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Aliases for KCNK16 Gene

Aliases for KCNK16 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 16 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 16 2 3
  • TWIK-Related Alkaline PH-Activated K(+) Channel 1 3 4
  • Potassium Channel, Subfamily K, Member 16 2 3
  • 2P Domain Potassium Channel Talk-1 3 4
  • TALK-1 3 4
  • TALK1 3 4
  • Potassium Channel Subfamily K Member 16 3
  • Pancreatic Potassium Channel Talk-1 3
  • K2p16.1 3

External Ids for KCNK16 Gene

Previous GeneCards Identifiers for KCNK16 Gene

  • GC06M039284
  • GC06M039329
  • GC06M039390
  • GC06M039282
  • GC06M039000
  • GC06M039317
  • GC06M039353
  • GC06M039393
  • GC06M039432
  • GC06M039446
  • GC06M039481
  • GC06M039522
  • GC06M039561

Summaries for KCNK16 Gene

Entrez Gene Summary for KCNK16 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK16 Gene

KCNK16 (Potassium Two Pore Domain Channel Subfamily K Member 16) is a Protein Coding gene. Among its related pathways are Hepatic ABC Transporters and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK17.

UniProtKB/Swiss-Prot for KCNK16 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Tocris Summary for KCNK16 Gene

Gene Wiki entry for KCNK16 Gene

Additional gene information for KCNK16 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK16 Gene

Genomics for KCNK16 Gene

GeneHancer (GH) Regulatory Elements for KCNK16 Gene

Promoters and enhancers for KCNK16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J039320 Enhancer 0.6 FANTOM5 dbSUPER 61.6 +2.7 2653 0.4 RXRA EZH2 NR2F2 KCNK16 KCNK17 GLP1R SAYSD1 LOC105375047 GC06M039634
GH06J039312 Enhancer 0.6 FANTOM5 dbSUPER 41.6 +9.9 9873 0.4 HNF4A EZH2 KCNK17 LOC105375047 KCNK16 GLP1R SAYSD1 GC06M039632 GC06M039634
GH06J039361 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 -39.4 -39437 1.1 CTCF MXI1 TFAP4 ESRRA RB1 MAX ZNF48 RAD21 ZNF335 ZNF207 KCNK17 KCNK16 LOC100124373 GC06M039634 KIF6
GH06J039269 Enhancer 0.7 ENCODE 10.1 +52.3 52319 2 NCOA3 PKNOX1 CLOCK ESRRA NFIB NEUROD1 ZKSCAN1 CTBP1 GATA3 RCOR1 KCNK17 KCNK5 GLP1R KCNK16 SAYSD1 PIR44224 GC06M039634
GH06J039358 Enhancer 0.6 Ensembl dbSUPER 11.1 -35.3 -35315 0.2 OSR2 NFIC NFIA KCNK17 KCNK16 LOC100124373 GC06M039634 KIF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNK16 gene promoter:
  • RFX1
  • Pax-2a
  • Pax-2
  • Pbx1a
  • Nkx6-1
  • E47
  • Tal-1beta
  • SEF-1 (1)
  • oct-B2
  • Oct-B1

Genomic Locations for KCNK16 Gene

Genomic Locations for KCNK16 Gene
8,288 bases
Minus strand
8,271 bases
Minus strand

Genomic View for KCNK16 Gene

Genes around KCNK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK16 Gene

Proteins for KCNK16 Gene

  • Protein details for KCNK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 16
    Protein Accession:
    Secondary Accessions:
    • B5TJL9
    • Q2M2N9
    • Q5TCF3
    • Q6X6Z3
    • Q6X6Z4
    • Q6X6Z5
    • Q9H591

    Protein attributes for KCNK16 Gene

    309 amino acids
    Molecular mass:
    34153 Da
    Quaternary structure:
    • Homodimer.
    • Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH.

