Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCTD16 Gene

Aliases for KCTD16 Gene

  • Potassium Channel Tetramerization Domain Containing 16 2 3 5
  • Potassium Channel Tetramerization Domain-Containing Protein 16 4
  • Potassium Channel Tetramerisation Domain Containing 16 2
  • KIAA1317 4

External Ids for KCTD16 Gene

Previous GeneCards Identifiers for KCTD16 Gene

  • GC05P143613
  • GC05P143565
  • GC05P138699

Summaries for KCTD16 Gene

GeneCards Summary for KCTD16 Gene

KCTD16 (Potassium Channel Tetramerization Domain Containing 16) is a Protein Coding gene. An important paralog of this gene is KCTD8.

UniProtKB/Swiss-Prot for KCTD16 Gene

  • Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

Additional gene information for KCTD16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD16 Gene

Genomics for KCTD16 Gene

GeneHancer (GH) Regulatory Elements for KCTD16 Gene

Promoters and enhancers for KCTD16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I144169 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.4 -441 2.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 YIPF5 KCTD16 RN7SL87P
GH05I144206 Promoter 1 EPDnew 561 +34.6 34612 0.1 MXI1 ZIC2 HIC1 ZNF335 GLIS2 POLR2A ZNF600 EZH2 MAZ ZNF189 KCTD16 YIPF5 GC05P144326
GH05I144205 Promoter 1 Ensembl 11 +34.3 34341 0.2 MXI1 HIC1 ZNF335 POLR2A ZNF600 EZH2 MAZ ZNF189 ZEB2 ATF2 YIPF5 KCTD16 GC05P144326
GH05I144198 Enhancer 0.8 FANTOM5 Ensembl 11.3 +27.9 27862 0.8 ZNF189 KLF17 SIN3A ELF1 REST SP1 PRDM6 POLR2A FOSL2 TRIM28 YIPF5 KCTD16 GC05P144326
GH05I143535 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 5.1 -634.1 -634132 1.8 JUND POLR2A FOSL2 FOS NR3C1 KCTD16 RNU7-156P LOC105378208
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCTD16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCTD16 gene promoter:

Genomic Locations for KCTD16 Gene

Genomic Locations for KCTD16 Gene
314,927 bases
Plus strand

Genomic View for KCTD16 Gene

Genes around KCTD16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD16 Gene

Proteins for KCTD16 Gene

  • Protein details for KCTD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD16
    Protein Accession:
    Secondary Accessions:
    • Q9P2M9

    Protein attributes for KCTD16 Gene

    428 amino acids
    Molecular mass:
    49138 Da
    Quaternary structure:
    • Homopentamer; forms an open pentamer (PubMed:28963344). In contrast to other BTB domain-containing proteins, does not interact with CUL3 (PubMed:28963344). Interacts as a tetramer with GABRB1 and GABRB2.
    • Sequence=BAA92555.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD16 Gene

neXtProt entry for KCTD16 Gene

Post-translational modifications for KCTD16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD16 Gene

No data available for DME Specific Peptides for KCTD16 Gene

Domains & Families for KCTD16 Gene

Gene Families for KCTD16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD16 Gene

Suggested Antigen Peptide Sequences for KCTD16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD16: view

No data available for UniProtKB/Swiss-Prot for KCTD16 Gene

Function for KCTD16 Gene

Molecular function for KCTD16 Gene

UniProtKB/Swiss-Prot Function:
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

Phenotypes From GWAS Catalog for KCTD16 Gene

genes like me logo Genes that share phenotypes with KCTD16: view

Animal Models for KCTD16 Gene

MGI Knock Outs for KCTD16:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCTD16 Gene

Localization for KCTD16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD16 Gene

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD16 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCTD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0042734 presynaptic membrane IEA --
GO:0043235 receptor complex IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with KCTD16: view

Pathways & Interactions for KCTD16 Gene

SuperPathways for KCTD16 Gene

No Data Available

Interacting Proteins for KCTD16 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)
Selected Interacting proteins: ENSP00000424151 Q68DU8-KCD16_HUMAN for KCTD16 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KCTD16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD16: view

