Aliases for KDM4A Gene
- Lysine Demethylase 4A 2 3 5
- JHDM3A 2 3 4
- JmjC Domain-Containing Histone Demethylation Protein 3A 3 4
- Jumonji C Domain-Containing Histone Demethylase 3A 2 3
- [Histone H3]-Trimethyl-L-Lysine(36) Demethylase 4A 3 4
- [Histone H3]-Trimethyl-L-Lysine(9) Demethylase 4A 3 4
- Jumonji Domain-Containing Protein 2A 3 4
- Lysine (K)-Specific Demethylase 4A 2 3
- Lysine-Specific Demethylase 4A 3 4
- Jumonji Domain Containing 2A 2 3
External Ids for KDM4A Gene
Previous HGNC Symbols for KDM4A Gene
Previous GeneCards Identifiers for KDM4A Gene
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
GeneCards Summary for KDM4A Gene
KDM4A (Lysine Demethylase 4A) is a Protein Coding gene. Diseases associated with KDM4A include Familial Isolated Hypoparathyroidism and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Chromatin organization and DNA Double Strand Break Response. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is KDM4C.
UniProtKB/Swiss-Prot Summary for KDM4A Gene
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
[Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.