    Alternative splice isoforms for KCNK16 Gene


neXtProt entry for KCNK16 Gene

Post-translational modifications for KCNK16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNK16 Gene

Domains & Families for KCNK16 Gene

Gene Families for KCNK16 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNK16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK16: view

Function for KCNK16 Gene

Molecular function for KCNK16 Gene

UniProtKB/Swiss-Prot Function:
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Phenotypes From GWAS Catalog for KCNK16 Gene

Gene Ontology (GO) - Molecular Function for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IDA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK16: view
genes like me logo Genes that share phenotypes with KCNK16: view

Animal Models for KCNK16 Gene

MGI Knock Outs for KCNK16:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK16

miRNA for KCNK16 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK16 Gene

Localization for KCNK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK16 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK16 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNK16 Gene

Pathways & Interactions for KCNK16 Gene

genes like me logo Genes that share pathways with KCNK16: view

Gene Ontology (GO) - Biological Process for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IDA 11263999
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK16: view

No data available for SIGNOR curated interactions for KCNK16 Gene

Drugs & Compounds for KCNK16 Gene

(2) Drugs for KCNK16 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK16 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK16: view

Transcripts for KCNK16 Gene

mRNA/cDNA for KCNK16 Gene

Unigene Clusters for KCNK16 Gene

Potassium channel, subfamily K, member 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK16 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for KCNK16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK16 Gene

This gene is overexpressed in Pancreas (x44.6).

Protein differential expression in normal tissues from HIPED for KCNK16 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK16 Gene

Protein tissue co-expression partners for KCNK16 Gene

NURSA nuclear receptor signaling pathways regulating expression of KCNK16 Gene:


SOURCE GeneReport for Unigene cluster for KCNK16 Gene:


mRNA Expression by UniProt/SwissProt for KCNK16 Gene:

Tissue specificity: Highly expressed in pancreas. Not detectable in the other tissues tested.

Evidence on tissue expression from TISSUES for KCNK16 Gene

  • Pancreas(4.5)
genes like me logo Genes that share expression patterns with KCNK16: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK16 Gene

Orthologs for KCNK16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KCNK16 34 33
  • 89.8 (n)
(Canis familiaris)
Mammalia KCNK16 33
  • 89.57 (n)
(Rattus norvegicus)
Mammalia Kcnk16 33
  • 86.99 (n)
(Mus musculus)
Mammalia Kcnk16 16 34 33
  • 86.76 (n)
(Pan troglodytes)
Mammalia KCNK16 34
  • 76 (a)
(Monodelphis domestica)
Mammalia KCNK16 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia KCNK16 34
  • 60 (a)
(Gallus gallus)
Aves KCNK16 34 33
  • 68.96 (n)
(Anolis carolinensis)
Reptilia KCNK16 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk16 33
  • 68.61 (n)
(Danio rerio)
Actinopterygii LOC101882139 33
  • 50.28 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6929 34
  • 27 (a)
-- 34
  • 20 (a)
Species where no ortholog for KCNK16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK16 Gene

Gene Tree for KCNK16 (if available)
Gene Tree for KCNK16 (if available)
Evolutionary constrained regions (ECRs) for KCNK16: view image

Paralogs for KCNK16 Gene

Paralogs for KCNK16 Gene

(8) SIMAP similar genes for KCNK16 Gene using alignment to 2 proteins:

  • D6RC57_HUMAN
genes like me logo Genes that share paralogs with KCNK16: view

Variants for KCNK16 Gene

Sequence variations from dbSNP and Humsavar for KCNK16 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000334771 -- 39,321,888(-) A/G intron_variant
rs1000401187 -- 39,320,251(-) G/T intron_variant
rs1000479957 -- 39,315,723(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000708011 -- 39,321,652(-) C/G intron_variant
rs1000855572 -- 39,322,075(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK16 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV loss 17160897
nsv830645 CNV loss 17160897

Variation tolerance for KCNK16 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK16 Gene

Disorders for KCNK16 Gene

Additional Disease Information for KCNK16

No disorders were found for KCNK16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK16 Gene

Publications for KCNK16 Gene

  1. Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. (PMID: 12724142) Han J … Kim D (American journal of physiology. Cell physiology 2003) 3 4 22 58
  2. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PMID: 11263999) Girard C … Lesage F (Biochemical and biophysical research communications 2001) 2 3 4 58
  3. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 44 58
  4. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PMID: 18516069) Gierten J … Thomas D (British journal of pharmacology 2008) 3 4 58
  5. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3 58

Products for KCNK16 Gene

Sources for KCNK16 Gene

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