Aliases for KDELR3 Gene
External Ids for KDELR3 Gene
Previous GeneCards Identifiers for KDELR3 Gene
This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for KDELR3 Gene
KDELR3 (KDEL Endoplasmic Reticulum Protein Retention Receptor 3) is a Protein Coding gene. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include ER retention sequence binding. An important paralog of this gene is KDELR2.
UniProtKB/Swiss-Prot for KDELR3 Gene
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).