Aliases for KDM7A Gene
External Ids for KDM7A Gene
Previous HGNC Symbols for KDM7A Gene
Previous GeneCards Identifiers for KDM7A Gene
GeneCards Summary for KDM7A Gene
KDM7A (Lysine Demethylase 7A) is a Protein Coding gene. Diseases associated with KDM7A include Syndromic X-Linked Intellectual Disability Siderius Type. Among its related pathways are Oncogenic MAPK signaling and Chromatin organization. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. An important paralog of this gene is PHF2.
UniProtKB/Swiss-Prot Summary for KDM7A Gene
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.