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Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This ... See more...
Aliases for KDELR1 Gene
Aliases for KDELR1 Gene
External Ids for KDELR1 Gene
- HGNC: 6304
- Entrez Gene: 10945
- Ensembl: ENSG00000105438
- OMIM: 131235
- UniProtKB: P24390
Previous GeneCards Identifiers for KDELR1 Gene
- GC19M049530
- GC19M049253
- GC19M053561
- GC19M053577
- GC19M048885
- GC19M045266
Summaries for KDELR1 Gene
-
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]
GeneCards Summary for KDELR1 Gene
KDELR1 (KDEL Endoplasmic Reticulum Protein Retention Receptor 1) is a Protein Coding gene. Diseases associated with KDELR1 include Actinobacillosis and Mental Retardation, X-Linked, Syndromic, Wu Type. Among its related pathways are Signal transduction_PKA signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include ER retention sequence binding and KDEL sequence binding. An important paralog of this gene is KDELR2.
UniProtKB/Swiss-Prot Summary for KDELR1 Gene
-
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
Additional gene information for KDELR1 Gene
- HGNC(6304)
- Entrez Gene(10945)
- Ensembl(ENSG00000105438)
- OMIM(131235)
- UniProtKB(P24390)
- Open Targets Platform(ENSG00000105438)
- Search for KDELR1 at DataMed
- Search for KDELR1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KDELR1 Gene
Genomics for KDELR1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KDELR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KDELR1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KDELR1
- Top Transcription factor binding sites by QIAGEN in the KDELR1 gene promoter:
-
- C/EBPalpha
- FOXO1
- FOXO1a
- GATA-1
- NF-kappaB1
- p53
- PPAR-gamma1
- PPAR-gamma2
- SEF-1 (1)
- STAT3
Genomic Locations for KDELR1 Gene
Genomic Locations for KDELR1 Gene
- chr19:48,382,575-48,391,551
- (GRCh38/hg38)
- Size:
- 8,977 bases
- Orientation:
- Minus strand
- chr19:48,885,827-48,894,810
- (GRCh37/hg19)
- Size:
- 8,984 bases
- Orientation:
- Minus strand
Genomic View for KDELR1 Gene
Genes around KDELR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
KDELR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KDELR1 Gene
Proteins for KDELR1 Gene
-
Protein details for KDELR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24390-ERD21_HUMAN
- Recommended name:
- ER lumen protein-retaining receptor 1
- Protein Accession:
- P24390
- B2R6N4
- Q54A39
- Q8NBW7
Protein attributes for KDELR1 Gene
- Size:
- 212 amino acids
- Molecular mass:
- 24542 Da
- Quaternary structure:
-
- Upon ligand binding the receptor oligomerizes and interacts with components of the transport machinery such as ARFGAP1 and ARF1.
Protein Expression for KDELR1 Gene
Post-translational modifications for KDELR1 Gene
- Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for KDELR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ KDEL Antibody
-
Custom Antibody ServicesOriGene Antibodies for KDELR1
- Novus Biologicals Antibodies for KDELR1
-
Abcam antibodies for KDELR1
- Invitrogen Antibodies for KDELR1 (AFLGC-Kdelr1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for KDELR1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for KDELR1
- Origene Custom Protein Services for KDELR1
- Novus Biologicals lysates for KDELR1
-
Abcam proteins for KDELR1
No data available for DME Specific Peptides for KDELR1 Gene
Domains & Families for KDELR1 Gene
Gene Families for KDELR1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for KDELR1 Gene
- InterPro:
- Blocks:
-
- ER lumen protein retaining receptor
- ProtoNet:
Suggested Antigen Peptide Sequences for KDELR1 Gene
- GenScript: Design optimal peptide antigens:
-
- Putative MAPK-activating protein PM23 (ERD21_HUMAN)
- ER lumen protein retaining receptor (Q8NBW7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P24390UniProtKB/Swiss-Prot:
ERD21_HUMAN :- Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (PubMed:30846601).
- Belongs to the ERD2 family.
- Domain:
-
- Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (PubMed:30846601).
- Family:
-
- Belongs to the ERD2 family.
