Aliases for KCNK10 Gene
- Potassium Two Pore Domain Channel Subfamily K Member 10 2 3 5
- Potassium Channel, Two Pore Domain Subfamily K, Member 10 2 3
- Outward Rectifying Potassium Channel Protein TREK-2 3 4
- Protein Phosphatase 1, Regulatory Subunit 97 2 3
- Potassium Channel, Subfamily K, Member 10 2 3
- TREK-2 K(+) Channel Subunit 3 4
- TREK2 3 4
- Potassium Channel Subfamily K Member 10 3
External Ids for KCNK10 Gene
Previous GeneCards Identifiers for KCNK10 Gene
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for KCNK10 Gene
KCNK10 (Potassium Two Pore Domain Channel Subfamily K Member 10) is a Protein Coding gene. Diseases associated with KCNK10 include Birk-Barel Mental Retardation Dysmorphism Syndrome and Dentin Sensitivity. Among its related pathways are Hepatic ABC Transporters and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK2.
UniProtKB/Swiss-Prot for KCNK10 Gene
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.