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Aliases for KCTD10 Gene

Aliases for KCTD10 Gene

  • Potassium Channel Tetramerization Domain Containing 10 2 3 5
  • BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 3 3 4
  • Potassium Channel Tetramerization Domain-Containing Protein 10 3 4
  • Potassium Channel Tetramerisation Domain Containing 10 2 3
  • BTB/POZ Domain-Containing Protein KCTD10 3 4
  • HBACURD3 3 4
  • MSTP028 3
  • BTBD28 3
  • ULRO61 3
  • ULR061 4

External Ids for KCTD10 Gene

Previous GeneCards Identifiers for KCTD10 Gene

  • GC12M108349
  • GC12M109887
  • GC12M106904

Summaries for KCTD10 Gene

Entrez Gene Summary for KCTD10 Gene

  • The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for KCTD10 Gene

KCTD10 (Potassium Channel Tetramerization Domain Containing 10) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Hepatic ABC Transporters. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TNFAIP1.

UniProtKB/Swiss-Prot for KCTD10 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Additional gene information for KCTD10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCTD10 Gene

Genomics for KCTD10 Gene

GeneHancer (GH) Regulatory Elements for KCTD10 Gene

Promoters and enhancers for KCTD10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J109475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 637.8 +0.6 558 4.4 ZFX CC2D1A MNT SIX5 ZNF148 NKRF ZNF121 POLR2A GTF2F1 CSDE1 KCTD10 UBE3B SART3 IFT81 RNU4-32P ALKBH2 FAM216A USP30 ARPC3 CORO1C
GH12J109457 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +14.3 14342 11.2 SP1 ZFX ZKSCAN8 ZNF148 GTF2F1 MAFK TRIM24 SP7 SP5 PRDM1 KCTD10 MYO1H TRPV4 UBE3B MVK ENSG00000255655
GH12J109571 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 -95.9 -95930 3.4 MTA3 ZNF652 SP1 ELF3 CC2D1A ZFX MNT CBFA2T2 NKRF POLR2A MVK MMAB KCTD10 UBE3B ANAPC7 RNU4-32P TCHP GPN3 MYO1H
GH12J108514 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.4 +961.8 961839 2.6 CC2D1A SP1 ELF3 ZKSCAN8 NKRF POLR2A ZNF121 FOS SP7 ELF1 FICD SART3 PWP1 KCTD10 LOC101929162 PRDM4 ALKBH2 UBE3B ISCU PIR52944
GH12J109878 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 -403.1 -403052 3.6 ZNF473 SP1 ZFX ELF3 CTCF MNT SIX5 ZNF148 NKRF MLLT1 GLTP TCHP ENSG00000249094 RNU4-32P KCTD10 IFT81 ANKRD13A PPP1CC FAM216A UBE3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCTD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCTD10 gene promoter:
  • GCNF
  • GCNF-1
  • GCNF-2
  • HOXA3
  • Nkx5-1
  • YY1

Genomic Locations for KCTD10 Gene

Genomic Locations for KCTD10 Gene
chr12:109,448,655-109,477,359
(GRCh38/hg38)
Size:
28,705 bases
Orientation:
Minus strand
chr12:109,886,460-109,915,349
(GRCh37/hg19)
Size:
28,890 bases
Orientation:
Minus strand

Genomic View for KCTD10 Gene

Genes around KCTD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD10 Gene

Proteins for KCTD10 Gene

  • Protein details for KCTD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3F6-BACD3_HUMAN
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    Protein Accession:
    Q9H3F6
    Secondary Accessions:
    • Q53HN2
    • Q59FV1
    • Q6PL47
    • Q96SU0

    Protein attributes for KCTD10 Gene

    Size:
    313 amino acids
    Molecular mass:
    35432 Da
    Quaternary structure:
    • Homotetramer; forms a two-fold symmetric tetramer in solution (PubMed:28963344). Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer (PubMed:28963344). Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1 (By similarity). Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA (PubMed:19125419).
    SequenceCaution:
    • Sequence=BAB55188.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92595.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD10 Gene

