Aliases for KCTD6 Gene
External Ids for KCTD6 Gene
Previous GeneCards Identifiers for KCTD6 Gene
GeneCards Summary for KCTD6 Gene
KCTD6 (Potassium Channel Tetramerization Domain Containing 6) is a Protein Coding gene. Diseases associated with KCTD6 include Medulloblastoma. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ankyrin binding. An important paralog of this gene is KCTD21.
UniProtKB/Swiss-Prot Summary for KCTD6 Gene
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).