This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [prov... See more...

Aliases for KDM4A Gene

Aliases for KDM4A Gene

  • Lysine Demethylase 4A 2 3 5
  • JHDM3A 2 3 4
  • JmjC Domain-Containing Histone Demethylation Protein 3A 3 4
  • Jumonji C Domain-Containing Histone Demethylase 3A 2 3
  • [Histone H3]-Trimethyl-L-Lysine(36) Demethylase 4A 3 4
  • [Histone H3]-Trimethyl-L-Lysine(9) Demethylase 4A 3 4
  • Jumonji Domain-Containing Protein 2A 3 4
  • Lysine (K)-Specific Demethylase 4A 2 3
  • Lysine-Specific Demethylase 4A 3 4
  • Jumonji Domain Containing 2A 2 3
  • Tudor Domain Containing 14A 2 3
  • Jumonji Domain Containing 2 2 3
  • KIAA0677 2 4
  • TDRD14A 2 3
  • JMJD2A 3 4
  • JMJD2 3 4
  • EC 1.14.11.66 4
  • EC 1.14.11.69 4
  • EC 1.14.11 51
  • KDM4A 5

External Ids for KDM4A Gene

Previous HGNC Symbols for KDM4A Gene

  • JMJD2
  • JMJD2A

Previous GeneCards Identifiers for KDM4A Gene

  • GC01P043889
  • GC01P044115
  • GC01P042237

Summaries for KDM4A Gene

Entrez Gene Summary for KDM4A Gene

  • This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]

GeneCards Summary for KDM4A Gene

KDM4A (Lysine Demethylase 4A) is a Protein Coding gene. Diseases associated with KDM4A include Familial Isolated Hypoparathyroidism and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Chromatin organization and DNA Double Strand Break Response. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is KDM4C.

UniProtKB/Swiss-Prot Summary for KDM4A Gene

  • Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
  • [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.

Gene Wiki entry for KDM4A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KDM4A Gene

Genomics for KDM4A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KDM4A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J043648 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.2 226 4.6 SP1 CREB1 PRDM10 REST ZNF629 RFX1 LEF1 IKZF1 RFX5 KDM1A ENSG00000284989 KDM4A DMAP1 ZNF691 KDM4A-AS1 MED8 ATP6V0B ARTN HYI SVBP
GH01J043706 Promoter 0.4 EPDnew 600.2 +55.2 55208 0.1 CTCF ST3GAL3 piR-36409 KDM4A KDM4A-AS1 ENSG00000284989
GH01J044212 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 22.7 +563.3 563333 2.3 ZNF221 SP1 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 SIX5 LEF1 IKZF1 DMAP1 lnc-ERI3-8 SZT2 HYI KDM4A-AS1 ARTN HECTD3 RPS8 ENSG00000237950 MED8
GH01J043521 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.9 -126.6 -126648 7.8 RNF2 ARHGAP35 CREB1 GATAD2A ZBTB33 ATF7 ZNF629 ZNF512 LEF1 IKZF1 PTPRF SZT2 KDM4A-AS1 P3H1 PPIH MED8 DMAP1 KDM4A HYI CDC20
GH01J044628 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 +981.3 981330 6.6 ARHGAP35 HNRNPL PRDM10 ZNF629 TFE3 ZNF512 RFX1 ZNF692 POLR2A BACH1 lnc-TMEM53-2 piR-53648 TOE1 DMAP1 ARMH1 KDM4A MUTYH CCDC17 ARTN RNU5F-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KDM4A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KDM4A

Top Transcription factor binding sites by QIAGEN in the KDM4A gene promoter:
  • AP-4
  • C/EBPalpha
  • Hlf
  • IRF-7A
  • LCR-F1
  • MAZR
  • Spz1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for KDM4A Gene

Genomic Locations for KDM4A Gene
chr1:43,650,149-43,705,518
(GRCh38/hg38)
Size:
55,370 bases
Orientation:
Plus strand
chr1:44,115,797-44,171,189
(GRCh37/hg19)
Size:
55,393 bases
Orientation:
Plus strand

Genomic View for KDM4A Gene

Genes around KDM4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDM4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDM4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM4A Gene

Proteins for KDM4A Gene

  • Protein details for KDM4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75164-KDM4A_HUMAN
    Recommended name:
    Lysine-specific demethylase 4A
    Protein Accession:
    O75164
    Secondary Accessions:
    • Q5VVB1

    Protein attributes for KDM4A Gene

    Size:
    1064 amino acids
    Molecular mass:
    120662 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1.
    • (Microbial infection) Interacts with HTLV-1 Tax protein.
    SequenceCaution:
    • Sequence=BAA31652.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KDM4A Gene

