Aliases for KCNK6 Gene
External Ids for KCNK6 Gene
Previous GeneCards Identifiers for KCNK6 Gene
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNK6 Gene
KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6) is a Protein Coding gene. Diseases associated with KCNK6 include Sickle Cell Anemia and Dyskeratosis Congenita, Autosomal Dominant 1. Among its related pathways are Activation of cAMP-Dependent PKA and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK1.
UniProtKB/Swiss-Prot Summary for KCNK6 Gene
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.