Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KDELC2 Gene

Aliases for KDELC2 Gene

  • KDEL Motif Containing 2 2 3 5
  • KDEL (Lys-Asp-Glu-Leu) Containing 2 2

External Ids for KDELC2 Gene

Previous GeneCards Identifiers for KDELC2 Gene

  • GC11M107848
  • GC11M108342
  • GC11M104268

Summaries for KDELC2 Gene

GeneCards Summary for KDELC2 Gene

KDELC2 (KDEL Motif Containing 2) is a Protein Coding gene. An important paralog of this gene is KDELC1.

Additional gene information for KDELC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDELC2 Gene

Genomics for KDELC2 Gene

GeneHancer (GH) Regulatory Elements for KDELC2 Gene

Promoters and enhancers for KDELC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I108496 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 576.8 +0.7 659 3.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 KDELC2 LOC101928561 NPAT DDX10 ACAT1 ATM LOC105369479
GH11I108219 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.4 +272.7 272658 12.2 MLX DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 NFYC NPAT ATM ACAT1 DDX10 KDELC2 CWF19L2 ENSG00000255467 C11orf65 ENSG00000206967 GC11M108232
GH11I108551 Enhancer 1.1 Ensembl ENCODE 31.3 -53.5 -53488 2 HDAC1 PKNOX1 ATF1 RAD21 ZBTB40 YY1 ZNF335 TCF12 ZNF766 GATA2 KDELC2 DDX10 GC11M108506 EXPH5
GH11I108008 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 +488.8 488766 3.1 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF766 CUL5 NPAT CWF19L2 ALKBH8 DDX10 KDELC2 ACAT1 GC11P108085
GH11I108559 Enhancer 0.7 ENCODE 34.2 -62.9 -62882 4.1 PKNOX1 FEZF1 ZIC2 ZNF2 ZFHX2 ZNF366 RUNX3 ZNF10 ZEB2 TSHZ1 KDELC2 EXPH5 ATM GC11M108506
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KDELC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KDELC2 gene promoter:

Genomic Locations for KDELC2 Gene

Genomic Locations for KDELC2 Gene
26,415 bases
Minus strand

Genomic View for KDELC2 Gene

Genes around KDELC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDELC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDELC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDELC2 Gene

Proteins for KDELC2 Gene

  • Protein details for KDELC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    KDEL motif-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6UWW2
    • Q6ZUM9
    • Q8N7L8
    • Q8NE24

    Protein attributes for KDELC2 Gene

    507 amino acids
    Molecular mass:
    58572 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05260.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KDELC2 Gene


neXtProt entry for KDELC2 Gene

Post-translational modifications for KDELC2 Gene

  • Glycosylation at posLast=6161, posLast=158158, and isoforms=2, 3306

Other Protein References for KDELC2 Gene

No data available for DME Specific Peptides for KDELC2 Gene

Domains & Families for KDELC2 Gene

Gene Families for KDELC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for KDELC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the KDELC family.
  • Belongs to the KDELC family.
genes like me logo Genes that share domains with KDELC2: view

Function for KDELC2 Gene

Phenotypes From GWAS Catalog for KDELC2 Gene

Gene Ontology (GO) - Molecular Function for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0046527 glucosyltransferase activity IBA --
genes like me logo Genes that share ontologies with KDELC2: view
genes like me logo Genes that share phenotypes with KDELC2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KDELC2 Gene

Localization for KDELC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDELC2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KDELC2 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IBA --
genes like me logo Genes that share ontologies with KDELC2: view

Pathways & Interactions for KDELC2 Gene

SuperPathways for KDELC2 Gene

No Data Available

Interacting Proteins for KDELC2 Gene

Gene Ontology (GO) - Biological Process for KDELC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006664 glycolipid metabolic process IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KDELC2: view

No data available for Pathways by source and SIGNOR curated interactions for KDELC2 Gene

Drugs & Compounds for KDELC2 Gene

No Compound Related Data Available

Transcripts for KDELC2 Gene

Unigene Clusters for KDELC2 Gene

KDEL (Lys-Asp-Glu-Leu) containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDELC2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP3: - -
SP4: - -
SP6: -

Relevant External Links for KDELC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KDELC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KDELC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KDELC2 Gene

This gene is overexpressed in Uterus (11.8), Placenta (9.6), and Ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KDELC2 Gene

Protein tissue co-expression partners for KDELC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KDELC2 Gene:


SOURCE GeneReport for Unigene cluster for KDELC2 Gene:


Evidence on tissue expression from TISSUES for KDELC2 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with KDELC2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KDELC2 Gene

Orthologs for KDELC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KDELC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KDELC2 33 34
  • 99.54 (n)
(Bos Taurus)
Mammalia KDELC2 33 34
  • 90.01 (n)
(Canis familiaris)
Mammalia KDELC2 33 34
  • 89.28 (n)
(Mus musculus)
Mammalia Kdelc2 33 16 34
  • 85.86 (n)
(Rattus norvegicus)
Mammalia Kdelc2 33
  • 85.17 (n)
(Gallus gallus)
Aves KDELC2 33 34
  • 76.55 (n)
(Anolis carolinensis)
Reptilia KDELC2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kdelc2 33
  • 72.6 (n)
Str.926 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25802 33
(Danio rerio)
Actinopterygii kdelc2 33 34
  • 64.64 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6610 33
fruit fly
(Drosophila melanogaster)
Insecta CG31139 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for KDELC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KDELC2 Gene

Gene Tree for KDELC2 (if available)
Gene Tree for KDELC2 (if available)

Paralogs for KDELC2 Gene

Paralogs for KDELC2 Gene

(1) SIMAP similar genes for KDELC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KDELC2: view

Variants for KDELC2 Gene

Sequence variations from dbSNP and Humsavar for KDELC2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000007132 -- 108,482,662(-) C/T intron_variant
rs1000282722 -- 108,488,683(-) A/C intron_variant
rs1000353504 -- 108,495,743(-) T/C intron_variant
rs1000386513 -- 108,495,999(-) G/A/T intron_variant
rs1000405849 -- 108,496,075(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KDELC2 Gene

Variant ID Type Subtype PubMed ID
nsv832263 CNV gain 17160897
esv3627677 CNV loss 21293372

Variation tolerance for KDELC2 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KDELC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDELC2 Gene

Disorders for KDELC2 Gene

Additional Disease Information for KDELC2

No disorders were found for KDELC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KDELC2 Gene

Publications for KDELC2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58

Products for KDELC2 Gene

Sources for KDELC2 Gene

Loading form....