Aliases for KCNK5 Gene
- Potassium Two Pore Domain Channel Subfamily K Member 5 2 3 5
- TASK2 2 3 4
- Potassium Channel, Two Pore Domain Subfamily K, Member 5 2 3
- Acid-Sensitive Potassium Channel Protein TASK-2 3 4
- TWIK-Related Acid-Sensitive K(+) Channel 2 3 4
- Potassium Channel Subfamily K Member 5 3 4
- TWIK-Related Acid-Sensitive K+ 2 2 3
- K2p5.1 2 3
External Ids for KCNK5 Gene
Previous GeneCards Identifiers for KCNK5 Gene
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNK5 Gene
KCNK5 (Potassium Two Pore Domain Channel Subfamily K Member 5) is a Protein Coding gene. Diseases associated with KCNK5 include Danubian Endemic Familial Nephropathy and Central Hypoventilation Syndrome, Congenital. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK17.
UniProtKB/Swiss-Prot Summary for KCNK5 Gene
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.