This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008] See more...

Aliases for KCNK6 Gene

Aliases for KCNK6 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 6 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 6 2 3
  • Inward Rectifying Potassium Channel Protein TWIK-2 3 4
  • Potassium Channel Subfamily K Member 6 3 4
  • TWIK-Originated Similarity Sequence 3 4
  • K2p6.1 2 3
  • TWIK-2 2 3
  • TWIK2 3 4
  • TOSS 3 4
  • TWIK-Originated Sodium Similarity Sequence 3
  • Potassium Channel, Subfamily K, Member 6 2
  • K2P6.1 Potassium Channel 3
  • KCNK8 3
  • KCNK6 5

External Ids for KCNK6 Gene

Previous GeneCards Identifiers for KCNK6 Gene

  • GC19P039425
  • GC19P039201
  • GC19P043487
  • GC19P043505
  • GC19P043506
  • GC19P043507
  • GC19P038810
  • GC19P035258

Summaries for KCNK6 Gene

Entrez Gene Summary for KCNK6 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK6 Gene

KCNK6 (Potassium Two Pore Domain Channel Subfamily K Member 6) is a Protein Coding gene. Diseases associated with KCNK6 include Thoracic Outlet Syndrome and Gingival Recession. Among its related pathways are Cardiac conduction and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK1.

UniProtKB/Swiss-Prot Summary for KCNK6 Gene

  • Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.

Tocris Summary for KCNK6 Gene

Gene Wiki entry for KCNK6 Gene

Additional gene information for KCNK6 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNK6 Gene

Genomics for KCNK6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCNK6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNK6

Top Transcription factor binding sites by QIAGEN in the KCNK6 gene promoter:
  • AhR
  • Arnt
  • ATF-2
  • CRE-BP1
  • GATA-1
  • GATA-2
  • GATA-3

Genomic Locations for KCNK6 Gene

Genomic Locations for KCNK6 Gene
chr19:38,319,845-38,332,076
(GRCh38/hg38)
Size:
12,232 bases
Orientation:
Plus strand
chr19:38,810,484-38,819,660
(GRCh37/hg19)
Size:
9,177 bases
Orientation:
Plus strand

Genomic View for KCNK6 Gene

Genes around KCNK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK6 Gene

Proteins for KCNK6 Gene

  • Protein details for KCNK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y257-KCNK6_HUMAN
    Recommended name:
    Potassium channel subfamily K member 6
    Protein Accession:
    Q9Y257
    Secondary Accessions:
    • Q9HB47

    Protein attributes for KCNK6 Gene

    Size:
    313 amino acids
    Molecular mass:
    33747 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.

    Alternative splice isoforms for KCNK6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK6 Gene

Post-translational modifications for KCNK6 Gene

  • Glycosylation at Asn79 and Asn85
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK6 Gene

No data available for DME Specific Peptides for KCNK6 Gene

Domains & Families for KCNK6 Gene

Gene Families for KCNK6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for KCNK6 Gene

InterPro:
Blocks:
  • Two pore domain K+ channel signature
  • Ion transport 2, bacterial
  • TWIK-1/TWIK-2 K+ channel family signature
  • TWIK-2 K+ channel signature
ProtoNet:

Suggested Antigen Peptide Sequences for KCNK6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ96744, Homo sapiens potassium channel, subfamily K, member 6 (KCNK6),mRNA (B2RDS2_HUMAN)
  • TWIK-originated similarity sequence (KCNK6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y257

UniProtKB/Swiss-Prot:

KCNK6_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK6: view

Function for KCNK6 Gene

Molecular function for KCNK6 Gene

UniProtKB/Swiss-Prot Function:
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
GENATLAS Biochemistry:
potassium non voltage gated,weakly inwardly rectifying subfamily K,member 6,expressed in eyes,lung,stomach and embryo

Phenotypes From GWAS Catalog for KCNK6 Gene

Gene Ontology (GO) - Molecular Function for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005242 inward rectifier potassium channel activity TAS 10075682
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IEA --
GO:0022841 potassium ion leak channel activity IBA 21873635
genes like me logo Genes that share ontologies with KCNK6: view
genes like me logo Genes that share phenotypes with KCNK6: view

Animal Models for KCNK6 Gene

MGI Knock Outs for KCNK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK6

CRISPR Products

miRNA for KCNK6 Gene

miRTarBase miRNAs that target KCNK6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK6 Gene

Localization for KCNK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK6 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK6 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 3
extracellular 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0008076 voltage-gated potassium channel complex TAS 10075682
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK6: view

