KDR Gene (Protein Coding)

Kinase Insert Domain Receptor

GC04M055078
GIFtS:
54
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The ... See more...

Aliases for KDR Gene

Aliases for KDR Gene

  • Kinase Insert Domain Receptor 2 3 4 5
  • Vascular Endothelial Growth Factor Receptor 2 2 3 4
  • VEGFR2 2 3 4
  • FLK1 2 3 4
  • Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase) 2 3
  • Protein-Tyrosine Kinase Receptor Flk-1 3 4
  • Fetal Liver Kinase 1 2 4
  • EC 2.7.10.1 4 50
  • CD309 2 3
  • VEGFR 2 3
  • Tyrosine Kinase Growth Factor Receptor 3
  • Fetal Liver Kinase-1 3
  • Soluble VEGFR2 3
  • CD309 Antigen 4
  • EC 2.7.10 50
  • VEGFR-2 4
  • FLK-1 4
  • KDR 5

External Ids for KDR Gene

Previous GeneCards Identifiers for KDR Gene

  • GC04M055748
  • GC04M055906
  • GC04M055860
  • GC04M055785
  • GC04M055639
  • GC04M055944
  • GC04M051893

Summaries for KDR Gene

Entrez Gene Summary for KDR Gene

  • Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

CIViC Summary for KDR Gene

GeneCards Summary for KDR Gene

KDR (Kinase Insert Domain Receptor) is a Protein Coding gene. Diseases associated with KDR include Hemangioma, Capillary Infantile and Hemangioma. Among its related pathways are Notch-mediated HES/HEY network and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FLT1.

UniProtKB/Swiss-Prot Summary for KDR Gene

  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

Gene Wiki entry for KDR Gene

Additional gene information for KDR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KDR Gene

Genomics for KDR Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for KDR Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J055123 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +1.8 1794 5.2 POLR2A FOXA1 ETS1 SIN3A FOXA2 KLF9 RARA SPI1 TAF1 GLIS1 KDR SRD5A3 lnc-KDR-3-001 lnc-KDR-3-002 piR-57460-521 KIT
GH04J055183 Enhancer 0.8 ENCODE dbSUPER 61.1 -59.9 -59921 4.8 JUND REST CTCF SIN3A SMC3 YY1 RAD21 ZNF143 ZNF644 ATF3 KDR HSALNG0034522 lnc-SRD5A3-6 lnc-KDR-5 HSALNG0034517 SRD5A3
GH04J055169 Enhancer 0.7 Ensembl ENCODE 55.6 -44.1 -44112 1 NFE2 CTCF FOXA1 MAFG MNT PKNOX1 EMSY piR-55361-412 KDR piR-43105-492 HSALNG0034517 SRD5A3
GH04J055175 Enhancer 0.6 ENCODE dbSUPER 50.9 -50.4 -50430 1.9 GABPA JUND SPI1 ETV1 GABPB1 FOS HSALNG0034522 lnc-SRD5A3-6 piR-43105-492 KDR HSALNG0034517 SRD5A3
GH04J055172 Enhancer 0.7 FANTOM5 ENCODE dbSUPER 40.4 -47.4 -47365 0.3 JUND NR2F2 EP300 piR-43105-492 KDR piR-55361-412 HSALNG0034517 SRD5A3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KDR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KDR

Top Transcription factor binding sites by QIAGEN in the KDR gene promoter:
  • AML1a

Genomic Locations for KDR Gene

Latest Assembly
chr4:55,078,481-55,125,595
(GRCh38/hg38)
Size:
47,115 bases
Orientation:
Minus strand

Previous Assembly
chr4:55,944,648-55,991,762
(GRCh37/hg19 by Entrez Gene)
Size:
47,115 bases
Orientation:
Minus strand

chr4:55,944,644-55,991,756
(GRCh37/hg19 by Ensembl)
Size:
47,113 bases
Orientation:
Minus strand

