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Aliases for KCP Gene

Aliases for KCP Gene

  • Kielin/Chordin-Like Protein 2 3 5
  • Cysteine Rich BMP Regulator 2 (Chordin-Like) 2 3
  • Cysteine-Rich Motor Neuron 2 Protein 3 4
  • Cysteine-Rich BMP Regulator 2 3 4
  • Kielin/Chordin-Like Protein 1 3 4
  • Kielin 2 3
  • CRIM-2 3 4
  • CRIM2 3 4
  • KCP-1 3 4
  • KCP1 3 4
  • NET67 3

External Ids for KCP Gene

Previous HGNC Symbols for KCP Gene

  • CRIM2

Previous GeneCards Identifiers for KCP Gene

  • GC07Mg27914
  • GC07M128503
  • GC07M122878

Summaries for KCP Gene

GeneCards Summary for KCP Gene

KCP (Kielin/Chordin-Like Protein) is a Protein Coding gene. An important paralog of this gene is BMPER.

UniProtKB/Swiss-Prot for KCP Gene

  • Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Additional gene information for KCP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCP Gene

Genomics for KCP Gene

GeneHancer (GH) Regulatory Elements for KCP Gene

Promoters and enhancers for KCP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I128909 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 558.1 +0.4 414 1.7 HDGF ZBTB6 SP2 KLF17 EBF1 ZBTB8A ZIC2 ZFP69B ZNF335 ZFHX2 KCP LOC392787 LOC105375497 GC07P128966
GH07I128911 Enhancer 0.6 ENCODE 550.8 -1.0 -1033 0.8 MAZ SP2 KLF17 EBF1 ZBTB8A ZIC2 ZFP69B GLIS2 ZNF692 PATZ1 KCP IRF5 OPN1SW METTL2B LOC392787 GC07P128966
GH07I128936 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 12.5 -28.9 -28867 5.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A IRF4 GLIS2 ZNF207 ZNF143 ATF7 IRF5 GC07P128964 GC07P128965 GC07P128967 GC07P128963 KCP ENSG00000242162 FLNC FLNC-AS1 ATP6V1F
GH07I128932 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -23.7 -23721 3.3 HDGF PKNOX1 BATF KLF5 IRF4 ZNF335 ZNF143 ATF7 ETV6 BCLAF1 IRF5 ATP6V1F KCP ENSG00000242162 FLNC FLNC-AS1 TSPAN33 TNPO3 TPI1P2 LOC392787
GH07I128937 Enhancer 1 ENCODE dbSUPER 12.5 -25.7 -25683 0.2 ELF3 FOXA2 ARID4B ZBTB40 THRB ZSCAN9 RARA YY1 CREM THAP11 GC07P128964 GC07P128967 IRF5 GC07P128963 KCP ENSG00000242162 FLNC FLNC-AS1 ATP6V1F TSPAN33
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCP gene promoter:

Genomic Locations for KCP Gene

Genomic Locations for KCP Gene
chr7:128,862,451-128,910,719
(GRCh38/hg38)
Size:
48,269 bases
Orientation:
Minus strand
chr7:128,502,505-128,550,773
(GRCh37/hg19)

Genomic View for KCP Gene

Genes around KCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCP Gene

Proteins for KCP Gene

  • Protein details for KCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZWJ8-KCP_HUMAN
    Recommended name:
    Kielin/chordin-like protein
    Protein Accession:
    Q6ZWJ8
    Secondary Accessions:
    • Q8NBE0

    Protein attributes for KCP Gene

    Size:
    1503 amino acids
    Molecular mass:
    159938 Da
    Quaternary structure:
    • Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine/threonine protein kinase domains. Also able to interact with activin-A and TGFB1 (By similarity).

    Alternative splice isoforms for KCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCP Gene

Post-translational modifications for KCP Gene

  • Glycosylation at isoforms=278
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCP Gene

Domains & Families for KCP Gene

Gene Families for KCP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for KCP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCP: view

No data available for UniProtKB/Swiss-Prot for KCP Gene

Function for KCP Gene

Molecular function for KCP Gene

UniProtKB/Swiss-Prot Function:
Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Phenotypes From GWAS Catalog for KCP Gene

genes like me logo Genes that share phenotypes with KCP: view

Animal Models for KCP Gene

MGI Knock Outs for KCP:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KCP Gene

Localization for KCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCP Gene

Secreted.

