strand
Genomic View for KEAP1 Gene
Genes around KEAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
KEAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KEAP1 Gene
Proteins for KEAP1 Gene
-
Protein details for KEAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14145-KEAP1_HUMAN
- Recommended name:
- Kelch-like ECH-associated protein 1
- Protein Accession:
- Q14145
- B3KPD5
- Q6LEP0
- Q8WTX1
- Q9BPY9
Protein attributes for KEAP1 Gene
- Size:
- 624 amino acids
- Molecular mass:
- 69666 Da
- Quaternary structure:
-
- Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of CUL3, 2 molecules of KEAP1, and RBX1 (PubMed:15572695, PubMed:15983046, PubMed:15601839, PubMed:17127771, PubMed:18251510, PubMed:24896564). Interacts with NFE2L2/NRF2; the interaction is direct (PubMed:15379550, PubMed:15601839, PubMed:16006525, PubMed:18387606, PubMed:16888629). Forms a ternary complex with NFE2L2/NRF2 and PGAM5 (PubMed:17046835). Interacts with (phosphorylated) SQSTM1/p62; the interaction is direct and inactivates the BCR(KEAP1) complex by sequestering it in inclusion bodies, promoting its degradation (PubMed:20495340, PubMed:20452972). Interacts with NFE2L1 (PubMed:16687406). Interacts with BPTF and PTMA (PubMed:15657435). Interacts with MAP1LC3B (PubMed:24089205). Interacts indirectly with ENC1 (PubMed:19424503). Interacts with SESN1 and SESN2 (PubMed:23274085). Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
- (Microbial infection) Interacts with ebolavirus protein VP24; this interaction activates transcription factor NFE2L2/NRF2 by blocking its interaction with KEAP1.
- SequenceCaution:
-
- Sequence=BAA09481.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for KEAP1 Gene
Post-translational modifications for KEAP1 Gene
- Non-enzymatic covalent modifications of reactive cysteines by electrophile metabolites inactivate the BCR(KEAP1) complex (PubMed:17127771, PubMed:18251510, PubMed:29590092, PubMed:30323285). Accumulation of fumarate promotes the formation of cysteine S-succination (S-(2-succinyl)cysteine), leading to inactivate the BCR(KEAP1) complex and promote NFE2L2/NRF2 nuclear accumulation and activation (By similarity). Nitric oxide-dependent 8-Nitro-cGMP formation promotes cysteine guanylation (S-cGMP-cysteine), leading to NFE2L2/NRF2 nuclear accumulation and activation (By similarity). Itaconate, an anti-inflammatory metabolite generated in response to lipopolysaccharide, alkylates cysteines, activating NFE2L2/NRF2 (PubMed:29590092). Methylglyoxal, a reactive metabolite that accumulates when the glycolytic enzyme PGK1 is inhibited, promotes formation of a methylimidazole cross-link between proximal Cys-151 and Arg-135 on another KEAP1 molecule, resulting in an inactive dimer that inactivates the BCR(KEAP1) complex (PubMed:30323285).
- Degraded via a proteasomal-independent process during selective autophagy: interaction with phosphorylated SQSTM1/p62 sequesters KEAP1 in inclusion bodies, leading to its degradation.
- Auto-ubiquitinated by the BCR(KEAP1) complex (PubMed:15572695, PubMed:15983046). Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination (PubMed:15572695, PubMed:15983046). Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress (PubMed:15572695, PubMed:15983046).
