This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-... See more...

Aliases for KDM2A Gene

Aliases for KDM2A Gene

  • Lysine Demethylase 2A 2 3 5
  • F-Box And Leucine-Rich Repeat Protein 11 2 3 4
  • JHDM1A 2 3 4
  • CXXC8 2 3 4
  • FBL11 2 3 4
  • FBL7 2 3 4
  • JmjC Domain-Containing Histone Demethylation Protein 1A 3 4
  • Jumonji C Domain-Containing Histone Demethylase 1A 2 3
  • [Histone-H3]-Lysine-36 Demethylase 1A 3 4
  • Lysine (K)-Specific Demethylase 2A 2 3
  • CXXC-Type Zinc Finger Protein 8 3 4
  • Lysine-Specific Demethylase 2A 3 4
  • F-Box/LRR-Repeat Protein 11 3 4
  • EC 1.14.11.27 4 51
  • KIAA1004 2 4
  • FBXL11 3 4
  • LILINA 2 3
  • F-Box Protein Lilina 4
  • F-Box Protein FBL11 2
  • F-Box Protein FBL7 4
  • DKFZP434M1735 2
  • FLJ00115 2
  • KDM2A 5

External Ids for KDM2A Gene

Previous HGNC Symbols for KDM2A Gene

  • FBXL11

Previous GeneCards Identifiers for KDM2A Gene

  • GC11P066646
  • GC11P066888
  • GC11P063214

Summaries for KDM2A Gene

Entrez Gene Summary for KDM2A Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for KDM2A Gene

KDM2A (Lysine Demethylase 2A) is a Protein Coding gene. Diseases associated with KDM2A include Duodenum Adenoma and Familial Isolated Hypoparathyroidism. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include histone demethylase activity (H3-K36 specific) and unmethylated CpG binding. An important paralog of this gene is KDM2B.

UniProtKB/Swiss-Prot Summary for KDM2A Gene

  • Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310).

Gene Wiki entry for KDM2A Gene

Additional gene information for KDM2A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KDM2A Gene

Genomics for KDM2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KDM2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KDM2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KDM2A

Top Transcription factor binding sites by QIAGEN in the KDM2A gene promoter:
  • AhR
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • C/EBPalpha
  • CREB
  • deltaCREB
  • FOXO4
  • MZF-1

Genomic Locations for KDM2A Gene

Genomic Locations for KDM2A Gene
chr11:67,119,263-67,258,082
(GRCh38/hg38)
Size:
138,820 bases
Orientation:
Plus strand
chr11:66,886,740-67,025,558
(GRCh37/hg19)
Size:
138,819 bases
Orientation:
Plus strand

Genomic View for KDM2A Gene

Genes around KDM2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDM2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDM2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDM2A Gene

Proteins for KDM2A Gene

  • Protein details for KDM2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K7-KDM2A_HUMAN
    Recommended name:
    Lysine-specific demethylase 2A
    Protein Accession:
    Q9Y2K7
    Secondary Accessions:
    • D4QA03
    • E9PIL6
    • I3VM55
    • Q49A21
    • Q4G0M3
    • Q69YY8
    • Q9BVH5
    • Q9H7H5
    • Q9UK66

    Protein attributes for KDM2A Gene

    Size:
    1162 amino acids
    Molecular mass:
    132793 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with CBX5/HP1A; the interaction promotes CBX5 localization to chromatin. The SKP1-KDM2A complex interacts with UBB (PubMed:30033217).
    SequenceCaution:
    • Sequence=AAD56012.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA76848.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15795.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAJ05817.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KDM2A Gene

    Alternative splice isoforms for KDM2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDM2A Gene

Selected DME Specific Peptides for KDM2A Gene

Q9Y2K7:
  • IPSGWIHAV
  • GTSVWYH
  • GLGIKMP
  • CQRIELKQG
  • KFRYPFYYEMCWYVLERYV
  • ELPNCWECPKC
  • WCCDKRLWT
  • DNRSKLRN
  • IHAVYTP
  • DVMDVNTQK

Post-translational modifications for KDM2A Gene

  • Ubiquitination at Lys518
  • Modification sites at PhosphoSitePlus

Domains & Families for KDM2A Gene

Gene Families for KDM2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KDM2A Gene

