Aliases for KCTD6 Gene
External Ids for KCTD6 Gene
Previous GeneCards Identifiers for KCTD6 Gene
GeneCards Summary for KCTD6 Gene
KCTD6 (Potassium Channel Tetramerization Domain Containing 6) is a Protein Coding gene. Diseases associated with KCTD6 include Medulloblastoma. Among its related pathways are Sweet Taste Signaling and Hepatic ABC Transporters. Gene Ontology (GO) annotations related to this gene include ankyrin binding. An important paralog of this gene is KCTD21.
UniProtKB/Swiss-Prot Summary for KCTD6 Gene
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).