-
Ubiquitination at Lys61, Lys84, Lys108, Lys287, Lys312, and Lys615
- NX_Q14145 (NX_Q14145-1)
- Modification sites at PhosphoSitePlus
Other Protein References for KEAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences KEAP1 Antibody (LS-B8363) and KEAP1 Antibody (LS-B8871)
- G Biosciences Immunotag™ KEAP1 Antibody and Immunotag™ Keap1 Antibody
- GeneTex Anti-KEAP1 antibody [C1C3]
- NSJ Bioreagents KEAP1 Antibody
- HUABIO Anti-KEAP1 Antibody
- Novus Biologicals Antibodies for KEAP1
-
Abcam antibodies for KEAP1
- Invitrogen Antibodies for KEAP1 (AFLGC-Keap1)
- antibodies-online: Show 44 available KEAP1 Antibodies ranked by validation data
- Compare Top KEAP1 Antibodies
-
Recommended
- 141 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 62 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 48 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for KEAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for KEAP1
- Sino Biological Antibodies for KEAP1
Protein Products
-
OriGene Purified Proteins for KEAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for KEAP1
- Origene Custom Protein Services for KEAP1
- Sino Biological Recombinant Proteins for KEAP1
- Sino Biological Cell Lysates for KEAP1
-
Abcam proteins for KEAP1
Assay Products
No data available for DME Specific Peptides for KEAP1 Gene
Domains & Families for KEAP1 Gene
Gene Families for KEAP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for KEAP1 Gene
- InterPro:
- Blocks:
-
- BTB/POZ domain
- BTB/Kelch-associated
- Kelch repeat signature
- ProtoNet:
Suggested Antigen Peptide Sequences for KEAP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Kelch-like protein 19 (KEAP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14145UniProtKB/Swiss-Prot:
KEAP1_HUMAN :- KEAP1 contains reactive cysteine residues that act as sensors for endogenously produced and exogenously encountered small molecules, which react with sulfhydryl groups and modify the cysteine sensors, leading to impair ability of the BCR(KEAP1) complex to ubiquitinate target proteins.
- Belongs to the KEAP1 family.
- Domain:
-
- KEAP1 contains reactive cysteine residues that act as sensors for endogenously produced and exogenously encountered small molecules, which react with sulfhydryl groups and modify the cysteine sensors, leading to impair ability of the BCR(KEAP1) complex to ubiquitinate target proteins.
- The Kelch repeats mediate interaction with NFE2L2/NRF2, BPTF and PGAM5.
- Family:
-
- Belongs to the KEAP1 family.
Function for KEAP1 Gene
Molecular function for KEAP1 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Ubiquitin ligase activity of the BCR(KEAP1) complex is inhibited by oxidative stress and electrophile metabolites such as sulforaphane (PubMed:15983046, PubMed:17046835, PubMed:29590092, PubMed:30323285). Electrophile metabolites react with reactive cysteine residues in KEAP1 and trigger non-enzymatic covalent modifications of these cysteine residues, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex (PubMed:19489739, PubMed:17127771, PubMed:18251510, PubMed:29590092, PubMed:30323285). Selective autophagy also inactivates the BCR(KEAP1) complex via interaction between KEAP1 and SQSTM1/p62, which sequesters the complex in inclusion bodies and promotes its degradation (PubMed:20495340, PubMed:20452972).
Phenotypes From GWAS Catalog for KEAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 15601839 |
| GO:0008134 | transcription factor binding | IEA,IPI | 17015834 |
| GO:0042802 | identical protein binding | IEA | -- |
| GO:0097718 | disordered domain specific binding | IEA | -- |
Phenotypes for KEAP1 Gene
- MGI mutant phenotypes for KEAP1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for KEAP1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased cell death HMECs cells
- Decreased vaccinia virus (VACV) infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased shRNA abundance
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased POU5F1-GFP protein expression
- Polylobed nuclei
- Elongated cells
- Synthetic lethal with c-Myc after tamoxifen stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for KEAP1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KEAP1 - Select products 50% OFF >
- * KEAP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KEAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
miRNA for KEAP1 Gene
- miRTarBase miRNAs that target KEAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KEAP1
- Browse OriGene Inhibitory RNA Products For KEAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KEAP1
Clone Products
- Applied Biological Materials (abm): Clones for KEAP1 - Select products 50% OFF >
- * KEAP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KEAP1
- Addgene plasmids for KEAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KEAP1
Cell Line Products
-
Horizon Cell Lines for KEAP1
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KEAP1 Gene
Localization for KEAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KEAP1 Gene
