Aliases for KCTD18 Gene

Aliases for KCTD18 Gene

  • Potassium Channel Tetramerization Domain Containing 18 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 18 2 3
  • BTB/POZ Domain-Containing Protein KCTD18 3 4
  • 6530404F10Rik 3

External Ids for KCTD18 Gene

Previous GeneCards Identifiers for KCTD18 Gene

  • GC02M201180
  • GC02M201061
  • GC02M201353
  • GC02M193206

Summaries for KCTD18 Gene

GeneCards Summary for KCTD18 Gene

KCTD18 (Potassium Channel Tetramerization Domain Containing 18) is a Protein Coding gene. An important paralog of this gene is KCTD19.

Additional gene information for KCTD18 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCTD18 Gene

Genomics for KCTD18 Gene

GeneHancer (GH) Regulatory Elements for KCTD18 Gene

Promoters and enhancers for KCTD18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J200508 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 +10.0 9982 2.4 HNRNPK ZBTB40 EP300 CTCF POLR2G SP1 PHF8 ZFX ZIC2 POLR2A SGO2 HSALNG0021474 KCTD18 AOX1 ENSG00000287299
GH02J200608 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 500.2 -89.6 -89594 2.1 JUND FOS EP300 RBM25 SMARCC1 FOSL2 CEBPB JUN BATF IRF4 AOX1 KCTD18 SGO2 BICD1P1 AOX3P
GH02J200304 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +211.6 211580 7.7 EP300 FOXK2 ZBTB40 ZNF217 CTCF NRF1 POLR2G NCOR1 ZFX ZIC2 SPATS2L NONHSAG030212.2 ORC2 CLK1 TYW5 RNU6-312P RNU6-762P PPIL3 KCTD18 ENSG00000252759
GH02J200962 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.6 -443.8 -443764 3.5 FOXK2 ZBTB40 ZNF217 EP300 CTCF NRF1 TCF12 MYC POLR2G SP1 ORC2 ENSG00000183308 LOC105373835 lnc-NIF3L1-3 PPIL3 CDK15 KCTD18 RNU6-312P CLK1 CASP8
GH02J200859 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -343.0 -342978 6.1 EP300 ZBTB40 SIN3A NRF1 TCF12 POLR2G USF1 SP1 GTF2E2 PHF8 CLK1 ENSG00000252759 lnc-CLK1-3 piR-53338-085 PPIL3 ORC2 TYW5 NIF3L1 BZW1 BZW1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCTD18 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCTD18

Top Transcription factor binding sites by QIAGEN in the KCTD18 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • HNF-3beta
  • Lhx3a
  • LHX3b
  • POU2F1
  • POU2F1a

Genomic Locations for KCTD18 Gene

Genomic Locations for KCTD18 Gene
chr2:200,488,952-200,519,784
(GRCh38/hg38)
Size:
30,833 bases
Orientation:
Minus strand
chr2:201,353,675-201,384,507
(GRCh37/hg19)
Size:
30,833 bases
Orientation:
Minus strand

Genomic View for KCTD18 Gene

Genes around KCTD18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD18 Gene

Proteins for KCTD18 Gene

  • Protein details for KCTD18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI47-KCD18_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD18
    Protein Accession:
    Q6PI47
    Secondary Accessions:
    • Q53T21
    • Q6NW26
    • Q6PCD8
    • Q8N9B7
    • Q96N73

    Protein attributes for KCTD18 Gene

    Size:
    426 amino acids
    Molecular mass:
    46739 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KCTD18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD18 Gene

Post-translational modifications for KCTD18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD18 Gene

No data available for DME Specific Peptides for KCTD18 Gene

Domains & Families for KCTD18 Gene

Gene Families for KCTD18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD18 Gene

Blocks:
  • BTB/POZ domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KCTD18 Gene

GenScript: Design optimal peptide antigens:
  • BTB/POZ domain-containing protein KCTD18 (KCD18_HUMAN)
genes like me logo Genes that share domains with KCTD18: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KCTD18 Gene

Function for KCTD18 Gene

Phenotypes From GWAS Catalog for KCTD18 Gene

genes like me logo Genes that share phenotypes with KCTD18: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCTD18 Gene

Localization for KCTD18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD18 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD18 Gene

Pathways & Interactions for KCTD18 Gene

PathCards logo

SuperPathways for KCTD18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KCTD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD18: view

No data available for Pathways by source and SIGNOR curated interactions for KCTD18 Gene

Drugs & Compounds for KCTD18 Gene

No Compound Related Data Available

Transcripts for KCTD18 Gene

mRNA/cDNA for KCTD18 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for KCTD18 Gene

GeneLoc Exon Structure for
KCTD18

Expression for KCTD18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCTD18 Gene

Protein differential expression in normal tissues from HIPED for KCTD18 Gene

This gene is overexpressed in CD4 Tcells (47.3) and Pancreatic juice (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KCTD18 Gene



Protein tissue co-expression partners for KCTD18 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCTD18

SOURCE GeneReport for Unigene cluster for KCTD18 Gene:

Hs.605775

Evidence on tissue expression from TISSUES for KCTD18 Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with KCTD18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD18 Gene

Orthologs for KCTD18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD18 31 30
  • 99.45 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd18 30
  • 84.38 (n)
mouse
(Mus musculus)
Mammalia Kctd18 17 31 30
  • 83.98 (n)
cow
(Bos Taurus)
Mammalia KCTD18 31 30
  • 83.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD18 31 30
  • 80.19 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD18 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD18 31 30
  • 67.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCTD18 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494936 30
  • 62.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32838 30
Species where no ortholog for KCTD18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCTD18 Gene

ENSEMBL:
Gene Tree for KCTD18 (if available)
TreeFam:
Gene Tree for KCTD18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCTD18: view image

Paralogs for KCTD18 Gene

genes like me logo Genes that share paralogs with KCTD18: view

Variants for KCTD18 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCTD18 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
775804 Benign: not provided 200,490,143(-) G/A MISSENSE_VARIANT
775805 Benign: not provided 200,490,375(-) C/A MISSENSE_VARIANT
776345 Benign: not provided 200,490,214(-) AGGCGCGGT/A FRAMESHIFT_VARIANT
rs10203042 - p.Ala413Val
rs10203154 - p.Gly336Cys

Additional dbSNP identifiers (rs#s) for KCTD18 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCTD18 Gene

Variant ID Type Subtype PubMed ID
nsv474056 CNV novel sequence insertion 20440878

Variation tolerance for KCTD18 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD18 Gene

Human Gene Mutation Database (HGMD)
KCTD18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD18 Gene

Disorders for KCTD18 Gene

Additional Disease Information for KCTD18

No disorders were found for KCTD18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD18 Gene

Publications for KCTD18 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation. (PMID: 30404837) Nagai T … Mizuno K (Journal of cell science 2018) 3 54
  5. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3 54

Products for KCTD18 Gene

Sources for KCTD18 Gene