The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015] See more...

Aliases for KCTD10 Gene

Aliases for KCTD10 Gene

  • Potassium Channel Tetramerization Domain Containing 10 2 3 5
  • BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 3 3 4
  • Potassium Channel Tetramerization Domain-Containing Protein 10 3 4
  • Potassium Channel Tetramerisation Domain Containing 10 2 3
  • BTB/POZ Domain-Containing Protein KCTD10 3 4
  • HBACURD3 3 4
  • MSTP028 2 3
  • BTBD28 2 3
  • ULRO61 3
  • KCTD10 5
  • ULR061 4

External Ids for KCTD10 Gene

Previous GeneCards Identifiers for KCTD10 Gene

  • GC12M108349
  • GC12M109887
  • GC12M106904

Summaries for KCTD10 Gene

Entrez Gene Summary for KCTD10 Gene

  • The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for KCTD10 Gene

KCTD10 (Potassium Channel Tetramerization Domain Containing 10) is a Protein Coding gene. Diseases associated with KCTD10 include Methylmalonic Aciduria, Cblb Type and Occupational Dermatitis. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TNFAIP1.

UniProtKB/Swiss-Prot Summary for KCTD10 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCTD10 Gene

Genomics for KCTD10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCTD10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCTD10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCTD10

Top Transcription factor binding sites by QIAGEN in the KCTD10 gene promoter:
  • GCNF
  • GCNF-1
  • GCNF-2
  • HOXA3
  • Nkx5-1
  • YY1

Genomic Locations for KCTD10 Gene

Latest Assembly
chr12:109,448,655-109,477,359
(GRCh38/hg38)
Size:
28,705 bases
Orientation:
Minus strand

Previous Assembly
chr12:109,886,460-109,915,105
(GRCh37/hg19 by Entrez Gene)
Size:
28,646 bases
Orientation:
Minus strand

chr12:109,886,461-109,915,349
(GRCh37/hg19 by Ensembl)
Size:
28,889 bases
Orientation:
Minus strand

Genomic View for KCTD10 Gene

Genes around KCTD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCTD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCTD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCTD10 Gene

Proteins for KCTD10 Gene

  • Protein details for KCTD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3F6-BACD3_HUMAN
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    Protein Accession:
    Q9H3F6
    Secondary Accessions:
    • Q53HN2
    • Q59FV1
    • Q6PL47
    • Q96SU0

    Protein attributes for KCTD10 Gene

    Size:
    313 amino acids
    Molecular mass:
    35432 Da
    Quaternary structure:
    • Homotetramer; forms a two-fold symmetric tetramer in solution (PubMed:28963344). Interacts with CUL3; interaction is direct and forms a 5:5 heterodecamer (PubMed:28963344). Component of the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1 (By similarity). Interacts with DNA polymerase delta subunit 2/POLD2 (By similarity). Interacts with PCNA (PubMed:19125419).
    SequenceCaution:
    • Sequence=BAB55188.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAD92595.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KCTD10 Gene

    Alternative splice isoforms for KCTD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCTD10 Gene

Post-translational modifications for KCTD10 Gene

  • Ubiquitination at Lys25, Lys32, and Lys171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCTD10 Gene

Domains & Families for KCTD10 Gene

Gene Families for KCTD10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCTD10 Gene

InterPro:
Blocks:
  • BTB/POZ domain

Suggested Antigen Peptide Sequences for KCTD10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ41739 fis, clone HSYRA2002590, highly similar to BTB/POZ domain-containing protein KCTD10 (B3KVY5_HUMAN)
  • Potassium channel tetramerization domain-containing protein 10 (BACD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H3F6

UniProtKB/Swiss-Prot:

BACD3_HUMAN :
  • Belongs to the BACURD family.
Family:
  • Belongs to the BACURD family.
genes like me logo Genes that share domains with KCTD10: view

Function for KCTD10 Gene

Molecular function for KCTD10 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Phenotypes From GWAS Catalog for KCTD10 Gene

Gene Ontology (GO) - Molecular Function for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA,ISS --
GO:0005112 Notch binding IPI 25401743
GO:0005515 protein binding IEA,IPI 19615732
GO:0031267 small GTPase binding IBA --
GO:0042802 identical protein binding IPI 32296183
genes like me logo Genes that share ontologies with KCTD10: view
genes like me logo Genes that share phenotypes with KCTD10: view

Animal Models for KCTD10 Gene

MGI Knock Outs for KCTD10:

Animal Models for research

miRNA for KCTD10 Gene

miRTarBase miRNAs that target KCTD10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCTD10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCTD10 Gene

Localization for KCTD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCTD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCTD10 gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 3
plasma membrane 1
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA,ISS --
genes like me logo Genes that share ontologies with KCTD10: view

Pathways & Interactions for KCTD10 Gene

PathCards logo

SuperPathways for KCTD10 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Activation of cAMP-Dependent PKA
.77
.77
.56
3 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
4 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCTD10: view

Pathways by source for KCTD10 Gene

13 Qiagen pathways for KCTD10 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

UniProtKB/Swiss-Prot Q9H3F6-BACD3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KCTD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA 25401743
GO:0016567 protein ubiquitination IBA,ISS --
GO:0035024 negative regulation of Rho protein signal transduction IBA 21873635
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA,ISS --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with KCTD10: view

No data available for SIGNOR curated interactions for KCTD10 Gene

Drugs & Compounds for KCTD10 Gene

No Compound Related Data Available

Transcripts for KCTD10 Gene

mRNA/cDNA for KCTD10 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCTD10

Alternative Splicing Database (ASD) splice patterns (SP) for KCTD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - - -
SP13: - - - -
SP14: - -

