Aliases for KCNJ4 Gene
- IRK-3 3 4
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 4 2
- Potassium Channel, Inwardly Rectifying Subfamily J, Member 4 3
- Potassium Channel, Inwardly Rectifying Subfamily J Member 4 4
- Potassium Voltage-Gated Channel Subfamily J Member 4 3
- Hippocampal Inward Rectifier Potassium Channel 3
- Hippocampal Inward Rectifier 4
- KCNJ4 5
External Ids for KCNJ4 Gene
Previous GeneCards Identifiers for KCNJ4 Gene
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KCNJ4 Gene
KCNJ4 (Potassium Inwardly Rectifying Channel Subfamily J Member 4) is a Protein Coding gene. Diseases associated with KCNJ4 include Andersen Cardiodysrhythmic Periodic Paralysis and Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance. Among its related pathways are Inwardly rectifying K+ channels and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include PDZ domain binding and inward rectifier potassium channel activity. An important paralog of this gene is KCNJ12.
UniProtKB/Swiss-Prot Summary for KCNJ4 Gene
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.