This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in... See more...

Aliases for KCNK5 Gene

Aliases for KCNK5 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 5 2 3 5
  • TASK2 2 3 4
  • Potassium Channel, Two Pore Domain Subfamily K, Member 5 2 3
  • Acid-Sensitive Potassium Channel Protein TASK-2 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 2 3 4
  • Potassium Channel Subfamily K Member 5 3 4
  • TWIK-Related Acid-Sensitive K+ 2 2 3
  • K2p5.1 2 3
  • TASK-2 2 3
  • Potassium Channel, Subfamily K, Member 1 (TASK-2) 3
  • Potassium Channel, Subfamily, Member 5 (KCNK5) 3
  • Potassium Channel, Subfamily K, Member 5 2
  • TWIK-Related Acid-Sensitive K+ Channel 2 3
  • K2P5.1 Potassium Channel 3
  • KCNK5b 3
  • KCNK5 5

External Ids for KCNK5 Gene

Previous GeneCards Identifiers for KCNK5 Gene

  • GC06M039158
  • GC06M039203
  • GC06M039264
  • GC06M038875
  • GC06M039208
  • GC06M039242
  • GC06M039292
  • GC06M039246
  • GC06M039352
  • GC06M040039
  • GC06M040082
  • GC06M039984
  • GC06M041323
  • GC06M039381
  • GC06M039407
  • GC06M039442
  • GC06M039479
  • GC06M039519
  • GC06M039557
  • GC06M039600
  • GC06M039780

Summaries for KCNK5 Gene

Entrez Gene Summary for KCNK5 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK5 Gene

KCNK5 (Potassium Two Pore Domain Channel Subfamily K Member 5) is a Protein Coding gene. Diseases associated with KCNK5 include Alexia and Integrative Agnosia. Among its related pathways are Sweet Taste Signaling and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK10.

UniProtKB/Swiss-Prot Summary for KCNK5 Gene

  • pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.

Tocris Summary for KCNK5 Gene

Gene Wiki entry for KCNK5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNK5 Gene

Genomics for KCNK5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCNK5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J039223 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 604.2 +2.6 2647 6.9 CREB1 CTCF HNRNPL PRDM10 ZNF629 ZNF512 LEF1 IKZF1 KDM1A ZNF692 KCNK5 lnc-KCNK5-2 RF00017-5520 SAYSD1
GH06J039183 Enhancer 1.2 Ensembl ENCODE dbSUPER 18.3 +42.3 42256 6.8 CEBPG CTCF HNRNPL PRDM10 IKZF1 FOXA1 MTA2 PKNOX1 MTA1 REST lnc-KCNK5-2 KCNK5 KCNK17 RF00017-5520 SAYSD1
GH06J039279 Enhancer 1.1 FANTOM5 Ensembl ENCODE 13.9 -50.9 -50913 2.7 REST PRDM1 SP1 GABPA CTBP1 FOXA2 OSR2 NR2C2 ATF3 YY1 KCNK17 KCNK5 RF00017-5522 piR-41195-026
GH06J039251 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.4 -22.0 -22026 0.6 CREB1 ATF7 PRDM10 ZNF629 IKZF1 ZNF692 JUND RFX1 ZIC2 POLR2A SAYSD1 ANKRD18EP KCNK5 RF00017-5521 piR-41195-026 KCNK17 RF00017-5520
GH06J039101 Enhancer 1 Ensembl ENCODE dbSUPER 10.4 +127.4 127434 1.3 CTCF PKNOX1 REST RAD21 ZBTB20 ZNF184 CTBP1 ZBTB48 SMC3 ZNF335 piR-41727 SAYSD1 GLP1R KCNK17 KCNK5 lnc-SAYSD1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNK5

Top Transcription factor binding sites by QIAGEN in the KCNK5 gene promoter:
  • aMEF-2
  • GATA-1
  • MEF-2A
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for KCNK5 Gene

Genomic Locations for KCNK5 Gene
chr6:39,188,971-39,229,475
(GRCh38/hg38)
Size:
40,505 bases
Orientation:
Minus strand
chr6:39,156,747-39,197,251
(GRCh37/hg19)
Size:
40,505 bases
Orientation:
Minus strand

Genomic View for KCNK5 Gene

Genes around KCNK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK5 Gene

Proteins for KCNK5 Gene

  • Protein details for KCNK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95279-KCNK5_HUMAN
    Recommended name:
    Potassium channel subfamily K member 5
    Protein Accession:
    O95279
    Secondary Accessions:
    • B2RAQ6
    • B5TJL2
    • Q5VV76

    Protein attributes for KCNK5 Gene

    Size:
    499 amino acids
    Molecular mass:
    55130 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    Miscellaneous:
    • Inhibited by quinine, quinidine and external acidification.

neXtProt entry for KCNK5 Gene

Post-translational modifications for KCNK5 Gene

  • Glycosylation at Asn77
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KCNK5
  • Boster Bio Antibodies for KCNK5
  • Santa Cruz Biotechnology (SCBT) Antibodies for KCNK5

No data available for DME Specific Peptides for KCNK5 Gene

Domains & Families for KCNK5 Gene

Gene Families for KCNK5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for KCNK5 Gene

InterPro:
Blocks:
  • Two pore domain K+ channel signature
  • Ion transport 2, bacterial
  • TASK K+ channel signature
ProtoNet:

