Aliases for KDM6B Gene
Aliases for KDM6B Gene
External Ids for KDM6B Gene
- HGNC: 29012
- Entrez Gene: 23135
- Ensembl: ENSG00000132510
- OMIM: 611577
- UniProtKB: O15054
Previous HGNC Symbols for KDM6B Gene
- JMJD3
Previous GeneCards Identifiers for KDM6B Gene
- GC17P007686
Summaries for KDM6B Gene
-
The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
GeneCards Summary for KDM6B Gene
KDM6B (Lysine Demethylase 6B) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Chromatin organization. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and dioxygenase activity. An important paralog of this gene is KDM6A.
UniProtKB/Swiss-Prot for KDM6B Gene
-
Histone demethylase that specifically demethylates Lys-27 of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 Lys-27 (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).
-
Histone demethylases (KDMs) are a family of enzymes that catalyze the removal of methyl groups from lysine and arginine residues on histone tails. They reverse the methylation of lysine and arginine residues that is catalyzed by histone methyltransferases.
Additional gene information for KDM6B Gene
- Monarch Initiative
- Search for KDM6B at DataMed
- Search for KDM6B at HumanCyc
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDM6B Gene
Genomics for KDM6B Gene
GeneHancer (GH) Regulatory Elements for KDM6B Gene
Promoters and enhancers for KDM6B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KDM6B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KDM6B gene promoter:
Regulatory Element Products
Genomic Locations for KDM6B Gene
Genomic Locations for KDM6B Gene
- chr17:7,834,200-7,854,800
- (GRCh38/hg38)
- Size:
- 20,601 bases
- Orientation:
- Plus strand
- chr17:7,743,222-7,758,118
- (GRCh37/hg19)
Genomic View for KDM6B Gene
Genes around KDM6B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
KDM6B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KDM6B Gene
Proteins for KDM6B Gene
-
Protein details for KDM6B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15054-KDM6B_HUMAN
- Recommended name:
- Lysine-specific demethylase 6B
- Protein Accession:
- O15054
- C9IZ40
- Q96G33
Protein attributes for KDM6B Gene
- Size:
- 1643 amino acids
- Molecular mass:
- 176632 Da
- Cofactor:
- Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Cofactor:
- Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
- Quaternary structure:
-
- Interacts with TLE1 (By similarity). Component of the MLL4 complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, and KDM6B (PubMed:17825402). Interacts with TBX21, SMARCA4, SMARCC1 and SMARCC2 (By similarity).
- SequenceCaution:
-
- Sequence=BAA21572.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for KDM6B Gene
Protein Expression for KDM6B Gene
Selected DME Specific Peptides for KDM6B Gene
- O15054:
-
- QRPGDLVWINAGTVHWVQA
- GWCNNIAWNVGPLTA
- KLNPPTPSIYLE
- IKFGTNIDLSD
- SHTTIAKYAQYQA
Post-translational modifications for KDM6B Gene
Other Protein References for KDM6B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for KDM6B (Lysine (K)-specific Demethylase 6B/KDM6B)
- Novus Biologicals Antibodies for KDM6B
-
Abcam antibodies for KDM6B
- Invitrogen Antibodies for KDM6B
- GeneTex KDM6B antibody for KDM6B
-
Custom Antibody ServicesProSci Antibodies for KDM6B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KDM6B
- Origene Custom Protein Services for KDM6B
- Search GeneTex for Proteins for KDM6B
-
Abcam proteins for KDM6B
Assay Products
- antibodies-online: Search results for 1 available Kdm6b Elisa Kits ranked by validation data
- Compare Top Kdm6b Elisa Kits
-
Quality Products:
Domains & Families for KDM6B Gene
Gene Families for KDM6B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KDM6B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KDM6B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15054- Family:
-
- Belongs to the UTX family.
Function for KDM6B Gene
Molecular function for KDM6B Gene
- UniProtKB/Swiss-Prot Function:
- Histone demethylase that specifically demethylates Lys-27 of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 Lys-27 (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells.
