Aliases for KEAP1 Gene
Aliases for KEAP1 Gene
External Ids for KEAP1 Gene
- HGNC: 23177
- Entrez Gene: 9817
- Ensembl: ENSG00000079999
- OMIM: 606016
- UniProtKB: Q14145
Previous GeneCards Identifiers for KEAP1 Gene
- GC19M010727
- GC19M010819
- GC19M010442
- GC19M010596
- GC19M010176
Summaries for KEAP1 Gene
-
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KEAP1 Gene
KEAP1 (Kelch Like ECH Associated Protein 1) is a Protein Coding gene. Diseases associated with KEAP1 include Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors and Lung Papillary Adenocarcinoma. Among its related pathways are PAK Pathway and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is KLHL20.
UniProtKB/Swiss-Prot for KEAP1 Gene
-
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Additional gene information for KEAP1 Gene
- Monarch Initiative
- Search for KEAP1 at DataMed
- Search for KEAP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KEAP1 Gene
Genomics for KEAP1 Gene
GeneHancer (GH) Regulatory Elements for KEAP1 Gene
Promoters and enhancers for KEAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KEAP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for KEAP1 Gene
Genomic Locations for KEAP1 Gene
- chr19:10,486,120-10,503,741
- (GRCh38/hg38)
- Size:
- 17,622 bases
- Orientation:
- Minus strand
- chr19:10,596,796-10,614,417
- (GRCh37/hg19)
Genomic View for KEAP1 Gene
Genes around KEAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
KEAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KEAP1 Gene
Proteins for KEAP1 Gene
-
Protein details for KEAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14145-KEAP1_HUMAN
- Recommended name:
- Kelch-like ECH-associated protein 1
- Protein Accession:
- Q14145
- B3KPD5
- Q6LEP0
- Q8WTX1
- Q9BPY9
Protein attributes for KEAP1 Gene
- Size:
- 624 amino acids
- Molecular mass:
- 69666 Da
- Quaternary structure:
-
- Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1. Interacts with NFE2L1 and MAP1LC3B. Interacts indirectly with ENC1. Interacts with SESN1 and SESN2 (PubMed:23274085). Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).
- SequenceCaution:
-
- Sequence=BAA09481.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for KEAP1 Gene
Post-translational modifications for KEAP1 Gene
- Ubiquitinated by the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and is subject to proteasomal-independent degradation. Quinone-induced oxidative stress, but not sulforaphane, increases its ubiquitination. Ubiquitination and subsequent degradation is most pronounced following prolonged exposure of cells to oxidative stress, particularly in glutathione-deficient cells that are highly susceptible to oxidative stress.
- Ubiquitination at posLast=6161, posLast=8484, isoforms=108, isoforms=287, isoforms=312, and posLast=615615
- Modification sites at PhosphoSitePlus
Other Protein References for KEAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for KEAP1 (Keap1)
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-
Abcam antibodies for KEAP1
-
Cloud-Clone Corp. Antibodies for KEAP1
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-
Custom Antibody ServicesProSci Antibodies for KEAP1
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Santa Cruz Biotechnology (SCBT) Antibodies for KEAP1
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Protein Products
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-
Cloud-Clone Corp. Proteins for KEAP1
- Search GeneTex for Proteins for KEAP1
-
Abcam proteins for KEAP1
Assay Products
-
Cloud-Clone Corp. Assay Kits for KEAP1
No data available for DME Specific Peptides for KEAP1 Gene
Domains & Families for KEAP1 Gene
Gene Families for KEAP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for KEAP1 Gene
Suggested Antigen Peptide Sequences for KEAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14145UniProtKB/Swiss-Prot:
KEAP1_HUMAN :- The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.
- Domain:
-
- The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5.
Function for KEAP1 Gene
Molecular function for KEAP1 Gene
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Ubiquitination and subsequent degradation of PGAM5 is inhibited by oxidative stress and sulforaphane. Sulforaphane also inhibits ubiquitination of NFE2L2/NRF2.
