Aliases for KCNT2 Gene
- Potassium Sodium-Activated Channel Subfamily T Member 2 2 3 5
- SLICK 2 3 4
- Sodium And Chloride-Activated ATP-Sensitive Potassium Channel Slo2.1 3 4
- Sequence Like An Intermediate Conductance Potassium Channel Subunit 3 4
- Potassium Channel, Subfamily T, Member 2 2 3
- Potassium Channel Subfamily T Member 2 3 4
- KCa4.2 2 3
External Ids for KCNT2 Gene
Previous GeneCards Identifiers for KCNT2 Gene
GeneCards Summary for KCNT2 Gene
KCNT2 (Potassium Sodium-Activated Channel Subfamily T Member 2) is a Protein Coding gene. Diseases associated with KCNT2 include Developmental And Epileptic Encephalopathy 57 and Seizure Disorder. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include voltage-gated potassium channel activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNT1.
UniProtKB/Swiss-Prot Summary for KCNT2 Gene
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).
Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).