Aliases for KEAP1 Gene
Aliases for KEAP1 Gene
External Ids for KEAP1 Gene
- HGNC: 23177
- Entrez Gene: 9817
- Ensembl: ENSG00000079999
- OMIM: 606016
- UniProtKB: Q14145
Previous GeneCards Identifiers for KEAP1 Gene
- GC19M010727
- GC19M010819
- GC19M010442
- GC19M010596
- GC19M010176
Summaries for KEAP1 Gene
-
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KEAP1 Gene
KEAP1 (Kelch Like ECH Associated Protein 1) is a Protein Coding gene. Diseases associated with KEAP1 include Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors and Lung Papillary Adenocarcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Translational Control. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is KLHL20.
UniProtKB/Swiss-Prot for KEAP1 Gene
-
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Additional gene information for KEAP1 Gene
- Monarch Initiative
- Search for KEAP1 at DataMed
- Search for KEAP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KEAP1 Gene
Genomics for KEAP1 Gene
GeneHancer (GH) Regulatory Elements for KEAP1 Gene
Promoters and enhancers for KEAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KEAP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KEAP1 gene promoter:
-
- Pax-4a
- Egr-4
- AREB6
- c-Myc
- Max
Regulatory Element Products
Genomic Locations for KEAP1 Gene
Genomic Locations for KEAP1 Gene
- chr19:10,486,120-10,503,741
- (GRCh38/hg38)
- Size:
- 17,622 bases
- Orientation:
- Minus strand
- chr19:10,596,796-10,614,417
- (GRCh37/hg19)
- Size:
- 17,622 bases
- Orientation:
- Minus strand
Genomic View for KEAP1 Gene
Genes around KEAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
- 19p13.2 by Ensembl
KEAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KEAP1 Gene
Proteins for KEAP1 Gene
-
Protein details for KEAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14145-KEAP1_HUMAN
- Recommended name:
- Kelch-like ECH-associated protein 1
- Protein Accession:
- Q14145
- B3KPD5
- Q6LEP0
- Q8WTX1
- Q9BPY9
Protein attributes for KEAP1 Gene
- Size:
- 624 amino acids
- Molecular mass:
- 69666 Da
- Quaternary structure:
-
- Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1. Interacts with NFE2L1 and MAP1LC3B. Interacts indirectly with ENC1. Interacts with SESN1 and SESN2 (PubMed:23274085). Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
- SequenceCaution:
-
- Sequence=BAA09481.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for KEAP1 Gene
Post-translational modifications for KEAP1 Gene
- Ubiquitinated by the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and is subject to proteasomal-independent degradation. Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination. Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress.
- Ubiquitination at isoforms=615, Lys312, isoforms=287, isoforms=108, isoforms=84, and isoforms=61
- Modification sites at PhosphoSitePlus
Other Protein References for KEAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for KEAP1 (Keap1)
- Novus Biologicals Antibodies for KEAP1
-
Abcam antibodies for KEAP1
- Invitrogen Antibodies for KEAP1 (AFLGC-KEAP1)
- GeneTex KEAP1 Antibody for KEAP1
-
Custom Antibody ServicesProSci Antibodies for KEAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for KEAP1
- Sino Biological Antibodies for KEAP1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for KEAP1
- Origene Custom Protein Services for KEAP1
- Sino Biological Recombinant Proteins for KEAP1
- Sino Biological Cell Lysates for KEAP1
- Search GeneTex for Proteins for KEAP1
-
Abcam proteins for KEAP1
Assay Products
No data available for DME Specific Peptides for KEAP1 Gene
Domains & Families for KEAP1 Gene
Gene Families for KEAP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for KEAP1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KEAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14145UniProtKB/Swiss-Prot:
KEAP1_HUMAN :- The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.
- Domain:
-
- The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.
Function for KEAP1 Gene
Molecular function for KEAP1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. Sulforaphane also inhibits ubiquitination of NFE2L2/NRF2.
