Aliases for KCNJ16 Gene
- Potassium Voltage-Gated Channel Subfamily J Member 16 2 3 5
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16 2 3
- Potassium Channel, Inwardly Rectifying Subfamily J Member 16 3 4
- Inward Rectifier K(+) Channel Kir5.1 3 4
- Inward Rectifier Potassium Channel 16 3
- Inward Rectifier K+ Channel KIR5.1 3
- KIR5.1 3
- BIR9 3
External Ids for KCNJ16 Gene
Previous GeneCards Identifiers for KCNJ16 Gene
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
GeneCards Summary for KCNJ16 Gene
KCNJ16 (Potassium Voltage-Gated Channel Subfamily J Member 16) is a Protein Coding gene. Diseases associated with KCNJ16 include Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance and Campomelic Dysplasia. Among its related pathways are GABA receptor activation and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ13.
UniProtKB/Swiss-Prot for KCNJ16 Gene
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201).
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.