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Aliases for KCNS2 Gene

Aliases for KCNS2 Gene

  • Potassium Voltage-Gated Channel Modifier Subfamily S Member 2 2 3 5
  • Potassium Voltage-Gated Channel, Delayed-Rectifier, Subfamily S, Member 2 2 3
  • Delayed-Rectifier K(+) Channel Alpha Subunit 2 3 4
  • Voltage-Gated Potassium Channel Subunit Kv9.2 3 4
  • Potassium Voltage-Gated Channel, Modifier Subfamily S, Member 2 2
  • Potassium Voltage-Gated Channel Subfamily S Member 2 3
  • KIAA1144 4
  • KV9.2 3

External Ids for KCNS2 Gene

Previous GeneCards Identifiers for KCNS2 Gene

  • GC08P098448
  • GC08P099513
  • GC08P099108
  • GC08P099387
  • GC08P099395
  • GC08P099508
  • GC08P094643
  • GC08P099439

Summaries for KCNS2 Gene

GeneCards Summary for KCNS2 Gene

KCNS2 (Potassium Voltage-Gated Channel Modifier Subfamily S Member 2) is a Protein Coding gene. Among its related pathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Potassium Channels. Gene Ontology (GO) annotations related to this gene include ion channel activity and delayed rectifier potassium channel activity. An important paralog of this gene is KCNS3.

UniProtKB/Swiss-Prot for KCNS2 Gene

  • Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.

Tocris Summary for KCNS2 Gene

  • Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.

Gene Wiki entry for KCNS2 Gene

Additional gene information for KCNS2 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNS2 Gene

Genomics for KCNS2 Gene

GeneHancer (GH) Regulatory Elements for KCNS2 Gene

Promoters and enhancers for KCNS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J098426 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +0.1 56 0.9 ELF3 RB1 SIN3A ZNF143 CREM THAP11 EGR2 HCFC1 MIER2 ZNF398 KCNS2 ENSG00000272321 STK3
GH08J098397 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15 -27.2 -27230 4.3 SMARCE1 PKNOX1 DPF2 MNT FOXA1 NR2F2 SP1 ZFHX2 CTBP1 GATA3 KCNS2 NIPAL2 ENSG00000278914 LOC100131849 STK3
GH08J098391 Enhancer 0.4 dbSUPER 12.2 -35.0 -35013 1.4 SMAD5 JUNB FOS ENSG00000278914 LOC100131849 KCNS2 RNU6-914P STK3
GH08J098396 Enhancer 0.2 dbSUPER 13 -30.5 -30517 0.2 KCNS2 ENSG00000278914 LOC100131849 STK3
GH08J098416 Enhancer 0.5 VISTA 0.4 -10.3 -10293 1 POLR2A ERICH5 LOC100131849 KCNS2 STK3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNS2 gene promoter:
  • HFH-1
  • Pax-5
  • STAT5A
  • Sp1
  • SRY
  • AP-2gamma
  • FAC1
  • LCR-F1
  • CREB
  • deltaCREB

Genomic Locations for KCNS2 Gene

Genomic Locations for KCNS2 Gene
chr8:98,427,022-98,432,848
(GRCh38/hg38)
Size:
5,827 bases
Orientation:
Plus strand
chr8:99,439,250-99,445,076
(GRCh37/hg19)
Size:
5,827 bases
Orientation:
Plus strand

Genomic View for KCNS2 Gene

Genes around KCNS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNS2 Gene

Proteins for KCNS2 Gene

  • Protein details for KCNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULS6-KCNS2_HUMAN
    Recommended name:
    Potassium voltage-gated channel subfamily S member 2
    Protein Accession:
    Q9ULS6
    Secondary Accessions:
    • A8KAN1

    Protein attributes for KCNS2 Gene

    Size:
    477 amino acids
    Molecular mass:
    54237 Da
    Quaternary structure:
    • Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers.
    SequenceCaution:
    • Sequence=BAA86458.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KCNS2 Gene

Post-translational modifications for KCNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNS2 Gene

Domains & Families for KCNS2 Gene

Gene Families for KCNS2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULS6

UniProtKB/Swiss-Prot:

KCNS2_HUMAN :
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
  • Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily.
Domain:
  • The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Family:
  • Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily.
genes like me logo Genes that share domains with KCNS2: view

Function for KCNS2 Gene

Molecular function for KCNS2 Gene

UniProtKB/Swiss-Prot Function:
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
GENATLAS Biochemistry:
potassium voltage-gated channel delayed-rectifier,subfamily Shab,member 1,highly and selectively expressed in the brain,modulator of Kv2.1,Kv2.2

