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Aliases for KCNN2 Gene

Aliases for KCNN2 Gene

  • Potassium Calcium-Activated Channel Subfamily N Member 2 2 3 5
  • Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 2 2 3
  • Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 2 2 3
  • Small Conductance Calcium-Activated Potassium Channel 2 2 3
  • KCa2.2 3 4
  • SKCa 2 3 4
  • SK2 3 4
  • Apamin-Sensitive Small-Conductance Ca2+-Activated Potassium Channel 3
  • Small Conductance Calcium-Activated Potassium Channel Protein 2 3
  • SKCA2 3
  • SKCa2 4
  • HSK2 3

External Ids for KCNN2 Gene

Previous GeneCards Identifiers for KCNN2 Gene

  • GC05P113302
  • GC05P113728
  • GC05P113774
  • GC05P113725
  • GC05P108880
  • GC05P114360

Summaries for KCNN2 Gene

Entrez Gene Summary for KCNN2 Gene

  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for KCNN2 Gene

KCNN2 (Potassium Calcium-Activated Channel Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Aldosterone synthesis and secretion and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is KCNN3.

UniProtKB/Swiss-Prot for KCNN2 Gene

  • Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Tocris Summary for KCNN2 Gene

  • Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Gene Wiki entry for KCNN2 Gene

Additional gene information for KCNN2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNN2 Gene

Genomics for KCNN2 Gene

GeneHancer (GH) Regulatory Elements for KCNN2 Gene

Promoters and enhancers for KCNN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J114359 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.1 +305.6 305584 3.3 SIN3A RAD21 YY1 ZNF335 EGR1 SCRT2 ZNF143 ATF7 IKZF2 HCFC1 KCNN2 GC05P114405 RN7SKP89
GH05J114054 Enhancer 0.8 Ensembl ENCODE 650.7 -0.4 -432 1.3 MXI1 L3MBTL2 ZNF189 MAX ZNF398 ZIC2 E2F1 ZNF335 POLR2A ZNF341 KCNN2 ENSG00000251628 GC05P114046
GH05J114433 Promoter 0.5 EPDnew 650.1 +377.5 377486 0.1 KCNN2 PIR51428 GC05P114405 GC05P114557
GH05J114418 Enhancer 0.8 FANTOM5 13.6 +362.9 362934 0.2 PKNOX1 BACH1 STAT5A EBF1 BMI1 BATF IRF4 NFATC1 EED ZNF207 KCNN2 PIR51428 GC05P114405 GC05P114557
GH05J114243 Enhancer 0.3 ENCODE 5.4 +188.6 188553 2.9 FOS KCNN2 RN7SKP89 GC05P114101
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNN2 gene promoter:
  • Nkx6-1
  • E4BP4
  • RSRFC4
  • Elk-1
  • PPAR-gamma2
  • PPAR-gamma1
  • Evi-1
  • CUTL1
  • LCR-F1
  • AML1a

Genomic Locations for KCNN2 Gene

Genomic Locations for KCNN2 Gene
chr5:114,056,006-114,496,500
(GRCh38/hg38)
Size:
440,495 bases
Orientation:
Plus strand
chr5:113,696,642-113,832,337
(GRCh37/hg19)
Size:
135,696 bases
Orientation:
Plus strand

Genomic View for KCNN2 Gene

Genes around KCNN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNN2 Gene

Proteins for KCNN2 Gene

  • Protein details for KCNN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2S1-KCNN2_HUMAN
    Recommended name:
    Small conductance calcium-activated potassium channel protein 2
    Protein Accession:
    Q9H2S1
    Secondary Accessions:
    • A6NF94
    • Q0VFZ4
    • Q6PJI0
    • Q6X2Y2

    Protein attributes for KCNN2 Gene

    Size:
    579 amino acids
    Molecular mass:
    63760 Da
    Quaternary structure:
    • Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

    Three dimensional structures from OCA and Proteopedia for KCNN2 Gene

    Alternative splice isoforms for KCNN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNN2 Gene

Post-translational modifications for KCNN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNN2 Gene

Domains & Families for KCNN2 Gene

Gene Families for KCNN2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2S1

UniProtKB/Swiss-Prot:

KCNN2_HUMAN :
  • Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
Family:
  • Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
genes like me logo Genes that share domains with KCNN2: view

Function for KCNN2 Gene

Molecular function for KCNN2 Gene

UniProtKB/Swiss-Prot Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Phenotypes From GWAS Catalog for KCNN2 Gene

Gene Ontology (GO) - Molecular Function for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19815520
GO:0005516 calmodulin binding IBA --
GO:0015269 calcium-activated potassium channel activity IDA 17110593
GO:0016286 small conductance calcium-activated potassium channel activity ISS,TAS 10991935
GO:0019904 protein domain specific binding IPI 19815520
genes like me logo Genes that share ontologies with KCNN2: view
genes like me logo Genes that share phenotypes with KCNN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNN2

miRNA for KCNN2 Gene

miRTarBase miRNAs that target KCNN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNN2 Gene

Localization for KCNN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNN2 gene
Compartment Confidence
plasma membrane 5
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 19815520
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10991935
GO:0030018 Z disc ISS 24951510
genes like me logo Genes that share ontologies with KCNN2: view