- Cytoplasm. Nucleus. Note=Mainly cytoplasmic (PubMed:15601839). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20452972). {ECO:0000269 PubMed:15601839, ECO:0000269 PubMed:20452972}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| extracellular | 3 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| peroxisome | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Centriolar satellite (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 15601839 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | 17015834 |
Pathways & Interactions for KEAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Sertoli-Sertoli Cell Junction Dynamics |
Germ Cell-Sertoli Cell Junction Dynamics
.38
|
Sertoli-Sertoli Cell Junction Dynamics
.38
|
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Translational Control | ||
Pathways by source for KEAP1 Gene
3 BioSystems pathways for KEAP1 Gene
8 Reactome pathways for KEAP1 Gene
4 KEGG pathways for KEAP1 Gene
3 Qiagen pathways for KEAP1 Gene
- Epithelial Adherens Junctions
- Germ Cell-Sertoli Cell Junction Dynamics
- Sertoli-Sertoli Cell Junction Dynamics
1 Cell Signaling Technology pathway for KEAP1 Gene
UniProtKB/Swiss-Prot Q14145-KEAP1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for KEAP1 Gene
Selected Interacting proteins:
Q14145-KEAP1_HUMAN
ENSP00000171111
for KEAP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for KEAP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA,IDA | 15601839 |
| GO:0010506 | regulation of autophagy | IDA | 20452972 |
| GO:0016032 | viral process | IEA | -- |
Drugs & Compounds for KEAP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dimethyl fumarate | Approved, Investigational | Pharma | Target, binder | 102 | ||
| Carboplatin | Approved | Pharma | Antitumor agent that forms platinum-DNA adducts., Platinum | 2588 | ||
| Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist | Anti-inflammatory glucocorticoid | 2886 | |
| Dexamethasone acetate | Approved, Investigational, Vet_approved | Pharma | 2886 | |||
| Hydroxocobalamin | Approved | Pharma | 437 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) ApexBio Compounds for KEAP1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Curcumin | Tyrosinase inhibitor | 458-37-7 |
| Dimethyl Fumarate | 624-49-7 | |
| Omaveloxolone (RTA-408) | 1474034-05-3 |
Transcripts for KEAP1 Gene
mRNA/cDNA for KEAP1 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000171111 2565 nts (view in UCSC)
- ENST00000393623 2648 nts (view in UCSC)
- ENST00000585845 774 nts (view in UCSC)
- ENST00000588024 576 nts (view in UCSC)
- ENST00000590237 451 nts (view in UCSC)
CRISPR Products
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KEAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
miRNA Products
Inhibitory RNA Products
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KEAP1
Clone Products
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KEAP1
- Addgene plasmids for KEAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KEAP1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
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| SP9: |
Relevant External Links for KEAP1 Gene
- GeneLoc Exon Structure for
- KEAP1
Expression for KEAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for KEAP1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.9).
This gene is overexpressed in Breast (56.9) and Plasma (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KEAP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KEAP1
SOURCE GeneReport for Unigene cluster for KEAP1 Gene:
Hs.465870mRNA Expression by UniProt/SwissProt for KEAP1 Gene:
Q14145-KEAP1_HUMAN
Tissue specificity:
Broadly expressed, with highest levels in skeletal muscle.
Evidence on tissue expression from TISSUES for KEAP1 Gene
- Nervous system(5)
- Skin(4.7)
- Bone marrow(4.6)
- Liver(4.1)
- Lung(3.9)
- Muscle(3.5)
- Kidney(3.4)
- Pancreas(3.2)
- Intestine(3.2)
- Eye(3.2)
- Heart(3.2)
- Adrenal gland(3.1)
- Thyroid gland(3)
- Blood(2.8)
- Stomach(2.7)
- Spleen(2.6)
- Lymph node(2.6)
- Gall bladder(2.5)
Primer Products
-
OriGene qPCR primer pairs for KEAP1
-
OriGene qPCR primer pairs and template standards for KEAP1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KEAP1 Gene
Orthologs for KEAP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KEAP1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | KEAP1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KEAP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KEAP1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Keap1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Keap1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | KEAP1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | KEAP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | keap1 30 |
|
||
| Str.5652 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18653 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | keap1b 30 31 |
|
OneToOne | |
| keap1 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003645 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Keap1 30 31 32 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4993 30 |
|
- Species where no ortholog for KEAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for KEAP1 Gene
- ENSEMBL:
- Gene Tree for KEAP1 (if available)
- TreeFam:
- Gene Tree for KEAP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KEAP1: view image
Paralogs for KEAP1 Gene
