Aliases for KCNMB4 Gene
- Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4 2 3 5
- Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 4 2 3
- Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-4 3 4
- Potassium Channel Subfamily M Regulatory Beta Subunit 4 2 3
- Calcium-Activated Potassium Channel Subunit Beta-4 3 4
- Charybdotoxin Receptor Subunit Beta-4 3 4
- Big Potassium Channel Beta Subunit 4 2 3
- Maxi K Channel Subunit Beta-4 3 4
External Ids for KCNMB4 Gene
Previous GeneCards Identifiers for KCNMB4 Gene
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNMB4 Gene
KCNMB4 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4) is a Protein Coding gene. Diseases associated with KCNMB4 include Lymph Node Carcinoma and Juxtacortical Osteosarcoma. Among its related pathways are Nitric oxide stimulates guanylate cyclase and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is ENSG00000275163.
UniProtKB/Swiss-Prot Summary for KCNMB4 Gene
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.