Aliases for KCNS3 Gene
- Potassium Voltage-Gated Channel Modifier Subfamily S Member 3 2 3 5
- Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 3 2 3
- Potassium Voltage-Gated Channel Subfamily S Member 3 3 4
- Delayed-Rectifier K(+) Channel Alpha Subunit 3 3 4
- Voltage-Gated Potassium Channel Subunit Kv9.3 3 4
- Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 3 2
External Ids for KCNS3 Gene
Previous GeneCards Identifiers for KCNS3 Gene
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for KCNS3 Gene
KCNS3 (Potassium Voltage-Gated Channel Modifier Subfamily S Member 3) is a Protein Coding gene. Diseases associated with KCNS3 include Generalized Epilepsy With Febrile Seizures Plus, Type 4. Among its related pathways are Metabolism and Dopamine-DARPP32 Feedback onto cAMP Pathway. Gene Ontology (GO) annotations related to this gene include ion channel activity and potassium channel regulator activity. An important paralog of this gene is KCNS2.
UniProtKB/Swiss-Prot Summary for KCNS3 Gene
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.