    Alternative splice isoforms for KDM4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDM4A Gene

Selected DME Specific Peptides for KDM4A Gene

O75164:
  • RWIEYGK
  • EDMDLYSIN
  • VTGQSGLFTQYNIQKKAMTV
  • YTLDEELPKRVK
  • IEGVNTPYLYFGMWKT
  • PPEHGKRLERLA
  • LERKYWKN
  • VHASCYG
  • YSINYLH
  • AESTNFA
  • LRHKMTLISP
  • DMVKISM
  • AYIESQGAHRAGLAK

Post-translational modifications for KDM4A Gene

  • Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.
  • Ubiquitination at Lys224
  • Modification sites at PhosphoSitePlus

Other Protein References for KDM4A Gene

Domains & Families for KDM4A Gene

Gene Families for KDM4A Gene

Protein Domains for KDM4A Gene

InterPro:
Blocks:
  • Transcription factor jumonji, jmjC
  • Transcription factor jumonji, JmjN
ProtoNet:

Suggested Antigen Peptide Sequences for KDM4A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60146, highly similar to JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (B4DT38_HUMAN)
  • Jumonji domain-containing protein 2A (KDM4A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75164

UniProtKB/Swiss-Prot:

KDM4A_HUMAN :
  • The 2 Tudor domains recognize and bind methylated histone H3 'Lys-4' residue (H3K4me). Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 'Lys-4' (H3K4me3) is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are also able to bind trimethylated histone H3 'Lys-9' (H3K9me3), di- and trimethylated H4 'Lys-20' (H4K20me2 and H4K20me3). Has high affinity for H4K20me2, blocking recruitment of proteins such as TP53BP1.
  • Belongs to the JHDM3 histone demethylase family.
Domain:
  • The 2 Tudor domains recognize and bind methylated histone H3 'Lys-4' residue (H3K4me). Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 'Lys-4' (H3K4me3) is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are also able to bind trimethylated histone H3 'Lys-9' (H3K9me3), di- and trimethylated H4 'Lys-20' (H4K20me2 and H4K20me3). Has high affinity for H4K20me2, blocking recruitment of proteins such as TP53BP1.
Family:
  • Belongs to the JHDM3 histone demethylase family.
genes like me logo Genes that share domains with KDM4A: view

Function for KDM4A Gene

Molecular function for KDM4A Gene

UniProtKB/Swiss-Prot Function:
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60200, Rhea:RHEA-COMP:15538, Rhea:RHEA-COMP:15542, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.66; Evidence={ECO:0000269|PubMed:16603238};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60236, Rhea:RHEA-COMP:9786, Rhea:RHEA-COMP:15536, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; EC=1.14.11.69; Evidence={ECO:0000269|PubMed:16603238};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Several specific inhibitors are being developed and tested.

Enzyme Numbers (IUBMB) for KDM4A Gene

Phenotypes From GWAS Catalog for KDM4A Gene

Gene Ontology (GO) - Molecular Function for KDM4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16415788
GO:0008270 zinc ion binding IDA 27214403
GO:0016491 oxidoreductase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 22373579
GO:0032452 histone demethylase activity IBA 21873635
genes like me logo Genes that share ontologies with KDM4A: view
genes like me logo Genes that share phenotypes with KDM4A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDM4A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KDM4A Gene

Localization for KDM4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM4A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KDM4A gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KDM4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IMP 21914792
GO:0005654 nucleoplasm TAS --
GO:0035097 histone methyltransferase complex IBA 21873635
genes like me logo Genes that share ontologies with KDM4A: view

Pathways & Interactions for KDM4A Gene

genes like me logo Genes that share pathways with KDM4A: view

Pathways by source for KDM4A Gene

1 Cell Signaling Technology pathway for KDM4A Gene
1 GeneTex pathway for KDM4A Gene

Gene Ontology (GO) - Biological Process for KDM4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006338 chromatin remodeling IBA 21873635
GO:0010507 negative regulation of autophagy IMP 25660547
GO:0010629 negative regulation of gene expression IMP 25660547
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with KDM4A: view

No data available for SIGNOR curated interactions for KDM4A Gene

Drugs & Compounds for KDM4A Gene

(6) Drugs for KDM4A Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IOX 1 Pharma Histone demethylase inhibitor; cell permeable 0
JIB-04 Pharma Jumonji histone demethylase inihibitor 0
ML324 Pharma JMJD2 demethylase inhibitor, potent and cell-permeable 0
SP2509 Pharma Demethylase 1 (LSD1) antagonist, novel Lysine-specific 0
Tranylcypromine hydrochloride Pharma Irreversible inhibitor of LSD1; also inhibits MAO 0

