This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008] See more...

Aliases for KCNK15 Gene

Aliases for KCNK15 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 15 2 3 5
  • TASK5 2 3 4
  • Potassium Channel, Two Pore Domain Subfamily K, Member 15 2 3
  • Acid-Sensitive Potassium Channel Protein TASK-5 3 4
  • TWIK-Related Acid-Sensitive K(+) Channel 5 3 4
  • Potassium Channel Subfamily K Member 15 3 4
  • TWIK-Related Acid-Sensitive K+ 5 2 3
  • Two Pore Potassium Channel KT3.3 3 4
  • Two Pore K(+) Channel KT3.3 3 4
  • DJ781B1.1 2 3
  • K2p15.1 2 3
  • TASK-5 2 3
  • KT3.3 2 3
  • Potassium Channel, Subfamily K, Member 15 2
  • Potassium Channel, Subfamily K, Member 14 3
  • KIAA0237 2
  • KCNK11 3
  • KCNK14 3
  • KCNK15 5

External Ids for KCNK15 Gene

Previous HGNC Symbols for KCNK15 Gene

  • KCNK11
  • KCNK14

Previous GeneCards Identifiers for KCNK15 Gene

  • GC20P043102
  • GC20P044012
  • GC20P044059
  • GC20P042807
  • GC20P043374
  • GC20P040116

Summaries for KCNK15 Gene

Entrez Gene Summary for KCNK15 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK15 Gene

KCNK15 (Potassium Two Pore Domain Channel Subfamily K Member 15) is a Protein Coding gene. Diseases associated with KCNK15 include Lung Leiomyosarcoma and Apperceptive Agnosia. Among its related pathways are Sweet Taste Signaling and Hepatic ABC Transporters. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK9.

UniProtKB/Swiss-Prot Summary for KCNK15 Gene

  • Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

Tocris Summary for KCNK15 Gene

Gene Wiki entry for KCNK15 Gene

Additional gene information for KCNK15 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNK15 Gene

Genomics for KCNK15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KCNK15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNK15

Top Transcription factor binding sites by QIAGEN in the KCNK15 gene promoter:
  • C/EBPbeta
  • E47
  • Evi-1
  • GATA-2
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Olf-1
  • Tal-1

Genomic Locations for KCNK15 Gene

Genomic Locations for KCNK15 Gene
chr20:44,745,605-44,752,313
(GRCh38/hg38)
Size:
6,709 bases
Orientation:
Plus strand
chr20:43,374,421-43,380,954
(GRCh37/hg19)
Size:
6,534 bases
Orientation:
Plus strand

Genomic View for KCNK15 Gene

Genes around KCNK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK15 Gene

Proteins for KCNK15 Gene

  • Protein details for KCNK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H427-KCNKF_HUMAN
    Recommended name:
    Potassium channel subfamily K member 15
    Protein Accession:
    Q9H427
    Secondary Accessions:
    • Q52LL3
    • Q9HBC8

    Protein attributes for KCNK15 Gene

    Size:
    330 amino acids
    Molecular mass:
    36130 Da
    Quaternary structure:
    • Heterodimer.

neXtProt entry for KCNK15 Gene

Post-translational modifications for KCNK15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KCNK15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK15 Gene

Domains & Families for KCNK15 Gene

Gene Families for KCNK15 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for KCNK15 Gene

InterPro:
Blocks:
  • Two pore domain K+ channel signature
  • Ion transport 2, bacterial
  • TASK K+ channel signature
  • TASK-5 K+ channel signature
ProtoNet:

Suggested Antigen Peptide Sequences for KCNK15 Gene

GenScript: Design optimal peptide antigens:
  • Two pore potassium channel KT3.3 (KCNKF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H427

UniProtKB/Swiss-Prot:

KCNKF_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK15: view

Function for KCNK15 Gene

Molecular function for KCNK15 Gene

UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.