Genomic View for KDR Gene

Genes around KDR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDR Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KDR Gene

Proteins for KDR Gene

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  • Protein details for KDR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35968-VGFR2_HUMAN
    Recommended name:
    Vascular endothelial growth factor receptor 2
    Protein Accession:
    P35968
    Secondary Accessions:
    • A2RRS0
    • B5A925
    • C5IFA0
    • O60723
    • Q14178

    Protein attributes for KDR Gene

    Size:
    1356 amino acids
    Molecular mass:
    151527 Da
    Quaternary structure:
    • Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD ligands; monomeric in the absence of bound ligands. Can also form heterodimers with FLT1/VEGFR1 and KDR/VEGFR2. Interacts (tyrosine phosphorylated) with LFYN, NCK1, PLCG1. Interacts (tyrosine-phosphorylated active form preferentially) with DAB2IP (via C2 domain and active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity. Interacts with SHBSH2D2A/TSAD, GRB2, MYOF, CBL and PDCD6. Interacts (via C-terminus domain) with ERN1 (via kinase domain); the interaction is facilitated in a XBP1 isoform 1- and vascular endothelial growth factor (VEGF)-dependent manner in endothelial cells (PubMed:23529610). Interacts (via juxtamembrane region) with chaperone PDCL3 (via thioredoxin fold region); the interaction leads to increased KDR/VEGFR2 abundance through inhibition of its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Interacts (tyrosine phosphorylated) with CCDC88A/GIV (via SH2-like region); binding requires autophosphorylation of the KDR/VEGFR2 C-terminal region (PubMed:25187647). Interacts with isoform 2 of BSG (PubMed:25825981).
    • (Microbial infection) Interacts with HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for KDR Gene

    Alternative splice isoforms for KDR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDR Gene

Protein Expression for KDR Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for KDR Gene

P35968:
  • GTRMRAP
  • KMLKEGAT
  • GMEFLASRKCIHRDLAARNILLS
  • RLPLKWMAPE
  • RDLAARN
  • VAVKMLK
  • HLNVVNLLGACTK
  • YAGMVFCEAKI
  • ALMSELK
  • WEIFSLG
  • KTGYLSI
  • KICDFGLARD
  • DSGMVLASEE
  • LVEHLGNLLQA
  • FSLGASPYP
  • GNLENQTT
  • SNQTSGYQSGYHSDD
  • SRKCIHRDLAARNILLSE
  • GPLMVIVE
  • SKRKSRPVSVKTFEDIPL
  • MEEDSGLSLPTSP
  • WEFPRDRL
  • SLSDVEEE
  • RLDSITSSQSS
  • TLQITCRG
  • PDYVRKG
  • DFGLARDI
  • VVGYRIYD
  • CYSFQVA

Post-translational modifications for KDR Gene

  • N-glycosylated.
  • Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation via the proteasome or lysosomal proteases.
  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-951 is important for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton. Phosphorylation at Tyr-1175 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1214 is important for interaction with NCK1 and FYN. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214.
  • The inhibitory disulfide bond between Cys-1024 and Cys-1045 may serve as a specific molecular switch for H(2)S-induced modification that regulates KDR/VEGFR2 function.
  • Glycosylation at Asn46, Asn66, Asn96, Asn143, Asn158, Asn245, Asn318, Asn374, Asn395, Asn511, Asn523, Asn580, Asn613, Asn619, Asn631, Asn675, Asn704, and Asn721
  • Modification sites at PhosphoSitePlus

Other Protein References for KDR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for KDR Gene

Gene Families for KDR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for KDR Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin V-set
  • Receptor tyrosine kinase, class III
  • Tyrosine protein kinase, active site
  • Vascular endothelial growth factor receptor signature

Suggested Antigen Peptide Sequences for KDR Gene

GenScript: Design optimal peptide antigens:
  • Kinase insert domain receptor (A type III receptor tyrosine kinase) (A2RRS0_HUMAN)
  • Soluble VEGFR2 (B5A925_HUMAN)
  • Protein-tyrosine kinase receptor flk-1 (VGFR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35968

