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Aliases for KCNK2 Gene

Aliases for KCNK2 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 2 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 2 2 3
  • Outward Rectifying Potassium Channel Protein TREK-1 3 4
  • Two Pore Domain Potassium Channel TREK-1 3 4
  • Two Pore Potassium Channel TPKC1 3 4
  • TREK-1 K(+) Channel Subunit 3 4
  • TREK1 3 4
  • TREK 3 4
  • Potassium Inwardly-Rectifying Channel, Subfamily K, Member 2 3
  • Potassium Channel Subfamily K Member 2 Variant 1 3
  • Potassium Channel Subfamily K Member 2 Variant 2 3
  • Tandem-Pore-Domain Potassium Channel TREK-1 3
  • Potassium Channel, Subfamily K, Member 2 2
  • Potassium Channel Subfamily K Member 2 3
  • TWIK-Related Potassium Channel 1 3
  • Two-Pore Potassium Channel 1 3
  • K2P2.1 Potassium Channel 3
  • HTREK-1c 3
  • HTREK-1e 3
  • K2p2.1 3
  • TREK-1 3
  • TPKC1 3

External Ids for KCNK2 Gene

Previous GeneCards Identifiers for KCNK2 Gene

  • GC01P213914
  • GC01P211077
  • GC01P211795
  • GC01P212313
  • GC01P211645
  • GC01P213245
  • GC01P215178
  • GC01P185853

Summaries for KCNK2 Gene

Entrez Gene Summary for KCNK2 Gene

  • This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK2 Gene

KCNK2 (Potassium Two Pore Domain Channel Subfamily K Member 2) is a Protein Coding gene. Diseases associated with KCNK2 include Dentin Sensitivity. Among its related pathways are Hepatic ABC Transporters and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is KCNK10.

UniProtKB/Swiss-Prot for KCNK2 Gene

  • Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).

  • Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.

Tocris Summary for KCNK2 Gene

Gene Wiki entry for KCNK2 Gene

Additional gene information for KCNK2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK2 Gene

Genomics for KCNK2 Gene

GeneHancer (GH) Regulatory Elements for KCNK2 Gene

Promoters and enhancers for KCNK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J215082 Promoter 1.6 EPDnew Ensembl 650.2 +80.5 80462 1 KLF17 SIN3A BMI1 KLF14 ZNF335 GLIS2 ZNF207 ZNF280D GATAD2B ZNF398 KCNK2 GC01M215002 GC01P215194
GH01J215003 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.6 2635 2.9 CEBPB DPF2 CEBPG FOXA1 CTBP1 JUND GATA3 POLR2A RCOR1 CHD2 KCNK2 GC01M215002 GC01P215194
GH01J215001 Enhancer 0.9 ENCODE dbSUPER 650.7 -0.4 -434 1.9 EBF1 BMI1 IRF4 MTA3 NFATC1 EED ATF7 NFE2 ETV6 BCLAF1 KCNK2 GC01M215002 ENSG00000223869
GH01J215024 Enhancer 0.4 FANTOM5 19.9 +22.5 22476 0.3 JUND GATA3 KCNK2 GC01M215002 GC01P215194
GH01J214470 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -527.5 -527480 8.3 EBF1 CEBPG ZNF316 ZSCAN5C FOSL2 FOS NFE2 MAFK GATAD2A TEAD1 ABHD17AP3 PTPN14 KCNK2 GC01M214483 ENSG00000228470
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNK2 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2
  • c-Myc
  • FAC1
  • Max1
  • Nkx3-1 v1

Genomic Locations for KCNK2 Gene

Genomic Locations for KCNK2 Gene
chr1:215,002,639-215,237,093
(GRCh38/hg38)
Size:
234,455 bases
Orientation:
Plus strand
chr1:215,178,885-215,410,436
(GRCh37/hg19)
Size:
231,552 bases
Orientation:
Plus strand

Genomic View for KCNK2 Gene

Genes around KCNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK2 Gene

Proteins for KCNK2 Gene

  • Protein details for KCNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95069-KCNK2_HUMAN
    Recommended name:
    Potassium channel subfamily K member 2
    Protein Accession:
    O95069
    Secondary Accessions:
    • A1Z1V3
    • A8K618
    • B2RCS4
    • B7ZL56
    • D3DTA5
    • Q5DP47
    • Q5DP48
    • Q9NRT2
    • Q9UNE3

    Protein attributes for KCNK2 Gene

    Size:
    426 amino acids
    Molecular mass:
    47093 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (Ref.13). Heterodimer with KCNK1; disulfide-linked (By similarity). Interacts with BVES; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (PubMed:26642364).
    Miscellaneous:
    • Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.

    Three dimensional structures from OCA and Proteopedia for KCNK2 Gene

    Alternative splice isoforms for KCNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK2 Gene

Post-translational modifications for KCNK2 Gene

  • Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.
  • Glycosylation at isoforms=2, 3, 4134 and Asn110
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KCNK2 Gene

Domains & Families for KCNK2 Gene

Gene Families for KCNK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Voltage-gated ion channels

Graphical View of Domain Structure for InterPro Entry

O95069

UniProtKB/Swiss-Prot:

KCNK2_HUMAN :
  • The C-terminal region of isoform 4 mediates its intracellular retention.
Domain:
  • The C-terminal region of isoform 4 mediates its intracellular retention.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK2: view

Function for KCNK2 Gene

Molecular function for KCNK2 Gene

UniProtKB/Swiss-Prot Function:
Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.
GENATLAS Biochemistry:
potassium non voltage-gated channel inwardly rectifying,subfamily K,member 2

Phenotypes From GWAS Catalog for KCNK2 Gene

Gene Ontology (GO) - Molecular Function for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005249 voltage-gated potassium channel activity IEA --
GO:0005267 potassium channel activity IEA --
GO:0015271 outward rectifier potassium channel activity ISS,IEA --
GO:0022841 potassium ion leak channel activity ISS,IEA --
genes like me logo Genes that share ontologies with KCNK2: view
genes like me logo Genes that share phenotypes with KCNK2: view

Animal Models for KCNK2 Gene

MGI Knock Outs for KCNK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK2

Clone Products

  • Addgene plasmids for KCNK2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK2 Gene

Localization for KCNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK2 Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cell membrane; Multi-pass membrane protein.
Isoform 4: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IEA --
genes like me logo Genes that share ontologies with KCNK2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNK2 Gene

Pathways & Interactions for KCNK2 Gene

genes like me logo Genes that share pathways with KCNK2: view

Gene Ontology (GO) - Biological Process for KCNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003231 cardiac ventricle development IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007613 memory IEA --
genes like me logo Genes that share ontologies with KCNK2: view

No data available for SIGNOR curated interactions for KCNK2 Gene

Drugs & Compounds for KCNK2 Gene

(15) Drugs for KCNK2 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Inhibitor, Activator, antagonist 2
Riluzole Approved, Investigational Pharma Activator, blocker Sodium channel protein inhibitor 69
Dofetilide Approved, Investigational Pharma Pore Blocker, blocker, Target, inhibitor 16
Dronedarone Approved Pharma Target, inhibitor 0
Gliquidone Approved, Investigational Pharma 5

(2) Tocris Compounds for KCNK2 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK2: view

Transcripts for KCNK2 Gene

Unigene Clusters for KCNK2 Gene

Potassium channel, subfamily K, member 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for KCNK2

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for KCNK2 Gene

GeneLoc Exon Structure for
KCNK2
ECgene alternative splicing isoforms for
KCNK2

Expression for KCNK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK2 Gene

This gene is overexpressed in Adrenal Gland (x10.8).

