The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016] See more...

Aliases for KDM4E Gene

Aliases for KDM4E Gene

  • Lysine Demethylase 4E 2 3 5
  • [Histone H3]-Trimethyl-L-Lysine(9) Demethylase 4E 3 4
  • Lysine (K)-Specific Demethylase 4E 2 3
  • Lysine-Specific Demethylase 4E 3 4
  • KDM4D-Like Protein 3 4
  • JMJD2E 2 3
  • KDM4DL 3 4
  • KDM5E 2 3
  • Lysine (K)-Specific Demethylase 4D-Like 2
  • Lysine-Specific Demethylase 4D-Like 4
  • EC 1.14.11.66 4
  • KDM4E 5

External Ids for KDM4E Gene

Previous HGNC Symbols for KDM4E Gene

  • KDM4DL

Previous GeneCards Identifiers for KDM4E Gene

  • GC11P094759

Summaries for KDM4E Gene

Entrez Gene Summary for KDM4E Gene

  • The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]

GeneCards Summary for KDM4E Gene

KDM4E (Lysine Demethylase 4E) is a Protein Coding gene. Diseases associated with KDM4E include Familial Isolated Hypoparathyroidism. Gene Ontology (GO) annotations related to this gene include dioxygenase activity. An important paralog of this gene is KDM4F.

UniProtKB/Swiss-Prot Summary for KDM4E Gene

  • Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.

Additional gene information for KDM4E Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KDM4E Gene

Genomics for KDM4E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KDM4E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KDM4E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KDM4E

Genomic Locations for KDM4E Gene

Genomic Locations for KDM4E Gene
chr11:95,025,258-95,027,596
(GRCh38/hg38)
Size:
2,339 bases
Orientation:
Plus strand
chr11:94,758,422-94,760,760
(GRCh37/hg19)
Size:
2,339 bases
Orientation:
Plus strand

Genomic View for KDM4E Gene

Genes around KDM4E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDM4E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDM4E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM4E Gene

Proteins for KDM4E Gene

  • Protein details for KDM4E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RXH2-KDM4E_HUMAN
    Recommended name:
    Lysine-specific demethylase 4E
    Protein Accession:
    B2RXH2

    Protein attributes for KDM4E Gene

    Size:
    506 amino acids
    Molecular mass:
    56804 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KDM4E Gene

neXtProt entry for KDM4E Gene

Post-translational modifications for KDM4E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KDM4E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KDM4E Gene

Domains & Families for KDM4E Gene

Gene Families for KDM4E Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KDM4E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KDM4E Gene

GenScript: Design optimal peptide antigens:
  • KDM4D-like protein (KD4DL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B2RXH2

UniProtKB/Swiss-Prot:

KDM4E_HUMAN :
  • Belongs to the JHDM3 histone demethylase family.
Family:
  • Belongs to the JHDM3 histone demethylase family.
genes like me logo Genes that share domains with KDM4E: view

Function for KDM4E Gene

Molecular function for KDM4E Gene

UniProtKB/Swiss-Prot Function:
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA-COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.66; Evidence={ECO:0000305|PubMed:21914792};.

Enzyme Numbers (IUBMB) for KDM4E Gene

Phenotypes From GWAS Catalog for KDM4E Gene

Gene Ontology (GO) - Molecular Function for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0032452 histone demethylase activity IBA 21873635
GO:0032454 histone demethylase activity (H3-K9 specific) IDA 21914792
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with KDM4E: view
genes like me logo Genes that share phenotypes with KDM4E: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDM4E

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KDM4E Gene

Localization for KDM4E Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM4E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KDM4E gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 21914792
GO:0035097 histone methyltransferase complex IBA 21873635
genes like me logo Genes that share ontologies with KDM4E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KDM4E Gene

Pathways & Interactions for KDM4E Gene

PathCards logo

SuperPathways for KDM4E Gene

No Data Available

Interacting Proteins for KDM4E Gene

Gene Ontology (GO) - Biological Process for KDM4E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006338 chromatin remodeling IBA 21873635
GO:0033169 histone H3-K9 demethylation IDA 21914792
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with KDM4E: view

No data available for Pathways by source and SIGNOR curated interactions for KDM4E Gene

Drugs & Compounds for KDM4E Gene

(2) Drugs for KDM4E Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IOX 1 Pharma Histone demethylase inhibitor; cell permeable 0
JIB-04 Pharma Jumonji histone demethylase inihibitor 0

(2) ApexBio Compounds for KDM4E Gene

Compound Action Cas Number
IOX 1 5852-78-8
JIB-04 Jumonji histone demethylase inihibitor 199596-05-9
genes like me logo Genes that share compounds with KDM4E: view

Drug Products

Transcripts for KDM4E Gene

mRNA/cDNA for KDM4E Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDM4E

Alternative Splicing Database (ASD) splice patterns (SP) for KDM4E Gene

No ASD Table

Relevant External Links for KDM4E Gene

GeneLoc Exon Structure for
KDM4E

Expression for KDM4E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KDM4E Gene

mRNA differential expression in normal tissues according to GTEx for KDM4E Gene

This gene is overexpressed in Testis (x5.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KDM4E

SOURCE GeneReport for Unigene cluster for KDM4E Gene:

Hs.714692
genes like me logo Genes that share expression patterns with KDM4E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM4E Gene

Orthologs for KDM4E Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KDM4E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KDM4DL 30
  • 98.22 (n)
KDM4E 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 63 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 61 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 56 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Kdm4A 31
  • 37 (a)
ManyToMany
Kdm4B 31
  • 26 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPH1 31
  • 18 (a)
ManyToMany
GIS1 31
  • 13 (a)
ManyToMany
Species where no ortholog for KDM4E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KDM4E Gene

ENSEMBL:
Gene Tree for KDM4E (if available)
TreeFam:
Gene Tree for KDM4E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KDM4E: view image

Paralogs for KDM4E Gene

(5) SIMAP similar genes for KDM4E Gene using alignment to 1 proteins:

  • KDM4E_HUMAN

Pseudogenes.org Pseudogenes for KDM4E Gene

genes like me logo Genes that share paralogs with KDM4E: view

Variants for KDM4E Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KDM4E Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
740794 Likely Benign: not provided 95,027,042(+) G/A SYNONYMOUS_VARIANT
770403 Likely Benign: not provided 95,026,118(+) C/T SYNONYMOUS_VARIANT
770404 Likely Benign: not provided 95,026,127(+) A/G SYNONYMOUS_VARIANT
781030 Benign: not provided 95,025,682(+) A/G MISSENSE_VARIANT
781694 Benign: not provided 95,026,699(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for KDM4E Gene

Structural Variations from Database of Genomic Variants (DGV) for KDM4E Gene

Variant ID Type Subtype PubMed ID
esv2446980 CNV deletion 19546169
esv3892074 CNV loss 25118596
esv7852 CNV loss 19470904
nsv826045 CNV gain 20364138
nsv972063 CNV duplication 23825009

Variation tolerance for KDM4E Gene

Gene Damage Index Score: 4.72; 66.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KDM4E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KDM4E

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM4E Gene

Disorders for KDM4E Gene

MalaCards: The human disease database

(1) MalaCards diseases for KDM4E Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial isolated hypoparathyroidism
  • fih
- elite association - COSMIC cancer census association via MalaCards
Search KDM4E in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with KDM4E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KDM4E Gene

Publications for KDM4E Gene

  1. Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. (PMID: 21914792) Hillringhaus L … Oppermann U (The Journal of biological chemistry 2011) 3 4
  2. Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. (PMID: 21076780) Thalhammer A … Schofield CJ (Organic & biomolecular chemistry 2011) 2 3
  3. Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. (PMID: 23092293) Sánchez-Fernández EM … Flashman E (The Biochemical journal 2013) 3
  4. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity (PMID: 24260783) Rai G … Maloney DJ (Probe Reports from the NIH Molecular Libraries Program 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for KDM4E Gene

Sources for KDM4E Gene