This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] See more...

Aliases for KCNRG Gene

Aliases for KCNRG Gene

  • Potassium Channel Regulator 2 3 4 5
  • Potassium Channel Regulatory Protein 3 4
  • Putative Potassium Channel Regulatory Protein 3
  • Protein CLLD4 4
  • DLTET 3
  • CLLD4 4

External Ids for KCNRG Gene

Previous GeneCards Identifiers for KCNRG Gene

  • GC13P044577
  • GC13P049526
  • GC13P048387
  • GC13P049470
  • GC13P049487
  • GC13P050589
  • GC13P031384

Summaries for KCNRG Gene

Entrez Gene Summary for KCNRG Gene

  • This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for KCNRG Gene

KCNRG (Potassium Channel Regulator) is a Protein Coding gene. Diseases associated with KCNRG include Autoimmune Polyendocrine Syndrome Type 1 and Autoimmune Polyendocrine Syndrome. Among its related pathways are Sweet Taste Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is KCTD12.

UniProtKB/Swiss-Prot Summary for KCNRG Gene

  • Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.

Gene Wiki entry for KCNRG Gene

Additional gene information for KCNRG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNRG Gene

Genomics for KCNRG Gene

GeneHancer (GH) Regulatory Elements for KCNRG Gene

Promoters and enhancers for KCNRG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNRG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNRG

Top Transcription factor binding sites by QIAGEN in the KCNRG gene promoter:
  • GATA-1
  • HOXA5
  • Ik-2
  • ISGF-3
  • Pax-4a
  • PPAR-gamma2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT5A

Genomic Locations for KCNRG Gene

Genomic Locations for KCNRG Gene
chr13:50,015,254-50,020,922
(GRCh38/hg38)
Size:
5,669 bases
Orientation:
Plus strand
chr13:50,589,390-50,595,058
(GRCh37/hg19)
Size:
5,669 bases
Orientation:
Plus strand

Genomic View for KCNRG Gene

Genes around KCNRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNRG Gene

Proteins for KCNRG Gene

  • Protein details for KCNRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5I3-KCNRG_HUMAN
    Recommended name:
    Potassium channel regulatory protein
    Protein Accession:
    Q8N5I3
    Secondary Accessions:
    • A2A2X9
    • Q0P6D0
    • Q8IU75
    • Q8N3Q9

    Protein attributes for KCNRG Gene

    Size:
    272 amino acids
    Molecular mass:
    31048 Da
    Quaternary structure:
    • Can form homooligomers. Interacts with KCNA1 (via cytoplasmic N-terminal domain) and KCNA4.

    Alternative splice isoforms for KCNRG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNRG Gene

Post-translational modifications for KCNRG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNRG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNRG Gene

Domains & Families for KCNRG Gene

Gene Families for KCNRG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KCNRG Gene

Blocks:
  • BTB/POZ domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KCNRG Gene

GenScript: Design optimal peptide antigens:
  • Protein CLLD4 (KCNRG_HUMAN)
genes like me logo Genes that share domains with KCNRG: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KCNRG Gene

Function for KCNRG Gene

Molecular function for KCNRG Gene

UniProtKB/Swiss-Prot Function:
Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.

Phenotypes From GWAS Catalog for KCNRG Gene

Gene Ontology (GO) - Molecular Function for KCNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19968958
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with KCNRG: view
genes like me logo Genes that share phenotypes with KCNRG: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNRG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNRG Gene

Localization for KCNRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNRG Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNRG gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endosome 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KCNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 19968958
genes like me logo Genes that share ontologies with KCNRG: view

Pathways & Interactions for KCNRG Gene

PathCards logo

SuperPathways for KCNRG Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Activation of cAMP-Dependent PKA
.77
.77
.56
3 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
4 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCNRG: view

Pathways by source for KCNRG Gene

13 Qiagen pathways for KCNRG Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
GO:1902260 negative regulation of delayed rectifier potassium channel activity IDA 19968958
genes like me logo Genes that share ontologies with KCNRG: view

No data available for SIGNOR curated interactions for KCNRG Gene

Drugs & Compounds for KCNRG Gene

No Compound Related Data Available

Transcripts for KCNRG Gene

mRNA/cDNA for KCNRG Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNRG

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNRG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3: -
SP4: -

Relevant External Links for KCNRG Gene

GeneLoc Exon Structure for
KCNRG

Expression for KCNRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNRG Gene

mRNA differential expression in normal tissues according to GTEx for KCNRG Gene

This gene is overexpressed in Fallopian Tube (x8.7) and Cervix - Endocervix (x6.7).

Protein differential expression in normal tissues from HIPED for KCNRG Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNRG Gene



Protein tissue co-expression partners for KCNRG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNRG

SOURCE GeneReport for Unigene cluster for KCNRG Gene:

Hs.660161

mRNA Expression by UniProt/SwissProt for KCNRG Gene:

Q8N5I3-KCNRG_HUMAN
Tissue specificity: Ubiquitous in normal tissues and expressed in some tumor tissues.

Evidence on tissue expression from TISSUES for KCNRG Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with KCNRG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNRG Gene

Orthologs for KCNRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNRG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNRG 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KCNRG 31 30
  • 89.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KCNRG 31 30
  • 87.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnrg 17 31 30
  • 83.14 (n)
rat
(Rattus norvegicus)
Mammalia Kcnrg 30
  • 81.57 (n)
oppossum
(Monodelphis domestica)
Mammalia KCNRG 31
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNRG 31
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves KCNRG 31 30
  • 62.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNRG 31
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnrg 30
  • 60.66 (n)
zebrafish
(Danio rerio)
Actinopterygii kctd12.1 31
  • 22 (a)
ManyToMany
Species where no ortholog for KCNRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNRG Gene

ENSEMBL:
Gene Tree for KCNRG (if available)
TreeFam:
Gene Tree for KCNRG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNRG: view image

Paralogs for KCNRG Gene

genes like me logo Genes that share paralogs with KCNRG: view

Variants for KCNRG Gene

Additional dbSNP identifiers (rs#s) for KCNRG Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNRG Gene

Variant ID Type Subtype PubMed ID
esv3580637 CNV loss 25503493
nsv1035151 CNV loss 25217958
nsv561618 CNV loss 21841781

Variation tolerance for KCNRG Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNRG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNRG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNRG Gene

Disorders for KCNRG Gene

MalaCards: The human disease database

(4) MalaCards diseases for KCNRG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autoimmune polyendocrine syndrome type 1
  • autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
autoimmune polyendocrine syndrome
  • autoimmune polyendocrinopathy
fungal esophagitis
chronic mucocutaneous candidiasis
  • cmc
- elite association - COSMIC cancer census association via MalaCards
Search KCNRG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KCNRG

genes like me logo Genes that share disorders with KCNRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNRG Gene

Publications for KCNRG Gene

  1. A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. (PMID: 12650944) Ivanov DV … Baranova AV (FEBS letters 2003) 3 4 23 54
  2. Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region. (PMID: 20237900) Birerdinc A … Baranova A (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2010) 3 23 54
  3. Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels. (PMID: 19968958) Usman H … Mathew MK (Biochemical and biophysical research communications 2010) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for KCNRG Gene

Sources for KCNRG Gene