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Aliases for KCTD5 Gene

Aliases for KCTD5 Gene

  • Potassium Channel Tetramerization Domain Containing 5 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 5 2

External Ids for KCTD5 Gene

Previous GeneCards Identifiers for KCTD5 Gene

  • GC16P002732
  • GC16P002672

Summaries for KCTD5 Gene

GeneCards Summary for KCTD5 Gene

KCTD5 (Potassium Channel Tetramerization Domain Containing 5) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein complex binding. An important paralog of this gene is KCTD2.

UniProtKB/Swiss-Prot for KCTD5 Gene

  • Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.

Additional gene information for KCTD5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD5 Gene

Genomics for KCTD5 Gene

GeneHancer (GH) Regulatory Elements for KCTD5 Gene

Promoters and enhancers for KCTD5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I002679 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.9 -924 4.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 KCTD5 PIR43814 PIR61225 PIR38297 ENSG00000279901 ENSG00000261613 TBL3 ZNF597 E4F1 ENSG00000261207
GH16I003455 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 +776.3 776277 6.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 NAA60 ENSG00000263212 CREBBP SRRM2 LOC105371055 ZNF263 ZNF597 ZNF200 AMDHD2 THOC6
GH16I002689 Enhancer 1 FANTOM5 ENCODE dbSUPER 20.1 +9.4 9391 4 USF1 ZIC2 ZNF335 MITF POLR2A ZNF341 HSF1 ZNF600 GC16M002686 KCTD5 PRSS27 SRRM2-AS1 SRRM2 PAQR4 KREMEN2 ABCA17P ABCA3 ENSG00000269937
GH16I003262 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.7 +581.4 581433 2.8 CLOCK DMAP1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 ZNF263 LINC00921 ZNF75A CREBBP ZNF597 ZNF205 ENSG00000261938 AMDHD2 ZNF213-AS1 ERVK13-1
GH16I003148 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.7 +468.7 468710 4.9 CLOCK MLX ZFP64 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TRP-AGG6-1 TRR-CCG1-3 TRR-CCT3-1 GC16P003506 ZNF205 ZNF213-AS1 ZNF75A THOC6 MTCO1P28 E4F1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCTD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCTD5 gene promoter:

Genomic Locations for KCTD5 Gene

Genomic Locations for KCTD5 Gene
chr16:2,682,475-2,709,030
(GRCh38/hg38)
Size:
26,556 bases
Orientation:
Plus strand
chr16:2,732,476-2,759,031
(GRCh37/hg19)

Genomic View for KCTD5 Gene

Genes around KCTD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD5 Gene

Proteins for KCTD5 Gene

  • Protein details for KCTD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXV2-KCTD5_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD5
    Protein Accession:
    Q9NXV2
    Secondary Accessions:
    • D3DU96

    Protein attributes for KCTD5 Gene

    Size:
    234 amino acids
    Molecular mass:
    26093 Da
    Quaternary structure:
    • Homopentamer. Interacts (via C-terminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with adeno-associated virus 2 (AAV-2) REP proteins.

    Three dimensional structures from OCA and Proteopedia for KCTD5 Gene

neXtProt entry for KCTD5 Gene

Post-translational modifications for KCTD5 Gene

  • Ubiquitination at isoforms=223
  • Modification sites at PhosphoSitePlus

Other Protein References for KCTD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD5 Gene

Domains & Families for KCTD5 Gene

Gene Families for KCTD5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD5 Gene

Suggested Antigen Peptide Sequences for KCTD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXV2

UniProtKB/Swiss-Prot:

KCTD5_HUMAN :
  • The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.
Domain:
  • The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118.
genes like me logo Genes that share domains with KCTD5: view

Function for KCTD5 Gene

Molecular function for KCTD5 Gene

UniProtKB/Swiss-Prot Function:
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripheral blood lymphocytes stimulated through the T-cell receptor.