Suggested Antigen Peptide Sequences for KCNK5 Gene

GenScript: Design optimal peptide antigens:
  • TWIK-related acid-sensitive K(+) channel 2 (KCNK5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95279

UniProtKB/Swiss-Prot:

KCNK5_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK5: view

Function for KCNK5 Gene

Molecular function for KCNK5 Gene

UniProtKB/Swiss-Prot Function:
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.
GENATLAS Biochemistry:
potassium non voltage-gated channel inwardly rectifying,subfamily K,member 5,mainly expressed in cortical tubules and collecting ducts of kidneys

Phenotypes From GWAS Catalog for KCNK5 Gene

Gene Ontology (GO) - Molecular Function for KCNK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005267 potassium channel activity ISS --
GO:0022841 potassium ion leak channel activity IBA 21873635
genes like me logo Genes that share ontologies with KCNK5: view
genes like me logo Genes that share phenotypes with KCNK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK5

CRISPR Products

miRNA for KCNK5 Gene

miRTarBase miRNAs that target KCNK5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNK5 Gene

Localization for KCNK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK5 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK5 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KCNK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK5: view

Pathways & Interactions for KCNK5 Gene

PathCards logo

SuperPathways for KCNK5 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Activation of cAMP-Dependent PKA
.77
.77
.56
3 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
4 Cardiac conduction
5 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCNK5: view

Pathways by source for KCNK5 Gene

13 Qiagen pathways for KCNK5 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCNK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport TAS 9812978
GO:0007588 excretion TAS 9812978
GO:0030322 stabilization of membrane potential IBA 21873635
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK5: view

No data available for SIGNOR curated interactions for KCNK5 Gene

Drugs & Compounds for KCNK5 Gene

(7) Drugs for KCNK5 Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxapram HCl Pharma 0
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK5 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0

(1) ApexBio Compounds for KCNK5 Gene

Compound Action Cas Number
Doxapram HCl 7081-53-0
genes like me logo Genes that share compounds with KCNK5: view

Drug Products

Transcripts for KCNK5 Gene

mRNA/cDNA for KCNK5 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK5

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK5 Gene

No ASD Table

Relevant External Links for KCNK5 Gene

GeneLoc Exon Structure for
KCNK5

Expression for KCNK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK5 Gene

This gene is overexpressed in Kidney - Cortex (x9.8) and Skin - Sun Exposed (Lower leg) (x5.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNK5

SOURCE GeneReport for Unigene cluster for KCNK5 Gene:

Hs.444448

mRNA Expression by UniProt/SwissProt for KCNK5 Gene:

O95279-KCNK5_HUMAN
Tissue specificity: Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.

Evidence on tissue expression from TISSUES for KCNK5 Gene

  • Nervous system(4.6)
  • Kidney(4.5)
  • Skin(2.4)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with KCNK5: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK5 Gene

Orthologs for KCNK5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KCNK5 30 31
  • 99 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KCNK5 30 31
  • 88.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KCNK5 30 31
  • 87.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Kcnk5 30 17 31
  • 84.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kcnk5 30
  • 84.17 (n)
Oppossum
(Monodelphis domestica)
Mammalia KCNK5 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KCNK5 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KCNK5 30 31
  • 68.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KCNK5 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kcnk5 30
  • 68.45 (n)
Str.16771 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7279 30
Zebrafish
(Danio rerio)
Actinopterygii kcnk5a 30 31
  • 57.42 (n)
OneToMany
kcnk5b 31
  • 44 (a)
OneToMany
Dr.17953 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6929 31
  • 29 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1682 30
Species where no ortholog for KCNK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KCNK5 Gene

ENSEMBL:
Gene Tree for KCNK5 (if available)
TreeFam:
Gene Tree for KCNK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK5: view image

Paralogs for KCNK5 Gene

(1) SIMAP similar genes for KCNK5 Gene using alignment to 1 proteins:

  • KCNK5_HUMAN
genes like me logo Genes that share paralogs with KCNK5: view

Variants for KCNK5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNK5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
739754 Likely Benign: not provided 39,191,205(-) C/T SYNONYMOUS_VARIANT
790348 Benign: not provided 39,191,171(-) C/T MISSENSE_VARIANT
rs9462487 - p.Pro465Thr

Additional dbSNP identifiers (rs#s) for KCNK5 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNK5 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV loss 17160897
nsv950167 CNV deletion 24416366

Variation tolerance for KCNK5 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK5 Gene

Human Gene Mutation Database (HGMD)
KCNK5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK5 Gene

Disorders for KCNK5 Gene

MalaCards: The human disease database

(8) MalaCards diseases for KCNK5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alexia
  • acquired dyslexia
integrative agnosia
breast leiomyosarcoma
  • leiomyosarcoma of the breast
epithelial-stromal tgfbi dystrophy
central hypoventilation syndrome, congenital
  • cchs
- elite association - COSMIC cancer census association via MalaCards
Search KCNK5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KCNK5

genes like me logo Genes that share disorders with KCNK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK5 Gene

Publications for KCNK5 Gene

  1. Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. (PMID: 9812978) Reyes R … Lazdunski M (The Journal of biological chemistry 1998) 2 3 4 23
  2. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PMID: 18516069) Gierten J … Thomas D (British journal of pharmacology 2008) 3 4
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for KCNK5 Gene

Sources for KCNK5 Gene