KEAP1 Gene (Protein Coding)

Kelch Like ECH Associated Protein 1

GC19M010486
GIFtS:
48
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic su... See more...

Aliases for KEAP1 Gene

Aliases for KEAP1 Gene

  • Kelch Like ECH Associated Protein 1 2 3 5
  • Kelch-Like ECH-Associated Protein 1 3 4
  • Cytosolic Inhibitor Of Nrf2 3 4
  • Kelch-Like Family Member 19 2 3
  • Kelch-Like Protein 19 3 4
  • KLHL19 3 4
  • INrf2 3 4
  • KEAP1 Delta C 3
  • KIAA0132 4
  • INRF2 4

External Ids for KEAP1 Gene

Previous GeneCards Identifiers for KEAP1 Gene

  • GC19M010727
  • GC19M010819
  • GC19M010442
  • GC19M010457
  • GC19M010596
  • GC19M010176

Summaries for KEAP1 Gene

Entrez Gene Summary for KEAP1 Gene

  • This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KEAP1 Gene

KEAP1 (Kelch Like ECH Associated Protein 1) is a Protein Coding gene. Diseases associated with KEAP1 include Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors and Lung Papillary Adenocarcinoma. Among its related pathways are Ubiquitin mediated proteolysis and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is KLHL17.

UniProtKB/Swiss-Prot Summary for KEAP1 Gene

  • Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Gene Wiki entry for KEAP1 Gene

Additional gene information for KEAP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KEAP1 Gene

Genomics for KEAP1 Gene

GeneHancer (GH) Regulatory Elements for KEAP1 Gene

Promoters and enhancers for KEAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J010501 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +1.1 1051 3 ZNF24 ZBTB40 SP1 ZBTB6 SMARCE1 POLR2A HCFC1 MIXL1 ZNF362 MYC KEAP1 ILF3 KRI1 PPAN FBXL12 ZNF561 DNMT1 RAVER1 PRKCSH ZNF562
GH19J010118 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.6 +383.0 383012 3.9 ZNF24 SP1 ZBTB40 CTCF SIX5 RBPJ POLR2A HCFC1 MIXL1 MYC EIF3G lnc-EIF3G-1 KRI1 ZNF266 RAVER1 FBXL12 PPAN ZNF561 ZNF699 ZNF177
GH19J010478 Promoter/Enhancer 1.1 ENCODE CraniofacialAtlas 5.1 +24.2 24224 1.3 SP1 CTCF NFYC L3MBTL2 ZNF148 ZNF687 PKNOX1 ZNF740 ATF1 NRF1 piR-54764-311 PDE4A KEAP1 lnc-PDE4A-2 lnc-TIMM29-1
GH19J010411 Enhancer 0.9 FANTOM5 ENCODE 5.6 +91.2 91156 2.3 SP1 ETV6 RELA MLLT1 CREM ZBED1 IKZF1 IKZF2 PKNOX1 CBFB lnc-PDE4A-1 KEAP1 TYK2 S1PR5 ATG4D ICAM3 SHFL PDE4A CDC37 lnc-TIMM29-1
GH19J010889 Enhancer 0.9 Ensembl ENCODE dbSUPER 5 -388.0 -387961 3.4 ZNF121 SP7 PRDM1 ZIC2 PRDM10 SP2 POLR2A SCRT2 SCRT1 ZNF18 SMARCA4 ILF3-DT KEAP1 CARM1 RF00017-2810 RF00017-2811 lnc-TIMM29-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KEAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KEAP1 gene promoter:
  • AREB6
  • c-Myc
  • Egr-4
  • Max
  • Pax-4a

Genomic Locations for KEAP1 Gene

Genomic Locations for KEAP1 Gene
chr19:10,486,120-10,503,558
(GRCh38/hg38)
Size:
17,439 bases
Orientation:
Minus strand
chr19:10,596,796-10,614,417
(GRCh37/hg19)
Size:
17,622 bases
Orientation:
Minus strand

Genomic View for KEAP1 Gene

Genes around KEAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KEAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KEAP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KEAP1 Gene

Proteins for KEAP1 Gene

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  • Protein details for KEAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14145-KEAP1_HUMAN
    Recommended name:
    Kelch-like ECH-associated protein 1
    Protein Accession:
    Q14145
    Secondary Accessions:
    • B3KPD5
    • Q6LEP0
    • Q8WTX1
    • Q9BPY9

