Aliases for KCNJ18 Gene
External Ids for KCNJ18 Gene
Previous GeneCards Identifiers for KCNJ18 Gene
This gene encodes a member of the inwardly rectifying potassium channel family. Transcription of this locus is regulated by thyroid hormone, and the encoded protein plays a role in resting membrane potential maintenance. Mutations in this locus have been associated with thyrotoxic hypokalemic periodic paralysis. [provided by RefSeq, Jan 2013]
GeneCards Summary for KCNJ18 Gene
KCNJ18 (Potassium Inwardly Rectifying Channel Subfamily J Member 18) is a Protein Coding gene. Diseases associated with KCNJ18 include Thyrotoxic Periodic Paralysis 2 and Thyrotoxic Periodic Paralysis 1. Among its related pathways are Oxytocin signaling pathway and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ12.
UniProtKB/Swiss-Prot Summary for KCNJ18 Gene
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.