Enzyme Numbers (IUBMB) for KDM6B Gene
Phenotypes From GWAS Catalog for KDM6B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 21841772 |
| GO:0008013 | beta-catenin binding | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0032452 | histone demethylase activity | TAS | -- |
Phenotypes for KDM6B Gene
- MGI mutant phenotypes for KDM6B:
-
inferred from 9 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- skeleton phenotype
- no phenotypic analysis
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for KDM6B:
Animal Models for KDM6B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KDM6B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for KDM6B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM6B gene
- Search ViGene Biosciences for KDM6B
CRISPR Products
-
OriGene CRISPR knockouts for KDM6B
- genomics-online: gRNA clones - Search results for 58 available Kdm6b gene related products
- Overview of 58 available Kdm6b gene related products
- Applied Biological Materials CRISPR for KDM6B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KDM6B
- GenScript: Design CRISPR guide RNA sequences for KDM6B
miRNA for KDM6B Gene
- miRTarBase miRNAs that target KDM6B
-
- hsa-mir-335-5p (MIRT017568)
- hsa-mir-186-5p (MIRT021179)
- hsa-mir-101-3p (MIRT027296)
- hsa-mir-18a-3p (MIRT040965)
- hsa-mir-92a-3p (MIRT049017)
- hsa-let-7a-5p (MIRT052574)
- hsa-mir-5787 (MIRT079165)
- hsa-mir-17-5p (MIRT289570)
- hsa-mir-20a-5p (MIRT289571)
- hsa-mir-93-5p (MIRT289573)
- hsa-mir-106a-5p (MIRT289575)
- hsa-mir-106b-5p (MIRT289577)
- hsa-mir-20b-5p (MIRT289579)
- hsa-mir-526b-3p (MIRT289581)
- hsa-mir-519d-3p (MIRT289583)
- hsa-mir-941 (MIRT289587)
- hsa-mir-127-5p (MIRT440397)
- hsa-mir-3175 (MIRT493410)
- hsa-mir-3178 (MIRT493411)
- hsa-mir-6731-5p (MIRT493412)
- hsa-mir-8085 (MIRT493413)
- hsa-mir-4749-5p (MIRT493414)
- hsa-mir-4706 (MIRT493415)
- hsa-mir-2277-5p (MIRT493416)
- hsa-mir-4746-5p (MIRT493417)
- hsa-mir-6889-5p (MIRT493418)
- hsa-mir-6777-5p (MIRT493419)
- hsa-mir-6791-5p (MIRT493420)
- hsa-mir-4292 (MIRT493421)
- hsa-mir-4308 (MIRT493422)
- hsa-mir-3940-3p (MIRT493423)
- hsa-mir-7109-5p (MIRT570644)
- hsa-mir-4472 (MIRT570645)
- hsa-mir-6771-5p (MIRT570646)
- hsa-mir-4447 (MIRT570647)
- hsa-mir-7704 (MIRT570648)
- hsa-mir-615-5p (MIRT570649)
- hsa-mir-6885-5p (MIRT570650)
- hsa-mir-328-5p (MIRT570651)
- hsa-mir-6887-5p (MIRT570652)
- hsa-mir-6795-5p (MIRT570653)
- hsa-mir-4652-5p (MIRT570654)
- hsa-mir-8052 (MIRT570655)
- hsa-mir-3199 (MIRT570656)
- hsa-mir-4515 (MIRT570657)
- hsa-mir-4745-5p (MIRT570658)
- hsa-mir-4481 (MIRT570659)
- hsa-mir-7152-3p (MIRT570660)
- hsa-mir-6746-5p (MIRT570661)
- hsa-mir-1296-3p (MIRT570662)
- mmu-mir-20a-5p (MIRT735174)
- hsa-mir-1203 (MIRT735963)
- hsa-mir-1267 (MIRT736710)
- hsa-mir-1286 (MIRT737054)
- hsa-mir-146a-5p (MIRT737642)
- hsa-mir-146b-5p (MIRT737649)
- hsa-mir-149-3p (MIRT737740)
- hsa-mir-29a-3p (MIRT739567)
- hsa-mir-29b-3p (MIRT739590)
- hsa-mir-29c-3p (MIRT739602)
- hsa-mir-3135b (MIRT740131)
- hsa-mir-3648 (MIRT741863)
- hsa-mir-3652 (MIRT741893)
- hsa-mir-3663-3p (MIRT742006)
- hsa-mir-367-5p (MIRT742143)
- hsa-mir-4430 (MIRT744331)
- hsa-mir-4501 (MIRT745497)
- hsa-mir-4711-3p (MIRT747436)
