Aliases for KCTD4 Gene

Aliases for KCTD4 Gene

  • Potassium Channel Tetramerization Domain Containing 4 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 4 2 3
  • BTB/POZ Domain-Containing Protein KCTD4 3 4
  • BA321C24.3 3

External Ids for KCTD4 Gene

Previous GeneCards Identifiers for KCTD4 Gene

  • GC13U900202
  • GC13M043564
  • GC13M044664
  • GC13M045766
  • GC13M026568

Summaries for KCTD4 Gene

GeneCards Summary for KCTD4 Gene

KCTD4 (Potassium Channel Tetramerization Domain Containing 4) is a Protein Coding gene. Diseases associated with KCTD4 include Gerstmann-Straussler Disease. Among its related pathways are Sweet Taste Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. An important paralog of this gene is KCTD15.

Additional gene information for KCTD4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCTD4 Gene

Genomics for KCTD4 Gene

GeneHancer (GH) Regulatory Elements for KCTD4 Gene

Promoters and enhancers for KCTD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J045177 Enhancer 1.2 Ensembl ENCODE dbSUPER 20.5 +31.3 31301 4.8 ZSCAN5C NCOR1 FOS ZNF639 ZNF10 TRIM28 ATF2 ZEB1 OSR2 BCL11A KCTD4 GTF2F2 ERICH6B TPT1-AS1 RF00017-1412 piR-50437-142
GH13J045204 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.4 +3.8 3802 5.4 ZSCAN5C JUND FOS RELA BCL11A ZNF316 CBFB MAFF FOSL2 CEBPB GTF2F2 KCTD4 TPT1 COG3 RF00017-1412
GH13J045215 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.2 -7.4 -7399 9 EP300 ZSCAN5C TCF12 NCOR1 JUND ZNF639 ZNF10 CUX1 TEAD1 ZNF341 COG3 TPT1-AS1 KCTD4 LOC105370190 GTF2F2
GH13J045238 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -30.0 -29961 5.9 JUND ZNF10 ZBTB17 FOS CTCF ZNF384 PRDM6 ZNF664 RXRA HNF4A GTF2F2 KCTD4 SLC25A30 LOC105370190
GH13J045372 Enhancer 0.8 ENCODE 11.1 -162.0 -161993 1.6 ZSCAN5C ZNF10 ATF2 OSR2 WT1 ZBTB17 ZNF524 NCOR1 ZNF707 POLR2A lnc-TPT1-2-001 TPT1-AS1 SLC25A30 TPT1 SLC25A30-AS1 KCTD4 SERP2 piR-37004-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCTD4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCTD4

Top Transcription factor binding sites by QIAGEN in the KCTD4 gene promoter:
  • CUTL1
  • POU3F2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B

Genomic Locations for KCTD4 Gene

Genomic Locations for KCTD4 Gene
chr13:45,192,853-45,211,102
(GRCh38/hg38)
Size:
18,250 bases
Orientation:
Minus strand
chr13:45,766,988-45,775,175
(GRCh37/hg19)
Size:
8,188 bases
Orientation:
Minus strand

Genomic View for KCTD4 Gene

Genes around KCTD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD4 Gene

Proteins for KCTD4 Gene

  • Protein details for KCTD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVF5-KCTD4_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD4
    Protein Accession:
    Q8WVF5
    Secondary Accessions:
    • Q5W0P9

    Protein attributes for KCTD4 Gene

    Size:
    259 amino acids
    Molecular mass:
    29967 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCTD4 Gene

Post-translational modifications for KCTD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KCTD4
  • Santa Cruz Biotechnology (SCBT) Antibodies for KCTD4

No data available for DME Specific Peptides for KCTD4 Gene

Domains & Families for KCTD4 Gene

Gene Families for KCTD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KCTD4 Gene

Blocks:
  • BTB/POZ domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KCTD4 Gene

GenScript: Design optimal peptide antigens:
  • BTB/POZ domain-containing protein KCTD4 (KCTD4_HUMAN)
genes like me logo Genes that share domains with KCTD4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KCTD4 Gene

Function for KCTD4 Gene

Phenotypes From GWAS Catalog for KCTD4 Gene

Gene Ontology (GO) - Molecular Function for KCTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25910212
genes like me logo Genes that share ontologies with KCTD4: view
genes like me logo Genes that share phenotypes with KCTD4: view

Animal Model Products

CRISPR Products

miRNA for KCTD4 Gene

miRTarBase miRNAs that target KCTD4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD4 Gene

Localization for KCTD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD4 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD4 Gene

Pathways & Interactions for KCTD4 Gene

PathCards logo

SuperPathways for KCTD4 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Activation of cAMP-Dependent PKA
.77
.77
.56
3 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
4 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCTD4: view

Pathways by source for KCTD4 Gene

13 Qiagen pathways for KCTD4 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCTD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD4: view

No data available for SIGNOR curated interactions for KCTD4 Gene

Drugs & Compounds for KCTD4 Gene

No Compound Related Data Available

Transcripts for KCTD4 Gene

mRNA/cDNA for KCTD4 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD4 Gene

No ASD Table

Relevant External Links for KCTD4 Gene

GeneLoc Exon Structure for
KCTD4

Expression for KCTD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCTD4 Gene

mRNA differential expression in normal tissues according to GTEx for KCTD4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.4), Brain - Amygdala (x8.6), Brain - Caudate (basal ganglia) (x6.8), Brain - Hippocampus (x4.0), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for KCTD4 Gene

This gene is overexpressed in Frontal cortex (46.4) and Spinal cord (22.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KCTD4 Gene



Protein tissue co-expression partners for KCTD4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCTD4

SOURCE GeneReport for Unigene cluster for KCTD4 Gene:

Hs.23406

Evidence on tissue expression from TISSUES for KCTD4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KCTD4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD4 Gene

Orthologs for KCTD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD4 31 30
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD4 31 30
  • 97.3 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD4 31
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCTD4 31 30
  • 94.34 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCTD4 31
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kctd4 17 31 30
  • 92.41 (n)
rat
(Rattus norvegicus)
Mammalia Kctd4 30
  • 91.12 (n)
chicken
(Gallus gallus)
Aves KCTD4 31 30
  • 81.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD4 31
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd4 30
  • 77.04 (n)
zebrafish
(Danio rerio)
Actinopterygii kctd4 31 30
  • 59.27 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
OneToMany
Species where no ortholog for KCTD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD4 Gene

ENSEMBL:
Gene Tree for KCTD4 (if available)
TreeFam:
Gene Tree for KCTD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCTD4: view image

Paralogs for KCTD4 Gene

genes like me logo Genes that share paralogs with KCTD4: view

Variants for KCTD4 Gene

Additional dbSNP identifiers (rs#s) for KCTD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCTD4 Gene

Variant ID Type Subtype PubMed ID
nsv832596 CNV loss 17160897

Variation tolerance for KCTD4 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCTD4 Gene

Disorders for KCTD4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCTD4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gerstmann-straussler disease
  • gsd
- elite association - COSMIC cancer census association via MalaCards
Search KCTD4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KCTD4

genes like me logo Genes that share disorders with KCTD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCTD4 Gene

Publications for KCTD4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation. (PMID: 30404837) Nagai T … Mizuno K (Journal of cell science 2018) 3 54
  3. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 54
  4. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 54
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 54

Products for KCTD4 Gene

Sources for KCTD4 Gene