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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the s... See more...
Aliases for KCNJ15 Gene
Aliases for KCNJ15 Gene
- Potassium Inwardly Rectifying Channel Subfamily J Member 15 2 3 5
- Potassium Channel, Inwardly Rectifying Subfamily J Member 15 3 4
- ATP-Sensitive Inward Rectifier Potassium Channel 15 3 4
- Inward Rectifier K(+) Channel Kir1.3 3 4
- Inward Rectifier K(+) Channel Kir4.2 3 4
- IRKK 2 3
- Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 2
External Ids for KCNJ15 Gene
- HGNC: 6261
- Entrez Gene: 3772
- Ensembl: ENSG00000157551
- OMIM: 602106
- UniProtKB: Q99712
Previous GeneCards Identifiers for KCNJ15 Gene
- GC21P036206
- GC21P036289
- GC21P038549
- GC21P038550
- GC21P039628
- GC21P025098
- GC21P039529
Summaries for KCNJ15 Gene
-
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
GeneCards Summary for KCNJ15 Gene
KCNJ15 (Potassium Inwardly Rectifying Channel Subfamily J Member 15) is a Protein Coding gene. Diseases associated with KCNJ15 include Hypomagnesemia 4, Renal and Vitreoretinal Degeneration, Snowflake Type. Among its related pathways are Inwardly rectifying K+ channels and Transmission across Chemical Synapses. Gene Ontology (GO) annotations related to this gene include potassium channel activity and inward rectifier potassium channel activity. An important paralog of this gene is KCNJ10.
UniProtKB/Swiss-Prot Summary for KCNJ15 Gene
-
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
-
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.
Additional gene information for KCNJ15 Gene
- HGNC(6261)
- Entrez Gene(3772)
- Ensembl(ENSG00000157551)
- OMIM(602106)
- UniProtKB(Q99712)
- Open Targets Platform(ENSG00000157551)
- Search for KCNJ15 at DataMed
- Search for KCNJ15 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KCNJ15 Gene
Genomics for KCNJ15 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KCNJ15 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH21J038256 | Promoter/Enhancer | 1.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 617.3 | +103.0 | 102979 | 3.2 | CEBPB SP1 BMI1 FOS FOSL2 BHLHE40 SPI1 MAFK NFE2L2 | KCNJ15 LOC105372801 SPATA20P1 lnc-ETS2-10 lnc-ETS2-12 ERG | |
| GH21J038272 | Promoter/Enhancer | 0.5 | EPDnew dbSUPER | 605.4 | +116.9 | 116940 | 0.1 | KCNJ15 lnc-ETS2-10 LOC105372801 lnc-ETS2-12 ERG | ||
| GH21J038257 | Promoter | 0.3 | EPDnew | 600.1 | +101.2 | 101173 | 0.1 | LOC105372801 KCNJ15 lnc-ETS2-10 lnc-ETS2-12 ERG | ||
| GH21J038348 | Enhancer | 1.5 | FANTOM5 ENCODE CraniofacialAtlas dbSUPER | 19.6 | +195.4 | 195406 | 5.2 | CREB1 CTCF PRDM10 ZNF629 ZNF512 ZNF692 PRDM1 PATZ1 REST RAD21 | LOC107985513 lnc-ERG-10 HMGN1 KCNJ15 LINC01423 ETS2 ERG | |
| GH21J038227 | Enhancer | 0.9 | FANTOM5 ENCODE dbSUPER | 32.1 | +72.9 | 72852 | 1.5 | CTBP1 ZNF217 NBN DPF2 BATF TRIM28 SMARCE1 SP1 | lnc-ETS2-12 KCNJ15 L13714-295 ERG |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KCNJ15 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KCNJ15
- Top Transcription factor binding sites by QIAGEN in the KCNJ15 gene promoter:
-
- ATF-2
- c-Jun
- CREB
- GR
- GR-alpha
- GR-beta
- IRF-7A
Genomic Locations for KCNJ15 Gene
Genomic Locations for KCNJ15 Gene
- chr21:38,155,549-38,307,357
- (GRCh38/hg38)
- Size:
- 151,809 bases
- Orientation:
- Plus strand
- chr21:39,529,128-39,679,279
- (GRCh37/hg19)
- Size:
- 150,152 bases
- Orientation:
- Plus strand
Genomic View for KCNJ15 Gene
Genes around KCNJ15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.13-q22.2 by HGNC
- 21q22.13-q22.2 by Entrez Gene
- 21q22.13 by Ensembl
KCNJ15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KCNJ15 Gene
Proteins for KCNJ15 Gene
-
Protein details for KCNJ15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99712-KCJ15_HUMAN
- Recommended name:
- ATP-sensitive inward rectifier potassium channel 15
- Protein Accession:
- Q99712
- D3DSH5
- O00564
- Q96L28
- Q99446
Protein attributes for KCNJ15 Gene
- Size:
- 375 amino acids
- Molecular mass:
- 42577 Da
- Quaternary structure:
-
- Interacts with PATJ.
