The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding... See more...

Aliases for KCNK16 Gene

Aliases for KCNK16 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 16 2 3 5
  • TALK-1 2 3 4
  • TALK1 2 3 4
  • Potassium Channel, Two Pore Domain Subfamily K, Member 16 2 3
  • TWIK-Related Alkaline PH-Activated K(+) Channel 1 3 4
  • Potassium Channel, Subfamily K, Member 16 2 3
  • Potassium Channel Subfamily K Member 16 3 4
  • 2P Domain Potassium Channel Talk-1 3 4
  • K2p16.1 2 3
  • Pancreatic Potassium Channel Talk-1 3
  • KCNK16 5

External Ids for KCNK16 Gene

Previous GeneCards Identifiers for KCNK16 Gene

  • GC06M039284
  • GC06M039329
  • GC06M039390
  • GC06M039282
  • GC06M039000
  • GC06M039317
  • GC06M039353
  • GC06M040041
  • GC06M040084
  • GC06M039986
  • GC06M041325
  • GC06M039393
  • GC06M039432
  • GC06M039446
  • GC06M039481
  • GC06M039522
  • GC06M039561
  • GC06M039602
  • GC06M039782

Summaries for KCNK16 Gene

Entrez Gene Summary for KCNK16 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK16 Gene

KCNK16 (Potassium Two Pore Domain Channel Subfamily K Member 16) is a Protein Coding gene. Diseases associated with KCNK16 include Birk-Barel Syndrome and Maturity-Onset Diabetes Of The Young. Among its related pathways are Cardiac conduction and Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is KCNK17.

UniProtKB/Swiss-Prot Summary for KCNK16 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Tocris Summary for KCNK16 Gene

Gene Wiki entry for KCNK16 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNK16 Gene

Genomics for KCNK16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCNK16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J039320 Enhancer 0.6 FANTOM5 dbSUPER 61.5 +2.6 2636 0.4 NR2F2 EZH2 RXRA KCNK16 KCNK17 GLP1R SAYSD1 LOC105375047
GH06J039312 Enhancer 0.5 FANTOM5 dbSUPER 41.6 +9.9 9856 0.4 EZH2 HNF4A KCNK17 LOC105375047 KCNK16 GLP1R SAYSD1 piR-50225 KCNK5
GH06J039361 Enhancer 1 Ensembl ENCODE dbSUPER 11.1 -39.5 -39453 1.2 CTCF TEAD4 ZNF143 REST RAD21 TRIM22 ZNF600 NRF1 RUNX3 TCF12 piR-50437-571 KCNK17 KCNK16 LOC100124373 LOC107986594 KIF6
GH06J039262 Enhancer 0.8 Ensembl ENCODE 10.9 +59.5 59467 1.8 CEBPG KDM1A FOXA1 SP1 SCRT2 ATF3 YY1 JUND GATA3 RAD21 KCNK17 KCNK5 KCNK16 SAYSD1 piR-41195-026 RF00017-5521 RF00017-5520
GH06J039365 Enhancer 0.7 Ensembl dbSUPER 11.6 -42.5 -42533 0.6 JUND PKNOX1 FOSL1 ZNF335 FOSL2 ATF3 PRDM10 FOS KCNK16 DAAM2-AS1 piR-50437-571 LOC107986594 HSALNG0049921 KIF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNK16

Top Transcription factor binding sites by QIAGEN in the KCNK16 gene promoter:
  • E47
  • Nkx6-1
  • Oct-B1
  • oct-B2
  • Pax-2
  • Pax-2a
  • Pbx1a
  • RFX1
  • SEF-1 (1)
  • Tal-1beta

Genomic Locations for KCNK16 Gene

Genomic Locations for KCNK16 Gene
chr6:39,314,566-39,322,968
(GRCh38/hg38)
Size:
8,403 bases
Orientation:
Minus strand
chr6:39,282,474-39,290,744
(GRCh37/hg19)
Size:
8,271 bases
Orientation:
Minus strand

Genomic View for KCNK16 Gene

Genes around KCNK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK16 Gene

Proteins for KCNK16 Gene

  • Protein details for KCNK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T55-KCNKG_HUMAN
    Recommended name:
    Potassium channel subfamily K member 16
    Protein Accession:
    Q96T55
    Secondary Accessions:
    • B5TJL9
    • Q2M2N9
    • Q5TCF3
    • Q6X6Z3
    • Q6X6Z4
    • Q6X6Z5
    • Q9H591

    Protein attributes for KCNK16 Gene

    Size:
    309 amino acids
    Molecular mass:
    34153 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Inhibited by Ba(2+), quinine, quinidine, chloroform and halothane. Activated at alkaline pH.

