The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthet... See more...

Aliases for KCNK10 Gene

Aliases for KCNK10 Gene

  • Potassium Two Pore Domain Channel Subfamily K Member 10 2 3 5
  • Potassium Channel, Two Pore Domain Subfamily K, Member 10 2 3
  • Outward Rectifying Potassium Channel Protein TREK-2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 97 2 3
  • Potassium Channel, Subfamily K, Member 10 2 3
  • Potassium Channel Subfamily K Member 10 3 4
  • TREK-2 K(+) Channel Subunit 3 4
  • TREK2 3 4
  • 2P Domain Potassium Channel TREK2 3
  • TWIK-Related K+ Channel 2 3
  • Potassium Channel TREK-2 3
  • K2p10.1 3
  • PPP1R97 3
  • TREK-2 3

External Ids for KCNK10 Gene

Previous GeneCards Identifiers for KCNK10 Gene

  • GC14M086156
  • GC14M082468
  • GC14M086641
  • GC14M087720
  • GC14M088648
  • GC14M068816
  • GC14M088649
  • GC14M088927
  • GC14M089528
  • GC14M089829
  • GC14M090241

Summaries for KCNK10 Gene

Entrez Gene Summary for KCNK10 Gene

  • The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for KCNK10 Gene

KCNK10 (Potassium Two Pore Domain Channel Subfamily K Member 10) is a Protein Coding gene. Diseases associated with KCNK10 include Birk-Barel Syndrome and Chemical Colitis. Among its related pathways are Salivary secretion and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK2.

UniProtKB/Swiss-Prot Summary for KCNK10 Gene

  • Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

Tocris Summary for KCNK10 Gene

Gene Wiki entry for KCNK10 Gene

Additional gene information for KCNK10 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNK10 Gene

Genomics for KCNK10 Gene

GeneHancer (GH) Regulatory Elements for KCNK10 Gene

Promoters and enhancers for KCNK10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J088325 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 500.7 +3.5 3512 1.6 EP300 ZBTB26 EZH2 ZNF341 MXI1 PHF8 ZFHX2 ZNF335 IKZF1 NR2F1 KCNK10 AB372778-009
GH14J088269 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 506.4 +56.3 56294 1.8 RAD21 HNF4A ZNF143 SP1 KCNK10 AB372778-009
GH14J088326 Promoter 1 EPDnew Ensembl 500.7 +0.2 211 0.6 ZIC2 EZH2 ZNF341 ZBTB17 ZNF335 RNF2 SUZ12 PRDM10 ZBTB20 KCNK10 ENSG00000258983 PTPN21 AB372778-009
GH14J088305 Enhancer 0.5 FANTOM5 Ensembl 14.6 +21.2 21207 1 OSR2 PRDM6 KCNK10 SPATA7 AB372778-009
GH14J088194 Enhancer 0.6 Ensembl 11 +131.2 131211 2.2 EP300 CTBP1 ZBTB17 GATA3 ZFP36 CEBPB ZFHX2 PKNOX1 ATF4 RFX5 KCNK10 HSALNG0103029 piR-52897
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KCNK10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNK10

Top Transcription factor binding sites by QIAGEN in the KCNK10 gene promoter:
  • c-Myb
  • Cart-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • POU3F1

Genomic Locations for KCNK10 Gene

Genomic Locations for KCNK10 Gene
chr14:88,180,103-88,326,912
(GRCh38/hg38)
Size:
146,810 bases
Orientation:
Minus strand
chr14:88,646,452-88,793,256
(GRCh37/hg19)
Size:
146,805 bases
Orientation:
Minus strand

Genomic View for KCNK10 Gene

Genes around KCNK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KCNK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KCNK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KCNK10 Gene

Proteins for KCNK10 Gene

  • Protein details for KCNK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57789-KCNKA_HUMAN
    Recommended name:
    Potassium channel subfamily K member 10
    Protein Accession:
    P57789
    Secondary Accessions:
    • B2R8T4
    • B2RCT3
    • B5TJL4
    • Q6B014
    • Q8TDK7
    • Q8TDK8
    • Q9HB59

    Protein attributes for KCNK10 Gene

    Size:
    538 amino acids
    Molecular mass:
    59765 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KCNK10 Gene

    Alternative splice isoforms for KCNK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KCNK10 Gene

Post-translational modifications for KCNK10 Gene

  • Glycosylation at Asn144, Asn147, and Asn148
  • Modification sites at PhosphoSitePlus

Other Protein References for KCNK10 Gene

No data available for DME Specific Peptides for KCNK10 Gene

Domains & Families for KCNK10 Gene

Protein Domains for KCNK10 Gene

Blocks:
  • Two pore domain K+ channel signature
  • Ion transport 2, bacterial
  • Trek K+ channel signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KCNK10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94053, Homo sapiens potassium channel, subfamily K, member 10 (KCNK10),transcript variant 2, mRNA (B2R8T4_HUMAN)
  • Potassium channel, subfamily K, member 10, isoform CRA_c (B5TJL4_HUMAN)
  • TREK-2 K(+) channel subunit (KCNKA_HUMAN)
  • Potassium channel, subfamily K, member 10, isoform CRA_a (Q6B014_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P57789

UniProtKB/Swiss-Prot:

KCNKA_HUMAN :
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Domain:
  • Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
genes like me logo Genes that share domains with KCNK10: view

Function for KCNK10 Gene

Molecular function for KCNK10 Gene

UniProtKB/Swiss-Prot Function:
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

Phenotypes From GWAS Catalog for KCNK10 Gene

Gene Ontology (GO) - Molecular Function for KCNK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IEA,TAS 10880510
GO:0022841 potassium ion leak channel activity IBA 21873635
genes like me logo Genes that share ontologies with KCNK10: view
genes like me logo Genes that share phenotypes with KCNK10: view

Animal Models for KCNK10 Gene

MGI Knock Outs for KCNK10:

Animal Model Products

  • Taconic Biosciences Mouse Models for KCNK10

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNK10 Gene

Localization for KCNK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KCNK10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KCNK10 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for KCNK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KCNK10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KCNK10 Gene

Pathways & Interactions for KCNK10 Gene

PathCards logo

SuperPathways for KCNK10 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
.72
.72
.46
.44
.37
2 Cardiac conduction
3 Activation of cAMP-Dependent PKA
.77
.77
.56
4 Neuropathic Pain-Signaling in Dorsal Horn Neurons
.47
.47
.40
5 Hepatic ABC Transporters
.41
.41
genes like me logo Genes that share pathways with KCNK10: view

Pathways by source for KCNK10 Gene

1 KEGG pathway for KCNK10 Gene
13 Qiagen pathways for KCNK10 Gene
  • Activation of cAMP-Dependent PKA
  • Aldosterone Signaling in Epithelial Cells
  • Bitter Taste Signaling
  • cAMP Pathway
  • Cellular Effects of Sildenafil

Gene Ontology (GO) - Biological Process for KCNK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0007165 signal transduction NAS 10880510
GO:0007613 memory IEA --
GO:0030322 stabilization of membrane potential IBA 21873635
genes like me logo Genes that share ontologies with KCNK10: view

No data available for SIGNOR curated interactions for KCNK10 Gene

Drugs & Compounds for KCNK10 Gene

(6) Drugs for KCNK10 Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Halothane Approved, Vet_approved Pharma Inhibitor, Activator, antagonist 2
Riluzole Approved, Investigational Pharma Activator, blocker Sodium channel protein inhibitor 76
arachidonic acid Experimental Pharma Activator, Inhibitor, Agonist, Activation, Potentiation 39
Cesium chloride Pharma Potassium channel blocker, Potassium channel blocker; neuroprotective 0
YS-035 hydrochloride Pharma Inhibits K+ outward/pacemaker current 0

(2) Tocris Compounds for KCNK10 Gene

Compound Action Cas Number
Cesium chloride Potassium channel blocker; neuroprotective 7647-17-8
YS-035 hydrochloride Inhibits K+ outward/pacemaker current 89805-39-0
genes like me logo Genes that share compounds with KCNK10: view

Transcripts for KCNK10 Gene

mRNA/cDNA for KCNK10 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNK10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KCNK10 Gene

No ASD Table

Relevant External Links for KCNK10 Gene

GeneLoc Exon Structure for
KCNK10

Expression for KCNK10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KCNK10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KCNK10 Gene

This gene is overexpressed in Brain - Amygdala (x5.3), Brain - Putamen (basal ganglia) (x4.9), Brain - Hippocampus (x4.6), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for KCNK10 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNK10 Gene



Protein tissue co-expression partners for KCNK10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNK10

SOURCE GeneReport for Unigene cluster for KCNK10 Gene:

Hs.560255

mRNA Expression by UniProt/SwissProt for KCNK10 Gene:

P57789-KCNKA_HUMAN
Tissue specificity: Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Evidence on tissue expression from TISSUES for KCNK10 Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with KCNK10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNK10 Gene

Orthologs for KCNK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KCNK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KCNK10 31 30
  • 99.08 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KCNK10 31
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KCNK10 31 30
  • 92.3 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 90 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kcnk10 30
  • 89.76 (n)
mouse
(Mus musculus)
Mammalia Kcnk10 17 31 30
  • 89.21 (n)
cow
(Bos Taurus)
Mammalia KCNK10 31 30
  • 87.21 (n)
OneToOne
chicken
(Gallus gallus)
Aves KCNK10 31 30
  • 81.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KCNK10 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kcnk10 30
  • 73.31 (n)
zebrafish
(Danio rerio)
Actinopterygii kcnk10b 31 30
  • 69.56 (n)
OneToMany
kcnk10a 31
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOK1 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6929 31
  • 33 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
Species where no ortholog for KCNK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KCNK10 Gene

ENSEMBL:
Gene Tree for KCNK10 (if available)
TreeFam:
Gene Tree for KCNK10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KCNK10: view image

Paralogs for KCNK10 Gene

(5) SIMAP similar genes for KCNK10 Gene using alignment to 3 proteins:

  • KCNKA_HUMAN
  • G3V5Y5_HUMAN
  • L0R6J0_HUMAN
genes like me logo Genes that share paralogs with KCNK10: view

Variants for KCNK10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNK10 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
742543 Likely Benign: not provided 88,185,637(-) C/T SYNONYMOUS_VARIANT
742544 Likely Benign: not provided 88,185,817(-) G/A SYNONYMOUS_VARIANT
rs17762463 - p.Ala512Thr
rs398263 - p.Lys70Gln

Additional dbSNP identifiers (rs#s) for KCNK10 Gene

Structural Variations from Database of Genomic Variants (DGV) for KCNK10 Gene

Variant ID Type Subtype PubMed ID
esv2748991 CNV deletion 23290073
esv3433882 CNV insertion 20981092
esv3581376 CNV loss 25503493
nsv1115975 CNV insertion 24896259
nsv1149100 CNV insertion 26484159
nsv84705 CNV insertion 16902084
nsv85763 CNV deletion 16902084
nsv952880 CNV deletion 24416366

Variation tolerance for KCNK10 Gene

Residual Variation Intolerance Score: 5.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.10; 69.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KCNK10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KCNK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNK10 Gene

Disorders for KCNK10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KCNK10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
birk-barel syndrome
  • birk-barel mental retardation dysmorphism syndrome
chemical colitis
migraine with or without aura 1
  • migraine with or without aura, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KCNK10

genes like me logo Genes that share disorders with KCNK10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KCNK10 Gene

Publications for KCNK10 Gene

  1. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. (PMID: 10880510) Lesage F … Lazdunski M (The Journal of biological chemistry 2000) 2 3 4 23 54
  2. Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. (PMID: 11897838) Gu W … Daut J (The Journal of physiology 2002) 3 4 23 54
  3. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. (PMID: 18516069) Gierten J … Thomas D (British journal of pharmacology 2008) 3 4 54
  4. Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. (PMID: 17689202) Huang D … Yu B (Medical hypotheses 2008) 3 23 54
  5. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. (PMID: 16382106) Goldstein SA … Rajan S (Pharmacological reviews 2005) 2 3 54

Products for KCNK10 Gene

Sources for KCNK10 Gene