UniProtKB/Swiss-Prot:

VGFR2_HUMAN :
  • The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Domain:
  • The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with KDR: view

Function for KDR Gene

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  6. Cell Lines for research

Molecular function for KDR Gene

UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:10037737, ECO:0000269|PubMed:10102632};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by the small molecule PTK inhibitor SU5614 ((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one). May be regulated by hydrogen sulfide (H(2)S) levels via a H(2)S-sensitive intracellular disulfide bond.
GENATLAS Biochemistry:
vascular endothelial growth factor receptor,expressed on the surface of endothelial cells,activated by VEGF in cooperation with integrin alpha V (ITGAV) beta 3 (ITGB3),involved in angiogenesis,also regulating the migration of early mesodermally derived precursors into a microenvironnement that is permissive for hematopoiesis (marker defining hematopoietic stem cells)

Enzyme Numbers (IUBMB) for KDR Gene

Phenotypes From GWAS Catalog for KDR Gene

Gene Ontology (GO) - Molecular Function for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity EXP,IDA 10037737
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 1417831
GO:0005021 vascular endothelial growth factor-activated receptor activity IDA 1417831
genes like me logo Genes that share ontologies with KDR: view

Phenotypes for KDR Gene

MGI mutant phenotypes for KDR:
inferred from 17 alleles
GenomeRNAi human phenotypes for KDR:
genes like me logo Genes that share phenotypes with KDR: view

Human Phenotype Ontology for KDR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KDR Gene

MGI Knock Outs for KDR:
  • Kdr Kdr<tm1Jrt>
  • Kdr Kdr<tm2.1Jrt>
  • Kdr Kdr<tm1.1Eia>
  • Kdr Kdr<tm1.2Jamb>
  • Kdr Kdr<tm1.1Jrt>
  • Kdr Kdr<tm3.1Jrt>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDR

No data available for Transcription Factor Targets and HOMER Transcription for KDR Gene

Localization for KDR Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDR Gene

Cell junction. Endoplasmic reticulum. Cell membrane. Note=Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000250, ECO:0000269 PubMed:23529610}.
[Isoform 1]: Cell membrane. Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.
[Isoform 2]: Secreted.
[Isoform 3]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KDR gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
cytoskeleton 3
cytosol 3
mitochondrion 2
peroxisome 2
lysosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA,IDA 23262137
GO:0005769 early endosome ISS --
genes like me logo Genes that share ontologies with KDR: view

Pathways & Interactions for KDR Gene

PathCards logo

SuperPathways for KDR Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Nuclear Receptor Activation by Vitamin-A
.57
2 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
3 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
4 Nanog in Mammalian ESC Pluripotency
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
5 CREB Pathway
CREB Pathway
.68
IP3 Pathway
.68
Activation of PKC through GPCR
.63
Intracellular Calcium Signaling
.50
genes like me logo Genes that share pathways with KDR: view

Pathways by source for KDR Gene

6 GeneGo (Thomson Reuters) pathways for KDR Gene
  • Cell adhesion_Plasmin signaling
  • Cytoskeleton remodeling FAK signaling
  • Development VEGF signaling and activation
  • Development VEGF signaling via VEGFR2 - generic cascades
  • Development VEGF-family signaling
59 Qiagen pathways for KDR Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
2 Cell Signaling Technology pathways for KDR Gene

SIGNOR curated interactions for KDR Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 10022831
GO:0001569 branching involved in blood vessel morphogenesis IMP 23688497
GO:0001570 vasculogenesis ISS --
GO:0001934 positive regulation of protein phosphorylation IDA 19033661
GO:0001938 positive regulation of endothelial cell proliferation IMP 10022831
genes like me logo Genes that share ontologies with KDR: view

Drugs & Compounds for KDR Gene

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  1. Drug products for research