Suggested Antigen Peptide Sequences for KDM2A Gene

GenScript: Design optimal peptide antigens:
  • [Histone-H3]-lysine-36 demethylase 1A (KDM2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2K7

UniProtKB/Swiss-Prot:

KDM2A_HUMAN :
  • The JmjC domain mediates demethylation activity and is required for satellite silencing.
  • Belongs to the JHDM1 histone demethylase family.
Domain:
  • The JmjC domain mediates demethylation activity and is required for satellite silencing.
  • The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated (PubMed:20417597). It is essential for its ability to repress the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer (PubMed:26037310).
  • The F-box domain mediates interaction with UBB.
Family:
  • Belongs to the JHDM1 histone demethylase family.
genes like me logo Genes that share domains with KDM2A: view

Function for KDM2A Gene

Molecular function for KDM2A Gene

UniProtKB/Swiss-Prot Function:
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:42032, Rhea:RHEA-COMP:9785, Rhea:RHEA-COMP:9787, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, ChEBI:CHEBI:29969, ChEBI:CHEBI:30031, ChEBI:CHEBI:61976; EC=1.14.11.27; Evidence={ECO:0000269|PubMed:16362057};.

Enzyme Numbers (IUBMB) for KDM2A Gene

Phenotypes From GWAS Catalog for KDM2A Gene

Gene Ontology (GO) - Molecular Function for KDM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA,IPI 15070733
GO:0008168 methyltransferase activity IEA --
GO:0008270 zinc ion binding IEA,IDA 29276034
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with KDM2A: view
genes like me logo Genes that share phenotypes with KDM2A: view

Animal Models for KDM2A Gene

MGI Knock Outs for KDM2A:
  • Kdm2a Kdm2a<tm1d(KOMP)Mtok>
  • Kdm2a Kdm2a<tm1a(KOMP)Mtok>

Animal Model Products

CRISPR Products

miRNA for KDM2A Gene

miRTarBase miRNAs that target KDM2A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDM2A

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KDM2A Gene

Localization for KDM2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDM2A Gene

Nucleus, nucleoplasm. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KDM2A gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KDM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with KDM2A: view

Pathways & Interactions for KDM2A Gene

genes like me logo Genes that share pathways with KDM2A: view

Pathways by source for KDM2A Gene

1 GeneTex pathway for KDM2A Gene

SIGNOR curated interactions for KDM2A Gene

Inactivates:

Gene Ontology (GO) - Biological Process for KDM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006303 double-strand break repair via nonhomologous end joining IMP 21187428
GO:0006325 chromatin organization IEA --
GO:0010944 negative regulation of transcription by competitive promoter binding IMP 26037310
GO:0032259 methylation IEA --
GO:0032922 circadian regulation of gene expression IMP 26037310
genes like me logo Genes that share ontologies with KDM2A: view

Drugs & Compounds for KDM2A Gene

(12) Drugs for KDM2A Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Formaldehyde Approved, Vet_approved Pharma 142
Oxygen Approved, Vet_approved Pharma 0
D-Lysine Approved, Experimental Nutra Agonist, Full agonist 0
Succinic acid Approved Nutra Agonist, Full agonist 0

(6) ApexBio Compounds for KDM2A Gene

Compound Action Cas Number
Daminozide KDM2A inhibitor 1596-84-5
IOX 1 5852-78-8
ML324 JMJD2 demethylase inhibitor, potent and cell-permeable 1222800-79-4
SP2509 Demethylase 1 (LSD1) antagonist, novel Lysine-specific 1423715-09-6
TC-E 5002 1453071-47-0
Tranylcypromine hydrochloride 1986-47-6
genes like me logo Genes that share compounds with KDM2A: view

Drug Products

Transcripts for KDM2A Gene

mRNA/cDNA for KDM2A Gene

2 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDM2A

Alternative Splicing Database (ASD) splice patterns (SP) for KDM2A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a ·
SP1: - - - - - - - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
SP1: - - - -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for KDM2A Gene

GeneLoc Exon Structure for
KDM2A

Expression for KDM2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KDM2A Gene

Protein differential expression in normal tissues from HIPED for KDM2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.0), Plasma (9.2), CD8 Tcells (7.1), and Bone marrow stromal cell (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KDM2A Gene



Protein tissue co-expression partners for KDM2A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KDM2A

SOURCE GeneReport for Unigene cluster for KDM2A Gene:

Hs.124147

mRNA Expression by UniProt/SwissProt for KDM2A Gene:

Q9Y2K7-KDM2A_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain, testis and ovary, followed by lung.