Gene Ontology (GO) - Cellular Components for KCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with KCP: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KCP Gene

Pathways & Interactions for KCP Gene

No Data Available

Interacting Proteins for KCP Gene

Selected Interacting proteins: Q6ZWJ8-KCP_HUMAN for KCP Gene via IID

Symbol External ID(s) Details
BMP7

Gene Ontology (GO) - Biological Process for KCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030513 positive regulation of BMP signaling pathway IEA --
genes like me logo Genes that share ontologies with KCP: view

No data available for Pathways by source and SIGNOR curated interactions for KCP Gene

Drugs & Compounds for KCP Gene

No Compound Related Data Available

Transcripts for KCP Gene

mRNA/cDNA for KCP Gene

(13) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCP Gene

Kielin/chordin-like protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCP Gene

No ASD Table

Relevant External Links for KCP Gene

GeneLoc Exon Structure for
KCP
ECgene alternative splicing isoforms for
KCP

Expression for KCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCP Gene

This gene is overexpressed in Kidney - Cortex (x18.7), Brain - Cerebellum (x5.5), and Brain - Cerebellar Hemisphere (x5.3).

Protein differential expression in normal tissues from HIPED for KCP Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCP Gene



Protein tissue co-expression partners for KCP Gene

NURSA nuclear receptor signaling pathways regulating expression of KCP Gene:

KCP

SOURCE GeneReport for Unigene cluster for KCP Gene:

Hs.371746
genes like me logo Genes that share expression patterns with KCP: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCP Gene

Orthologs for KCP Gene

This gene was present in the common ancestor of mammals.

Orthologs for KCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC463713 33
  • 99.02 (n)
dog
(Canis familiaris)
Mammalia KCP 33
  • 87.25 (n)
cow
(Bos Taurus)
Mammalia LOC515624 33
  • 86.3 (n)
mouse
(Mus musculus)
Mammalia Kcp 33 16
  • 81.37 (n)
rat
(Rattus norvegicus)
Mammalia Kcp 33
  • 80.9 (n)
Species where no ortholog for KCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCP Gene

ENSEMBL:
Gene Tree for KCP (if available)
TreeFam:
Gene Tree for KCP (if available)

Paralogs for KCP Gene

Paralogs for KCP Gene

(1) SIMAP similar genes for KCP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KCP Gene

genes like me logo Genes that share paralogs with KCP: view

Variants for KCP Gene

Sequence variations from dbSNP and Humsavar for KCP Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000137428 -- 128,909,526(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000192188 -- 128,873,449(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000341189 -- 128,903,954(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000367261 -- 128,870,159(-) T/G downstream_transcript_variant
rs1000403868 -- 128,890,267(-) C/A/T coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for KCP Gene

Variant ID Type Subtype PubMed ID
dgv11611n54 CNV loss 21841781
dgv11612n54 CNV loss 21841781
dgv3941e59 CNV duplication 20981092
esv22837 CNV gain 19812545
esv2670312 CNV deletion 23128226
esv2735137 CNV deletion 23290073
esv2735145 CNV deletion 23290073
esv3614990 CNV loss 21293372
nsv1109913 CNV deletion 24896259
nsv1145158 CNV deletion 24896259
nsv464713 CNV loss 19166990
nsv464715 CNV loss 19166990
nsv464717 CNV loss 19166990
nsv470392 CNV gain 18288195
nsv517371 CNV gain+loss 19592680
nsv517923 CNV gain 19592680
nsv5946 CNV deletion 18451855
nsv608409 CNV loss 21841781
nsv608415 CNV loss 21841781
nsv831125 CNV loss 17160897
nsv949944 CNV deletion 24416366
nsv949945 CNV deletion 24416366

Additional Variant Information for KCP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for KCP Gene

Disorders for KCP Gene

Additional Disease Information for KCP

No disorders were found for KCP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCP Gene

Publications for KCP Gene

  1. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. (PMID: 15793581) Lin J … Dressler GR (Nature medicine 2005) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 44 58
  4. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han JW … Zhang XJ (Nature genetics 2009) 44 58
  5. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. (PMID: 18446379) Zeisberg M … Kalluri R (Pediatric nephrology (Berlin, Germany) 2008) 22 58

Products for KCP Gene

Sources for KCP Gene

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