Function for KDELR1 Gene
Molecular function for KDELR1 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
- GENATLAS Biochemistry:
- endoplasmic reticulum protein retention receptor 1 (Lys-Asp-Glu-Leu),S cerevisiae ERD2 ortholog,allowing the retrieval of proteins from Golgi complex to ER,mimicking the brefeldin A (BFA)-like phenotype,when overexpressed
Phenotypes From GWAS Catalog for KDELR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005046 | KDEL sequence binding | IDA | 8392934 |
| GO:0046923 | ER retention sequence binding | IEA,IBA | 21873635 |
Phenotypes for KDELR1 Gene
- MGI mutant phenotypes for KDELR1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for KDELR1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KDELR1 - Select products 50% OFF >
- * KDELR1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KDELR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KDELR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for KDELR1
miRNA for KDELR1 Gene
- miRTarBase miRNAs that target KDELR1
-
- hsa-miR-1-3p (MIRT023631)
- hsa-miR-96-5p (MIRT027910)
- hsa-miR-877-3p (MIRT037161)
- hsa-miR-769-3p (MIRT039070)
- hsa-miR-615-3p (MIRT040446)
- hsa-miR-423-3p (MIRT042609)
- hsa-miR-320a (MIRT044760)
- hsa-miR-92a-3p (MIRT049826)
- hsa-let-7b-5p (MIRT052299)
- hsa-miR-500b-3p (MIRT235394)
- hsa-miR-3664-5p (MIRT293854)
- hsa-miR-340-5p (MIRT348558)
- hsa-miR-548c-3p (MIRT348559)
- hsa-miR-4260 (MIRT474871)
- hsa-miR-1227-5p (MIRT474872)
- hsa-miR-128-2-5p (MIRT474873)
- hsa-miR-128-1-5p (MIRT474874)
- hsa-miR-6845-5p (MIRT474875)
- hsa-miR-6762-5p (MIRT474876)
- hsa-miR-3163 (MIRT474877)
- hsa-miR-5197-3p (MIRT474878)
- hsa-miR-4797-5p (MIRT474879)
- hsa-miR-548ad-3p (MIRT474880)
- hsa-miR-4252 (MIRT522881)
- hsa-miR-6807-5p (MIRT522882)
- hsa-miR-4744 (MIRT522883)
- hsa-miR-3130-3p (MIRT522884)
- hsa-miR-1273g-3p (MIRT522885)
- hsa-miR-6504-3p (MIRT522886)
- hsa-miR-3133 (MIRT522887)
- hsa-miR-186-5p (MIRT522888)
- hsa-miR-4279 (MIRT542109)
- hsa-miR-1976 (MIRT542110)
- hsa-miR-3653-5p (MIRT542111)
- hsa-miR-6872-3p (MIRT542112)
- hsa-miR-5571-5p (MIRT542113)
- hsa-miR-544a (MIRT637554)
- hsa-miR-7977 (MIRT637555)
- hsa-miR-150-3p (MIRT637556)
- hsa-miR-8069 (MIRT637557)
- hsa-miR-20b-3p (MIRT637558)
- hsa-miR-17-3p (MIRT637559)
- hsa-miR-1205 (MIRT637560)
- hsa-miR-1184 (MIRT637561)
- hsa-miR-3158-5p (MIRT637562)
- hsa-miR-26a-2-3p (MIRT637563)
- hsa-miR-26a-1-3p (MIRT637564)
- hsa-miR-4778-5p (MIRT637565)
- hsa-miR-5579-5p (MIRT637566)
- hsa-miR-2114-5p (MIRT637567)
- hsa-miR-5588-3p (MIRT637568)
- hsa-miR-744-3p (MIRT667742)
- hsa-miR-4423-5p (MIRT667743)
- hsa-miR-6501-5p (MIRT667744)
- hsa-miR-3944-5p (MIRT667745)
- hsa-miR-4430 (MIRT667746)
- hsa-miR-3652 (MIRT667747)
- hsa-miR-122-5p (MIRT667748)
- hsa-miR-504-3p (MIRT667749)
- hsa-miR-3135b (MIRT667750)
- hsa-miR-107 (MIRT667751)
- hsa-miR-103a-3p (MIRT667752)
- hsa-miR-367-5p (MIRT667753)
- hsa-miR-1267 (MIRT667754)
- hsa-miR-922 (MIRT667755)
- hsa-miR-106a-3p (MIRT667756)
- hsa-miR-6879-3p (MIRT667757)
- hsa-miR-215-3p (MIRT667758)
- hsa-miR-6773-3p (MIRT667759)
- hsa-miR-454-3p (MIRT667760)
- hsa-miR-4295 (MIRT667761)
- hsa-miR-3666 (MIRT667762)
- hsa-miR-301b-3p (MIRT667763)
- hsa-miR-301a-3p (MIRT667764)
- hsa-miR-130b-3p (MIRT667765)
- hsa-miR-130a-3p (MIRT667766)
- hsa-miR-5585-3p (MIRT673461)
- hsa-miR-4465 (MIRT673462)
- hsa-miR-26b-5p (MIRT673463)
- hsa-miR-26a-5p (MIRT673464)
- hsa-miR-1297 (MIRT673465)
- hsa-miR-6829-3p (MIRT673466)
- hsa-miR-6791-3p (MIRT673467)
- hsa-miR-4427 (MIRT673468)
- hsa-miR-6747-3p (MIRT673469)
- hsa-miR-6727-3p (MIRT673470)
- hsa-miR-4722-3p (MIRT673471)
- hsa-miR-3140-5p (MIRT673472)
- hsa-miR-660-3p (MIRT673473)
- hsa-miR-4726-3p (MIRT673474)
- hsa-miR-6764-5p (MIRT673475)
- hsa-miR-1915-3p (MIRT673476)
- hsa-miR-6840-3p (MIRT673477)
- hsa-miR-6513-3p (MIRT673478)
- hsa-miR-8062 (MIRT673479)
- hsa-miR-432-3p (MIRT702502)
- hsa-miR-452-3p (MIRT702503)
- hsa-miR-6802-3p (MIRT702504)
- hsa-miR-6739-5p (MIRT702505)
- hsa-miR-6733-5p (MIRT702506)
- hsa-miR-3153 (MIRT702507)
- hsa-miR-4668-5p (MIRT702508)
- hsa-miR-1193 (MIRT702509)
- hsa-miR-3182 (MIRT702510)
- hsa-miR-6515-3p (MIRT702511)
- hsa-miR-4308 (MIRT702512)
- hsa-miR-224-5p (MIRT702513)
- hsa-miR-331-3p (MIRT702514)
- hsa-miR-3190-5p (MIRT765370)
- hsa-miR-34c-3p (MIRT765819)
- hsa-miR-3622a-3p (MIRT766126)
- hsa-miR-3675-3p (MIRT766675)
- hsa-miR-3926 (MIRT767714)
- hsa-miR-4433a-3p (MIRT769009)
- hsa-miR-4434 (MIRT769093)
- hsa-miR-4516 (MIRT769926)
- hsa-miR-4531 (MIRT770071)
- hsa-miR-4786-5p (MIRT772298)
- hsa-miR-4802-3p (MIRT772551)
- hsa-miR-4999-3p (MIRT772875)
- hsa-miR-520f-5p (MIRT773830)
- hsa-miR-548s (MIRT774506)