Evidence on tissue expression from TISSUES for KDM2A Gene

  • Nervous system(4.7)
  • Blood(4.5)
  • Eye(4.4)
  • Liver(4.4)
  • Spleen(4.4)
  • Skin(2.6)
  • Intestine(2.4)
  • Bone marrow(2.3)
  • Kidney(2.3)
  • Lymph node(2.2)
  • Muscle(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with KDM2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDM2A Gene

Orthologs for KDM2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KDM2A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KDM2A 30 31
  • 99.89 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KDM2A 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia KDM2A 30 31
  • 95.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KDM2A 30 31
  • 94.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kdm2a 30
  • 92.28 (n)
Mouse
(Mus musculus)
Mammalia Kdm2a 30 17 31
  • 92.08 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KDM2A 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KDM2A 30 31
  • 79.37 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KDM2A 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kdm2a 30
  • 65.66 (n)
Str.10470 30
Zebrafish
(Danio rerio)
Actinopterygii kdm2a 30
  • 63.93 (n)
CT955967.1 31
  • 50 (a)
OneToMany
kdm2aa 31
  • 48 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Kdm2 30 31
  • 52.46 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea jhdm-1 31
  • 23 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JHD1 31 33
  • 26 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8451 30
Species where no ortholog for KDM2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KDM2A Gene

ENSEMBL:
Gene Tree for KDM2A (if available)
TreeFam:
Gene Tree for KDM2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KDM2A: view image

Paralogs for KDM2A Gene

Paralogs for KDM2A Gene

(4) SIMAP similar genes for KDM2A Gene using alignment to 5 proteins:

  • KDM2A_HUMAN
  • I3VM53_HUMAN
  • I3VM54_HUMAN
  • I3VM55_HUMAN
  • L0R5B6_HUMAN
genes like me logo Genes that share paralogs with KDM2A: view

Variants for KDM2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KDM2A Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
787378 Benign: not provided 67,255,019(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for KDM2A Gene

Structural Variations from Database of Genomic Variants (DGV) for KDM2A Gene

Variant ID Type Subtype PubMed ID
dgv1976n54 CNV loss 21841781
esv1081118 CNV insertion 17803354
esv23935 CNV loss 19812545
esv2661599 CNV deletion 23128226
esv2669621 CNV deletion 23128226
esv2744644 CNV deletion 23290073
esv3328967 CNV duplication 20981092
esv3626707 CNV loss 21293372
esv3626709 CNV loss 21293372
nsv1069600 CNV deletion 25765185
nsv1121839 CNV deletion 24896259
nsv436787 CNV insertion 17901297
nsv472571 CNV novel sequence insertion 20440878
nsv509419 CNV insertion 20534489
nsv513322 CNV insertion 21212237
nsv555252 CNV loss 21841781
nsv825958 CNV gain 20364138
nsv825959 CNV gain 20364138
nsv972951 CNV duplication 23825009

Variation tolerance for KDM2A Gene

Residual Variation Intolerance Score: 1.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KDM2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KDM2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDM2A Gene

Disorders for KDM2A Gene

MalaCards: The human disease database

(2) MalaCards diseases for KDM2A Gene - From: DISEASES

Disorder Aliases PubMed IDs
duodenum adenoma
familial isolated hypoparathyroidism
  • fih
- elite association - COSMIC cancer census association via MalaCards
Search KDM2A in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with KDM2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KDM2A Gene

Publications for KDM2A Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. (PMID: 30033217) Gorelik M … Sicheri F (Structure (London, England : 1993) 2018) 3 4
  3. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. (PMID: 28262558) Tumber A … Brennan PE (Cell chemical biology 2017) 3 4
  4. Fbxl11 Is a Novel Negative Element of the Mammalian Circadian Clock. (PMID: 26037310) Reischl S … Kramer A (Journal of biological rhythms 2015) 3 4
  5. CpG islands recruit a histone H3 lysine 36 demethylase. (PMID: 20417597) Blackledge NP … Klose RJ (Molecular cell 2010) 3 4

Products for KDM2A Gene

Sources for KDM2A Gene