- UniProtKB/Swiss-Prot Function:
- Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Phenotypes From GWAS Catalog for KEAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | contributes_to ubiquitin-protein transferase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008134 | transcription factor binding | IPI,IEA | 17015834 |
| GO:0042802 | identical protein binding | IEA | -- |
| GO:0042803 | protein homodimerization activity | IEA | -- |
Phenotypes for KEAP1 Gene
- MGI mutant phenotypes for KEAP1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for KEAP1:
-
- Increased vaccinia virus (VACV) infection
- Lamellipodia cells
- Dynamic nuclei (hole, folded or small irregular)
- Decreased POU5F1-GFP protein expression
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Effect on mitosis
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Weakly decreased NFAT1-GFP nuclear translocation
Animal Model Products
-
Taconic Biosciences Mouse Models for KEAP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for KEAP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for KEAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KEAP1 gene
- Search ViGene Biosciences for KEAP1
CRISPR Products
-
OriGene CRISPR knockouts for KEAP1
- genomics-online: gRNA clones - Search results for available KEAP1 gene related products
- Applied Biological Materials CRISPR for KEAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
- GenScript: Design CRISPR guide RNA sequences for KEAP1
miRNA for KEAP1 Gene
- miRTarBase miRNAs that target KEAP1
miRNA Products
- Search ViGene Biosciences for KEAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KEAP1
- Browse OriGene Inhibitory RNA Products For KEAP1
- genomics-online: shRNA clones - Search results for available KEAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KEAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for KEAP1
- VectorBuilder custom plasmid, inducible vectors for KEAP1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KEAP1
- genomics-online: cdna clones - Search results for available KEAP1 gene related products
- orf clones - Search results for available KEAP1 gene related products
- Applied Biological Materials Clones for KEAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KEAP1
-
ViGene Biosciences adenoviral particle packaged cDNA for KEAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KEAP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KEAP1 gene
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KEAP1 Gene
Localization for KEAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KEAP1 Gene
- Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 3 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| peroxisome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Microtubule organizing center (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 19424503 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005815 | microtubule organizing center | IDA | -- |
Pathways & Interactions for KEAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Sertoli-Sertoli Cell Junction Dynamics | ||
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for KEAP1 Gene
3 BioSystems pathways for KEAP1 Gene
8 Reactome pathways for KEAP1 Gene
4 KEGG pathways for KEAP1 Gene
3 Qiagen pathways for KEAP1 Gene
1 Cell Signaling Technology pathway for KEAP1 Gene
UniProtKB/Swiss-Prot Q14145-KEAP1_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for KEAP1 Gene
Selected Interacting proteins:
Q14145-KEAP1_HUMAN
ENSP00000171111
for KEAP1 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0010499 | proteasomal ubiquitin-independent protein catabolic process | IDA | 15983046 |
| GO:0016567 | protein ubiquitination | IEA | -- |
Drugs & Compounds for KEAP1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) ApexBio Compounds for KEAP1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Curcumin | Tyrosinase inhibitor | 458-37-7 |
| Dimethyl Fumarate | 624-49-7 | |
| Omaveloxolone (RTA-408) | 1474034-05-3 |
Transcripts for KEAP1 Gene
mRNA/cDNA for KEAP1 Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (459) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KEAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for KEAP1
- genomics-online: gRNA clones - Search results for available KEAP1 gene related products
- Applied Biological Materials CRISPR for KEAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
- GenScript: Design CRISPR guide RNA sequences for KEAP1
miRNA Products
- Search ViGene Biosciences for KEAP1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for KEAP1
- Browse OriGene Inhibitory RNA Products For KEAP1
- genomics-online: shRNA clones - Search results for available KEAP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KEAP1 gene
Clone Products
- Sino Biological Human cDNA Clone for KEAP1
- VectorBuilder custom plasmid, inducible vectors for KEAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KEAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KEAP1
- genomics-online: cdna clones - Search results for available KEAP1 gene related products
- orf clones - Search results for available KEAP1 gene related products
- Applied Biological Materials Clones for KEAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
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| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
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| SP9: |
Expression for KEAP1 Gene
mRNA differential expression in normal tissues according to GTEx for KEAP1 Gene
This gene is overexpressed in Muscle - Skeletal (x4.9).
This gene is overexpressed in Breast (56.9) and Plasma (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KEAP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of KEAP1 Gene:
KEAP1SOURCE GeneReport for Unigene cluster for KEAP1 Gene:
Hs.465870mRNA Expression by UniProt/SwissProt for KEAP1 Gene:
Q14145-KEAP1_HUMAN
Tissue specificity:
Broadly expressed, with highest levels in skeletal muscle.
