Aliases for KCNN4 Gene
- Potassium Calcium-Activated Channel Subfamily N Member 4 2 3 5
- Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 4 2 3
- Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 4 2 3
- Intermediate Conductance Calcium-Activated Potassium Channel Protein 4 3 4
- Small Conductance Calcium-Activated Potassium Channel 4 2 3
- Putative Gardos Channel 3 4
- KCa3.1 3 4
- SKCa 4 3 4
- IKCA1 3 4
- SKCa4 3 4
- KCA4 3 4
External Ids for KCNN4 Gene
Previous GeneCards Identifiers for KCNN4 Gene
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNN4 Gene
KCNN4 (Potassium Calcium-Activated Channel Subfamily N Member 4) is a Protein Coding gene. Diseases associated with KCNN4 include Dehydrated Hereditary Stomatocytosis 2 and Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema. Among its related pathways are CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF) and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include calmodulin binding and potassium channel activity. An important paralog of this gene is KCNN3.
UniProtKB/Swiss-Prot Summary for KCNN4 Gene
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).
Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).