Aliases for KCNN1 Gene
- Potassium Calcium-Activated Channel Subfamily N Member 1 2 3 5
- Potassium Channel, Calcium Activated Intermediate/Small Conductance Subfamily N Alpha, Member 1 2 3
- Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 1 2 3
- Small Conductance Calcium-Activated Potassium Channel Protein 1 3 4
- Small Conductance Calcium-Activated Potassium Channel 1 2 3
- KCa2.1 3 4
External Ids for KCNN1 Gene
Previous GeneCards Identifiers for KCNN1 Gene
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNN1 Gene
KCNN1 (Potassium Calcium-Activated Channel Subfamily N Member 1) is a Protein Coding gene. Diseases associated with KCNN1 include Dyskeratosis Congenita, Autosomal Dominant 3 and Mental Retardation, Autosomal Dominant 29. Among its related pathways are Aldosterone synthesis and secretion and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN2.
UniProtKB/Swiss-Prot Summary for KCNN1 Gene
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).