This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009] See more...

Aliases for KDM8 Gene

Aliases for KDM8 Gene

  • Lysine Demethylase 8 2 3 5
  • Bifunctional Peptidase And Arginyl-Hydroxylase JMJD5 3 4
  • Jumonji C Domain-Containing Protein 5 3 4
  • Lysine (K)-Specific Demethylase 8 2 3
  • L-Arginine (3R)-Hydroxylase KDM8 3 4
  • JmjC Domain-Containing Protein 5 3 4
  • Jumonji Domain Containing 5 2 3
  • JmjC Arginyl-Hydroxylase 2 3
  • JMJD5 3 4
  • Jumonji Domain-Containing Protein 5 3
  • Lysine-Specific Demethylase 8 3
  • Arginyl C3-Hydroxylase KDM8 3
  • EC 1.14.11.- 4
  • EC 3.4.-.- 4
  • FLJ13798 2
  • KDM8 5

External Ids for KDM8 Gene

Previous HGNC Symbols for KDM8 Gene

  • JMJD5

Summaries for KDM8 Gene

Entrez Gene Summary for KDM8 Gene

  • This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

GeneCards Summary for KDM8 Gene

KDM8 (Lysine Demethylase 8) is a Protein Coding gene. Diseases associated with KDM8 include Glycogen Storage Disease Xv and Familial Isolated Hypoparathyroidism. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is HSPBAP1.

UniProtKB/Swiss-Prot Summary for KDM8 Gene

  • Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29459673, PubMed:28982940, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:29459673, PubMed:28982940). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KDM8 Gene

Genomics for KDM8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KDM8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J027202 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 607.4 +0.5 507 2.2 SP1 CREB1 GATAD2A PRDM10 ZNF629 TFE3 RFX1 IKZF1 NFKBIZ ZNF692 KDM8 lnc-NSMCE1-12 ENSG00000259940 NSMCE1
GH16J027211 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 600.4 +9.9 9914 4.4 GATAD2A REST ZSCAN4 RXRB IRF2 SP1 FOXA2 TGIF2 ATF3 YY1 ENSG00000259940 KDM8 NSMCE1-DT lnc-NSMCE1-12 NSMCE1
GH16J027169 Enhancer 1.2 FANTOM5 Ensembl ENCODE 20.2 -31.3 -31265 8 CREB1 ATF7 KDM1A CTCF JUND FOXA1 ZIC2 HDAC1 CTBP1 RUNX3 KDM8 IL21R KATNIP LINC02129 lnc-KDM8-4 RF00017-2028 C16orf82
GH16J027221 Enhancer 0.9 Ensembl ENCODE dbSUPER 21.3 +21.0 20963 6.5 ZIC2 SP1 ZBTB20 CTCF RCOR1 NR2F2 POLR2A RAD21 HNF4A RXRA KDM8 ENSG00000259940 NSMCE1 lnc-GTF3C1-5
GH16J027267 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.4 +65.4 65416 3.1 SP1 HNRNPL CREB1 GATAD2A ZNF629 PRDM10 TFE3 NFKBIZ ZNF692 POLR2A NSMCE1 NSMCE1-DT lnc-GTF3C1-4 IL4R KDM8 ENSG00000259940 FJ601684-149
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KDM8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KDM8

Genomic Locations for KDM8 Gene

Genomic Locations for KDM8 Gene
chr16:27,203,486-27,222,305
(GRCh38/hg38)
Size:
18,820 bases
Orientation:
Plus strand
chr16:27,214,807-27,233,089
(GRCh37/hg19)
Size:
18,283 bases
Orientation:
Plus strand

Genomic View for KDM8 Gene

Genes around KDM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM8 Gene

Proteins for KDM8 Gene

  • Protein details for KDM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N371-KDM8_HUMAN
    Recommended name:
    Bifunctional peptidase and arginyl-hydroxylase JMJD5
    Protein Accession:
    Q8N371
    Secondary Accessions:
    • B4DLU9
    • Q6VAK5
    • Q9H8B1

    Protein attributes for KDM8 Gene

    Size:
    416 amino acids
    Molecular mass:
    47270 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Can form homodimers (via JmjC domain) (PubMed:24100311, PubMed:28982940). Found in a complex with RCCD1 (PubMed:24981860). Interacts (via N-terminus) with RCCD1 (via N-terminus); this interaction stimulates H3K36me3 and H3K36me2 demethylation (PubMed:28455245, PubMed:24981860). Interacts (via JmjC domain) with H3C1 (PubMed:28982940). Interacts with FBXL3 and PSMD2 (By similarity). Interacts with CRY1 in a FBXL3-dependent manner (By similarity).

    Three dimensional structures from OCA and Proteopedia for KDM8 Gene

    Alternative splice isoforms for KDM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDM8 Gene

Post-translational modifications for KDM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for KDM8
  • Boster Bio Antibodies for KDM8

No data available for DME Specific Peptides for KDM8 Gene

Domains & Families for KDM8 Gene

Gene Families for KDM8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for KDM8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KDM8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61151 (B4DPM6_HUMAN)
  • Jumonji domain-containing protein 5 (KDM8_HUMAN)
genes like me logo Genes that share domains with KDM8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KDM8 Gene

Function for KDM8 Gene

Molecular function for KDM8 Gene

UniProtKB/Swiss-Prot Function:
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961, PubMed:29459673, PubMed:28982940, PubMed:29563586). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:29459673, PubMed:28982940). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionnally, acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition (PubMed:24740926). Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation (PubMed:20457893). Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (PubMed:28455245). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a catalytically-independent manner (PubMed:30500822). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (PubMed:30500822).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate; Xref=Rhea:RHEA:56744, Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:14712, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29965, ChEBI:CHEBI:30031, ChEBI:CHEBI:78294; Evidence={ECO:0000269|PubMed:29563586};.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon starvation, DNA replication stress, UV treatment and by camptothecin and etoposide treatment.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=60.4 uM for ARG-137 of RPS6 {ECO:0000269|PubMed:29563586}; Note=KM>300 uM for ARG-141 of RCCD1. {ECO:0000269|PubMed:29563586};

Enzyme Numbers (IUBMB) for KDM8 Gene

Phenotypes From GWAS Catalog for KDM8 Gene

Gene Ontology (GO) - Molecular Function for KDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 20457893
GO:0004175 endopeptidase activity IDA 28847961
GO:0004177 aminopeptidase activity IEA,IDA 28847961
GO:0008233 peptidase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with KDM8: view
genes like me logo Genes that share phenotypes with KDM8: view

Animal Models for KDM8 Gene

MGI Knock Outs for KDM8:
  • Kdm8 Kdm8<tm1a(EUCOMM)Wtsi>
  • Kdm8 Kdm8<tm1.2Tasu>
  • Kdm8 Kdm8<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for KDM8 Gene

miRTarBase miRNAs that target KDM8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDM8

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KDM8 Gene

Localization for KDM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM8 Gene

Nucleus. Chromosome. Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000269 PubMed:24981860}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KDM8 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 20457893
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with KDM8: view

Pathways & Interactions for KDM8 Gene

genes like me logo Genes that share pathways with KDM8: view

Pathways by source for KDM8 Gene

Gene Ontology (GO) - Biological Process for KDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 20457893
GO:0006325 chromatin organization IEA --
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
GO:0031648 protein destabilization IMP 30500822
genes like me logo Genes that share ontologies with KDM8: view

No data available for SIGNOR curated interactions for KDM8 Gene

Drugs & Compounds for KDM8 Gene

(4) Drugs for KDM8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Formaldehyde Approved, Vet_approved Pharma 142
Oxygen Approved, Vet_approved Pharma 0
Succinic acid Approved Nutra Agonist, Full agonist 0
Oxogluric acid Experimental, Investigational Nutra 0
genes like me logo Genes that share compounds with KDM8: view

Transcripts for KDM8 Gene

mRNA/cDNA for KDM8 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDM8

Alternative Splicing Database (ASD) splice patterns (SP) for KDM8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ·
SP1: -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6:
SP7: - -
SP8: -
SP9: - - - - - - -
SP10: - - - - - - - - - - - -

ExUns: 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for KDM8 Gene

GeneLoc Exon Structure for
KDM8

Expression for KDM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KDM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for KDM8 Gene

This gene is overexpressed in Liver (x15.6).