Pathways & Interactions for KCNN2 Gene

genes like me logo Genes that share pathways with KCNN2: view

Pathways by source for KCNN2 Gene

SIGNOR curated interactions for KCNN2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for KCNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport NAS 10991935
GO:0071805 potassium ion transmembrane transport ISS 19139040
GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential ISS 19139040
GO:1901379 regulation of potassium ion transmembrane transport IDA 17110593
genes like me logo Genes that share ontologies with KCNN2: view

Drugs & Compounds for KCNN2 Gene

(21) Drugs for KCNN2 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miconazole Approved, Investigational, Vet_approved Pharma Channel blocker, Antagonist, Pore Blocker, Target, inhibitor 3838
calcium Approved Nutra 0
Procaine Approved, Investigational, Vet_approved Pharma Channel blocker, Target, binder 60
Trimebutine Approved Pharma Target, inhibitor Antimuscarinic 7
Tubocurarine Approved Pharma antagonist 0

(4) Additional Compounds for KCNN2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist, Pore Blocker

(4) Tocris Compounds for KCNN2 Gene

Compound Action Cas Number
1-EBIO Activator of epithelial KCa channels 10045-45-1
BMS 191011 Potent BKCa (KCa1.1) channel opener 202821-81-6
CyPPA Activator of KCa2.2 and KCa2.3 channels 73029-73-9
SKA 31 Activator of KCa3.1 and KCa2 channels 40172-65-4
genes like me logo Genes that share compounds with KCNN2: view

Transcripts for KCNN2 Gene

Unigene Clusters for KCNN2 Gene

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3:

Relevant External Links for KCNN2 Gene

GeneLoc Exon Structure for
KCNN2
ECgene alternative splicing isoforms for
KCNN2

Expression for KCNN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNN2 Gene

mRNA differential expression in normal tissues according to GTEx for KCNN2 Gene

This gene is overexpressed in Adrenal Gland (x10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KCNN2 Gene



NURSA nuclear receptor signaling pathways regulating expression of KCNN2 Gene:

KCNN2

SOURCE GeneReport for Unigene cluster for KCNN2 Gene:

Hs.98280

mRNA Expression by UniProt/SwissProt for KCNN2 Gene:

Q9H2S1-KCNN2_HUMAN
Tissue specificity: Expressed in atrial myocytes (at protein level). Widely expressed.

Evidence on tissue expression from TISSUES for KCNN2 Gene

  • Heart(4.4)
  • Muscle(4.4)
  • Nervous system(4.4)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with KCNN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNN2 Gene

Orthologs for KCNN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNN2 34 33
  • 99.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KCNN2 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC474640 33
  • 94.72 (n)
KCNN2 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100910229 33
  • 92.22 (n)
mouse
(Mus musculus)
Mammalia Kcnn2 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNN2 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SK2 34
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNN2 34
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1499 33
zebrafish
(Danio rerio)
Actinopterygii KCNN2 34
  • 86 (a)
OneToOne
si:dkey-76p7.5 33
  • 76.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta SK 34 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C03F11.1 35
  • 39 (a)
kcnl-2 34
  • 30 (a)
ManyToMany
C53A5.5 35
  • 29 (a)
kcnl-4 34
  • 26 (a)
ManyToMany
kcnl-1 34
  • 24 (a)
ManyToMany
kcnl-3 34
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 64 (a)
OneToMany
Species where no ortholog for KCNN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KCNN2 Gene

ENSEMBL:
Gene Tree for KCNN2 (if available)
TreeFam:
Gene Tree for KCNN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNN2: view image

Paralogs for KCNN2 Gene

Paralogs for KCNN2 Gene

(4) SIMAP similar genes for KCNN2 Gene using alignment to 2 proteins:

  • KCNN2_HUMAN
  • D6RGY7_HUMAN
genes like me logo Genes that share paralogs with KCNN2: view

Variants for KCNN2 Gene

Sequence variations from dbSNP and Humsavar for KCNN2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000005016 -- 114,121,995(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000010913 -- 114,468,625(+) A/C intron_variant
rs1000013083 -- 114,113,484(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000019751 -- 114,306,710(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000021223 -- 114,449,000(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNN2 Gene

Variant ID Type Subtype PubMed ID
esv3606340 CNV loss 21293372
esv8535 CNV gain 19470904
nsv599433 CNV gain 21841781
nsv830451 CNV gain+loss 17160897
nsv830452 CNV loss 17160897

Variation tolerance for KCNN2 Gene

Residual Variation Intolerance Score: 5.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNN2 Gene

Disorders for KCNN2 Gene

Additional Disease Information for KCNN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KCNN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNN2 Gene

Publications for KCNN2 Gene

  1. Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts. (PMID: 13679367) Xu Y … Chiamvimonvat N (The Journal of biological chemistry 2003) 3 4 22 58
  2. Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. (PMID: 10991935) Desai R … Attali B (The Journal of biological chemistry 2000) 3 4 22 58
  3. Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). (PMID: 19815520) Lu L … Chiamvimonvat N (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 58
  4. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PMID: 16382103) Wei AD … Wulff H (Pharmacological reviews 2005) 2 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for KCNN2 Gene

Sources for KCNN2 Gene

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