- hsa-mir-4722-5p (MIRT747600)
- hsa-mir-4728-5p (MIRT747836)
- hsa-mir-4767 (MIRT748602)
- hsa-mir-505-5p (MIRT749583)
- hsa-mir-519a-3p (MIRT750109)
- hsa-mir-519b-3p (MIRT750127)
- hsa-mir-519c-3p (MIRT750145)
- hsa-mir-581 (MIRT751508)
- hsa-mir-589-5p (MIRT751569)
- hsa-mir-592 (MIRT751585)
- hsa-mir-6090 (MIRT752038)
- hsa-mir-6783-5p (MIRT755750)
- hsa-mir-6785-5p (MIRT755831)
- hsa-mir-6808-3p (MIRT756547)
- hsa-mir-6824-5p (MIRT756945)
- hsa-mir-6825-5p (MIRT756988)
- hsa-mir-6846-3p (MIRT757420)
- hsa-mir-6859-3p (MIRT757807)
- hsa-mir-6883-5p (MIRT758416)
- hsa-mir-7153-5p (MIRT759206)
- hsa-mir-767-5p (MIRT759678)
- hsa-mir-7973 (MIRT759970)
- hsa-mir-8055 (MIRT760023)
- hsa-mir-873-5p (MIRT760312)
- hsa-mir-1178-3p (MIRT761178)
- hsa-mir-125a-3p (MIRT761668)
- hsa-mir-143-5p (MIRT762683)
- hsa-mir-148a-3p (MIRT762748)
- hsa-mir-148b-3p (MIRT762758)
- hsa-mir-152-3p (MIRT762890)
- hsa-mir-185-3p (MIRT763168)
- hsa-mir-1913 (MIRT763390)
- hsa-mir-210-5p (MIRT763778)
- hsa-mir-3151-5p (MIRT765042)
- hsa-mir-324-3p (MIRT765567)
- hsa-mir-331-3p (MIRT765634)
- hsa-mir-3620-3p (MIRT766109)
- hsa-mir-381-5p (MIRT767549)
- hsa-mir-3934-5p (MIRT767834)
- hsa-mir-423-5p (MIRT767946)
- hsa-mir-4283 (MIRT768371)
- hsa-mir-4433a-3p (MIRT769010)
- hsa-mir-4466 (MIRT769433)
- hsa-mir-4489 (MIRT769701)
- hsa-mir-4492 (MIRT769717)
- hsa-mir-4498 (MIRT769751)
- hsa-mir-4505 (MIRT769826)
- hsa-mir-4524a-3p (MIRT770010)
- hsa-mir-4700-3p (MIRT771291)
- hsa-mir-4731-5p (MIRT771780)
- hsa-mir-4737 (MIRT771817)
- hsa-mir-4749-3p (MIRT771926)
- hsa-mir-486-3p (MIRT772674)
- hsa-mir-5001-5p (MIRT772916)
- hsa-mir-6499-3p (MIRT776283)
- hsa-mir-675-5p (MIRT778392)
- hsa-mir-6784-3p (MIRT779086)
- hsa-mir-6804-5p (MIRT779514)
- hsa-mir-6852-5p (MIRT780457)
- hsa-mir-6862-3p (MIRT780596)
- hsa-mir-6865-3p (MIRT780646)
- hsa-mir-762 (MIRT781790)
- hsa-mir-764 (MIRT781812)
- hsa-mir-92a-2-5p (MIRT782661)
miRNA Products
- Search ViGene Biosciences for KDM6B
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for KDM6B
- Browse OriGene Inhibitory RNA Products For KDM6B
- genomics-online: shRNA clones - Search results for 58 available Kdm6b gene related products
- Overview of 58 available Kdm6b gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM6B gene
Clone Products
-
OriGene ORF clones in human for KDM6B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for KDM6B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KDM6B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KDM6B
- Applied Biological Materials Clones for KDM6B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KDM6B
-
ViGene Biosciences adenoviral particle packaged cDNA for KDM6B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KDM6B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM6B gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KDM6B Gene
Localization for KDM6B Gene
Subcellular locations from UniProtKB/Swiss-Prot for KDM6B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,ISS | 23856522 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for KDM6B Gene
Pathways by source for KDM6B Gene
1 GeneTex pathway for KDM6B Gene
1 BioSystems pathway for KDM6B Gene
6 Reactome pathways for KDM6B Gene