    Protein attributes for KEAP1 Gene

    Size:
    624 amino acids
    Molecular mass:
    69666 Da
    Quaternary structure:
    • Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1. Interacts with NFE2L1 and MAP1LC3B. Interacts indirectly with ENC1. Interacts with SESN1 and SESN2 (PubMed:23274085). Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
    • (Microbial infection) Interacts with ebolavirus protein VP24; this interaction activates transcription factor NRF2 by blocking its interaction with KEAP1.
    SequenceCaution:
    • Sequence=BAA09481.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KEAP1 Gene

neXtProt entry for KEAP1 Gene

Protein Expression for KEAP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KEAP1 Gene

  • Ubiquitinated by the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and is subject to proteasomal-independent degradation. Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination. Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress.
  • Ubiquitination at Lys61, Lys84, Lys108, Lys287, Lys312, and Lys615
  • Modification sites at PhosphoSitePlus

Other Protein References for KEAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KEAP1
  • Boster Bio Antibodies for KEAP1

No data available for DME Specific Peptides for KEAP1 Gene

Domains & Families for KEAP1 Gene

Gene Families for KEAP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for KEAP1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KEAP1 Gene

GenScript: Design optimal peptide antigens:
  • Kelch-like protein 19 (KEAP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14145

UniProtKB/Swiss-Prot:

KEAP1_HUMAN :
  • The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.
Domain:
  • The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.
genes like me logo Genes that share domains with KEAP1: view

Function for KEAP1 Gene

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Molecular function for KEAP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
UniProtKB/Swiss-Prot EnzymeRegulation:
Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. Sulforaphane also inhibits ubiquitination of NFE2L2/NRF2.

Phenotypes From GWAS Catalog for KEAP1 Gene

Gene Ontology (GO) - Molecular Function for KEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 16189514
GO:0008134 transcription factor binding IEA,IPI 17015834
GO:0042802 identical protein binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0097718 disordered domain specific binding IEA --
genes like me logo Genes that share ontologies with KEAP1: view
genes like me logo Genes that share phenotypes with KEAP1: view

Human Phenotype Ontology for KEAP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KEAP1

Clone Products

  • Addgene plasmids for KEAP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KEAP1 Gene

Localization for KEAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KEAP1 Gene

Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KEAP1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
endoplasmic reticulum 3
mitochondrion 2
plasma membrane 1
extracellular 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 19424503
GO:0005783 endoplasmic reticulum IEA --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with KEAP1: view

Pathways & Interactions for KEAP1 Gene

genes like me logo Genes that share pathways with KEAP1: view

Pathways by source for KEAP1 Gene

3 Qiagen pathways for KEAP1 Gene
  • Epithelial Adherens Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • Sertoli-Sertoli Cell Junction Dynamics
1 Cell Signaling Technology pathway for KEAP1 Gene

UniProtKB/Swiss-Prot Q14145-KEAP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for KEAP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for KEAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010499 proteasomal ubiquitin-independent protein catabolic process IDA 15983046
GO:0016032 viral process IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KEAP1: view

Drugs & Compounds for KEAP1 Gene

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  1. Drug

(10) Drugs for KEAP1 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dimethyl fumarate Approved, Investigational Pharma Target, binder 96
Curcumin Approved, Experimental, Investigational Pharma Tyrosinase inhibitor 195
Omaveloxolone (RTA-408) Pharma 0

(6) Additional Compounds for KEAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for KEAP1 Gene

Compound Action Cas Number
Curcumin Tyrosinase inhibitor 458-37-7
Dimethyl Fumarate 624-49-7
Omaveloxolone (RTA-408) 1474034-05-3
genes like me logo Genes that share compounds with KEAP1: view

Transcripts for KEAP1 Gene

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mRNA/cDNA for KEAP1 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(459) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KEAP1

Clone Products

  • Addgene plasmids for KEAP1

Alternative Splicing Database (ASD) splice patterns (SP) for KEAP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8: -
SP9:

Relevant External Links for KEAP1 Gene

GeneLoc Exon Structure for
KEAP1
ECgene alternative splicing isoforms for
KEAP1

Expression for KEAP1 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KEAP1 Gene

mRNA expression in normal human tissues for KEAP1 Gene
mRNA expression by BioGPS for KEAP1 GenemRNA expression by GTEx for KEAP1 Gene

mRNA differential expression in normal tissues according to GTEx for KEAP1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.9).