No data available for Pathways by source and SIGNOR curated interactions for KCTD16 Gene

Drugs & Compounds for KCTD16 Gene

No Compound Related Data Available

Transcripts for KCTD16 Gene

mRNA/cDNA for KCTD16 Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCTD16 Gene

Potassium channel tetramerisation domain containing 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD16 Gene

No ASD Table

Relevant External Links for KCTD16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCTD16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD16 Gene

mRNA differential expression in normal tissues according to GTEx for KCTD16 Gene

This gene is overexpressed in Brain - Cortex (x6.0), Brain - Frontal Cortex (BA9) (x5.8), and Brain - Anterior cingulate cortex (BA24) (x5.5).

Protein differential expression in normal tissues from HIPED for KCTD16 Gene

This gene is overexpressed in Brain (21.2), Fetal Brain (17.5), Frontal cortex (15.4), and Heart (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCTD16 Gene

Protein tissue co-expression partners for KCTD16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCTD16 Gene:


SOURCE GeneReport for Unigene cluster for KCTD16 Gene:


Evidence on tissue expression from TISSUES for KCTD16 Gene

  • Nervous system(4.3)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with KCTD16: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD16 Gene

Orthologs for KCTD16 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD16 33 34
  • 99.84 (n)
(Monodelphis domestica)
Mammalia KCTD16 34
  • 94 (a)
(Bos Taurus)
Mammalia KCTD16 33 34
  • 93.77 (n)
(Canis familiaris)
Mammalia KCTD16 33 34
  • 93.15 (n)
(Rattus norvegicus)
Mammalia Kctd16 33
  • 90.09 (n)
(Mus musculus)
Mammalia Kctd16 33 16 34
  • 89.7 (n)
(Ornithorhynchus anatinus)
Mammalia KCTD16 34
  • 87 (a)
(Gallus gallus)
Aves KCTD16 33 34
  • 81.3 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
-- 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd16 33
  • 78.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13002 33
(Danio rerio)
Actinopterygii kctd16b 33 34
  • 70.18 (n)
kctd16a 34
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10830 34
  • 50 (a)
(Caenorhabditis elegans)
Secernentea VM106R.1 34
  • 37 (a)
Species where no ortholog for KCTD16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD16 Gene

Gene Tree for KCTD16 (if available)
Gene Tree for KCTD16 (if available)

Paralogs for KCTD16 Gene

Paralogs for KCTD16 Gene

(2) SIMAP similar genes for KCTD16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCTD16: view

Variants for KCTD16 Gene

Sequence variations from dbSNP and Humsavar for KCTD16 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000001420 -- 144,403,161(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000002554 -- 144,184,763(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000011600 -- 144,227,840(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000012086 -- 144,420,213(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000013796 -- 144,271,882(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD16 Gene

Variant ID Type Subtype PubMed ID
dgv1047e199 CNV deletion 23128226
esv2207447 CNV deletion 18987734
esv2730867 CNV deletion 23290073
esv3075877 CNV deletion 24192839
esv3306963 CNV mobile element insertion 20981092
esv3326768 CNV insertion 20981092
esv3376809 CNV insertion 20981092
esv3575886 CNV gain 25503493
esv3607038 CNV loss 21293372
esv3890745 CNV loss 25118596
nsv1137033 CNV deletion 24896259
nsv478898 CNV novel sequence insertion 20440878
nsv5045 CNV insertion 18451855
nsv5046 CNV insertion 18451855
nsv830513 CNV gain 17160897

Variation tolerance for KCTD16 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD16 Gene

Disorders for KCTD16 Gene

Additional Disease Information for KCTD16

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KCTD16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD16 Gene

Publications for KCTD16 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases. (PMID: 28963344) Pinkas DM … Bullock AN (The Biochemical journal 2017) 4 58

Products for KCTD16 Gene

Sources for KCTD16 Gene

Loading form....