Paralogs for KEAP1 Gene
- KLHL17 5
- KLHL20 5
- KLHL2 5
- KLHL3 5
- KLHL5 5
- KLHL1 5
- KLHL12 5
- KLHL28 5
- KLHL18 5
- IPP 5
- KLHL4 5
- KLHL10 5
- KLHL8 5
- KLHL7 5
- KLHL24 5
- IVNS1ABP 5
- KLHL23 5
- KLHL21 5
- KLHL38 5
- KLHL26 5
- KLHL36 5
- KLHL9 5
- KLHL22 5
- KLHL13 5
- KLHL29 5
- KBTBD12 5
- KLHL6 5
- KLHL14 5
- KLHL30 5
- KLHL35 5
- KLHL32 5
- KLHL31 5
- KLHL41 5
- KLHL15 5
- KLHL40 5
- KBTBD3 5
- KBTBD2 5
- KBTBD8 5
- KBTBD6 5
- KBTBD7 5
- KLHL34 5
- KBTBD11 5
- KLHL42 5
- BTBD18 5
- GAN 5
- BACH2 5
- KLHL33 5
- KBTBD13 5
- KLHDC7A 5
- KLHDC7B 5
- CCIN 5
- GRIK1-AS2 5
- KLHDC8B 5
- KLHDC8A 5
- ENSG00000277971 5
(32) SIMAP similar genes for KEAP1 Gene using alignment to 7 proteins:
- KEAP1_HUMAN
- K7EJ49_HUMAN
- K7EJD8_HUMAN
- K7EMY1_HUMAN
- K7EPZ3_HUMAN
- K7EQX2_HUMAN
- K7ESE0_HUMAN
Variants for KEAP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KEAP1 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 694079 | Uncertain Significance: Squamous cell carcinoma of the head and neck | 10,492,202(-) | G/A | MISSENSE_VARIANT | |
| 716698 | Likely Benign: not provided | 10,489,655(-) | G/A | SYNONYMOUS_VARIANT | |
| 720212 | Benign: not provided | 10,499,944(-) | C/T | SYNONYMOUS_VARIANT | |
| 722217 | Likely Benign: not provided | 10,491,786(-) | C/T | SYNONYMOUS_VARIANT | |
| 725487 | Likely Benign: not provided | 10,491,691(-) | G/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
8.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.90;
18.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KEAP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KEAP1 Gene
Disorders for KEAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| goiter, multinodular 1, with or without sertoli-leydig cell tumors |
|
|
| papillary adenocarcinoma |
|
|
| paget's disease of bone |
|
|
| lung squamous cell carcinoma |
|
|
| fumarase deficiency |
|
|
Search KEAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KEAP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KEAP1 Gene
Publications for KEAP1 Gene
- Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer. (PMID: 20213688) Takahashi T … Wada H (Journal of surgical oncology 2010) 3 23 41
- Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. (PMID: 19424503) Wang XJ … Zhang DD (PloS one 2009) 3 4 23
- Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. (PMID: 19489739) Eggler AL … Mesecar AD (The Biochemical journal 2009) 3 4 23
- PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. (PMID: 18387606) Lo SC … Hannink M (Experimental cell research 2008) 3 4 23
- Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3. (PMID: 18251510) Rachakonda G … Freeman ML (Chemical research in toxicology 2008) 3 4 23
ExternalLinks
Products for KEAP1 Gene
- Custom Antibody ServicesOriGene Antibodies for KEAP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for KEAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for KEAP1
- Origene Custom Protein Services for KEAP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KEAP1
- Browse OriGene Inhibitory RNA Products For KEAP1
- OriGene qPCR primer pairs for KEAP1
- OriGene qPCR primer pairs and template standards for KEAP1
- MG209525
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- RC202189L3V
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- RC202513L1V
- RC202513L2V
- RC202513L3V
- RC202513L4V
- RR201988L3V
- RR201988L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KEAP1
- Sino Biological Human cDNA Clone for KEAP1
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- Novus Biologicals proteins and lysates for KEAP1
- Browse Antibodies
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- Taconic Biosciences Mouse Models for KEAP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for KEAP1 (AFLGC-Keap1)
- ApexBio compounds for KEAP1
- VectorBuilder Custom and pre-made DNA vectors for KEAP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for KEAP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for KEAP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for KEAP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for KEAP1
- Addgene plasmids for KEAP1
- antibodies-online: Show 44 available KEAP1 Antibodies ranked by validation data
- Compare Top KEAP1 Antibodies
- Recommended
- 141 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 62 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 48 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- antibodies-online: Show 25 available KEAP1 Elisa Kits ranked by validation data
- Compare Top KEAP1 Elisa Kits
- antibodies-online: Show 11 available KEAP1 Proteins ranked by validation data
- Compare Top KEAP1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for KEAP1
- Search Santa Cruz Biotechnology (SCBT) for KEAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
- Custom Antibody ServicesProSci Antibodies for KEAP1
- Search for KEAP1 Proteins at ProSci
- Horizon Cell Lines for KEAP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KEAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KEAP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KEAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KEAP1
Sources for KEAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB