Aliases for KDM4E Gene
External Ids for KDM4E Gene
Previous HGNC Symbols for KDM4E Gene
Previous GeneCards Identifiers for KDM4E Gene
The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]
GeneCards Summary for KDM4E Gene
KDM4E (Lysine Demethylase 4E) is a Protein Coding gene. Diseases associated with KDM4E include Familial Isolated Hypoparathyroidism. Gene Ontology (GO) annotations related to this gene include dioxygenase activity. An important paralog of this gene is KDM4F.
UniProtKB/Swiss-Prot Summary for KDM4E Gene
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.