- hsa-miR-5703 (MIRT775220)
- hsa-miR-6884-3p (MIRT780975)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KDELR1
- Browse OriGene Inhibitory RNA Products For KDELR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDELR1
Clone Products
- Applied Biological Materials (abm): Clones for KDELR1 - Select products 50% OFF >
- * KDELR1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for KDELR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KDELR1
Cell Line Products
-
Horizon Cell Lines for KDELR1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KDELR1 Gene
Localization for KDELR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KDELR1 Gene
- Golgi apparatus membrane. Multi-pass membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. {ECO:0000269 PubMed:18086916, ECO:0000269 PubMed:30846601, ECO:0000269 PubMed:8392934}.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| plasma membrane | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
- Golgi apparatus (3)
- Vesicles (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005783 | endoplasmic reticulum | IEA,IBA | 21873635 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IDA | 15308636 |
| GO:0005794 | Golgi apparatus | IBA | 21873635 |
Pathways & Interactions for KDELR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | Transport to the Golgi and subsequent modification | ||
| 3 | Golgi-to-ER retrograde transport | ||
| 4 | Vesicle-mediated transport | ||
| 5 | Metabolism of proteins | ||
Pathways by source for KDELR1 Gene
11 Reactome pathways for KDELR1 Gene
1 KEGG pathway for KDELR1 Gene
2 GeneGo (Thomson Reuters) pathways for KDELR1 Gene
- Signal transduction cAMP signaling
- Signal transduction_PKA signaling
4 Qiagen pathways for KDELR1 Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- cAMP Pathway
- PKA Signaling
Interacting Proteins for KDELR1 Gene
Selected Interacting proteins:
P24390-ERD21_HUMAN
ENSP00000329471
for KDELR1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KDELR1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002369 | T cell cytokine production | IEA | -- |
| GO:0006621 | protein retention in ER lumen | IEA,IBA | 21873635 |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | TAS | -- |
| GO:0015031 | protein transport | IEA | -- |
Transcripts for KDELR1 Gene
mRNA/cDNA for KDELR1 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000330720 1550 nts (view in UCSC)
- ENST00000594643 561 nts (view in UCSC)
- ENST00000597017 1594 nts (view in UCSC)
- ENST00000599084 582 nts (view in UCSC)
- ENST00000600980 815 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KDELR1 - Select products 50% OFF >
- * KDELR1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KDELR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KDELR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for KDELR1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KDELR1
- Browse OriGene Inhibitory RNA Products For KDELR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDELR1
Clone Products
- Applied Biological Materials (abm): Clones for KDELR1 - Select products 50% OFF >
- * KDELR1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for KDELR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KDELR1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: |
Relevant External Links for KDELR1 Gene
- GeneLoc Exon Structure for
- KDELR1
Expression for KDELR1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Negative 2 Thymocytes Thymus
- Intestine (Gastrointestinal Tract)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Nasal epithelium (32.7) and Fetal gut (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KDELR1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KDELR1
SOURCE GeneReport for Unigene cluster for KDELR1 Gene:
Hs.515515Evidence on tissue expression from TISSUES for KDELR1 Gene
- Lung(4.7)
- Skin(4.7)
- Nervous system(4.4)
- Intestine(3.6)
- Kidney(3.1)
- Eye(3.1)
- Stomach(2.8)
- Muscle(2.7)
- Liver(2.7)
- Heart(2.4)
- Blood(2.4)
- Thyroid gland(2.3)
- Pancreas(2.2)
- Spleen(2.1)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for KDELR1
-
OriGene qPCR primer pairs and template standards for KDELR1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDELR1 Gene
Orthologs for KDELR1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KDELR1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | KDELR1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KDELR1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | KDELR1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Kdelr1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Kdelr1 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | KDELR1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kdelr2 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | KdelR 30 31 32 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012756 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | C28H8.4 31 32 |
