Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KCTD14 Gene

Aliases for KCTD14 Gene

  • Potassium Channel Tetramerization Domain Containing 14 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 14 2

External Ids for KCTD14 Gene

Previous GeneCards Identifiers for KCTD14 Gene

  • GC11M077453
  • GC11M077404
  • GC11M077726
  • GC11M074025

Summaries for KCTD14 Gene

GeneCards Summary for KCTD14 Gene

KCTD14 (Potassium Channel Tetramerization Domain Containing 14) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is KCTD7.

Additional gene information for KCTD14 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD14 Gene

Genomics for KCTD14 Gene

GeneHancer (GH) Regulatory Elements for KCTD14 Gene

Promoters and enhancers for KCTD14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I078044 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 635 2.7 HDGF SMAD1 ATF1 ARID4B SIN3A ZNF2 ZNF48 SLC30A9 E2F8 ARID2 KCTD14 KCTD21-AS1 INTS4 NDUFC2 ALG8 AAMDC ENSG00000254675 NDUFC2-KCTD14
GH11I078021 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.3 +23.3 23288 2.2 FOXA2 ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 YY1 ETS1 SLC30A9 KLF11 ENSG00000254675 KCTD14 KCTD21-AS1 ENSG00000254829 NDUFC2-KCTD14
GH11I078090 Enhancer 0.9 ENCODE 11 -44.7 -44690 1.6 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 RXRA SP5 PPARG NFIL3 KCTD21-AS1 KCTD14 THRSP ENSG00000254829 INTS4 NDUFC2 KCTD21 GC11P078094 LOC105369401
GH11I078082 Enhancer 0.9 ENCODE 11 -39.1 -39095 4.6 ELF3 FOXA2 MLX NFIB ARID4B RAD21 DNMT3B ZNF48 RARA CREM KCTD21-AS1 THRSP KCTD14 ENSG00000254829 INTS4 NDUFC2 ALG8 AAMDC LOC105369401 GC11P078094
GH11I078019 Enhancer 0.6 ENCODE 11.1 +26.2 26241 0.2 FOXA2 INSM2 ATF2 NFIL3 JUND ZNF629 CREB1 BCL6 FOS ATF7 INTS4 KCTD14 THRSP NDUFC2 ENSG00000254675 ENSG00000254829 NDUFC2-KCTD14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCTD14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCTD14 gene promoter:

Genomic Locations for KCTD14 Gene

Genomic Locations for KCTD14 Gene
chr11:78,015,715-78,046,191
(GRCh38/hg38)
Size:
30,477 bases
Orientation:
Minus strand
chr11:77,726,761-77,757,237
(GRCh37/hg19)

Genomic View for KCTD14 Gene

Genes around KCTD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD14 Gene

Proteins for KCTD14 Gene

  • Protein details for KCTD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ13-KCD14_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein KCTD14
    Protein Accession:
    Q9BQ13
    Secondary Accessions:
    • B2R9R8

    Protein attributes for KCTD14 Gene

    Size:
    255 amino acids
    Molecular mass:
    29591 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01062.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01929.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BX359005; Type=Frameshift; Positions=182; Evidence={ECO:0000305};

    Alternative splice isoforms for KCTD14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD14 Gene

Post-translational modifications for KCTD14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCTD14 Gene

Domains & Families for KCTD14 Gene

Gene Families for KCTD14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD14 Gene

Suggested Antigen Peptide Sequences for KCTD14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCTD14: view

No data available for UniProtKB/Swiss-Prot for KCTD14 Gene

Function for KCTD14 Gene

Phenotypes From GWAS Catalog for KCTD14 Gene

Gene Ontology (GO) - Molecular Function for KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCTD14: view
genes like me logo Genes that share phenotypes with KCTD14: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD14 Gene

Localization for KCTD14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD14 gene
Compartment Confidence
nucleus 2
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for KCTD14 Gene

Pathways & Interactions for KCTD14 Gene

genes like me logo Genes that share pathways with KCTD14: view

Gene Ontology (GO) - Biological Process for KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD14: view

No data available for SIGNOR curated interactions for KCTD14 Gene

Drugs & Compounds for KCTD14 Gene

No Compound Related Data Available

Transcripts for KCTD14 Gene

mRNA/cDNA for KCTD14 Gene

Unigene Clusters for KCTD14 Gene

Potassium channel tetramerisation domain containing 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD14 Gene

No ASD Table

Relevant External Links for KCTD14 Gene

GeneLoc Exon Structure for
KCTD14
ECgene alternative splicing isoforms for
KCTD14

Expression for KCTD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD14 Gene

This gene is overexpressed in Adrenal Gland (x8.2) and Pancreas (x7.0).

Protein differential expression in normal tissues from HIPED for KCTD14 Gene

This gene is overexpressed in Salivary gland (27.2) and Skin (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KCTD14 Gene



NURSA nuclear receptor signaling pathways regulating expression of KCTD14 Gene:

KCTD14

SOURCE GeneReport for Unigene cluster for KCTD14 Gene:

Hs.709780

Evidence on tissue expression from TISSUES for KCTD14 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KCTD14: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD14 Gene

Orthologs for KCTD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD14 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia KCTD14 33 34
  • 74.31 (n)
rat
(Rattus norvegicus)
Mammalia Kctd14 33
  • 69.68 (n)
mouse
(Mus musculus)
Mammalia Kctd14 33 16 34
  • 69.44 (n)
cow
(Bos Taurus)
Mammalia KCTD14 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD14 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCTD14 33 34
  • 60.25 (n)
lizard
(Anolis carolinensis)
Reptilia KCTD14 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd14 33
  • 59.42 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-39g20.5 33
  • 57.96 (n)
KCTD14 34
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for KCTD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCTD14 Gene

ENSEMBL:
Gene Tree for KCTD14 (if available)
TreeFam:
Gene Tree for KCTD14 (if available)

Paralogs for KCTD14 Gene

Paralogs for KCTD14 Gene

(1) SIMAP similar genes for KCTD14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KCTD14: view

Variants for KCTD14 Gene

Sequence variations from dbSNP and Humsavar for KCTD14 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000233296 -- 78,032,773(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000364909 -- 78,026,534(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000403569 -- 78,032,138(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000609121 -- 78,038,501(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000661311 -- 78,038,668(-) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD14 Gene

Variant ID Type Subtype PubMed ID
esv2660024 CNV deletion 23128226
esv3626891 CNV loss 21293372
nsv1050891 CNV gain 25217958
nsv516638 CNV loss 19592680
nsv520740 CNV gain 19592680

Variation tolerance for KCTD14 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD14 Gene

Disorders for KCTD14 Gene

Additional Disease Information for KCTD14

No disorders were found for KCTD14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD14 Gene

Publications for KCTD14 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for KCTD14 Gene

Sources for KCTD14 Gene

Content
Loading form....