This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for KCNK7 Gene

Aliases for KCNK7 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 7 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 7 2 3
  • Potassium Channel, Subfamily K, Member 7 2 3
  • Potassium Channel Subfamily K Member 7 3 4
  • K2p7.1 2 3
  • Two Pore Domain K+ Channel 3
  • TWIK3 3
  • KCNK7 5

External Ids for KCNK7 Gene

Previous GeneCards Identifiers for KCNK7 Gene

  • GC11M067876
  • GC11M067042
  • GC11M065610
  • GC11M065136
  • GC11M065139
  • GC11M065116
  • GC11M065360
  • GC11M061687

Summaries for KCNK7 Gene

Entrez Gene Summary for KCNK7 Gene

  • This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK7 Gene

KCNK7 (Potassium Two Pore Domain Channel Subfamily K Member 7) is a Protein Coding gene. Diseases associated with KCNK7 include Adrenal Cortical Adenocarcinoma. Among its related pathways are Cardiac conduction and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK1.

UniProtKB/Swiss-Prot Summary for KCNK7 Gene

  • Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

Tocris Summary for KCNK7 Gene

Gene Wiki entry for KCNK7 Gene

Additional gene information for KCNK7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNK7 Gene

Genomics for KCNK7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCNK7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065595 Promoter 0.7 EPDnew 600.7 +0.2 177 0.1 ZIC2 RBFOX2 ZNF24 EGR1 ZFHX2 GLIS1 ZNF398 KLF1 POLR2A EGR2 KCNK7 CTSW lnc-KCNK7-1 EHBP1L1 L13304-005
GH11J065596 Promoter 0.6 EPDnew 600.7 -0.2 -167 0.1 ZNF24 FOXA2 ZFP91 POLR2A KCNK7 MN309267 PCNX3 L13304-005
GH11J065636 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 20.9 -44.7 -44686 8.2 SP1 HNRNPL CTCF PRDM10 ZNF512 IKZF1 ZNF692 POLR2A BACH1 JUND SIPA1 ZNRD2 KCNK7 RNASEH2C MAP3K11 ENSG00000254855 EHBP1L1 ZFPL1 TIGD3 EIF1AD
GH11J065567 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.5 +22.1 22058 12.5 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 RFX1 EHBP1L1 ZNRD2 FAM89B PCNX3 SF1 SF3B2 KAT5 EIF1AD POLA2 SART1
GH11J065470 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 +105.9 105851 40.1 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 ATF7 TEAD4 MALAT1 LINC02736 SF1 ZFPL1 POLA2 PCNX3 ENSG00000254855 MUS81 EIF1AD SART1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNK7

Top Transcription factor binding sites by QIAGEN in the KCNK7 gene promoter:
  • AP-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E47
  • NF-1
  • NF-1/L
  • NF-kappaB1
  • p53

Genomic Locations for KCNK7 Gene

Genomic Locations for KCNK7 Gene
chr11:65,592,836-65,595,996
(GRCh38/hg38)
Size:
3,161 bases
Orientation:
Minus strand
chr11:65,360,326-65,363,467
(GRCh37/hg19)
Size:
3,142 bases
Orientation:
Minus strand

Genomic View for KCNK7 Gene

Genes around KCNK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK7 Gene

Proteins for KCNK7 Gene

  • Protein details for KCNK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2U2-KCNK7_HUMAN
    Recommended name:
    Potassium channel subfamily K member 7
    Protein Accession:
    Q9Y2U2
    Secondary Accessions:
    • Q3SYI2
    • Q9Y2U3
    • Q9Y2U4

    Protein attributes for KCNK7 Gene

    Size:
    307 amino acids
    Molecular mass:
    31947 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for KCNK7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK7 Gene

Post-translational modifications for KCNK7 Gene

  • Glycosylation at Asn83

No data available for DME Specific Peptides for KCNK7 Gene

Domains & Families for KCNK7 Gene

Gene Families for KCNK7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Voltage-gated ion channels

Protein Domains for KCNK7 Gene

InterPro:
Blocks:
  • Two pore domain K+ channel signature
  • Ion transport 2, bacterial
  • TWIK-1/TWIK-2 K+ channel family signature
ProtoNet:

Suggested Antigen Peptide Sequences for KCNK7 Gene

GenScript: Design optimal peptide antigens:
  • Potassium channel subfamily K member 7 (KCNK7_HUMAN)
  • KCNK7 protein (Q3MI97_HUMAN)
  • Potassium channel, subfamily K, member 7 (Q3SYI1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y2U2

UniProtKB/Swiss-Prot:

KCNK7_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK7: view

Function for KCNK7 Gene

Molecular function for KCNK7 Gene

UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.
GENATLAS Biochemistry:
potassium non voltage gated,weakly inwardly rectifying subfamily K,member 7

Phenotypes From GWAS Catalog for KCNK7 Gene

Gene Ontology (GO) - Molecular Function for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity TAS 10206991
GO:0022841 potassium ion leak channel activity IBA 21873635
genes like me logo Genes that share ontologies with KCNK7: view
genes like me logo Genes that share phenotypes with KCNK7: view

Animal Models for KCNK7 Gene

MGI Knock Outs for KCNK7:

Animal Model Products

CRISPR Products

miRNA for KCNK7 Gene

miRTarBase miRNAs that target KCNK7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK7 Gene

Localization for KCNK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK7 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK7 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK7: view

Pathways & Interactions for KCNK7 Gene

PathCards logo

SuperPathways for KCNK7 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Cardiac conduction
3 Activation of cAMP-Dependent PKA
.77
.77
.56
4 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
5 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCNK7: view

Pathways by source for KCNK7 Gene

13 Qiagen pathways for KCNK7 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCNK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 10206991
GO:0030322 stabilization of membrane potential IBA 21873635
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA 21873635
genes like me logo Genes that share ontologies with KCNK7: view

No data available for SIGNOR curated interactions for KCNK7 Gene

Drugs & Compounds for KCNK7 Gene

(2) Drugs for KCNK7 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK7 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK7: view

Transcripts for KCNK7 Gene

mRNA/cDNA for KCNK7 Gene

5 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK7

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for KCNK7 Gene

GeneLoc Exon Structure for
KCNK7

Expression for KCNK7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNK7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.7) and Skin - Sun Exposed (Lower leg) (x15.1).

Protein differential expression in normal tissues from HIPED for KCNK7 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK7 Gene



Protein tissue co-expression partners for KCNK7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNK7

SOURCE GeneReport for Unigene cluster for KCNK7 Gene:

Hs.175218

Evidence on tissue expression from TISSUES for KCNK7 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KCNK7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK7 Gene

Orthologs for KCNK7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KCNK7 30 31
  • 99.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KCNK7 30 31
  • 84.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KCNK7 30 31
  • 81.87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Kcnk7 30 17 31
  • 80.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kcnk7 30
  • 78.66 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia KCNK7 31
  • 56 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii KCNK7 31
  • 36 (a)
OneToOne
Species where no ortholog for KCNK7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KCNK7 Gene

ENSEMBL:
Gene Tree for KCNK7 (if available)
TreeFam:
Gene Tree for KCNK7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK7: view image

Paralogs for KCNK7 Gene

(2) SIMAP similar genes for KCNK7 Gene using alignment to 5 proteins:

  • KCNK7_HUMAN
  • H0YCM4_HUMAN
  • H0YEB9_HUMAN
  • Q3MI97_HUMAN
  • Q3SYI1_HUMAN
genes like me logo Genes that share paralogs with KCNK7: view

Variants for KCNK7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNK7 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
768454 Benign: not provided 65,593,838(-) T/C MISSENSE_VARIANT
768455 Benign: not provided 65,593,867(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for KCNK7 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNK7 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
esv2761680 CNV gain 21179565
nsv951018 CNV deletion 24416366

Variation tolerance for KCNK7 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK7 Gene

Disorders for KCNK7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNK7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adrenal cortical adenocarcinoma
  • adrenocortical carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search KCNK7 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with KCNK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK7 Gene

Publications for KCNK7 Gene

  1. Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. (PMID: 10206991) Salinas M … Lazdunski M (The Journal of biological chemistry 1999) 2 3 4 23
  2. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3
  3. Potassium leak channels and the KCNK family of two-P-domain subunits. (PMID: 11256078) Goldstein SA … Zilberberg N (Nature reviews. Neuroscience 2001) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for KCNK7 Gene

Sources for KCNK7 Gene