Pathways & Interactions for KCNK6 Gene

PathCards logo

SuperPathways for KCNK6 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Cardiac conduction
3 Activation of cAMP-Dependent PKA
.77
.77
.56
4 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
5 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCNK6: view

Pathways by source for KCNK6 Gene

13 Qiagen pathways for KCNK6 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCNK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003073 regulation of systemic arterial blood pressure IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 10075682
GO:0030322 stabilization of membrane potential IBA 21873635
genes like me logo Genes that share ontologies with KCNK6: view

No data available for SIGNOR curated interactions for KCNK6 Gene

Drugs & Compounds for KCNK6 Gene

(4) Drugs for KCNK6 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ibutilide Approved Pharma Target, inhibitor 8
Quinidine Approved, Investigational Pharma Pore Blocker, Inhibitor, Inhibition, Target, inhibitor 57
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK6 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK6: view

Transcripts for KCNK6 Gene

mRNA/cDNA for KCNK6 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK6

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK6 Gene

No ASD Table

Relevant External Links for KCNK6 Gene

GeneLoc Exon Structure for
KCNK6

Expression for KCNK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KCNK6 Gene

This gene is overexpressed in Platelet (32.6), Peripheral blood mononuclear cells (29.6), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK6 Gene



Protein tissue co-expression partners for KCNK6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNK6

SOURCE GeneReport for Unigene cluster for KCNK6 Gene:

Hs.240395

mRNA Expression by UniProt/SwissProt for KCNK6 Gene:

Q9Y257-KCNK6_HUMAN
Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.

Evidence on tissue expression from TISSUES for KCNK6 Gene

  • Nervous system(4.5)
  • Pancreas(4.3)
  • Skin(3)
  • Muscle(2.4)
  • Heart(2.3)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with KCNK6: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK6 Gene

Orthologs for KCNK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KCNK6 30 31
  • 99.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KCNK6 30 31
  • 86.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KCNK6 30 31
  • 85.73 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Kcnk6 30 17 31
  • 83.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kcnk6 30
  • 83.6 (n)
Oppossum
(Monodelphis domestica)
Mammalia KCNK6 31
  • 66 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KCNK6 31
  • 63 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KCNK6 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kcnk6 30
  • 57.63 (n)
Str.15611 30
African clawed frog
(Xenopus laevis)
Amphibia kcnk6-prov 30
Zebrafish
(Danio rerio)
Actinopterygii kcnk6 30 31
  • 59.39 (n)
OneToOne
Dr.27093 30
Worm
(Caenorhabditis elegans)
Secernentea Y39B6A.19 32
  • 35 (a)
Species where no ortholog for KCNK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KCNK6 Gene

ENSEMBL:
Gene Tree for KCNK6 (if available)
TreeFam:
Gene Tree for KCNK6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK6: view image

Paralogs for KCNK6 Gene

(7) SIMAP similar genes for KCNK6 Gene using alignment to 3 proteins:

  • KCNK6_HUMAN
  • B2RDS2_HUMAN
  • L8E851_HUMAN
genes like me logo Genes that share paralogs with KCNK6: view

Variants for KCNK6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNK6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs34989303 - p.Val259Met
rs35496032 - p.Val240Ile
rs35762773 - p.Thr150Ile

Additional dbSNP identifiers (rs#s) for KCNK6 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNK6 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for KCNK6 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK6 Gene

Human Gene Mutation Database (HGMD)
KCNK6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK6 Gene

Disorders for KCNK6 Gene

MalaCards: The human disease database

(9) MalaCards diseases for KCNK6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
thoracic outlet syndrome
  • tos - thoracic outlet syndrome
gingival recession
  • gingival recession, localized
shoulder impingement syndrome
  • impingement syndrome of shoulder region
root caries
  • cementum caries
anterior cerebral artery infarction
  • infarction, anterior cerebral artery
- elite association - COSMIC cancer census association via MalaCards
Search KCNK6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KCNK6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KCNK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK6 Gene

Publications for KCNK6 Gene

  1. TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. (PMID: 10075682) Chavez RA … Yost CS (The Journal of biological chemistry 1999) 2 3 4
  2. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. (PMID: 20029952) Sebastiani P … Steinberg MH (American journal of hematology 2010) 3 41
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. TWIK-2, an inactivating 2P domain K+ channel. (PMID: 10887187) Patel AJ … Honoré E (The Journal of biological chemistry 2000) 3 4

Products for KCNK6 Gene

Sources for KCNK6 Gene