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Aliases for KCNK6 Gene

Aliases for KCNK6 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 6 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 6 2 3
  • Inward Rectifying Potassium Channel Protein TWIK-2 3 4
  • TWIK-Originated Similarity Sequence 3 4
  • TWIK2 3 4
  • TOSS 3 4
  • TWIK-Originated Sodium Similarity Sequence 3
  • Potassium Channel, Subfamily K, Member 6 2
  • Potassium Channel Subfamily K Member 6 3
  • K2P6.1 Potassium Channel 3
  • K2p6.1 3
  • TWIK-2 3
  • KCNK8 3

External Ids for KCNK6 Gene

Previous GeneCards Identifiers for KCNK6 Gene

  • GC19P039425
  • GC19P039201
  • GC19P043487
  • GC19P043505
  • GC19P043506
  • GC19P043507
  • GC19P038810
  • GC19P035258

Summaries for KCNK6 Gene

Entrez Gene Summary for KCNK6 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK6 Gene

KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6) is a Protein Coding gene. Diseases associated with KCNK6 include Hemopericardium and Brachial Plexus Lesion. Among its related pathways are Hepatic ABC Transporters and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK1.

UniProtKB/Swiss-Prot for KCNK6 Gene

  • Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

Tocris Summary for KCNK6 Gene

Gene Wiki entry for KCNK6 Gene

Additional gene information for KCNK6 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK6 Gene

Genomics for KCNK6 Gene

GeneHancer (GH) Regulatory Elements for KCNK6 Gene

Promoters and enhancers for KCNK6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J038312 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 656 -2.2 -2194 9.9 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 KCNK6 YIF1B HNRNPL C19orf33 ZNF527 ZNF571 ZNF573 CATSPERG ZFP30 ENSG00000269688
GH19J038299 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.4 -16.9 -16868 6.3 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B POLR2B ZNF766 C19orf33 KCNK6 ZNF781 ZNF540 ZNF527 ZFP30 ZNF571 ZNF793 ENSG00000267152 CATSPERG
GH19J038373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16.2 +55.6 55578 3.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A PSMD8 HNRNPL ZFP30 ZNF571 ZNF793 ZNF607 RN7SL566P ZNF781 ZNF540 ENSG00000267152
GH19J038262 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.9 -53.9 -53948 6.7 HDGF PKNOX1 NEUROD1 SIN3A ZNF2 YY1 ZNF143 FOS SP3 ZC3H11A C19orf33 SPINT2 PIR58569 HNRNPL ZNF571 HKR1 ZFP30 ZNF527 CATSPERG ENSG00000266963
GH19J038269 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 -49.1 -49110 1.7 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF213 REST ZNF592 SMARCA4 ZSCAN16 CATSPERG C19orf33 ENSG00000266963 HNRNPL HKR1 ZNF607 ENSG00000269445 ENSG00000267375 ENSG00000269172 ZNF793
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNK6 gene promoter:
  • Arnt
  • AhR
  • CRE-BP1
  • ATF-2
  • GATA-3
  • GATA-1
  • GATA-2

Genomic Locations for KCNK6 Gene

Genomic Locations for KCNK6 Gene
12,263 bases
Plus strand
9,177 bases
Plus strand

Genomic View for KCNK6 Gene

Genes around KCNK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK6 Gene

Proteins for KCNK6 Gene

  • Protein details for KCNK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 6
    Protein Accession:
    Secondary Accessions:
    • Q9HB47

    Protein attributes for KCNK6 Gene

    313 amino acids
    Molecular mass:
    33747 Da
    Quaternary structure:
    • Homodimer.
    • Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.

    Alternative splice isoforms for KCNK6 Gene


neXtProt entry for KCNK6 Gene

Post-translational modifications for KCNK6 Gene

  • Glycosylation at isoforms=85 and Asn79
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK6 Gene

No data available for DME Specific Peptides for KCNK6 Gene

Domains & Families for KCNK6 Gene

Gene Families for KCNK6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNK6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK6: view

Function for KCNK6 Gene

Molecular function for KCNK6 Gene

UniProtKB/Swiss-Prot Function:
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
GENATLAS Biochemistry:
potassium non voltage gated,weakly inwardly rectifying subfamily K,member 6,expressed in eyes,lung,stomach and embryo

Phenotypes From GWAS Catalog for KCNK6 Gene

Gene Ontology (GO) - Molecular Function for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity TAS 10075682
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity TAS --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK6: view
genes like me logo Genes that share phenotypes with KCNK6: view