Phenotypes From GWAS Catalog for KEAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | contributes_to ubiquitin-protein transferase activity | IBA | -- |
| GO:0005515 | protein binding | IEA,IPI | 16189514 |
| GO:0008134 | transcription factor binding | IEA,IPI | 17015834 |
| GO:0042802 | identical protein binding | IEA | -- |
| GO:0042803 | protein homodimerization activity | IEA | -- |
Phenotypes for KEAP1 Gene
- MGI mutant phenotypes for KEAP1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for KEAP1:
-
- Decreased POU5F1-GFP protein expression
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Moderately decreased NFAT1-GFP nuclear translocation
- Increased cell death HMECs cells
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Lamellipodia cells
Animal Model Products
-
Taconic Biosciences Mouse Models for KEAP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for KEAP1
-
CRISPR Products
-
OriGene CRISPR knockouts for KEAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KEAP1
- genomics-online: gRNA clones - Search results for available KEAP1 gene related products
- Applied Biological Materials CRISPR for KEAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
- GenScript: Design CRISPR guide RNA sequences for KEAP1
miRNA for KEAP1 Gene
- miRTarBase miRNAs that target KEAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KEAP1
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- genomics-online: shRNA clones - Search results for available KEAP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KEAP1
- Addgene plasmids for KEAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KEAP1
- genomics-online: cdna clones - Search results for available KEAP1 gene related products
- orf clones - Search results for available KEAP1 gene related products
- Applied Biological Materials Clones for KEAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KEAP1
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KEAP1 Gene
Localization for KEAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KEAP1 Gene
- Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 3 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| peroxisome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Microtubule organizing center (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 19424503 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005815 | microtubule organizing center | IDA | -- |
Pathways & Interactions for KEAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Sertoli-Sertoli Cell Junction Dynamics | ||
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for KEAP1 Gene
3 BioSystems pathways for KEAP1 Gene
8 Reactome pathways for KEAP1 Gene
4 KEGG pathways for KEAP1 Gene
3 Qiagen pathways for KEAP1 Gene
1 Cell Signaling Technology pathway for KEAP1 Gene
UniProtKB/Swiss-Prot Q14145-KEAP1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for KEAP1 Gene
Selected Interacting proteins:
Q14145-KEAP1_HUMAN
ENSP00000171111
for KEAP1 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for KEAP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0010499 | proteasomal ubiquitin-independent protein catabolic process | IDA | 15983046 |
| GO:0016567 | protein ubiquitination | IEA | -- |
Drugs & Compounds for KEAP1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for KEAP1 Gene
mRNA/cDNA for KEAP1 Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (459) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000171111 2955 bps (uc002mor.2)
- ENST00000592478 1044 bps (uc060tio.1)
- ENST00000393623 2648 bps (uc002moq.2)
- ENST00000590237 451 bps (uc060tip.1)
- ENST00000590593 582 bps (uc060tiq.1)
Unigene Clusters for KEAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KEAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KEAP1
- genomics-online: gRNA clones - Search results for available KEAP1 gene related products
- Applied Biological Materials CRISPR for KEAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
- GenScript: Design CRISPR guide RNA sequences for KEAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KEAP1
- Browse OriGene Inhibitory RNA Products For KEAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KEAP1
- genomics-online: shRNA clones - Search results for available KEAP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KEAP1
- Addgene plasmids for KEAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KEAP1
- genomics-online: cdna clones - Search results for available KEAP1 gene related products
- orf clones - Search results for available KEAP1 gene related products
- Applied Biological Materials Clones for KEAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
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| SP9: |
Expression for KEAP1 Gene
mRNA differential expression in normal tissues according to GTEx for KEAP1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.9).
This gene is overexpressed in Breast (56.9) and Plasma (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KEAP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of KEAP1 Gene:
KEAP1SOURCE GeneReport for Unigene cluster for KEAP1 Gene:
Hs.465870mRNA Expression by UniProt/SwissProt for KEAP1 Gene:
Q14145-KEAP1_HUMAN
Tissue specificity:
Broadly expressed, with highest levels in skeletal muscle.
