Aliases for KDM1B Gene
External Ids for KDM1B Gene
Previous HGNC Symbols for KDM1B Gene
Previous GeneCards Identifiers for KDM1B Gene
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]
GeneCards Summary for KDM1B Gene
KDM1B (Lysine Demethylase 1B) is a Protein Coding gene. Diseases associated with KDM1B include Loeys-Dietz Syndrome 1. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and histone demethylase activity (H3-dimethyl-K4 specific). An important paralog of this gene is KDM1A.
UniProtKB/Swiss-Prot Summary for KDM1B Gene
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.