    Alternative splice isoforms for KCTD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD10 Gene

Post-translational modifications for KCTD10 Gene

  • Ubiquitination at posLast=171171, isoforms=225, and isoforms=232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCTD10 Gene

Domains & Families for KCTD10 Gene

Gene Families for KCTD10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD10 Gene

Suggested Antigen Peptide Sequences for KCTD10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ41739 fis, clone HSYRA2002590, highly similar to BTB/POZ domain-containing protein KCTD10 (B3KVY5_HUMAN)
  • Potassium channel tetramerization domain-containing protein 10 (BACD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H3F6

UniProtKB/Swiss-Prot:

BACD3_HUMAN :
  • Belongs to the BACURD family.
Family:
  • Belongs to the BACURD family.
genes like me logo Genes that share domains with KCTD10: view

Function for KCTD10 Gene

Molecular function for KCTD10 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Phenotypes From GWAS Catalog for KCTD10 Gene

Gene Ontology (GO) - Molecular Function for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity ISS --
GO:0005112 Notch binding IPI 25401743
GO:0005515 protein binding IEA,IPI 19615732
GO:0017049 GTP-Rho binding IBA 21873635
genes like me logo Genes that share ontologies with KCTD10: view
genes like me logo Genes that share phenotypes with KCTD10: view

Animal Models for KCTD10 Gene

MGI Knock Outs for KCTD10:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for KCTD10 - Now 50% OFF >
  • * KCTD10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * KCTD10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCTD10 Gene

Localization for KCTD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD10 gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with KCTD10: view

Pathways & Interactions for KCTD10 Gene

genes like me logo Genes that share pathways with KCTD10: view

UniProtKB/Swiss-Prot Q9H3F6-BACD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA 25401743
GO:0016567 protein ubiquitination ISS --
GO:0035024 negative regulation of Rho protein signal transduction IBA 21873635
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD10: view

No data available for SIGNOR curated interactions for KCTD10 Gene

Drugs & Compounds for KCTD10 Gene

No Compound Related Data Available

Transcripts for KCTD10 Gene

mRNA/cDNA for KCTD10 Gene

Unigene Clusters for KCTD10 Gene

Potassium channel tetramerisation domain containing 10:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for KCTD10 - Now 50% OFF >
  • * KCTD10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * KCTD10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - - -
SP14: - -

Relevant External Links for KCTD10 Gene

GeneLoc Exon Structure for
KCTD10
ECgene alternative splicing isoforms for
KCTD10

Expression for KCTD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCTD10 Gene

Protein differential expression in normal tissues from HIPED for KCTD10 Gene

This gene is overexpressed in Bone marrow stromal cell (49.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KCTD10 Gene



NURSA nuclear receptor signaling pathways regulating expression of KCTD10 Gene:

KCTD10

SOURCE GeneReport for Unigene cluster for KCTD10 Gene:

Hs.524731

Evidence on tissue expression from TISSUES for KCTD10 Gene

  • Nervous system(4.9)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with KCTD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD10 Gene