    Alternative splice isoforms for KCNK16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK16 Gene

Post-translational modifications for KCNK16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KCNK16 Gene

Domains & Families for KCNK16 Gene

Gene Families for KCNK16 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for KCNK16 Gene

InterPro:
Blocks:
  • Two pore domain K+ channel signature
  • Ion transport 2, bacterial
  • TASK K+ channel signature
ProtoNet:

Suggested Antigen Peptide Sequences for KCNK16 Gene

GenScript: Design optimal peptide antigens:
  • Potassium channel, subfamily K, member 16, isoform CRA_c (B5TJL9_HUMAN)
  • TWIK-related alkaline pH-activated K(+) channel 1 (KCNKG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96T55

UniProtKB/Swiss-Prot:

KCNKG_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK16: view

Function for KCNK16 Gene

Molecular function for KCNK16 Gene

UniProtKB/Swiss-Prot Function:
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

Phenotypes From GWAS Catalog for KCNK16 Gene

Gene Ontology (GO) - Molecular Function for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IDA 11263999
GO:0005515 protein binding IPI 25416956
GO:0022841 potassium ion leak channel activity IBA 21873635
genes like me logo Genes that share ontologies with KCNK16: view
genes like me logo Genes that share phenotypes with KCNK16: view

Animal Models for KCNK16 Gene

MGI Knock Outs for KCNK16:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK16

CRISPR Products

miRNA for KCNK16 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK16 Gene

Localization for KCNK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK16 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK16 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1
peroxisome 0
lysosome 0

Gene Ontology (GO) - Cellular Components for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNK16 Gene

Pathways & Interactions for KCNK16 Gene

PathCards logo

SuperPathways for KCNK16 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Cardiac conduction
3 Activation of cAMP-Dependent PKA
.77
.77
.56
4 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
5 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCNK16: view

Pathways by source for KCNK16 Gene

13 Qiagen pathways for KCNK16 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCNK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IDA 11263999
GO:0030322 stabilization of membrane potential IBA 21873635
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0071805 potassium ion transmembrane transport IBA 21873635
genes like me logo Genes that share ontologies with KCNK16: view

No data available for SIGNOR curated interactions for KCNK16 Gene

Drugs & Compounds for KCNK16 Gene

(2) Drugs for KCNK16 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK16 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK16: view

Transcripts for KCNK16 Gene

mRNA/cDNA for KCNK16 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK16

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK16 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for KCNK16 Gene

GeneLoc Exon Structure for
KCNK16

Expression for KCNK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK16 Gene

This gene is overexpressed in Pancreas (x44.6).

Protein differential expression in normal tissues from HIPED for KCNK16 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK16 Gene



Protein tissue co-expression partners for KCNK16 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNK16

SOURCE GeneReport for Unigene cluster for KCNK16 Gene:

Hs.287765

mRNA Expression by UniProt/SwissProt for KCNK16 Gene:

Q96T55-KCNKG_HUMAN
Tissue specificity: Highly expressed in pancreas. Not detectable in the other tissues tested.

Evidence on tissue expression from TISSUES for KCNK16 Gene

  • Pancreas(4.5)
genes like me logo Genes that share expression patterns with KCNK16: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK16 Gene

Orthologs for KCNK16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KCNK16 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia KCNK16 30 31
  • 89.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KCNK16 30
  • 89.57 (n)
Rat
(Rattus norvegicus)
Mammalia Kcnk16 30
  • 86.99 (n)
Mouse
(Mus musculus)
Mammalia Kcnk16 30 17 31
  • 86.76 (n)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia KCNK16 31
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KCNK16 31
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KCNK16 31
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KCNK16 30 31
  • 68.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KCNK16 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kcnk16 30
  • 68.61 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101882139 30
  • 50.28 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6929 31
  • 27 (a)
ManyToMany
-- 31
  • 20 (a)
ManyToMany
Species where no ortholog for KCNK16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KCNK16 Gene

ENSEMBL:
Gene Tree for KCNK16 (if available)
TreeFam:
Gene Tree for KCNK16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK16: view image

Paralogs for KCNK16 Gene

(8) SIMAP similar genes for KCNK16 Gene using alignment to 2 proteins:

  • KCNKG_HUMAN
  • D6RC57_HUMAN
genes like me logo Genes that share paralogs with KCNK16: view

Variants for KCNK16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNK16 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs11756091 - p.Pro301His
rs1535500 - p.Ala275Gly
rs9462527 - p.Phe215Leu

Additional dbSNP identifiers (rs#s) for KCNK16 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNK16 Gene

Variant ID Type Subtype PubMed ID
nsv830644 CNV loss 17160897
nsv830645 CNV loss 17160897

Variation tolerance for KCNK16 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK16 Gene

Disorders for KCNK16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KCNK16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
birk-barel syndrome
  • birk-barel mental retardation dysmorphism syndrome
maturity-onset diabetes of the young
  • mody
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KCNK16

genes like me logo Genes that share disorders with KCNK16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK16 Gene

Publications for KCNK16 Gene

  1. Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. (PMID: 12724142) Han J … Kim D (American journal of physiology. Cell physiology 2003) 3 4 23
  2. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. (PMID: 11263999) Girard C … Lesage F (Biochemical and biophysical research communications 2001) 2 3 4
  3. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 41
  4. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PMID: 18516069) Gierten J … Thomas D (British journal of pharmacology 2008) 3 4
  5. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3

Products for KCNK16 Gene

Sources for KCNK16 Gene