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Aliases for KCNK17 Gene

Aliases for KCNK17 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 17 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 17 2 3
  • TWIK-Related Alkaline PH-Activated K(+) Channel 2 3 4
  • Acid-Sensitive Potassium Channel Protein TASK-4 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 4 3 4
  • 2P Domain Potassium Channel Talk-2 3 4
  • TALK-2 3 4
  • TALK2 3 4
  • TASK4 3 4
  • Potassium Channel, Subfamily K, Member 17 2
  • Potassium Channel Subfamily K Member 17 3
  • K2p17.1 3
  • TASK-4 3

External Ids for KCNK17 Gene

Previous GeneCards Identifiers for KCNK17 Gene

  • GC06M039268
  • GC06M039313
  • GC06M039374
  • GC06M039266
  • GC06M038985
  • GC06M039300
  • GC06M039357
  • GC06M039396
  • GC06M039434
  • GC06M039449
  • GC06M039482
  • GC06M039523
  • GC06M039562

Summaries for KCNK17 Gene

Entrez Gene Summary for KCNK17 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK17 Gene

KCNK17 (Potassium Two Pore Domain Channel Subfamily K Member 17) is a Protein Coding gene. Diseases associated with KCNK17 include Cerebral Hemorrhage. Among its related pathways are Hepatic ABC Transporters and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK4.

UniProtKB/Swiss-Prot for KCNK17 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Tocris Summary for KCNK17 Gene

Gene Wiki entry for KCNK17 Gene

Additional gene information for KCNK17 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK17 Gene

Genomics for KCNK17 Gene

GeneHancer (GH) Regulatory Elements for KCNK17 Gene

Promoters and enhancers for KCNK17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J039314 Promoter/Enhancer 0.9 EPDnew dbSUPER 650.7 +0.1 114 0.1 POLR2A SUZ12 EZH2 KCNK17 LOC105375047 GC06M039634
GH06J039312 Enhancer 0.6 FANTOM5 dbSUPER 679.7 +1.4 1441 0.4 HNF4A EZH2 KCNK17 LOC105375047 KCNK16 GLP1R SAYSD1 GC06M039632 GC06M039634
GH06J039315 Enhancer 0.2 dbSUPER 665.8 -1.7 -1741 0.6 KCNK17 LOC105375047 KCNK16 GC06M039634
GH06J039114 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 +199.5 199478 2.1 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GC06M039604 GC06M039606 GC06M039607 GC06M039609 GC06M039628 PIR34348 SAYSD1 PIR35108 PIR44528 KCNK17
GH06J039361 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.3 -47.9 -47869 1.1 CTCF MXI1 TFAP4 ESRRA RB1 MAX ZNF48 RAD21 ZNF335 ZNF207 KCNK17 KCNK16 LOC100124373 GC06M039634 KIF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNK17 gene promoter:
  • RFX1
  • Pax-2
  • Pax-2a
  • Pbx1a
  • Nkx6-1

Genomic Locations for KCNK17 Gene

Genomic Locations for KCNK17 Gene
chr6:39,299,001-39,314,553
(GRCh38/hg38)
Size:
15,553 bases
Orientation:
Minus strand
chr6:39,266,777-39,282,329
(GRCh37/hg19)
Size:
15,553 bases
Orientation:
Minus strand

Genomic View for KCNK17 Gene

Genes around KCNK17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK17 Gene

Proteins for KCNK17 Gene

  • Protein details for KCNK17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T54-KCNKH_HUMAN
    Recommended name:
    Potassium channel subfamily K member 17
    Protein Accession:
    Q96T54
    Secondary Accessions:
    • E9PB46
    • Q5TCF4
    • Q8TAW4
    • Q9BXD1
    • Q9H592

    Protein attributes for KCNK17 Gene

    Size:
    332 amino acids
    Molecular mass:
    36895 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.
    SequenceCaution:
    • Sequence=AAK28551.1; Type=Frameshift; Positions=260; Evidence={ECO:0000305};

    Alternative splice isoforms for KCNK17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK17 Gene

Post-translational modifications for KCNK17 Gene

  • Glycosylation at isoforms=494 and Asn65

Other Protein References for KCNK17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KCNK17
  • Boster Bio Antibodies for KCNK17