(192) Drugs for KDR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sorafenib Approved, Investigational Pharma Target, antagonist, inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 801
Sunitinib Approved, Investigational Pharma Target, inhibitor VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 556
Pazopanib Approved Pharma Target, inhibitor VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
regorafenib Approved Pharma Target, inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Axitinib Approved, Investigational Pharma Target, inhibitor, Inhibition Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 161

(33) Additional Compounds for KDR Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0

(57) ApexBio Compounds for KDR Gene

Compound Action Cas Number
(E)-FeCP-oxindole 884338-18-5
(Z)-FeCP-oxindole 1137967-28-2
AEE788 (NVP-AEE788) EGFR/HER-2/VEGFR inhibitor 497839-62-0
Apatinib VEGFR2 inhibitor, orally bioavailable, selective 811803-05-1
Axitinib (AG 013736) VEGFR1/ c-Kit inhibitor 319460-85-0
AZD2932 inhibitor of VEGFR-2, PDGFRβ, Flt-3, and c-Kit 883986-34-3
BMS-794833 Met/VEGFR-2 inhibitor,potent and ATP-competitive 1174046-72-0
Brivanib (BMS-540215) VEGFR-2 inhibitor,ATP-competitive 649735-46-6
Brivanib Alaninate (BMS-582664) VEGFR2 inhibitor,ATP-competitive 649735-63-7
Cabozantinib (XL184, BMS-907351) VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor 849217-68-1
Cabozantinib malate (XL184) MET andVEGF receptor2 inhibitor 1140909-48-3
Cediranib (AZD217) VEGFR inhibitor receptor,highly potent 288383-20-0
DMH4 515880-75-8
Dovitinib (TKI258) Lactate Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR) 915769-50-5
Dovitinib Dilactic acid 852433-84-2
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor 849217-64-7
Fruquintinib(HMPL-013) Potent and selective inhibitor of VEGFR 1, 2, 3 1194506-26-7
Golvatinib (E7050) C-Met/VEGFR-2 inhibitor 928037-13-2
Ki8751 VEGFR-2 inhibitor,potent and selective 228559-41-9
KRN 633 VEGFR inhibitor,ATP-competitive 286370-15-8
Lenvatinib (E7080) VEGFR inhibitor 417716-92-8
Linifanib (ABT-869) VEGFR/PDGFR inhibitor 796967-16-3
MGCD-265 Met/Flt/Flk/Ron/Tie-2 inhibitor 875337-44-3
Motesanib Diphosphate (AMG-706) VEGFR/ PDGFR/c-Kit/Ret inhibitor 857876-30-3
Nintedanib (BIBF 1120) VEGFR/PDGFR/FGFR inhibitor 928326-83-4
OSI-930 Inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck 728033-96-3
Pazopanib (GW-786034) VEGFR/PDGFR/FGFR inhibitor 635702-64-6
Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor 635702-64-6
PD 173074 FGFR inhibitor 219580-11-7
PF-477736 Chk1 inhibitor 952021-60-2
PP121 Dual inhibitor of tyrosine and phosphoinositide kinases 1092788-83-4
RAF265 Multiple intracellular kinases inhibitor 927880-90-8
Regorafenib Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1 755037-03-7
Regorafenib monohydrate Tyrosine kinase inhibitor 1019206-88-2
Semaxanib (SU5416) VEGFR(Flk-1/KDR) inhibitor 194413-58-6
SKLB1002 VEGFR2 inhibitor,potent and ATP-competitve 1225451-84-2
SKLB610 Potent VEGFR inhibitor 1125780-41-7
Sorafenib Raf kinases and tyrosine kinases inhibitor 284461-73-0
Sorafenib Tosylate Raf kinases and tyrosine kinases inhibitor 475207-59-1
SU 4312 5812-07-7
SU 5402 VEGFR2/FGFR/PDGFR/EGFR inhibitor 215543-92-3
SU14813 Tyrosine kinase inhibitor 627908-92-3
SU14813 maleate VEGFR/PDGFR/Kit/FLT-3 inhibitor 849643-15-8
SU5416 VEGF receptor inhibitor and AHR agonist 204005-46-9
Sunitinib RTK inhibitor 557795-19-4
Sunitinib malate VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor 341031-54-7
TAK-593 VEGFR2 inhibitor 1005780-62-0
Telatinib (BAY 57-9352) VEGFR-2/-3,PDGFR-β and c-Kit inhibitor 332012-40-5
TG 100801 Multi-kinase inhibitor 867331-82-6
Tivozanib (AV-951) VEGFR inhibitor,potent and selective 475108-18-0
TSU-68 (SU6668,Orantinib) PDGFR/Flk-1/FGFR1 inhibitor,potent and competitive 252916-29-3
Vandetanib (ZD6474) VEGFR2/EGFR antagonist 443913-73-3
Vandetanib hydrochloride VEGFR/EGFR inhibitor 524722-52-9
Vatalanib VEGFR-1/-2 inhibitor,cell-permeable 212141-54-3
Vatalanib (PTK787) 2HCl Tyrosine kinase receptor inhibitor 212141-51-0
ZM 306416 VEGFR (Flt and KDR) inhibitor 690206-97-4
ZM323881 VEGFR-2/KDR inhibitor,potent and selective 193001-14-8
genes like me logo Genes that share compounds with KDR: view

