Aliases for KCNK10 Gene
- Potassium Two Pore Domain Channel Subfamily K Member 10 2 3 5
- TREK2 2 3 4
- Potassium Channel, Two Pore Domain Subfamily K, Member 10 2 3
- Outward Rectifying Potassium Channel Protein TREK-2 3 4
- Protein Phosphatase 1, Regulatory Subunit 97 2 3
- Potassium Channel, Subfamily K, Member 10 2 3
- Potassium Channel Subfamily K Member 10 3 4
External Ids for KCNK10 Gene
Previous GeneCards Identifiers for KCNK10 Gene
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for KCNK10 Gene
KCNK10 (Potassium Two Pore Domain Channel Subfamily K Member 10) is a Protein Coding gene. Diseases associated with KCNK10 include Birk-Barel Syndrome and Migraine With Or Without Aura 1. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK2.
UniProtKB/Swiss-Prot Summary for KCNK10 Gene
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.