Phenotypes From GWAS Catalog for KCTD5 Gene

Gene Ontology (GO) - Molecular Function for KCTD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17239418
GO:0032403 protein complex binding IDA 23209302
GO:0042802 identical protein binding IPI 27152988
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with KCTD5: view
genes like me logo Genes that share phenotypes with KCTD5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD5 Gene

Localization for KCTD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD5 Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD5 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KCTD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IEA 18573101
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KCTD5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCTD5 Gene

Pathways & Interactions for KCTD5 Gene

genes like me logo Genes that share pathways with KCTD5: view

Gene Ontology (GO) - Biological Process for KCTD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD5: view

No data available for SIGNOR curated interactions for KCTD5 Gene

Drugs & Compounds for KCTD5 Gene

No Compound Related Data Available

Transcripts for KCTD5 Gene

Unigene Clusters for KCTD5 Gene

Potassium channel tetramerisation domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:
SP3: - -

Relevant External Links for KCTD5 Gene

GeneLoc Exon Structure for
KCTD5
ECgene alternative splicing isoforms for
KCTD5

Expression for KCTD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD5 Gene

Protein differential expression in normal tissues from HIPED for KCTD5 Gene

This gene is overexpressed in Breast (29.5) and Pancreas (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD5 Gene



Protein tissue co-expression partners for KCTD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCTD5 Gene:

KCTD5

SOURCE GeneReport for Unigene cluster for KCTD5 Gene:

Hs.61960

Evidence on tissue expression from TISSUES for KCTD5 Gene

  • Intestine(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with KCTD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD5 Gene

Orthologs for KCTD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC453840 33
  • 99.33 (n)
KCTD5 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD5 33 34
  • 92.59 (n)
rat
(Rattus norvegicus)
Mammalia Kctd5 33
  • 91.74 (n)
mouse
(Mus musculus)
Mammalia Kctd5 33 16 34
  • 91.45 (n)
cow
(Bos Taurus)
Mammalia KCTD5 33 34
  • 91.31 (n)
oppossum
(Monodelphis domestica)
Mammalia KCTD5 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD5 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD5 33 34
  • 77.34 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD5 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd5 33
  • 76.7 (n)
zebrafish
(Danio rerio)
Actinopterygii kctd5 34
  • 85 (a)
OneToMany
kctd5a 33
  • 77.83 (n)
KCTD5 (2 of 2) 34
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000083 33
  • 68.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta inc 33 34
  • 65.6 (n)
worm
(Caenorhabditis elegans)
Secernentea inso-1 34
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8310 34
  • 67 (a)
OneToMany
Species where no ortholog for KCTD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD5 Gene

ENSEMBL:
Gene Tree for KCTD5 (if available)
TreeFam:
Gene Tree for KCTD5 (if available)

Paralogs for KCTD5 Gene

Paralogs for KCTD5 Gene

(5) SIMAP similar genes for KCTD5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KCTD5 Gene

genes like me logo Genes that share paralogs with KCTD5: view

Variants for KCTD5 Gene

Sequence variations from dbSNP and Humsavar for KCTD5 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000134103 -- 2,704,401(+) C/T intron_variant
rs1000136576 -- 2,690,839(+) C/T intron_variant
rs1000192137 -- 2,696,711(+) C/T intron_variant
rs1000375491 -- 2,700,876(+) C/A intron_variant
rs1000466453 -- 2,691,051(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD5 Gene

Variant ID Type Subtype PubMed ID
dgv110n111 CNV duplication 26073780
dgv780e212 CNV gain 25503493
esv2421848 CNV duplication 20811451
esv2422427 CNV duplication 17116639
esv2760067 CNV gain+loss 17122850
esv29849 CNV gain+loss 19812545
esv33514 CNV gain+loss 17666407
esv3570143 CNV gain 25503493
esv3637635 CNV gain 21293372
esv3892757 CNV gain 25118596
nsv1037150 CNV gain 25217958
nsv457354 CNV gain 19166990
nsv471073 CNV loss 18288195
nsv473414 CNV novel sequence insertion 20440878
nsv519596 CNV loss 19592680
nsv571244 CNV gain 21841781
nsv817714 CNV loss 17921354
nsv827518 CNV gain 20364138
nsv833123 CNV gain+loss 17160897
nsv9337 CNV loss 18304495
nsv984253 CNV duplication 23825009

Variation tolerance for KCTD5 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD5 Gene

Disorders for KCTD5 Gene

Additional Disease Information for KCTD5

No disorders were found for KCTD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD5 Gene

Publications for KCTD5 Gene

  1. Pentameric assembly of potassium channel tetramerization domain-containing protein 5. (PMID: 19361449) Dementieva IS … Goldstein SA (Journal of molecular biology 2009) 3 4 58
  2. KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases. (PMID: 18573101) Bayón Y … Alonso A (The FEBS journal 2008) 3 4 58
  3. Identification of a cytoplasmic interaction partner of the large regulatory proteins Rep78/Rep68 of adeno-associated virus type 2 (AAV-2). (PMID: 17239418) Weger S … Heilbronn R (Virology 2007) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for KCTD5 Gene

Sources for KCTD5 Gene

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