Relevant External Links for KCTD10 Gene

GeneLoc Exon Structure for
KCTD10

Expression for KCTD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCTD10 Gene

Protein differential expression in normal tissues from HIPED for KCTD10 Gene

This gene is overexpressed in Bone marrow stromal cell (49.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KCTD10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCTD10

SOURCE GeneReport for Unigene cluster for KCTD10 Gene:

Hs.524731

Evidence on tissue expression from TISSUES for KCTD10 Gene

  • Nervous system(4.9)
  • Eye(4.1)
  • Skin(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with KCTD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCTD10 Gene

Orthologs for KCTD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCTD10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KCTD10 29
  • 99.04 (n)
Cow
(Bos Taurus)
Mammalia KCTD10 29 30
  • 93.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KCTD10 29 30
  • 92.37 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KCTD10 30
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kctd10 29
  • 89.99 (n)
Mouse
(Mus musculus)
Mammalia Kctd10 29 16 30
  • 89.67 (n)
OneToOne
Chicken
(Gallus gallus)
Aves KCTD10 29 30
  • 83.81 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kctd10 29
  • 77.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7517 29
Zebrafish
(Danio rerio)
Actinopterygii kctd10 29 30
  • 79.98 (n)
OneToOne
wufb30g12 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7817 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006173 29
  • 69.09 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10465 29 30
  • 63.35 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea D2045.8 29 30
  • 47.96 (n)
ManyToMany
ZC239.13 30
  • 39 (a)
ManyToMany
ZC239.16 30
  • 35 (a)
ManyToMany
ZC239.17 30
  • 34 (a)
ManyToMany
C40A11.6 30
  • 33 (a)
ManyToMany
B0281.6 30
  • 32 (a)
ManyToMany
C40A11.7 30
  • 31 (a)
ManyToMany
sdz-35 30
  • 31 (a)
ManyToMany
F22E5.6 30
  • 31 (a)
ManyToMany
ZC239.14 30
  • 30 (a)
ManyToMany
ZC239.15 30
  • 29 (a)
ManyToMany
C40A11.3 30
  • 29 (a)
ManyToMany
C17F4.8 30
  • 29 (a)
ManyToMany
B0281.5 30
  • 29 (a)
ManyToMany
T08G3.13 30
  • 27 (a)
ManyToMany
ZC239.4 30
  • 27 (a)
ManyToMany
ZC239.3 30
  • 27 (a)
ManyToMany
C40A11.2 30
  • 27 (a)
ManyToMany
F22E5.12 30
  • 26 (a)
ManyToMany
K02F6.5 30
  • 26 (a)
ManyToMany
K02F6.8 30
  • 25 (a)
ManyToMany
T05E12.3 30
  • 25 (a)
ManyToMany
ZC239.5 30
  • 25 (a)
ManyToMany
ZC239.6 30
  • 24 (a)
ManyToMany
C40A11.4 30
  • 24 (a)
ManyToMany
ZC239.2 30
  • 24 (a)
ManyToMany
F22E5.8 30
  • 24 (a)
ManyToMany
F22E5.11 30
  • 21 (a)
ManyToMany
F22E5.13 30
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9320 30
  • 68 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.106 29
Species where no ortholog for KCTD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KCTD10 Gene

ENSEMBL:
Gene Tree for KCTD10 (if available)
TreeFam:
Gene Tree for KCTD10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCTD10: view image
Alliance of Genome Resources:
Additional Orthologs for KCTD10

Paralogs for KCTD10 Gene

Paralogs for KCTD10 Gene

(6) SIMAP similar genes for KCTD10 Gene using alignment to 12 proteins:

  • BACD3_HUMAN
  • B3KVY5_HUMAN
  • F5GWA4_HUMAN
  • F5GWK6_HUMAN
  • F5GY15_HUMAN
  • F5H268_HUMAN
  • F5H497_HUMAN
  • F5H6V0_HUMAN
  • F8W8I7_HUMAN
  • L8E9A8_HUMAN
  • S4R3L9_HUMAN
  • S4R3Y7_HUMAN

Pseudogenes.org Pseudogenes for KCTD10 Gene

genes like me logo Genes that share paralogs with KCTD10: view

Variants for KCTD10 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KCTD10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KCTD10 Gene

Variant ID Type Subtype PubMed ID
esv3580463 CNV loss 25503493

Variation tolerance for KCTD10 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCTD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCTD10
Leiden Open Variation Database (LOVD)
KCTD10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCTD10 Gene

Disorders for KCTD10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KCTD10 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
methylmalonic aciduria, cblb type
  • methylmalonic acidemia, cblb type
occupational dermatitis
  • occupational allergic contact dermatitis
gastrointestinal stromal tumor
  • gist
scalp-ear-nipple syndrome
  • sens
branchiooculofacial syndrome
  • bofs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KCTD10

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KCTD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCTD10 Gene

Publications for KCTD10 Gene

  1. KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation. (PMID: 19125419) Wang Y … Hui R (Journal of cellular biochemistry 2009) 2 3 4
  2. Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases. (PMID: 28963344) Pinkas DM … Bullock AN (The Biochemical journal 2017) 3 4
  3. TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1. (PMID: 22810651) Hu X … Zhang J (Molecular biology reports 2012) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. (PMID: 20570916) Keebler ME … Kathiresan S (Circulation. Cardiovascular genetics 2010) 3 40

Products for KCTD10 Gene

Sources for KCTD10 Gene