1 Cell Signaling Technology pathway for KDM6B Gene
Interacting Proteins for KDM6B Gene
Selected Interacting proteins:
ENSP00000254846
O15054-KDM6B_HUMAN
for KDM6B Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002437 | inflammatory response to antigenic stimulus | IEA | -- |
| GO:0006338 | chromatin remodeling | ISS | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0010468 | regulation of gene expression | IEA | -- |
| GO:0014823 | response to activity | IEA | -- |
No data available for SIGNOR curated interactions for KDM6B Gene
Drugs & Compounds for KDM6B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Daminozide | Pharma | KDM2A inhibitor | 7 | |||
| GSK J1 | Pharma | H3K27 demethylase JMJD3 inhibitor | 0 | |||
| GSK J4 free base | Pharma | 0 | ||||
| GSK J4 HCl | Pharma | Inhibitor of H3K27 demethylase JMJD3,potent and cell-permeable | 0 | |||
| JIB-04 | Pharma | Jumonji histone demethylase inihibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| GSK J4 |
|
1373423-53-0 |
|
|
(5) Tocris Compounds for KDM6B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Daminozide | Selective KDM2/7 inhibitor | 1596-84-5 |
| GSK J1 | Potent JMJD3/UTX inhibitor | 1373422-53-7 |
| GSK J4 | Histone KDM inhibitor; cell permeable | 1373423-53-0 |
| IOX 1 | Histone demethylase inhibitor; cell permeable | 5852-78-8 |
| Tranylcypromine hydrochloride | Irreversible inhibitor of LSD1; also inhibits MAO | 1986-47-6 |
(5) ApexBio Compounds for KDM6B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Daminozide | KDM2A inhibitor | 1596-84-5 |
| GSK J1 | H3K27 demethylase JMJD3 inhibitor | 1373422-53-7 |
| GSK J4 free base | ||
| GSK J4 HCl | Inhibitor of H3K27 demethylase JMJD3,potent and cell-permeable | 1373423-53-0 |
| JIB-04 | Jumonji histone demethylase inihibitor | 199596-05-9 |
Transcripts for KDM6B Gene
mRNA/cDNA for KDM6B Gene
- (10) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (255) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KDM6B Gene
- Lysine (K)-specific demethylase 6B:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for KDM6B
- genomics-online: gRNA clones - Search results for 58 available Kdm6b gene related products
- Overview of 58 available Kdm6b gene related products
- Applied Biological Materials CRISPR for KDM6B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KDM6B
- GenScript: Design CRISPR guide RNA sequences for KDM6B
miRNA Products
- Search ViGene Biosciences for KDM6B
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for KDM6B
- Browse OriGene Inhibitory RNA Products For KDM6B
- genomics-online: shRNA clones - Search results for 58 available Kdm6b gene related products
- Overview of 58 available Kdm6b gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KDM6B gene
Clone Products
-
OriGene ORF clones in human for KDM6B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for KDM6B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KDM6B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for KDM6B
- Applied Biological Materials Clones for KDM6B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for KDM6B Gene
mRNA differential expression in normal tissues according to GTEx for KDM6B Gene
This gene is overexpressed in Whole Blood (x7.8).
