The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [pro... See more...

Aliases for KCNK17 Gene

Aliases for KCNK17 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 17 2 3 5
  • TALK-2 2 3 4
  • TALK2 2 3 4
  • TASK4 2 3 4
  • Potassium Channel, Two Pore Domain Subfamily K, Member 17 2 3
  • TWIK-Related Alkaline PH-Activated K(+) Channel 2 3 4
  • Acid-Sensitive Potassium Channel Protein TASK-4 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 4 3 4
  • Potassium Channel Subfamily K Member 17 3 4
  • 2P Domain Potassium Channel Talk-2 3 4
  • TWIK-Related Acid-Sensitive K+ 4 2 3
  • K2p17.1 2 3
  • TASK-4 2 3
  • Potassium Channel, Subfamily K, Member 17 2
  • KCNK17 5

External Ids for KCNK17 Gene

Previous GeneCards Identifiers for KCNK17 Gene

  • GC06M039268
  • GC06M039313
  • GC06M039374
  • GC06M039266
  • GC06M038985
  • GC06M039300
  • GC06M039357
  • GC06M040042
  • GC06M040085
  • GC06M039987
  • GC06M041326
  • GC06M039396
  • GC06M039434
  • GC06M039449
  • GC06M039482
  • GC06M039523
  • GC06M039562
  • GC06M039603
  • GC06M039783

Summaries for KCNK17 Gene

Entrez Gene Summary for KCNK17 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK17 Gene

KCNK17 (Potassium Two Pore Domain Channel Subfamily K Member 17) is a Protein Coding gene. Diseases associated with KCNK17 include Radial Nerve Lesion and Lung Leiomyosarcoma. Among its related pathways are Cardiac conduction and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK4.

UniProtKB/Swiss-Prot Summary for KCNK17 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Tocris Summary for KCNK17 Gene

Gene Wiki entry for KCNK17 Gene

Additional gene information for KCNK17 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNK17 Gene

Genomics for KCNK17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCNK17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J039314 Promoter/Enhancer 0.7 EPDnew dbSUPER 600.7 +0.0 22 0.1 EZH2 POLR2A LOC105375047 KCNK17 KCNK5
GH06J039316 Promoter/Enhancer 0.7 Ensembl dbSUPER 600.7 +0.4 360 0.2 EZH2 CTCF LOC105375047 KCNK17 piR-50225 KCNK5
GH06J039312 Enhancer 0.5 FANTOM5 dbSUPER 629.6 +1.3 1349 0.4 EZH2 HNF4A KCNK17 LOC105375047 KCNK16 GLP1R SAYSD1 piR-50225 KCNK5
GH06J039315 Enhancer 0.2 dbSUPER 615.7 -1.8 -1833 0.6 KCNK17 LOC105375047 KCNK16
GH06J039114 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +199.6 199602 2.5 ZNF221 RNF2 CEBPG HNRNPL PRDM10 TFE3 IKZF1 ZNF692 ZNF7 ETV6 SAYSD1 lnc-KCNK5-1 piR-39250 piR-41851 piR-42109 piR-41349 KCNK17 GLP1R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNK17

Top Transcription factor binding sites by QIAGEN in the KCNK17 gene promoter:
  • Nkx6-1
  • Pax-2
  • Pax-2a
  • Pbx1a
  • RFX1

Genomic Locations for KCNK17 Gene

Genomic Locations for KCNK17 Gene
chr6:39,299,001-39,314,461
(GRCh38/hg38)
Size:
15,461 bases
Orientation:
Minus strand
chr6:39,266,777-39,282,329
(GRCh37/hg19)
Size:
15,553 bases
Orientation:
Minus strand

Genomic View for KCNK17 Gene

Genes around KCNK17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK17 Gene

Proteins for KCNK17 Gene

  • Protein details for KCNK17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T54-KCNKH_HUMAN
    Recommended name:
    Potassium channel subfamily K member 17
    Protein Accession:
    Q96T54
    Secondary Accessions:
    • E9PB46
    • Q5TCF4
    • Q8TAW4
    • Q9BXD1
    • Q9H592

    Protein attributes for KCNK17 Gene

    Size:
    332 amino acids
    Molecular mass:
    36895 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAK28551.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.