Protein differential expression in normal tissues from HIPED for KDM8 Gene

This gene is overexpressed in Blymphocyte (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KDM8 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KDM8

SOURCE GeneReport for Unigene cluster for KDM8 Gene:

Hs.145717

mRNA Expression by UniProt/SwissProt for KDM8 Gene:

Q8N371-KDM8_HUMAN
Tissue specificity: Weakly expressed in most cells. Highly expressed in breast cancer cells (PubMed:20457893). Expressed in embryonic stem cells (PubMed:24740926).

Evidence on tissue expression from TISSUES for KDM8 Gene

  • Nervous system(4.5)
  • Lung(4.2)
  • Thyroid gland(4.1)
  • Liver(2.6)
genes like me logo Genes that share expression patterns with KDM8: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM8 Gene

Orthologs for KDM8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KDM8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia JMJD5 30
  • 99.34 (n)
KDM8 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia KDM8 30 31
  • 83.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KDM8 30 31
  • 83.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kdm8 30
  • 79.42 (n)
Mouse
(Mus musculus)
Mammalia Kdm8 30 17 31
  • 79.18 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KDM8 31
  • 71 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KDM8 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KDM8 30 31
  • 66.33 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KDM8 31
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kdm8 30
  • 61.68 (n)
Zebrafish
(Danio rerio)
Actinopterygii kdm8 30 31
  • 59.93 (n)
OneToOne
Dr.16868 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG13902 30 31
  • 52.35 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea jmjd-5 30 31
  • 46.34 (n)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G20810 30
  • 49.47 (n)
Soybean
(Glycine max)
eudicotyledons Gma.17248 30
Rice
(Oryza sativa)
Liliopsida Os09g0489200 30
  • 52.22 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.15579 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.718 31
  • 17 (a)
ManyToMany
Species where no ortholog for KDM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KDM8 Gene

ENSEMBL:
Gene Tree for KDM8 (if available)
TreeFam:
Gene Tree for KDM8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KDM8: view image

Paralogs for KDM8 Gene

Paralogs for KDM8 Gene

genes like me logo Genes that share paralogs with KDM8: view

Variants for KDM8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KDM8 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
710277 Likely Benign: not provided 27,210,412(+) A/G MISSENSE_VARIANT
710822 Likely Benign: not provided 27,220,479(+) G/A SYNONYMOUS_VARIANT
rs34445573 - p.Glu302Asp

Additional dbSNP identifiers (rs#s) for KDM8 Gene

Structural Variations from Database of Genomic Variants (DGV) for KDM8 Gene

Variant ID Type Subtype PubMed ID
dgv2828n100 CNV gain 25217958
esv3638319 CNV gain 21293372
nsv1059454 CNV gain 25217958
nsv952959 CNV deletion 24416366

Variation tolerance for KDM8 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KDM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KDM8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM8 Gene

Disorders for KDM8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KDM8 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search KDM8 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with KDM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KDM8 Gene

Publications for KDM8 Gene

  1. JMJD5 is a human arginyl C-3 hydroxylase. (PMID: 29563586) Wilkins SE … Chowdhury R (Nature communications 2018) 2 3 4
  2. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. (PMID: 20457893) Hsia DA … Izumiya Y (Proceedings of the National Academy of Sciences of the United States of America 2010) 2 3 4
  3. JMJD5 links CRY1 function and proteasomal degradation. (PMID: 30500822) Saran AR … DiTacchio L (PLoS biology 2018) 3 4
  4. Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. (PMID: 29459673) Liu H … Zhang G (Scientific reports 2018) 3 4
  5. JMJD5 cleaves monomethylated histone H3 N-tail under DNA damaging stress. (PMID: 28982940) Shen J … Chin YE (EMBO reports 2017) 3 4

Products for KDM8 Gene

  • Signalway Proteins for KDM8

Sources for KDM8 Gene