Transcripts for KDR Gene

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mRNA/cDNA for KDR Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDR

Alternative Splicing Database (ASD) splice patterns (SP) for KDR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
SP1:
SP2:
SP3:

Relevant External Links for KDR Gene

GeneLoc Exon Structure for
KDR

Expression for KDR Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KDR Gene

mRNA expression in normal human tissues for KDR Gene
mRNA expression by BioGPS for KDR GenemRNA expression by GTEx for KDR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KDR Gene

This gene is overexpressed in Uterus (x4.4) and Adipose - Visceral (Omentum) (x4.1).

Protein differential expression in normal tissues from HIPED for KDR Gene

This gene is overexpressed in Heart (25.4), Placenta (14.9), Lymph node (13.5), and Brain (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KDR Gene



Protein tissue co-expression partners for KDR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KDR

SOURCE GeneReport for Unigene cluster for KDR Gene:

Hs.479756

mRNA Expression by UniProt/SwissProt for KDR Gene:

P35968-VGFR2_HUMAN
Tissue specificity: Detected in cornea (at protein level). Widely expressed.

Evidence on tissue expression from TISSUES for KDR Gene

  • Heart(3.7)
  • Nervous system(3.6)
  • Blood(3.2)
  • Liver(3.2)
  • Kidney(3.2)
  • Muscle(3.1)
  • Lung(3)
  • Eye(3)
  • Intestine(2.8)
  • Skin(2.8)
  • Spleen(2.8)
  • Thyroid gland(2.8)
  • Bone marrow(2.7)
  • Lymph node(2.7)
  • Pancreas(2.6)
  • Bone(2.3)
  • Stomach(2.3)
  • Adrenal gland(2.2)
  • Gall bladder(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KDR Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
Regions:
General:
  • blood vessel
genes like me logo Genes that share expression patterns with KDR: view

Primer products for research

Orthologs for KDR Gene

This gene was present in the common ancestor of animals.

Orthologs for KDR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia KDR 29 30
  • 99.75 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia KDR 29 30
  • 91.39 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia KDR 29 30
  • 89.72 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Kdr 29
  • 85.55 (n)
Mouse
(Mus musculus)
 Mammalia Kdr 29 16 30
  • 85.46 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia KDR 30
  • 82 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia KDR 30
  • 74 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves KDR 29 30
  • 72.17 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia KDR 30
  • 70 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia kdr 29
  • 65.84 (n)
African clawed frog
(Xenopus laevis)
 Amphibia kdr-A-prov 29
Zebrafish
(Danio rerio)
 Actinopterygii kdr 29 30
  • 58.06 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta tor 31
  • 45 (a)
Cad96Ca 30
  • 27 (a)
 ManyToMany
Pvr 30
  • 21 (a)
 ManyToMany
Worm
(Caenorhabditis elegans)
 Secernentea R09D1.12 31
  • 30 (a)
ver-3 31
  • 28 (a)
ver-2 31
  • 27 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 35 (a)
 OneToMany
Species where no ortholog for KDR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KDR Gene