Protein differential expression in normal tissues from HIPED for KEAP1 Gene

This gene is overexpressed in Breast (56.9) and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KEAP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of KEAP1 Gene:

KEAP1

SOURCE GeneReport for Unigene cluster for KEAP1 Gene:

Hs.465870

mRNA Expression by UniProt/SwissProt for KEAP1 Gene:

Q14145-KEAP1_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle.

Evidence on tissue expression from TISSUES for KEAP1 Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Bone marrow(4.4)
  • Liver(3.9)
  • Lung(3.7)
  • Muscle(2.9)
  • Kidney(2.8)
  • Eye(2.7)
  • Adrenal gland(2.6)
  • Intestine(2.6)
  • Heart(2.4)
  • Pancreas(2.4)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with KEAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KEAP1 Gene

Orthologs for KEAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KEAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KEAP1 33 32
  • 99.63 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia KEAP1 33
  • 94 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia KEAP1 33 32
  • 91.51 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia KEAP1 33 32
  • 90.01 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Keap1 32
  • 86.56 (n)
mouse
(Mus musculus)
 Mammalia Keap1 17 33 32
  • 86.43 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia KEAP1 33
  • 85 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia KEAP1 33
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia keap1 32
  • 74.04 (n)
Str.5652 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.18653 32
zebrafish
(Danio rerio)
 Actinopterygii keap1b 33 32
  • 76.48 (n)
 OneToOne
keap1 32
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003645 32
  • 58.68 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Keap1 33 34 32
  • 56.64 (n)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 53 (a)
 OneToOne
Cin.4993 32
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4993 32
Species where no ortholog for KEAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KEAP1 Gene

ENSEMBL:
Gene Tree for KEAP1 (if available)
TreeFam:
Gene Tree for KEAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KEAP1: view image

Paralogs for KEAP1 Gene

Paralogs for KEAP1 Gene

(32) SIMAP similar genes for KEAP1 Gene using alignment to 7 proteins:

  • KEAP1_HUMAN
  • K7EJ49_HUMAN
  • K7EJD8_HUMAN
  • K7EMY1_HUMAN
  • K7EPZ3_HUMAN
  • K7EQX2_HUMAN
  • K7ESE0_HUMAN
genes like me logo Genes that share paralogs with KEAP1: view

Variants for KEAP1 Gene

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Sequence variations from dbSNP and Humsavar for KEAP1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1397945617 A lung adenocarcinoma cell line 10,491,812(-) C/A coding_sequence_variant, missense_variant
VAR_032102 A lung adenocarcinoma patient p.Val167Phe
VAR_032104 A lung adenocarcinoma patient p.Gln284Leu
VAR_032109 A lung adenocarcinoma patient p.Gly430Cys
VAR_036084 A breast cancer sample p.Cys23Tyr

Structural Variations from Database of Genomic Variants (DGV) for KEAP1 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897

Variation tolerance for KEAP1 Gene

Residual Variation Intolerance Score: 8.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KEAP1 Gene

Human Gene Mutation Database (HGMD)
KEAP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KEAP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KEAP1 Gene

Disorders for KEAP1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for KEAP1 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search KEAP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KEAP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KEAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KEAP1 Gene

Publications for KEAP1 Gene

  1. Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer. (PMID: 20213688) Takahashi T … Wada H (Journal of surgical oncology 2010) 3 23 43 56
  2. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. (PMID: 19424503) Wang XJ … Zhang DD (PloS one 2009) 3 4 23 56
  3. PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. (PMID: 18387606) Lo SC … Hannink M (Experimental cell research 2008) 3 4 23 56
  4. Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. (PMID: 16888629) Lo SC … Hannink M (The EMBO journal 2006) 3 4 23 56
  5. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. (PMID: 17020408) Singh A … Biswal S (PLoS medicine 2006) 3 4 23 56

ExternalLinks

View latest publications for KEAP1 gene in Mastermind

Products for KEAP1 Gene

  • Addgene plasmids for KEAP1

Sources for KEAP1 Gene