Phenotypes From GWAS Catalog for KCNK15 Gene

Gene Ontology (GO) - Molecular Function for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 NOT voltage-gated ion channel activity IDA 11749039
GO:0005267 potassium channel activity IEA --
GO:0022841 potassium ion leak channel activity IBA 21873635
genes like me logo Genes that share ontologies with KCNK15: view
genes like me logo Genes that share phenotypes with KCNK15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK15

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KCNK15 Gene

Localization for KCNK15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK15 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK15 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNK15 Gene

Pathways & Interactions for KCNK15 Gene

PathCards logo

SuperPathways for KCNK15 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Activation of cAMP-Dependent PKA
.77
.77
.56
3 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
4 Cardiac conduction
5 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCNK15: view

Pathways by source for KCNK15 Gene

13 Qiagen pathways for KCNK15 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Interacting Proteins for KCNK15 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000361952 Q9H427-KCNKF_HUMAN for KCNK15 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KCNK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0030322 stabilization of membrane potential IBA 21873635
GO:0034765 regulation of ion transmembrane transport IEA --
GO:0061337 cardiac conduction TAS --
genes like me logo Genes that share ontologies with KCNK15: view

No data available for SIGNOR curated interactions for KCNK15 Gene

Drugs & Compounds for KCNK15 Gene

(3) Drugs for KCNK15 Gene - From: DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Activator, Inhibitor, antagonist 3
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK15 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK15: view

Transcripts for KCNK15 Gene

mRNA/cDNA for KCNK15 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK15

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK15 Gene

No ASD Table

Relevant External Links for KCNK15 Gene

GeneLoc Exon Structure for
KCNK15

Expression for KCNK15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK15 Gene

This gene is overexpressed in Artery - Aorta (x11.9) and Artery - Coronary (x7.0).

Protein differential expression in normal tissues from HIPED for KCNK15 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK15 Gene



Protein tissue co-expression partners for KCNK15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNK15

SOURCE GeneReport for Unigene cluster for KCNK15 Gene:

Hs.528664

mRNA Expression by UniProt/SwissProt for KCNK15 Gene:

Q9H427-KCNKF_HUMAN
Tissue specificity: Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland.

Evidence on tissue expression from TISSUES for KCNK15 Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with KCNK15: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK15 Gene

Orthologs for KCNK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KCNK15 30 31
  • 98.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KCNK15 30 31
  • 88.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KCNK15 30 31
  • 87.02 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Kcnk15 30 17 31
  • 81.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Kcnk15 30
  • 81.38 (n)
Oppossum
(Monodelphis domestica)
Mammalia KCNK15 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KCNK15 31
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KCNK15 31
  • 54 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii kcnk15 30 31
  • 73.66 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG9637 32
  • 50 (a)
CG9361 32
  • 48 (a)
Task7 31
  • 37 (a)
ManyToMany
Task6 31
  • 33 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea twk-4 32
  • 42 (a)
sup-9 31
  • 41 (a)
ManyToMany
twk-20 31
  • 31 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToMany
Species where no ortholog for KCNK15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for KCNK15 Gene

ENSEMBL:
Gene Tree for KCNK15 (if available)
TreeFam:
Gene Tree for KCNK15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK15: view image

Paralogs for KCNK15 Gene

(3) SIMAP similar genes for KCNK15 Gene using alignment to 1 proteins:

  • KCNKF_HUMAN
genes like me logo Genes that share paralogs with KCNK15: view

Variants for KCNK15 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK15 Gene

KCNKF_HUMAN-Q9H427
Three variant polypeptides are known: TASK-5A, TASK-5B and TASK-5C. The sequence shown is that of TASK-5C.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNK15 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs1111032 - p.Gly95Glu
rs13037900 - p.Pro261His
rs13042905 - p.Pro323Leu
rs6073538 - p.Pro260Thr

Additional dbSNP identifiers (rs#s) for KCNK15 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNK15 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958
nsv458985 CNV gain 19166990
nsv586076 CNV gain 21841781

Variation tolerance for KCNK15 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK15

Disorders for KCNK15 Gene

MalaCards: The human disease database

(4) MalaCards diseases for KCNK15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lung leiomyosarcoma
  • pulmonary leiomyosarcoma
apperceptive agnosia
substernal goiter
  • retrosternal thyroid goiter
pericardial tuberculosis
  • tuberculous pericarditis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with KCNK15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK15 Gene

Publications for KCNK15 Gene

  1. KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. (PMID: 11431495) Vega-Saenz de Miera E … Rudy B (Journal of neurophysiology 2001) 2 3 4
  2. TASK-5, a new member of the tandem-pore K(+) channel family. (PMID: 11409881) Kim D … Gnatenco C (Biochemical and biophysical research communications 2001) 2 3 4
  3. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  5. TASK-5, a novel member of the tandem pore K+ channel family. (PMID: 11680614) Ashmole I … Stanfield PR (Pflugers Archiv : European journal of physiology 2001) 3 4

Products for KCNK15 Gene

Sources for KCNK15 Gene