ENSEMBL:
Gene Tree for KDR (if available)
TreeFam:
Gene Tree for KDR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KDR: view image
Alliance of Genome Resources:
Additional Orthologs for KDR

Paralogs for KDR Gene

Paralogs for KDR Gene

(4) SIMAP similar genes for KDR Gene using alignment to 1 proteins:

  • VGFR2_HUMAN
genes like me logo Genes that share paralogs with KDR: view

Variants for KDR Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KDR Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
932462 Uncertain Significance: not provided 55,102,484(-) C/T
NM_002253.3(KDR):c.2012G>A (p.Gly671Glu) 		MISSENSE
rs1037612393 Uncertain Significance: not provided 55,094,799(-) T/C
NM_002253.3(KDR):c.2971+3A>G 		INTRON
rs1057524286 Uncertain Significance: not provided 55,101,896(-) C/A
NM_002253.3(KDR):c.2266+1G>T 		SPLICE_DONOR
rs113121239 Benign: not specified; not provided 55,110,542(-) C/G
NM_002253.3(KDR):c.1116G>C (p.Glu372Asp) 		MISSENSE
rs121917766 Pathogenic: Hemangioma, capillary infantile; not specified. Hemangioma, capillary infantile (HCI) [MIM:602089] 55,088,939(-) G/Ap.Pro1147Ser
NM_002253.3(KDR):c.3439C>T (p.Pro1147Ser) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KDR Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KDR Gene

Variant ID Type Subtype PubMed ID
esv3569428 CNV loss 25503493
esv3569429 CNV loss 25503493
nsv526344 CNV gain 19592680
nsv829939 CNV gain 17160897

Variation tolerance for KDR Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KDR Gene

Human Gene Mutation Database (HGMD)
KDR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KDR
Leiden Open Variation Database (LOVD)
KDR

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDR Gene

Disorders for KDR Gene

MalaCards: The human disease database

(135) MalaCards diseases for KDR Gene - From: OMI, CVR, GTR, SWI, COP, and GCD

Disorder Aliases PubMed IDs
hemangioma, capillary infantile
  • hci
hemangioma
  • hemangiomas
cervical adenosquamous carcinoma
  • adenosquamous carcinoma of cervix
vascular cancer
  • blood vessel neoplasm
corneal neovascularization
- elite association - COSMIC cancer census association via MalaCards
Search KDR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VGFR2_HUMAN
  • Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. {ECO:0000269 PubMed:11807987, ECO:0000269 PubMed:17344846, ECO:0000269 PubMed:18931684}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
  • Note=Plays a major role in tumor angiogenesis. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Additional Disease Information for KDR

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KDR: view

No data available for Genatlas for KDR Gene

Publications for KDR Gene

  1. Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. (PMID: 11807987) Walter JW … Marchuk DA (Genes, chromosomes & cancer 2002) 3 4 22 72
  2. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. (PMID: 1417831) Terman BI … Böhlen P (Biochemical and biophysical research communications 1992) 2 3 4 22
  3. Structural determinants of growth factor binding and specificity by VEGF receptor 2. (PMID: 20145116) Leppänen VM … Alitalo K (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 22
  4. Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling. (PMID: 20080685) Yang Y … Schlessinger J (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 22
  5. Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head. (PMID: 20215856) Hong JM … Kim SY (Experimental & molecular medicine 2010) 3 22 40

ExternalLinks

View latest publications for KDR gene in Mastermind

Products for KDR Gene