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Aliases for KCNQ1DN Gene

Subcategory (RNA class) for KCNQ1DN Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for KCNQ1DN Gene

  • KCNQ1 Downstream Neighbor 2 2 3
  • KCNQ1 Downstream Neighbor (Non-Protein Coding) 2 3 5
  • BWRT 3 4
  • Beckwith-Wiedemann Region Transcript Protein 4
  • HSA404617 3

External Ids for KCNQ1DN Gene

Previous GeneCards Identifiers for KCNQ1DN Gene

  • GC11P002856
  • GC11P002679

Summaries for KCNQ1DN Gene

Entrez Gene Summary for KCNQ1DN Gene

  • Imprinting is a phenomenon in which epigenetic modifications lead to expression or suppression of alleles of some genes based on their parental origin. Wilms tumor-2 (WT2; MIM 194071) is defined by maternal-specific loss of heterozygosity of a critical region on chromosome 11p15.5 that includes several imprinted genes. KCNQ1DN is an imprinted gene located within the WT2 critical region that is expressed from the maternal allele (Xin et al., 2000 [PubMed 11056398]).[supplied by OMIM, Mar 2008]

GeneCards Summary for KCNQ1DN Gene

KCNQ1DN (KCNQ1 Downstream Neighbor) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with KCNQ1DN include Aging and Wilms Tumor 1.

Gene Wiki entry for KCNQ1DN Gene

Additional gene information for KCNQ1DN Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNQ1DN Gene

Genomics for KCNQ1DN Gene

GeneHancer (GH) Regulatory Elements for KCNQ1DN Gene

Promoters and enhancers for KCNQ1DN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002824 Enhancer 1.6 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.2 -44.0 -44004 3.4 JUN MAX ZIC2 RFX5 POLR2A SMC3 RCOR1 FOS CHD2 TCF7L2 KCNQ1-AS1 KCNQ1DN CDKN1C COX6CP18 KCNQ1
GH11J002777 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -90.4 -90354 5.3 HDGF PKNOX1 SMAD1 ATF1 FOXA2 ARNT TCF12 ZNF766 GLIS2 GATA2 KCNQ1-AS1 KCNQ1DN KCNQ1 CDKN1C COX6CP18
GH11J002549 Enhancer 0.5 ENCODE dbSUPER 10.7 -319.3 -319310 1.6 PRDM10 SLC22A18AS TRPM5 KCNQ1DN KCNQ1-AS1 SLC22A18 ENSG00000199550 CD81 GC11P002540 GC11P002570 KCNQ1
GH11J002822 Enhancer 0.3 FANTOM5 12.2 -47.0 -46964 0.3 TRIM28 KCNQ1-AS1 KCNQ1DN TSSC4 KCNQ1 COX6CP18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNQ1DN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNQ1DN gene promoter:
  • STAT1beta
  • STAT1alpha
  • STAT1
  • CP2
  • Sox5
  • AREB6
  • MyoD
  • C/EBPalpha
  • FOXO4
  • HOXA3

Genomic Locations for KCNQ1DN Gene

Genomic Locations for KCNQ1DN Gene
2,073 bases
Plus strand
2,073 bases
Plus strand

Genomic View for KCNQ1DN Gene

Genes around KCNQ1DN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNQ1DN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNQ1DN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNQ1DN Gene

Proteins for KCNQ1DN Gene

  • Protein details for KCNQ1DN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    KCNQ1 downstream neighbor protein
    Protein Accession:

    Protein attributes for KCNQ1DN Gene

    68 amino acids
    Molecular mass:
    7384 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KCNQ1DN Gene

Post-translational modifications for KCNQ1DN Gene

No Post-translational modifications

No data available for DME Specific Peptides for KCNQ1DN Gene

Domains & Families for KCNQ1DN Gene

Protein Domains for KCNQ1DN Gene


Suggested Antigen Peptide Sequences for KCNQ1DN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KCNQ1DN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KCNQ1DN Gene

Function for KCNQ1DN Gene

Phenotypes From GWAS Catalog for KCNQ1DN Gene

Gene Ontology (GO) - Molecular Function for KCNQ1DN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with KCNQ1DN: view