Evidence on tissue expression from TISSUES for KEAP1 Gene
- Nervous system(4.9)
- Skin(4.6)
- Bone marrow(4.4)
- Liver(3.9)
- Lung(3.6)
- Kidney(2.8)
- Muscle(2.8)
- Eye(2.7)
- Intestine(2.6)
- Adrenal gland(2.5)
- Pancreas(2.4)
- Heart(2.3)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for KEAP1
-
OriGene qPCR primer pairs and template standards for KEAP1
- genomics-online: primer clones - Search results for available KEAP1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KEAP1 Gene
Orthologs for KEAP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KEAP1 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KEAP1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KEAP1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | KEAP1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Keap1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Keap1 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KEAP1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KEAP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | keap1 33 |
|
||
| Str.5652 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18653 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | keap1b 33 34 |
|
||
| keap1 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003645 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Keap1 35 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4993 33 |
|
- Species where no ortholog for KEAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KEAP1 Gene
Paralogs for KEAP1 Gene
(32) SIMAP similar genes for KEAP1 Gene using alignment to 7 proteins:
Variants for KEAP1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_032102 | A lung adenocarcinoma patient | p.Val167Phe | |||
| VAR_032104 | A lung adenocarcinoma patient | p.Gln284Leu | |||
| VAR_032108 | A lung adenocarcinoma cell line | p.Gly364Cys | |||
| VAR_032109 | A lung adenocarcinoma patient | p.Gly430Cys | |||
| VAR_036084 | A breast cancer sample | p.Cys23Tyr |
Residual Variation Intolerance Score:
8.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.90;
18.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KEAP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KEAP1 Gene
Disorders for KEAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| goiter, multinodular 1, with or without sertoli-leydig cell tumors |
|
|
| lung papillary adenocarcinoma |
|
|
| deafness, autosomal recessive 68 |
|
|
| lung squamous cell carcinoma |
|
|
| microphthalmia, isolated 1 |
|
|
Search KEAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KEAP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KEAP1 Gene
Publications for KEAP1 Gene
- Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer. (PMID: 20213688) Takahashi T … Wada H (Journal of surgical oncology 2010) 3 22 44 58
- Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. (PMID: 19424503) Wang XJ … Zhang DD (PloS one 2009) 3 4 22 58
- PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. (PMID: 18387606) Lo SC … Hannink M (Experimental cell research 2008) 3 4 22 58
- Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. (PMID: 16507366) Padmanabhan B … Yamamoto M (Molecular cell 2006) 3 4 22 58
- Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. (PMID: 16888629) Lo SC … Hannink M (The EMBO journal 2006) 3 4 22 58
Products for KEAP1 Gene
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- Cloud-Clone Corp. Antibodies for KEAP1
- Cloud-Clone Corp. Proteins for KEAP1
- Cloud-Clone Corp. Assay Kits for KEAP1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for KEAP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for KEAP1
- ApexBio compounds for KEAP1
- Cyagen custom Knockout/knockin (KOKI) mouse models for KEAP1
- VectorBuilder custom plasmid, inducible vectors for KEAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KEAP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KEAP1
- antibodies-online: Search results for 164 available KEAP1 Antibodies ranked by validation data
- Compare Top KEAP1 Antibodies
- antibodies-online: Search results for 19 available KEAP1 Elisa Kits ranked by validation data
- Compare Top KEAP1 Elisa Kits
- antibodies-online: Search results for 11 available KEAP1 Proteins ranked by validation data
- Compare Top KEAP1 Proteins
- GeneTex KEAP1 antibody for KEAP1
- Search GeneTex for Proteins for KEAP1
- ViGene Biosciences adenoviral particle packaged cDNA for KEAP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KEAP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KEAP1 gene
- Search ViGene Biosciences for KEAP1
- Santa Cruz Biotechnology (SCBT) Antibodies for KEAP1
- Search Santa Cruz Biotechnology (SCBT) for KEAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KEAP1
- Custom Antibody ServicesProSci Antibodies for KEAP1
- Search for KEAP1 Proteins at ProSci
- Horizon Cell Lines for KEAP1
- genomics-online: cdna clones - Search results for available KEAP1 gene related products
- orf clones - Search results for available KEAP1 gene related products
- genomics-online: gRNA clones - Search results for available KEAP1 gene related products
- genomics-online: primer clones - Search results for available KEAP1 gene related products
- genomics-online: shRNA clones - Search results for available KEAP1 gene related products
Sources for KEAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
