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Aliases for KCNK7 Gene

Aliases for KCNK7 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 7 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 7 2 3
  • Potassium Channel, Subfamily K, Member 7 2 3
  • Potassium Channel Subfamily K Member 7 3
  • Two Pore Domain K+ Channel 3
  • K2p7.1 3
  • TWIK3 3

External Ids for KCNK7 Gene

Previous GeneCards Identifiers for KCNK7 Gene

  • GC11M067876
  • GC11M067042
  • GC11M065136
  • GC11M065139
  • GC11M065116
  • GC11M065360
  • GC11M061687

Summaries for KCNK7 Gene

Entrez Gene Summary for KCNK7 Gene

  • This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK7 Gene

KCNK7 (Potassium Two Pore Domain Channel Subfamily K Member 7) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK1.

UniProtKB/Swiss-Prot for KCNK7 Gene

  • Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

Tocris Summary for KCNK7 Gene

Gene Wiki entry for KCNK7 Gene

Additional gene information for KCNK7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK7 Gene

Genomics for KCNK7 Gene

GeneHancer (GH) Regulatory Elements for KCNK7 Gene

Promoters and enhancers for KCNK7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065595 Enhancer 0.6 Ensembl 550.8 +0.4 395 0.4 KLF1 ZNF398 ZIC2 ZFHX2 GLIS2 NFIC POLR2A EGR1 GLIS1 ZNF24 KCNK7 EHBP1L1
GH11I065636 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.9 -44.7 -44686 8.2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A YBX1 POLR2B ZNF207 ZNF143 SIPA1 EIF1AD RBM14 SF1 ZFPL1 RBM4 PCNX3 POLA2 SART1 MUS81
GH11I065567 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.4 +22.3 22322 12 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSSCA1 EHBP1L1 FAM89B PCNX3 SF1 EIF1AD POLA2 LOC105369352 NEAT1 ZFPL1
GH11I065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.9 +105.9 105912 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 PCNX3 POLA2 ZFPL1 EIF1AD SART1 MUS81 LOC105369352 KAT5
GH11I065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +171.8 171815 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 ENSG00000278050 ENSG00000278144 GC11P065529 SF1 ZFPL1 EIF1AD POLA2 PCNX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCNK7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNK7 gene promoter:

Genomic Locations for KCNK7 Gene

Genomic Locations for KCNK7 Gene
chr11:65,592,855-65,595,996
(GRCh38/hg38)
Size:
3,142 bases
Orientation:
Minus strand
chr11:65,360,326-65,363,467
(GRCh37/hg19)

Genomic View for KCNK7 Gene

Genes around KCNK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK7 Gene

Proteins for KCNK7 Gene

  • Protein details for KCNK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2U2-KCNK7_HUMAN
    Recommended name:
    Potassium channel subfamily K member 7
    Protein Accession:
    Q9Y2U2
    Secondary Accessions:
    • Q3SYI2
    • Q9Y2U3
    • Q9Y2U4

    Protein attributes for KCNK7 Gene

    Size:
    307 amino acids
    Molecular mass:
    31947 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for KCNK7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK7 Gene

Post-translational modifications for KCNK7 Gene

No data available for DME Specific Peptides for KCNK7 Gene

Domains & Families for KCNK7 Gene

Gene Families for KCNK7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNK7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2U2

UniProtKB/Swiss-Prot:

KCNK7_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK7: view

Function for KCNK7 Gene

Molecular function for KCNK7 Gene

GENATLAS Biochemistry:
potassium non voltage gated,weakly inwardly rectifying subfamily K,member 7
UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

Phenotypes From GWAS Catalog for KCNK7 Gene

Gene Ontology (GO) - Molecular Function for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity TAS --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK7: view
genes like me logo Genes that share phenotypes with KCNK7: view

Animal Models for KCNK7 Gene

MGI Knock Outs for KCNK7:

Animal Model Products

miRNA for KCNK7 Gene

miRTarBase miRNAs that target KCNK7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK7 Gene

Localization for KCNK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK7 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK7: view

Pathways & Interactions for KCNK7 Gene

genes like me logo Genes that share pathways with KCNK7: view

Gene Ontology (GO) - Biological Process for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 10206991
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK7: view

No data available for SIGNOR curated interactions for KCNK7 Gene

Drugs & Compounds for KCNK7 Gene

(3) Drugs for KCNK7 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for KCNK7 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) Tocris Compounds for KCNK7 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK7: view

Transcripts for KCNK7 Gene

Unigene Clusters for KCNK7 Gene

Potassium channel, subfamily K, member 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for KCNK7 Gene

GeneLoc Exon Structure for
KCNK7
ECgene alternative splicing isoforms for
KCNK7

Expression for KCNK7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.7) and Skin - Sun Exposed (Lower leg) (x15.1).

Protein differential expression in normal tissues from HIPED for KCNK7 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK7 Gene



Protein tissue co-expression partners for KCNK7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCNK7 Gene:

KCNK7

SOURCE GeneReport for Unigene cluster for KCNK7 Gene:

Hs.175218

Evidence on tissue expression from TISSUES for KCNK7 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with KCNK7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK7 Gene

Orthologs for KCNK7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK7 33 34
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia KCNK7 33 34
  • 84.35 (n)
dog
(Canis familiaris)
Mammalia KCNK7 33 34
  • 81.87 (n)
mouse
(Mus musculus)
Mammalia Kcnk7 33 16 34
  • 80.79 (n)
rat
(Rattus norvegicus)
Mammalia Kcnk7 33
  • 78.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK7 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii KCNK7 34
  • 36 (a)
OneToOne
Species where no ortholog for KCNK7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK7 Gene

ENSEMBL:
Gene Tree for KCNK7 (if available)
TreeFam:
Gene Tree for KCNK7 (if available)

Paralogs for KCNK7 Gene

Paralogs for KCNK7 Gene

(2) SIMAP similar genes for KCNK7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KCNK7: view

Variants for KCNK7 Gene

Sequence variations from dbSNP and Humsavar for KCNK7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000860898 -- 65,596,315(-) T/C upstream_transcript_variant
rs1000889063 -- 65,596,556(-) G/C upstream_transcript_variant
rs1002735291 -- 65,596,910(-) C/T upstream_transcript_variant
rs1003063963 -- 65,596,167(-) C/A upstream_transcript_variant
rs1003139102 -- 65,596,336(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK7 Gene

Variant ID Type Subtype PubMed ID
nsv951018 CNV deletion 24416366
esv2761680 CNV gain 21179565
dgv1969n54 CNV loss 21841781

Variation tolerance for KCNK7 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK7 Gene

Disorders for KCNK7 Gene

Additional Disease Information for KCNK7

No disorders were found for KCNK7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK7 Gene

Publications for KCNK7 Gene

  1. Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. (PMID: 10206991) Salinas M … Lazdunski M (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3 58
  3. Potassium leak channels and the KCNK family of two-P-domain subunits. (PMID: 11256078) Goldstein SA … Zilberberg N (Nature reviews. Neuroscience 2001) 2 3 58
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  5. Localization of TASK and TREK, two-pore domain K+ channels, in human cytotrophoblast cells. (PMID: 15695101) Bai X … Fyfe GK (Journal of the Society for Gynecologic Investigation 2005) 22 58

Products for KCNK7 Gene

Sources for KCNK7 Gene