No data available for DME Specific Peptides for KCNK17 Gene

Domains & Families for KCNK17 Gene

Gene Families for KCNK17 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Graphical View of Domain Structure for InterPro Entry

Q96T54

UniProtKB/Swiss-Prot:

KCNKH_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK17: view

Function for KCNK17 Gene

Molecular function for KCNK17 Gene

UniProtKB/Swiss-Prot Function:
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Phenotypes From GWAS Catalog for KCNK17 Gene

Gene Ontology (GO) - Molecular Function for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity TAS --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK17: view
genes like me logo Genes that share phenotypes with KCNK17: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNK17 Gene

Localization for KCNK17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK17 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK17 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNK17 Gene

Pathways & Interactions for KCNK17 Gene

genes like me logo Genes that share pathways with KCNK17: view

Gene Ontology (GO) - Biological Process for KCNK17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA,IDA 11248242
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK17: view

No data available for SIGNOR curated interactions for KCNK17 Gene

Drugs & Compounds for KCNK17 Gene

(2) Drugs for KCNK17 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK17 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK17: view

Transcripts for KCNK17 Gene

mRNA/cDNA for KCNK17 Gene

Unigene Clusters for KCNK17 Gene

Potassium channel, subfamily K, member 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK17 Gene

No ASD Table

Relevant External Links for KCNK17 Gene

GeneLoc Exon Structure for
KCNK17
ECgene alternative splicing isoforms for
KCNK17

Expression for KCNK17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK17 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK17 Gene

This gene is overexpressed in Artery - Aorta (x17.7), Artery - Coronary (x7.5), and Lung (x4.1).

Protein differential expression in normal tissues from HIPED for KCNK17 Gene

This gene is overexpressed in Ovary (58.7) and Peripheral blood mononuclear cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK17 Gene



Protein tissue co-expression partners for KCNK17 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNK17 Gene:

KCNK17

SOURCE GeneReport for Unigene cluster for KCNK17 Gene:

Hs.162282

Evidence on tissue expression from TISSUES for KCNK17 Gene

  • Lung(4.1)
  • Pancreas(4.1)
  • Adrenal gland(4)
  • Spleen(4)
genes like me logo Genes that share expression patterns with KCNK17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK17 Gene

Orthologs for KCNK17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK17 34 33
  • 98.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK17 34 33
  • 87.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KCNK17 34 33
  • 83.28 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 37 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 32 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KCNK17 34 33
  • 60.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK17 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk17 33
  • 62.14 (n)
zebrafish
(Danio rerio)
Actinopterygii KCNK17 34
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6929 34
  • 28 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
Species where no ortholog for KCNK17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK17 Gene

ENSEMBL:
Gene Tree for KCNK17 (if available)
TreeFam:
Gene Tree for KCNK17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK17: view image

Paralogs for KCNK17 Gene

Paralogs for KCNK17 Gene

(4) SIMAP similar genes for KCNK17 Gene using alignment to 2 proteins:

  • KCNKH_HUMAN
  • B2RCT9_HUMAN
genes like me logo Genes that share paralogs with KCNK17: view

Variants for KCNK17 Gene

Sequence variations from dbSNP and Humsavar for KCNK17 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs141016843 likely-pathogenic, not provided 39,310,983(-) C/T coding_sequence_variant, missense_variant
rs483353014 uncertain-significance, not provided 39,304,573(-) G/A/T coding_sequence_variant, synonymous_variant
rs483353015 uncertain-significance, not provided 39,299,433(-) G/A 3_prime_UTR_variant, coding_sequence_variant, synonymous_variant
rs1000052218 -- 39,311,803(-) T/C intron_variant
rs1000142649 -- 39,308,443(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK17 Gene

Variant ID Type Subtype PubMed ID
nsv478038 CNV novel sequence insertion 20440878
nsv830644 CNV loss 17160897
nsv830645 CNV loss 17160897

Variation tolerance for KCNK17 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK17 Gene

Human Gene Mutation Database (HGMD)
KCNK17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK17 Gene

Disorders for KCNK17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KCNK17 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
cerebral hemorrhage
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KCNK17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KCNK17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK17 Gene

Publications for KCNK17 Gene

  1. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 44 58
  2. Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke. (PMID: 19910543) Ding H … Wang DW (Stroke 2010) 3 44 58
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for KCNK17 Gene

Sources for KCNK17 Gene

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