Evidence on tissue expression from TISSUES for KEAP1 Gene
- Nervous system(4.9)
- Skin(4.6)
- Bone marrow(4.4)
- Liver(3.9)
- Lung(3.7)
- Muscle(2.9)
- Kidney(2.8)
- Eye(2.7)
- Adrenal gland(2.6)
- Intestine(2.6)
- Heart(2.4)
- Pancreas(2.4)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for KEAP1
-
OriGene qPCR primer pairs and template standards for KEAP1
- genomics-online: primer clones - Search results for available KEAP1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KEAP1 Gene
Orthologs for KEAP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KEAP1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KEAP1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KEAP1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KEAP1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Keap1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Keap1 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KEAP1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KEAP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | keap1 33 |
|
||
| Str.5652 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18653 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | keap1b 34 33 |
|
OneToOne | |
| keap1 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003645 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Keap1 34 35 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| Cin.4993 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4993 33 |
|
- Species where no ortholog for KEAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for KEAP1 Gene
- ENSEMBL:
- Gene Tree for KEAP1 (if available)
- TreeFam:
- Gene Tree for KEAP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KEAP1: view image
Paralogs for KEAP1 Gene
Paralogs for KEAP1 Gene
(32) SIMAP similar genes for KEAP1 Gene using alignment to 7 proteins:
- KEAP1_HUMAN
- K7EJ49_HUMAN
- K7EJD8_HUMAN
- K7EMY1_HUMAN
- K7EPZ3_HUMAN
- K7EQX2_HUMAN
- K7ESE0_HUMAN
Variants for KEAP1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_032102 | A lung adenocarcinoma patient | p.Val167Phe | |||
| VAR_032104 | A lung adenocarcinoma patient | p.Gln284Leu | |||
| VAR_032108 | A lung adenocarcinoma cell line | p.Gly364Cys | |||
| VAR_032109 | A lung adenocarcinoma patient | p.Gly430Cys | |||
| VAR_036084 | A breast cancer sample | p.Cys23Tyr |
Residual Variation Intolerance Score:
8.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.90;
18.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KEAP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KEAP1 Gene
Disorders for KEAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| goiter, multinodular 1, with or without sertoli-leydig cell tumors |
|
|
| lung papillary adenocarcinoma |
|
|
| deafness, autosomal recessive 68 |
|
|
| microphthalmia, isolated 1 |
|
|
| lung squamous cell carcinoma |
|
|
Search KEAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KEAP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KEAP1 Gene
Publications for KEAP1 Gene
- Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer. (PMID: 20213688) Takahashi T … Wada H (Journal of surgical oncology 2010) 3 22 44 58
- Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. (PMID: 19424503) Wang XJ … Zhang DD (PloS one 2009) 3 4 22 58
- PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. (PMID: 18387606) Lo SC … Hannink M (Experimental cell research 2008) 3 4 22 58
- Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. (PMID: 16507366) Padmanabhan B … Yamamoto M (Molecular cell 2006) 3 4 22 58
- Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. (PMID: 16888629) Lo SC … Hannink M (The EMBO journal 2006) 3 4 22 58
Products for KEAP1 Gene
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- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for KEAP1 (AFLGC-KEAP1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for KEAP1
- Addgene plasmids for KEAP1
- antibodies-online: Search results for 164 available KEAP1 Antibodies ranked by validation data
- Compare Top KEAP1 Antibodies
- antibodies-online: Search results for 19 available KEAP1 Elisa Kits ranked by validation data
- Compare Top KEAP1 Elisa Kits
- antibodies-online: Search results for 11 available KEAP1 Proteins ranked by validation data
- Compare Top KEAP1 Proteins
- GeneTex KEAP1 Antibody for KEAP1
- Search GeneTex for Proteins for KEAP1
- Santa Cruz Biotechnology (SCBT) Antibodies for KEAP1
- Search Santa Cruz Biotechnology (SCBT) for KEAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
- Custom Antibody ServicesProSci Antibodies for KEAP1
- Search for KEAP1 Proteins at ProSci
- Horizon Cell Lines for KEAP1
- genomics-online: cdna clones - Search results for available KEAP1 gene related products
- orf clones - Search results for available KEAP1 gene related products
- genomics-online: gRNA clones - Search results for available KEAP1 gene related products
- genomics-online: primer clones - Search results for available KEAP1 gene related products
- genomics-online: shRNA clones - Search results for available KEAP1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KEAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KEAP1
- GeneCopoeia miRNA 3'UTR Target clone products for KEAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KEAP1
Sources for KEAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt