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Aliases for KCNK12 Gene

Aliases for KCNK12 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 12 2 3 5
  • Tandem Pore Domain Halothane-Inhibited Potassium Channel 2 3 4
  • Potassium Channel, Two Pore Domain Subfamily K, Member 12 2 3
  • Potassium Channel, Subfamily K, Member 12 2 3
  • THIK-2 3 4
  • Tandem Pore Domain Potassium Channel THIK-2 3
  • Potassium Channel Subfamily K Member 12 3
  • K2p12.1 3
  • THIK2 3

External Ids for KCNK12 Gene

Previous GeneCards Identifiers for KCNK12 Gene

  • GC02M047763
  • GC02M047916
  • GC02M047722
  • GC02M047659
  • GC02M047747

Summaries for KCNK12 Gene

Entrez Gene Summary for KCNK12 Gene

  • This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for KCNK12 Gene

KCNK12 (Potassium Two Pore Domain Channel Subfamily K Member 12) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK13.

UniProtKB/Swiss-Prot for KCNK12 Gene

  • Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).

Tocris Summary for KCNK12 Gene

Gene Wiki entry for KCNK12 Gene

Additional gene information for KCNK12 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KCNK12 Gene

Genomics for KCNK12 Gene

GeneHancer (GH) Regulatory Elements for KCNK12 Gene

Promoters and enhancers for KCNK12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I047569 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.0 5 3.2 MLX ZFP64 ARID4B SIN3A ZNF48 SLC30A9 ZNF766 GLIS2 ZNF143 SP3 KCNK12 PPP1R21 PIR54322
GH02I047654 Enhancer 0.8 ENCODE 8.7 -84.4 -84363 0.9 ATF1 ZNF766 SCRT2 FOS CAVIN1 ZBTB11 USF2 HDAC8 ZNF592 MEF2D ENSG00000228925 MSH6 SOCS5 STON1 KCNK12 HCG2040054 GC02P047676
GH02I047297 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 3.7 +271.3 271281 3.7 PKNOX1 ATF1 ZNF766 ATF7 RUNX3 CAVIN1 ZNF592 MEF2D NBN NR2C1 PIR58315 LOC101927043 ENSG00000228925 MSH6 SOCS5 CALM2 EPCAM MIR559 KCNK12 PIR36995
GH02I047563 Enhancer 0.3 FANTOM5 7.5 +7.4 7420 0.2 HCG2040054 KCNK12 MSH2 PIR54322
GH02I047568 Enhancer 0.5 FANTOM5 3.5 +2.6 2631 0 ZSCAN21 RFX1 ATF7 BMI1 ATF2 ZBTB17 KCNK12 MSH2 MSH6 FBXO11 PIR54322
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KCNK12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KCNK12 gene promoter:

Genomic Locations for KCNK12 Gene

Genomic Locations for KCNK12 Gene
54,366 bases
Minus strand

Genomic View for KCNK12 Gene

Genes around KCNK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK12 Gene

Proteins for KCNK12 Gene

  • Protein details for KCNK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium channel subfamily K member 12
    Protein Accession:

    Protein attributes for KCNK12 Gene

    430 amino acids
    Molecular mass:
    46889 Da
    Quaternary structure:
    • Heterodimer.

neXtProt entry for KCNK12 Gene

Post-translational modifications for KCNK12 Gene

  • Glycosylation at posLast=7878
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KCNK12 Gene

Domains & Families for KCNK12 Gene

Gene Families for KCNK12 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Voltage-gated ion channels

Suggested Antigen Peptide Sequences for KCNK12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK12: view

Function for KCNK12 Gene

Molecular function for KCNK12 Gene

UniProtKB/Swiss-Prot Function:
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel (By similarity).

Phenotypes From GWAS Catalog for KCNK12 Gene

Gene Ontology (GO) - Molecular Function for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IEA --
GO:0022841 potassium ion leak channel activity IBA --
genes like me logo Genes that share ontologies with KCNK12: view

Phenotypes for KCNK12 Gene

genes like me logo Genes that share phenotypes with KCNK12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK12

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KCNK12 Gene

Localization for KCNK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK12 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNK12 Gene

Pathways & Interactions for KCNK12 Gene

genes like me logo Genes that share pathways with KCNK12: view

Interacting Proteins for KCNK12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000327611 Q9HB15-KCNKC_HUMAN for KCNK12 Gene via STRING IID

Gene Ontology (GO) - Biological Process for KCNK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0030322 stabilization of membrane potential IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with KCNK12: view

No data available for SIGNOR curated interactions for KCNK12 Gene

Drugs & Compounds for KCNK12 Gene

(4) Drugs for KCNK12 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Activator, antagonist 2

(2) Additional Compounds for KCNK12 Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) Tocris Compounds for KCNK12 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK12: view

Transcripts for KCNK12 Gene

mRNA/cDNA for KCNK12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KCNK12 Gene

Potassium channel, subfamily K, member 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK12 Gene

No ASD Table

Relevant External Links for KCNK12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KCNK12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KCNK12 Gene

mRNA differential expression in normal tissues according to GTEx for KCNK12 Gene

This gene is overexpressed in Nerve - Tibial (x13.5), Brain - Spinal cord (cervical c-1) (x6.5), and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for KCNK12 Gene

This gene is overexpressed in Saliva (50.8) and Urine (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KCNK12 Gene

Protein tissue co-expression partners for KCNK12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KCNK12 Gene:


SOURCE GeneReport for Unigene cluster for KCNK12 Gene:


Evidence on tissue expression from TISSUES for KCNK12 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with KCNK12: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK12 Gene

Orthologs for KCNK12 Gene

This gene was present in the common ancestor of animals.

Orthologs for KCNK12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KCNK12 33 34
  • 99.69 (n)
(Canis familiaris)
Mammalia KCNK12 33 34
  • 97.25 (n)
(Bos Taurus)
Mammalia KCNK12 33 34
  • 96.67 (n)
(Mus musculus)
Mammalia Kcnk12 33 16 34
  • 96.2 (n)
(Rattus norvegicus)
Mammalia Kcnk12 33
  • 95.97 (n)
(Monodelphis domestica)
Mammalia KCNK12 34
  • 88 (a)
(Gallus gallus)
Aves KCNK12 33 34
  • 73.47 (n)
(Anolis carolinensis)
Reptilia KCNK12 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk12 33
  • 66.33 (n)
(Danio rerio)
Actinopterygii LOC559153 33
  • 68.94 (n)
KCNK12 34
  • 61 (a)
(Caenorhabditis elegans)
Secernentea twk-14 33 34
  • 44.63 (n)
twk-12 35
  • 37 (a)
Species where no ortholog for KCNK12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KCNK12 Gene

Gene Tree for KCNK12 (if available)
Gene Tree for KCNK12 (if available)

Paralogs for KCNK12 Gene

Paralogs for KCNK12 Gene

(1) SIMAP similar genes for KCNK12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KCNK12: view

Variants for KCNK12 Gene

Sequence variations from dbSNP and Humsavar for KCNK12 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000006941 -- 47,556,865(-) G/A intron_variant
rs1000013184 -- 47,560,331(-) C/T intron_variant
rs1000079427 -- 47,529,126(-) A/G intron_variant
rs1000081125 -- 47,560,716(-) A/C intron_variant
rs1000099648 -- 47,551,602(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KCNK12 Gene

Variant ID Type Subtype PubMed ID
dgv6848n54 CNV loss 21841781
dgv6849n54 CNV gain 21841781
dgv6850n54 CNV gain+loss 21841781
dgv6851n54 CNV loss 21841781
dgv691e214 CNV loss 21293372
esv2675502 CNV deletion 23128226
esv29460 CNV loss 19812545
esv3590632 CNV gain 21293372
nsv1004828 CNV gain 25217958
nsv1144896 CNV deletion 24896259
nsv2717 CNV insertion 18451855
nsv998314 CNV loss 25217958
nsv999576 CNV gain 25217958

Variation tolerance for KCNK12 Gene

Gene Damage Index Score: 0.37; 8.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK12 Gene

Disorders for KCNK12 Gene

Additional Disease Information for KCNK12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KCNK12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KCNK12 Gene

Publications for KCNK12 Gene

  1. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. (PMID: 11060316) Rajan S … Derst C (The Journal of biological chemistry 2001) 2 3 4 58
  2. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. (PMID: 19890347) Birlea SA … Spritz RA (The Journal of investigative dermatology 2010) 3 44 58
  3. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. (PMID: 18209473) Theilig F … Derst C (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2008) 3 22 58
  4. A high-density association screen of 155 ion transport genes for involvement with common migraine. (PMID: 18676988) Nyholt DR … Palotie A (Human molecular genetics 2008) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for KCNK12 Gene

Sources for KCNK12 Gene

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