Phenotypes for KCNQ1DN Gene

genes like me logo Genes that share phenotypes with KCNQ1DN: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNQ1DN Gene

Localization for KCNQ1DN Gene

Gene Ontology (GO) - Cellular Components for KCNQ1DN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with KCNQ1DN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for KCNQ1DN Gene

Pathways & Interactions for KCNQ1DN Gene

SuperPathways for KCNQ1DN Gene

No Data Available

Interacting Proteins for KCNQ1DN Gene

Gene Ontology (GO) - Biological Process for KCNQ1DN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KCNQ1DN: view

No data available for Pathways by source and SIGNOR curated interactions for KCNQ1DN Gene

Drugs & Compounds for KCNQ1DN Gene

No Compound Related Data Available

Transcripts for KCNQ1DN Gene

mRNA/cDNA for KCNQ1DN Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Unigene Clusters for KCNQ1DN Gene

KCNQ1 downstream neighbor (non-protein coding):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNQ1DN Gene

No ASD Table

Relevant External Links for KCNQ1DN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNQ1DN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNQ1DN Gene

mRNA differential expression in normal tissues according to GTEx for KCNQ1DN Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x25.4), Testis (x9.7), and Brain - Substantia nigra (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of KCNQ1DN Gene:


SOURCE GeneReport for Unigene cluster for KCNQ1DN Gene:


mRNA Expression by UniProt/SwissProt for KCNQ1DN Gene:

Tissue specificity: Shows reduced expression in Wilms tumor samples.
genes like me logo Genes that share expression patterns with KCNQ1DN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNQ1DN Gene

Orthologs for KCNQ1DN Gene

Evolution for KCNQ1DN Gene

Gene Tree for KCNQ1DN (if available)
Gene Tree for KCNQ1DN (if available)

No data available for Orthologs for KCNQ1DN Gene

Paralogs for KCNQ1DN Gene

No data available for Paralogs for KCNQ1DN Gene

Variants for KCNQ1DN Gene

Sequence variations from dbSNP and Humsavar for KCNQ1DN Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000580640 -- 2,868,739(+) T/G upstream_transcript_variant
rs1001280416 -- 2,868,570(+) G/A upstream_transcript_variant
rs1001537528 -- 2,869,641(+) C/T upstream_transcript_variant
rs1001899277 -- 2,870,991(+) G/A intron_variant
rs1001915015 -- 2,870,557(+) T/C non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNQ1DN Gene

Variant ID Type Subtype PubMed ID
dgv1574n54 CNV loss 21841781
dgv1575n54 CNV loss 21841781
esv2759795 CNV gain 17122850
nsv1053066 CNV gain 25217958
nsv467655 CNV loss 19166990
nsv469930 CNV loss 18288195
nsv553111 CNV loss 21841781
nsv825715 CNV gain 20364138
nsv832050 CNV loss 17160897
nsv8765 CNV gain+loss 18304495
nsv951292 CNV deletion 24416366

Additional Variant Information for KCNQ1DN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for KCNQ1DN Gene

Disorders for KCNQ1DN Gene

MalaCards: The human disease database

(3) MalaCards diseases for KCNQ1DN Gene - From: LncRNADisease and GeneCards

Disorder Aliases PubMed IDs
wilms tumor 1
  • wt1
wilms tumor 2
  • wt2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KCNQ1DN

genes like me logo Genes that share disorders with KCNQ1DN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNQ1DN Gene

Publications for KCNQ1DN Gene

  1. A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and its reduced expression in Wilms' tumors. (PMID: 11056398) Xin Z … Mukai T (Journal of biochemistry 2000) 2 3 4 22 58
  2. Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting. (PMID: 11063728) Engemann S … Walter J (Human molecular genetics 2000) 2 3 4 58
  3. Epigenetic-aging-signature to determine age in different tissues. (PMID: 22067257) Koch CM … Wagner W (Aging 2011) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58

Products for KCNQ1DN Gene

Sources for KCNQ1DN Gene

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