    Alternative splice isoforms for KCNK17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK17 Gene

Post-translational modifications for KCNK17 Gene

  • Glycosylation at Asn65 and Asn94

Other Protein References for KCNK17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KCNK17
  • Boster Bio Antibodies for KCNK17

No data available for DME Specific Peptides for KCNK17 Gene

Domains & Families for KCNK17 Gene

Gene Families for KCNK17 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for KCNK17 Gene

InterPro:
Blocks:
  • Two pore domain K+ channel signature
  • Ion transport 2, bacterial
  • TASK K+ channel signature
ProtoNet:

Suggested Antigen Peptide Sequences for KCNK17 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ96285, highly similar to Homo sapiens potassium channel, subfamily K, member 17 (KCNK17), mRNA (B2RCT9_HUMAN)
  • TWIK-related alkaline pH-activated K(+) channel 2 (KCNKH_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96T54

UniProtKB/Swiss-Prot:

KCNKH_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK17: view

Function for KCNK17 Gene

Molecular function for KCNK17 Gene

UniProtKB/Swiss-Prot Function:
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Phenotypes From GWAS Catalog for KCNK17 Gene

Gene Ontology (GO) - Molecular Function for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IDA 11248242
GO:0022841 potassium ion leak channel activity IBA 21873635
genes like me logo Genes that share ontologies with KCNK17: view
genes like me logo Genes that share phenotypes with KCNK17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNK17 Gene

Localization for KCNK17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK17 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK17 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
endoplasmic reticulum 0
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK17: view

Pathways & Interactions for KCNK17 Gene

PathCards logo

SuperPathways for KCNK17 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Cardiac conduction
3 Activation of cAMP-Dependent PKA
.77
.77
.56
4 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
5 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCNK17: view

Pathways by source for KCNK17 Gene

13 Qiagen pathways for KCNK17 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA,IDA 11248242
GO:0030322 stabilization of membrane potential IBA 21873635
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA 21873635
genes like me logo Genes that share ontologies with KCNK17: view

No data available for SIGNOR curated interactions for KCNK17 Gene

Drugs & Compounds for KCNK17 Gene

(2) Drugs for KCNK17 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK17 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK17: view

Transcripts for KCNK17 Gene

mRNA/cDNA for KCNK17 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK17

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK17 Gene

No ASD Table

Relevant External Links for KCNK17 Gene

GeneLoc Exon Structure for
KCNK17

Expression for KCNK17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNK17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK17 Gene

This gene is overexpressed in Artery - Aorta (x17.7), Artery - Coronary (x7.5), and Lung (x4.1).

Protein differential expression in normal tissues from HIPED for KCNK17 Gene

This gene is overexpressed in Ovary (58.7) and Peripheral blood mononuclear cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK17 Gene



Protein tissue co-expression partners for KCNK17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNK17

SOURCE GeneReport for Unigene cluster for KCNK17 Gene:

Hs.162282

Evidence on tissue expression from TISSUES for KCNK17 Gene

  • Lung(4.3)
  • Pancreas(4.2)
  • Adrenal gland(4.2)
  • Spleen(4)
  • Skin(2)
genes like me logo Genes that share expression patterns with KCNK17: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK17 Gene

Orthologs for KCNK17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KCNK17 30 31
  • 98.9 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KCNK17 30 31
  • 87.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KCNK17 30 31
  • 83.28 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 37 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 32 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves KCNK17 30 31
  • 60.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KCNK17 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kcnk17 30
  • 62.14 (n)
Zebrafish
(Danio rerio)
Actinopterygii KCNK17 31
  • 36 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6929 31
  • 28 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
Species where no ortholog for KCNK17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KCNK17 Gene

ENSEMBL:
Gene Tree for KCNK17 (if available)
TreeFam:
Gene Tree for KCNK17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK17: view image

Paralogs for KCNK17 Gene

(4) SIMAP similar genes for KCNK17 Gene using alignment to 2 proteins:

  • KCNKH_HUMAN
  • B2RCT9_HUMAN
genes like me logo Genes that share paralogs with KCNK17: view

Variants for KCNK17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNK17 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
745978 Likely Benign: not provided 39,304,079(-) AG/A FRAMESHIFT_VARIANT
746199 Likely Benign: not provided 39,303,982(-) G/A SYNONYMOUS_VARIANT
778002 Benign: not provided 39,314,140(-) C/T MISSENSE_VARIANT
rs141016843 Likely Pathogenic: not provided 39,310,983(-) C/T MISSENSE_VARIANT
rs483353014 Uncertain Significance: not provided 39,304,573(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for KCNK17 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNK17 Gene

Variant ID Type Subtype PubMed ID
nsv478038 CNV novel sequence insertion 20440878
nsv830644 CNV loss 17160897
nsv830645 CNV loss 17160897

Variation tolerance for KCNK17 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK17 Gene

Human Gene Mutation Database (HGMD)
KCNK17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK17 Gene

Disorders for KCNK17 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KCNK17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
radial nerve lesion
  • lesion of radial nerve
lung leiomyosarcoma
  • pulmonary leiomyosarcoma
apperceptive agnosia
substernal goiter
  • retrosternal thyroid goiter
long qt syndrome
  • romano-ward syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KCNK17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KCNK17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK17 Gene

Publications for KCNK17 Gene

  1. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 41
  2. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PMID: 19910543) Ding H … Wang DW (Stroke 2010) 3 41
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for KCNK17 Gene

  • Signalway Proteins for KCNK17

Sources for KCNK17 Gene