This gene is overexpressed in Serum (36.7) and Cervix (21.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KDM6B Gene
NURSA nuclear receptor signaling pathways regulating expression of KDM6B Gene:
KDM6BSOURCE GeneReport for Unigene cluster for KDM6B Gene:
Hs.223678Evidence on tissue expression from TISSUES for KDM6B Gene
- Nervous system(4.5)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for KDM6B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM6B Gene
Orthologs for KDM6B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KDM6B 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | KDM6B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | KDM6B 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Kdm6b 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Kdm6b 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | KDM6B 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | KDM6B 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | KDM6B (2 of 2) 34 |
|
OneToMany | |
| kdm6bb 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | jmjd-3.3 34 |
|
OneToMany | |
| jmjd-3.1 34 |
|
OneToMany | |||
| jmjd-3.2 34 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CYC8 34 |
|
OneToMany |
- Species where no ortholog for KDM6B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for KDM6B Gene
(5) SIMAP similar genes for KDM6B Gene using alignment to 2 proteins:
Variants for KDM6B Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs148641957 | uncertain-significance, Inborn genetic diseases | 7,846,654(+) | G/T | coding_sequence_variant, missense_variant | |
| rs199964822 | uncertain-significance, Inborn genetic diseases | 7,848,258(+) | C/T | coding_sequence_variant, missense_variant | |
| rs61462443 | benign, uncertain-significance, not specified, Oromandibular-limb hypogenesis spectrum | 7,846,860(+) | ACCACCACCACCACCACCACCACCACCACCACCACCACC/ACCACCACCACCACC/ACCACCACCACCACCACCACCACCACCACC/ACCACCACCACCACCACCACCACCACCACCACC/ACCACCACCACCACCACCACCACCACCACCACCACC/ACCACCACCACCACCACCACCACCACCACCACCACCACCACC/ACCACCACCACCACCACCACCACCACCACCACCACCACCACCACC/ACCACCACCACCACCACCACCACCACCACCACCACCACCACCACCACC | coding_sequence_variant, inframe_deletion, inframe_insertion | |
| rs116930996 | likely-benign, not specified | 7,832,924(+) | C/A/G/T | upstream_transcript_variant | |
| rs59627144 | likely-benign, not specified | 7,848,541(+) | CACCACCACCACCACCACCACCACCACCACCAC/CACCACCACCACCACCACCAC/CACCACCACCACCACCACCACCAC/CACCACCACCACCACCACCACCACCAC/CACCACCACCACCACCACCACCACCACCAC/CACCACCACCACCACCACCACCACCACCACCACCAC/CACCACCACCACCACCACCACCACCACCACCACCACCAC | coding_sequence_variant, inframe_deletion, inframe_insertion |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv172e215 | CNV | deletion | 23714750 |
| dgv510n67 | CNV | gain | 20364138 |
| esv2715604 | CNV | deletion | 23290073 |
| esv2715605 | CNV | deletion | 23290073 |
| esv2715606 | CNV | deletion | 23290073 |
| esv3204242 | CNV | deletion | 24192839 |
| esv989512 | CNV | deletion | 20482838 |
| nsv1070804 | CNV | deletion | 25765185 |
| nsv833351 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.69;
97.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KDM6B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM6B Gene
Disorders for KDM6B Gene
Additional Disease Information for KDM6B
No disorders were found for KDM6B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDM6B Gene
Publications for KDM6B Gene
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
- Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. (PMID: 28262558) Tumber A … Brennan PE (Cell chemical biology 2017) 3 4 58
- UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. (PMID: 17713478) Agger K … Helin K (Nature 2007) 3 4 58
- The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. (PMID: 17825402) De Santa F … Natoli G (Cell 2007) 3 4 58
- Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. (PMID: 18003914) Hong S … Ge K (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 58
Products for KDM6B Gene
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