NURSA nuclear receptor signaling pathways regulating expression of KCNK2 Gene:

KCNK2

SOURCE GeneReport for Unigene cluster for KCNK2 Gene:

Hs.497745

mRNA Expression by UniProt/SwissProt for KCNK2 Gene:

O95069-KCNK2_HUMAN
Tissue specificity: Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.

Evidence on tissue expression from TISSUES for KCNK2 Gene

  • Nervous system(4.5)
  • Heart(4.3)
  • Lung(4.2)
  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with KCNK2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK2 Gene

Orthologs for KCNK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK2 34 33
  • 99.92 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNK2 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KCNK2 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK2 34 33
  • 91.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK2 34 33
  • 90.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Kcnk2 16 34 33
  • 88.97 (n)
rat
(Rattus norvegicus)
Mammalia Kcnk2 33
  • 88.81 (n)
chicken
(Gallus gallus)
Aves KCNK2 34 33
  • 83.65 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK2 34
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kcnk2a 34
  • 73 (a)
OneToMany
LOC559728 33
  • 71.37 (n)
kcnk2b 34
  • 67 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6929 34
  • 32 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Species where no ortholog for KCNK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK2 Gene

ENSEMBL:
Gene Tree for KCNK2 (if available)
TreeFam:
Gene Tree for KCNK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK2: view image

Paralogs for KCNK2 Gene

Paralogs for KCNK2 Gene

(6) SIMAP similar genes for KCNK2 Gene using alignment to 8 proteins:

  • KCNK2_HUMAN
  • B4DGU6_HUMAN
  • C9JDK1_HUMAN
  • C9JXY2_HUMAN
  • F8WDE6_HUMAN
  • Q6ZW95_HUMAN
  • U3N6F0_HUMAN
  • U3N834_HUMAN
genes like me logo Genes that share paralogs with KCNK2: view

Variants for KCNK2 Gene

Sequence variations from dbSNP and Humsavar for KCNK2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000017335 -- 215,179,717(+) C/T intron_variant
rs1000028722 -- 215,208,910(+) C/T intron_variant
rs1000029766 -- 215,044,936(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000034130 -- 215,134,672(+) G/A intron_variant
rs1000046033 -- 215,199,392(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK2 Gene

Variant ID Type Subtype PubMed ID
dgv24n21 CNV loss 19592680
esv1046148 CNV deletion 17803354
esv1227395 CNV insertion 17803354
esv2722695 CNV deletion 23290073
esv2722706 CNV deletion 23290073
esv2760086 CNV loss 21179565
esv3004990 CNV deletion 24192839
esv3307846 CNV mobile element insertion 20981092
esv3308609 CNV mobile element insertion 20981092
esv3337050 CNV insertion 20981092
esv3360711 CNV insertion 20981092
esv3388970 CNV insertion 20981092
esv3398251 CNV insertion 20981092
esv3421442 CNV insertion 20981092
esv3546478 CNV deletion 23714750
esv3588798 CNV loss 21293372
esv3588799 CNV loss 21293372
esv3588800 CNV loss 21293372
esv3588803 CNV loss 21293372
esv3588804 CNV loss 21293372
nsv1119758 CNV deletion 24896259
nsv1143476 CNV deletion 24896259
nsv160908 CNV deletion 16902084
nsv549182 CNV loss 21841781
nsv952099 CNV deletion 24416366

Variation tolerance for KCNK2 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK2 Gene

Disorders for KCNK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards
Search KCNK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KCNK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KCNK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK2 Gene

Publications for KCNK2 Gene

  1. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. (PMID: 18288090) Perlis RH … Smoller JW (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008) 3 22 44 58
  2. Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. (PMID: 9721223) Lesage F … Lazdunski M (Genomics 1998) 2 3 22 58
  3. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. (PMID: 24196565) Rinné S … Preisig-Müller R (Pflugers Archiv : European journal of physiology 2014) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for KCNK2 Gene

Sources for KCNK2 Gene

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