(5) ApexBio Compounds for KDM4A Gene

Compound Action Cas Number
IOX 1 5852-78-8
JIB-04 Jumonji histone demethylase inihibitor 199596-05-9
ML324 JMJD2 demethylase inhibitor, potent and cell-permeable 1222800-79-4
SP2509 Demethylase 1 (LSD1) antagonist, novel Lysine-specific 1423715-09-6
Tranylcypromine hydrochloride 1986-47-6
genes like me logo Genes that share compounds with KDM4A: view

Drug Products

Transcripts for KDM4A Gene

mRNA/cDNA for KDM4A Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDM4A

Alternative Splicing Database (ASD) splice patterns (SP) for KDM4A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
SP1: - - - - - -
SP2: -
SP3:
SP4: - -
SP5: -
SP6:
SP7:
SP8:

ExUns: 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -

Relevant External Links for KDM4A Gene

GeneLoc Exon Structure for
KDM4A

Expression for KDM4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KDM4A Gene

Protein differential expression in normal tissues from HIPED for KDM4A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (52.0) and Blymphocyte (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KDM4A Gene



Protein tissue co-expression partners for KDM4A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KDM4A

SOURCE GeneReport for Unigene cluster for KDM4A Gene:

Hs.155983

mRNA Expression by UniProt/SwissProt for KDM4A Gene:

O75164-KDM4A_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for KDM4A Gene

  • Nervous system(4.6)
  • Liver(2.9)
  • Skin(2.8)
  • Kidney(2.7)
  • Intestine(2.7)
  • Blood(2.6)
  • Heart(2.4)
  • Muscle(2.4)
  • Lung(2.3)
  • Spleen(2.3)
  • Thyroid gland(2.2)
  • Stomach(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with KDM4A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM4A Gene

Orthologs for KDM4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KDM4A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KDM4A 30 31
  • 96.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KDM4A 30 31
  • 91.94 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KDM4A 30 31
  • 89.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kdm4a 30
  • 86.99 (n)
Mouse
(Mus musculus)
Mammalia Kdm4a 30 17 31
  • 86.89 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KDM4A 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KDM4A 30 31
  • 74.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KDM4A 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kdm4a 30
  • 69.95 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-215f22.3 30
  • 70.03 (n)
kdm4ab 31
  • 59 (a)
OneToMany
KDM4A (1 of 2) 31
  • 32 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Kdm4A 31
  • 48 (a)
ManyToMany
Kdm4B 31
  • 39 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea jmjd-2 30 31
  • 50.25 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPH1 31
  • 24 (a)
ManyToMany
GIS1 31
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10508 31
  • 39 (a)
OneToMany
Species where no ortholog for KDM4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KDM4A Gene

ENSEMBL:
Gene Tree for KDM4A (if available)
TreeFam:
Gene Tree for KDM4A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KDM4A: view image

Paralogs for KDM4A Gene

(5) SIMAP similar genes for KDM4A Gene using alignment to 2 proteins:

  • KDM4A_HUMAN
  • L8ECF0_HUMAN
genes like me logo Genes that share paralogs with KDM4A: view

Variants for KDM4A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KDM4A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
691434 Uncertain Significance: Pyloric stenosis; Esophageal atresia 43,694,730(+) C/T MISSENSE_VARIANT
725132 Likely Benign: not provided 43,669,229(+) G/A SYNONYMOUS_VARIANT
732098 Benign: not provided 43,653,205(+) C/T SYNONYMOUS_VARIANT
741942 Likely Benign: not provided 43,703,697(+) A/G SYNONYMOUS_VARIANT
775542 Benign: not provided 43,653,223(+) C/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for KDM4A Gene

Variation tolerance for KDM4A Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KDM4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KDM4A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KDM4A Gene

Disorders for KDM4A Gene

MalaCards: The human disease database

(2) MalaCards diseases for KDM4A Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search KDM4A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KDM4A

genes like me logo Genes that share disorders with KDM4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KDM4A Gene

Publications for KDM4A Gene

  1. Structural insights into histone demethylation by JMJD2 family members. (PMID: 16677698) Chen Z … Zhang G (Cell 2006) 3 4 23
  2. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. (PMID: 16601153) Huang Y … Xu RM (Science (New York, N.Y.) 2006) 3 4 23
  3. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (PMID: 16603238) Whetstine JR … Shi Y (Cell 2006) 3 4 23
  4. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PMID: 15927959) Gray SG … Dangond F (The Journal of biological chemistry 2005) 3 4 23
  5. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PMID: 16024779) Zhang D … Wong J (Molecular and cellular biology 2005) 3 4 23

Products for KDM4A Gene

Sources for KDM4A Gene