Gene Ontology (GO) - Molecular Function for KCNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0005267 potassium channel activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KCNS2: view
genes like me logo Genes that share phenotypes with KCNS2: view

Animal Models for KCNS2 Gene

MGI Knock Outs for KCNS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNS2 Gene

Localization for KCNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNS2 Gene

Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2. {ECO:0000250 UniProtKB:O35174}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNS2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008076 colocalizes_with voltage-gated potassium channel complex ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with KCNS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNS2 Gene

Pathways & Interactions for KCNS2 Gene

genes like me logo Genes that share pathways with KCNS2: view

Pathways by source for KCNS2 Gene

1 Qiagen pathway for KCNS2 Gene

Gene Ontology (GO) - Biological Process for KCNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport ISS --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNS2: view

No data available for SIGNOR curated interactions for KCNS2 Gene

Drugs & Compounds for KCNS2 Gene

(4) Drugs for KCNS2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chromanol 293B Pharma Antagonist, Pore Blocker IKs blocker. Also blocks ICFTR 0
Flupirtine maleate Pharma KV7 channel activator 0
Kaliotoxin Pharma KV and KCa blocker 0
MaxiPost Pharma Potassium channel modulator; exerts subtype-specific effects 0

(4) Tocris Compounds for KCNS2 Gene

Compound Action Cas Number
Chromanol 293B IKs blocker. Also blocks ICFTR 163163-23-3
Flupirtine maleate KV7 channel activator 75507-68-5
Kaliotoxin KV and KCa blocker 145199-73-1
MaxiPost Potassium channel modulator; exerts subtype-specific effects 187523-35-9
genes like me logo Genes that share compounds with KCNS2: view

Transcripts for KCNS2 Gene

mRNA/cDNA for KCNS2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNS2 Gene

Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNS2 Gene

No ASD Table

Relevant External Links for KCNS2 Gene

GeneLoc Exon Structure for
KCNS2
ECgene alternative splicing isoforms for
KCNS2

Expression for KCNS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNS2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.1), Brain - Cortex (x7.9), and Brain - Anterior cingulate cortex (BA24) (x5.1).

Protein differential expression in normal tissues from HIPED for KCNS2 Gene

This gene is overexpressed in Retina (28.1) and Fetal heart (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNS2 Gene



Protein tissue co-expression partners for KCNS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNS2 Gene:

KCNS2

SOURCE GeneReport for Unigene cluster for KCNS2 Gene:

Hs.388045

Evidence on tissue expression from TISSUES for KCNS2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KCNS2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNS2 Gene

Orthologs for KCNS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNS2 34 33
  • 99.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KCNS2 34 33
  • 93.56 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNS2 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNS2 34 33
  • 92.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Kcns2 16 34 33
  • 90.34 (n)
rat
(Rattus norvegicus)
Mammalia Kcns2 33
  • 90.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNS2 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNS2 34 33
  • 78.55 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNS2 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcns2 33
  • 73.86 (n)
Species where no ortholog for KCNS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KCNS2 Gene

ENSEMBL:
Gene Tree for KCNS2 (if available)
TreeFam:
Gene Tree for KCNS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNS2: view image

Paralogs for KCNS2 Gene

Paralogs for KCNS2 Gene

(20) SIMAP similar genes for KCNS2 Gene using alignment to 1 proteins:

  • KCNS2_HUMAN
genes like me logo Genes that share paralogs with KCNS2: view

Variants for KCNS2 Gene

Sequence variations from dbSNP and Humsavar for KCNS2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000847535 -- 98,426,866(+) G/A upstream_transcript_variant
rs1001630997 -- 98,426,290(+) C/T upstream_transcript_variant
rs1002011492 -- 98,430,498(+) G/C 3_prime_UTR_variant
rs1002126209 -- 98,430,215(+) T/TT 3_prime_UTR_variant
rs1002575074 -- 98,425,033(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNS2 Gene

Variant ID Type Subtype PubMed ID
nsv1034492 CNV gain 25217958
nsv1076098 CNV deletion 25765185
nsv1145198 CNV deletion 24896259
nsv831406 CNV loss 17160897

Variation tolerance for KCNS2 Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNS2 Gene

Human Gene Mutation Database (HGMD)
KCNS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNS2 Gene

Disorders for KCNS2 Gene

Additional Disease Information for KCNS2

No disorders were found for KCNS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNS2 Gene

Publications for KCNS2 Gene

  1. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. (PMID: 16382104) Gutman GA … Wang X (Pharmacological reviews 2005) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  4. New modulatory alpha subunits for mammalian Shab K+ channels. (PMID: 9305895) Salinas M … Lazdunski M (The Journal of biological chemistry 1997) 2 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for KCNS2 Gene

Sources for KCNS2 Gene

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