Animal Models for KCNK6 Gene

MGI Knock Outs for KCNK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK6

CRISPR Products

miRNA for KCNK6 Gene

miRTarBase miRNAs that target KCNK6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK6 Gene

Localization for KCNK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK6 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0008076 voltage-gated potassium channel complex TAS 10075682
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK6: view

Pathways & Interactions for KCNK6 Gene

genes like me logo Genes that share pathways with KCNK6: view

Gene Ontology (GO) - Biological Process for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 10075682
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK6: view

No data available for SIGNOR curated interactions for KCNK6 Gene

Drugs & Compounds for KCNK6 Gene

(4) Drugs for KCNK6 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ibutilide Approved Pharma Target, inhibitor 6
Quinidine Approved, Investigational Pharma Pore Blocker, Inhibition, Inhibitor, Target, inhibitor 48
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK6 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK6: view

Transcripts for KCNK6 Gene

mRNA/cDNA for KCNK6 Gene

Unigene Clusters for KCNK6 Gene

Potassium channel, subfamily K, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK6

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK6 Gene

No ASD Table

Relevant External Links for KCNK6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCNK6 Gene

This gene is overexpressed in Platelet (32.6), Peripheral blood mononuclear cells (29.6), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK6 Gene

Protein tissue co-expression partners for KCNK6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCNK6 Gene:


SOURCE GeneReport for Unigene cluster for KCNK6 Gene:


mRNA Expression by UniProt/SwissProt for KCNK6 Gene:

Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.

Evidence on tissue expression from TISSUES for KCNK6 Gene

  • Nervous system(4.3)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with KCNK6: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK6 Gene

Orthologs for KCNK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCNK6 34 33
  • 99.57 (n)
(Bos Taurus)
Mammalia KCNK6 34 33
  • 86.54 (n)
(Canis familiaris)
Mammalia KCNK6 34 33
  • 85.73 (n)
(Mus musculus)
Mammalia Kcnk6 16 34 33
  • 83.81 (n)
(Rattus norvegicus)
Mammalia Kcnk6 33
  • 83.6 (n)
(Monodelphis domestica)
Mammalia KCNK6 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia KCNK6 34
  • 63 (a)
(Anolis carolinensis)
Reptilia KCNK6 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk6 33
  • 57.63 (n)
Str.15611 33
African clawed frog
(Xenopus laevis)
Amphibia kcnk6-prov 33
(Danio rerio)
Actinopterygii kcnk6 34 33
  • 59.39 (n)
Dr.27093 33
(Caenorhabditis elegans)
Secernentea Y39B6A.19 35
  • 35 (a)
Species where no ortholog for KCNK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK6 Gene

Gene Tree for KCNK6 (if available)
Gene Tree for KCNK6 (if available)
Evolutionary constrained regions (ECRs) for KCNK6: view image

Paralogs for KCNK6 Gene

Paralogs for KCNK6 Gene

(7) SIMAP similar genes for KCNK6 Gene using alignment to 3 proteins:

  • L8E851_HUMAN
genes like me logo Genes that share paralogs with KCNK6: view

Variants for KCNK6 Gene

Sequence variations from dbSNP and Humsavar for KCNK6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000308085 -- 38,322,165(+) G/T intron_variant
rs1000372110 -- 38,323,995(+) A/G intron_variant
rs1000387631 -- 38,317,897(+) A/C upstream_transcript_variant
rs1000488188 -- 38,324,309(+) G/A intron_variant
rs1000835862 -- 38,319,235(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK6 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for KCNK6 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK6 Gene

Disorders for KCNK6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KCNK6 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
  • haemopericardium
brachial plexus lesion
  • brachial plexus lesions
patellofemoral pain syndrome
gingival recession
  • gingival recession, localized
developmental coordination disorder
  • motor skills disorders
- elite association - COSMIC cancer census association via MalaCards
Search KCNK6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KCNK6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KCNK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK6 Gene

Publications for KCNK6 Gene

  1. TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. (PMID: 10075682) Chavez RA … Yost CS (The Journal of biological chemistry 1999) 2 3 4 58
  2. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. (PMID: 20029952) Sebastiani P … Steinberg MH (American journal of hematology 2010) 3 44 58
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. TWIK-2, an inactivating 2P domain K+ channel. (PMID: 10887187) Patel AJ … Honoré E (The Journal of biological chemistry 2000) 3 4 58

Products for KCNK6 Gene

Sources for KCNK6 Gene

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