|
ManyToMany | |
| erd-2 31 |
|
ManyToMany | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL323C 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E05611g 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ERD2 30 31 33 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ERD2 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.7842 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os05g0529300 30 |
|
||
| Os.18326 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.1313 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.3598 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.2753 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU06771 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | erd2 30 |
|
- Species where no ortholog for KDELR1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Zebrafish (Danio rerio)
Evolution for KDELR1 Gene
- ENSEMBL:
- Gene Tree for KDELR1 (if available)
- TreeFam:
- Gene Tree for KDELR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KDELR1: view image
Paralogs for KDELR1 Gene
Variants for KDELR1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2718676 | CNV | deletion | 23290073 |
| esv2718677 | CNV | deletion | 23290073 |
| esv34181 | CNV | loss | 18971310 |
| nsv833854 | CNV | loss | 17160897 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.72;
15.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KDELR1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KDELR1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KDELR1 Gene
Disorders for KDELR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| actinobacillosis |
|
|
| mental retardation, x-linked, syndromic, wu type |
|
|
| nemaline myopathy 1 |
|
|
| polycystic liver disease |
|
|
| short-rib thoracic dysplasia 1 with or without polydactyly |
|
|
Search KDELR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KDELR1
No data available for UniProtKB/Swiss-Prot and Genatlas for KDELR1 Gene
Publications for KDELR1 Gene
- A human homologue of the yeast HDEL receptor. (PMID: 2172835) Lewis MJ … Pelham HR (Nature 1990) 2 3 4 23
- A molecular specificity code for the three mammalian KDEL receptors. (PMID: 18086916) Raykhel I … Ruddock L (The Journal of cell biology 2007) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4
- The retrieval function of the KDEL receptor requires PKA phosphorylation of its C-terminus. (PMID: 14517323) Cabrera M … Velasco A (Molecular biology of the cell 2003) 3 4
ExternalLinks
Products for KDELR1 Gene
- Custom Antibody ServicesOriGene Antibodies for KDELR1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for KDELR1
- Origene Custom Protein Services for KDELR1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KDELR1
- Browse OriGene Inhibitory RNA Products For KDELR1
- OriGene qPCR primer pairs for KDELR1
- OriGene qPCR primer pairs and template standards for KDELR1
- OriGene CRISPR knockouts for KDELR1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KDELR1
- Sino Biological Human cDNA Clone for KDELR1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for KDELR1
- Novus Biologicals lysates for KDELR1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for KDELR1
- Abcam proteins for KDELR1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for KDELR1 (AFLGC-Kdelr1)
- VectorBuilder Custom and pre-made DNA vectors for KDELR1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for KDELR1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for KDELR1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for KDELR1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for KDELR1
- antibodies-online: Show 10 available KDELR1 Antibodies ranked by validation data
- Compare Top KDELR1 Antibodies
- antibodies-online: Search results for available KDELR1 related products ranked by validation data
- antibodies-online: Show 4 available KDELR1 Proteins ranked by validation data
- Compare Top KDELR1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for KDELR1
- Search Santa Cruz Biotechnology (SCBT) for KDELR1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KDELR1
- Horizon Cell Lines for KDELR1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KDELR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KDELR1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KDELR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KDELR1
Sources for KDELR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13)