Aliases for KCNMB1 Gene
- Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1 2 3 5
- Potassium Large Conductance Calcium-Activated Channel, Subfamily M, Beta Member 1 2 3
- Calcium-Activated Potassium Channel, Subfamily M Subunit Beta-1 3 4
- Potassium Channel Subfamily M Regulatory Beta Subunit 1 2 3
- Calcium-Activated Potassium Channel Subunit Beta-1 3 4
- Charybdotoxin Receptor Subunit Beta-1 3 4
- Big Potassium Channel Beta Subunit 1 2 3
- Maxi K Channel Subunit Beta-1 3 4
- MaxiK Channel Beta-Subunit 1 2 3
- BK Channel Beta Subunit 1 2 3
- BK Channel Subunit Beta-1 3 4
External Ids for KCNMB1 Gene
Previous GeneCards Identifiers for KCNMB1 Gene
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNMB1 Gene
KCNMB1 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1) is a Protein Coding gene. Diseases associated with KCNMB1 include Hypertension, Diastolic and Episodic Ataxia, Type 4. Among its related pathways are Nitric oxide stimulates guanylate cyclase and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include potassium channel regulator activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNMB2.
UniProtKB/Swiss-Prot Summary for KCNMB1 Gene
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers.