Aliases for KCTD14 Gene

Aliases for KCTD14 Gene

  • Potassium Channel Tetramerization Domain Containing 14 2 3 5
  • Potassium Channel Tetramerisation Domain Containing 14 2 3
  • BTB/POZ Domain-Containing Protein KCTD14 3 4
  • MGC2376 2
  • KCTD14 5

External Ids for KCTD14 Gene

Previous GeneCards Identifiers for KCTD14 Gene

  • GC11M077453
  • GC11M077404
  • GC11M077726
  • GC11M074025

Summaries for KCTD14 Gene

GeneCards Summary for KCTD14 Gene

KCTD14 (Potassium Channel Tetramerization Domain Containing 14) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is KCTD7.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCTD14 Gene

Genomics for KCTD14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCTD14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCTD14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCTD14

Top Transcription factor binding sites by QIAGEN in the KCTD14 gene promoter:
  • AML1a
  • Bach1
  • GCNF-1
  • GCNF-2
  • HNF-3beta
  • NF-1
  • NF-1/L
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for KCTD14 Gene

Latest Assembly
30,477 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
30,477 bases
Minus strand

(GRCh37/hg19 by Ensembl)
30,477 bases
Minus strand

Genomic View for KCTD14 Gene

Genes around KCTD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD14 Gene

Proteins for KCTD14 Gene

  • Protein details for KCTD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BTB/POZ domain-containing protein KCTD14
    Protein Accession:
    Secondary Accessions:
    • B2R9R8

    Protein attributes for KCTD14 Gene

    255 amino acids
    Molecular mass:
    29591 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01062.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH01929.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BX359005; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for KCTD14 Gene


neXtProt entry for KCTD14 Gene

Post-translational modifications for KCTD14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCTD14 Gene

No data available for DME Specific Peptides for KCTD14 Gene

Domains & Families for KCTD14 Gene

Gene Families for KCTD14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD14 Gene

  • BTB/POZ domain

Suggested Antigen Peptide Sequences for KCTD14 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94527 (B2R9R8_HUMAN)
  • BTB/POZ domain-containing protein KCTD14 (KCD14_HUMAN)
genes like me logo Genes that share domains with KCTD14: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KCTD14 Gene

Function for KCTD14 Gene

Phenotypes From GWAS Catalog for KCTD14 Gene

Gene Ontology (GO) - Molecular Function for KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCTD14: view
genes like me logo Genes that share phenotypes with KCTD14: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCTD14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCTD14 Gene

Localization for KCTD14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD14 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KCTD14 Gene

Pathways & Interactions for KCTD14 Gene

PathCards logo

SuperPathways for KCTD14 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
2 Activation of cAMP-Dependent PKA
3 Neuropathic Pain-Signaling in Dorsal Horn Neurons
4 Hepatic ABC Transporters
genes like me logo Genes that share pathways with KCTD14: view

Pathways by source for KCTD14 Gene

13 Qiagen pathways for KCTD14 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD14: view

No data available for SIGNOR curated interactions for KCTD14 Gene

Drugs & Compounds for KCTD14 Gene

No Compound Related Data Available

Transcripts for KCTD14 Gene

mRNA/cDNA for KCTD14 Gene

5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCTD14

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD14 Gene

No ASD Table

Relevant External Links for KCTD14 Gene

GeneLoc Exon Structure for

Expression for KCTD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCTD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCTD14 Gene

This gene is overexpressed in Adrenal Gland (x8.2) and Pancreas (x7.0).

Protein differential expression in normal tissues from HIPED for KCTD14 Gene

This gene is overexpressed in Salivary gland (27.2) and Skin (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KCTD14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCTD14

SOURCE GeneReport for Unigene cluster for KCTD14 Gene:


Evidence on tissue expression from TISSUES for KCTD14 Gene

  • Lung(4.2)
  • Nervous system(4.2)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with KCTD14: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD14 Gene

Orthologs for KCTD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCTD14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCTD14 29 30
  • 99.74 (n)
(Canis familiaris)
Mammalia KCTD14 29 30
  • 74.31 (n)
(Rattus norvegicus)
Mammalia Kctd14 29
  • 69.68 (n)
(Mus musculus)
Mammalia Kctd14 29 16 30
  • 69.44 (n)
(Bos Taurus)
Mammalia KCTD14 30
  • 68 (a)
(Monodelphis domestica)
Mammalia KCTD14 30
  • 57 (a)
(Gallus gallus)
Aves KCTD14 29 30
  • 60.25 (n)
(Anolis carolinensis)
Reptilia KCTD14 30
  • 52 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kctd14 29
  • 59.42 (n)
(Danio rerio)
Actinopterygii si:ch73-39g20.5 29
  • 57.96 (n)
KCTD14 30
  • 46 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 33 (a)
Species where no ortholog for KCTD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KCTD14 Gene

Gene Tree for KCTD14 (if available)
Gene Tree for KCTD14 (if available)
Evolutionary constrained regions (ECRs) for KCTD14: view image
Alliance of Genome Resources:
Additional Orthologs for KCTD14

Paralogs for KCTD14 Gene

(1) SIMAP similar genes for KCTD14 Gene using alignment to 2 proteins:

  • B2R9R8_HUMAN
genes like me logo Genes that share paralogs with KCTD14: view

Variants for KCTD14 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KCTD14 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KCTD14 Gene

Variant ID Type Subtype PubMed ID
esv2660024 CNV deletion 23128226
esv3626891 CNV loss 21293372
nsv1050891 CNV gain 25217958
nsv516638 CNV loss 19592680
nsv520740 CNV gain 19592680

Variation tolerance for KCTD14 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCTD14 Gene

Disorders for KCTD14 Gene

Additional Disease Information for KCTD14

No disorders were found for KCTD14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD14 Gene

Publications for KCTD14 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. (PMID: 29892012) Chen S … Yu H (Nature genetics 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for KCTD14 Gene

Sources for KCTD14 Gene