Orthologs for KCTD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCTD10 34
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia KCTD10 35 34
  • 93.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KCTD10 35 34
  • 92.37 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCTD10 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kctd10 34
  • 89.99 (n)
mouse
(Mus musculus)
Mammalia Kctd10 17 35 34
  • 89.67 (n)
chicken
(Gallus gallus)
Aves KCTD10 35 34
  • 83.81 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kctd10 34
  • 77.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7517 34
zebrafish
(Danio rerio)
Actinopterygii kctd10 35 34
  • 79.98 (n)
OneToOne
wufb30g12 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7817 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006173 34
  • 69.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10465 35 34
  • 63.35 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2045.8 35 34
  • 47.96 (n)
ManyToMany
ZC239.13 35
  • 39 (a)
ManyToMany
ZC239.16 35
  • 35 (a)
ManyToMany
ZC239.17 35
  • 34 (a)
ManyToMany
C40A11.6 35
  • 33 (a)
ManyToMany
B0281.6 35
  • 32 (a)
ManyToMany
C40A11.7 35
  • 31 (a)
ManyToMany
sdz-35 35
  • 31 (a)
ManyToMany
F22E5.6 35
  • 31 (a)
ManyToMany
ZC239.14 35
  • 30 (a)
ManyToMany
ZC239.15 35
  • 29 (a)
ManyToMany
C40A11.3 35
  • 29 (a)
ManyToMany
C17F4.8 35
  • 29 (a)
ManyToMany
B0281.5 35
  • 29 (a)
ManyToMany
T08G3.13 35
  • 27 (a)
ManyToMany
ZC239.4 35
  • 27 (a)
ManyToMany
ZC239.3 35
  • 27 (a)
ManyToMany
C40A11.2 35
  • 27 (a)
ManyToMany
F22E5.12 35
  • 26 (a)
ManyToMany
K02F6.5 35
  • 26 (a)
ManyToMany
K02F6.8 35
  • 25 (a)
ManyToMany
T05E12.3 35
  • 25 (a)
ManyToMany
ZC239.5 35
  • 25 (a)
ManyToMany
ZC239.6 35
  • 24 (a)
ManyToMany
C40A11.4 35
  • 24 (a)
ManyToMany
ZC239.2 35
  • 24 (a)
ManyToMany
F22E5.8 35
  • 24 (a)
ManyToMany
F22E5.11 35
  • 21 (a)
ManyToMany
F22E5.13 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9320 35
  • 68 (a)
OneToMany
Cin.106 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.106 34
Species where no ortholog for KCTD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCTD10 Gene

ENSEMBL:
Gene Tree for KCTD10 (if available)
TreeFam:
Gene Tree for KCTD10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCTD10: view image

Paralogs for KCTD10 Gene

Paralogs for KCTD10 Gene

(6) SIMAP similar genes for KCTD10 Gene using alignment to 12 proteins:

  • BACD3_HUMAN
  • B3KVY5_HUMAN
  • F5GWA4_HUMAN
  • F5GWK6_HUMAN
  • F5GY15_HUMAN
  • F5H268_HUMAN
  • F5H497_HUMAN
  • F5H6V0_HUMAN
  • F8W8I7_HUMAN
  • L8E9A8_HUMAN
  • S4R3L9_HUMAN
  • S4R3Y7_HUMAN

Pseudogenes.org Pseudogenes for KCTD10 Gene

genes like me logo Genes that share paralogs with KCTD10: view

Variants for KCTD10 Gene

Sequence variations from dbSNP and Humsavar for KCTD10 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000597960 -- 109,479,487(-) G/A upstream_transcript_variant
rs1000656628 -- 109,450,270(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000721947 -- 109,462,620(-) G/A intron_variant
rs1000794545 -- 109,462,279(-) T/A intron_variant
rs1000805943 -- 109,473,666(-) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCTD10 Gene

Variant ID Type Subtype PubMed ID
esv3580463 CNV loss 25503493

Variation tolerance for KCTD10 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCTD10 Gene

Disorders for KCTD10 Gene

Additional Disease Information for KCTD10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KCTD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCTD10 Gene

Publications for KCTD10 Gene

  1. KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. (PMID: 19125419) Wang Y … Hui R (Journal of cellular biochemistry 2009) 2 3 4 58
  2. Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases. (PMID: 28963344) Pinkas DM … Bullock AN (The Biochemical journal 2017) 3 4 58
  3. TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1. (PMID: 22810651) Hu X … Zhang J (Molecular biology reports 2012) 2 3 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  5. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PMID: 20570916) Keebler ME … Kathiresan S (Circulation. Cardiovascular genetics 2010) 3 45 58

Products for KCTD10 Gene

Sources for KCTD10 Gene

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