Protein Expression for KCNJ15 Gene
Post-translational modifications for KCNJ15 Gene
Other Protein References for KCNJ15 Gene
- ENSEMBL proteins:
-
- ENSP00000449140
- ENSP00000448770
- ENSP00000447111
- ENSP00000448676
- ENSP00000450254
- ENSP00000448886
- ENSP00000449419
- ENSP00000381899
- ENSP00000381902
- ENSP00000331698
- ENSP00000413013
- ENSP00000392951
- ENSP00000381911
- ENSP00000381905
- ENSP00000414487
- ENSP00000381904
- ENSP00000381901
- ENSP00000400849
- ENSP00000381907
- ENSP00000479100
- ENSP00000484960
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ KCNJ15 Antibody
- Novus Biologicals Antibodies for KCNJ15
-
Abcam antibodies for KCNJ15
- Invitrogen Antibodies for KCNJ15 (AFLGC-Kcnj15)
-
Boster Bio Antibodies for KCNJ15
-
Santa Cruz Biotechnology (SCBT) Antibodies for KCNJ15
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KCNJ15
- Origene Custom Protein Services for KCNJ15
- Novus Biologicals proteins for KCNJ15
- antibodies-online: Show 6 available KCNJ15 Proteins ranked by validation data
- Compare Top KCNJ15 Proteins
-
Quality Products:
-
Abcam proteins for KCNJ15
No data available for DME Specific Peptides for KCNJ15 Gene
Domains & Families for KCNJ15 Gene
Gene Families for KCNJ15 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Voltage-gated ion channels
Protein Domains for KCNJ15 Gene
- InterPro:
- Blocks:
-
- Inward rectifier K+ channel superfamily signature
- Kir1.3 inward rectifer K+ channel signature
- ProtoNet:
Suggested Antigen Peptide Sequences for KCNJ15 Gene
- GenScript: Design optimal peptide antigens:
-
- Potassium channel, inwardly rectifying subfamily J member 15 (IRK15_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q99712UniProtKB/Swiss-Prot:
KCJ15_HUMAN :- Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
- Family:
-
- Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.
Function for KCNJ15 Gene
Molecular function for KCNJ15 Gene
- UniProtKB/Swiss-Prot Function:
- Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
- GENATLAS Biochemistry:
- potassium non voltage-gated channel,inwardly rectifying subfamily J member 15 Kir4.2,expressed in kidney and brain
Phenotypes From GWAS Catalog for KCNJ15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005242 | inward rectifier potassium channel activity | TAS,IBA | 21873635 |
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 9647694 |
Phenotypes for KCNJ15 Gene
- MGI mutant phenotypes for KCNJ15:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KCNJ15:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Increased G2M DNA content
- Decreased shRNA abundance (Z-score < -2)
Animal Models for KCNJ15 Gene
- MGI Knock Outs for KCNJ15:
-
- Kcnj15 Kcnj15<tm1Dgen>
Animal Model Products
-
Taconic Biosciences Mouse Models for KCNJ15
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KCNJ15 - Select products 50% OFF >
- * KCNJ15 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KCNJ15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNJ15
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNJ15
miRNA for KCNJ15 Gene
- miRTarBase miRNAs that target KCNJ15
-
- hsa-miR-9-5p (MIRT021341)
- hsa-miR-98-5p (MIRT027409)
- hsa-miR-498 (MIRT569798)
- hsa-miR-298 (MIRT569799)
- hsa-miR-548ao-3p (MIRT569800)
- mmu-miR-3095-5p (MIRT578416)
- mmu-miR-129-5p (MIRT593840)
- mmu-miR-706 (MIRT598513)
- hsa-miR-4684-5p (MIRT687789)
- hsa-miR-6827-3p (MIRT687790)
- hsa-miR-340-3p (MIRT687791)
- hsa-miR-433-5p (MIRT687792)
- hsa-miR-6771-3p (MIRT687793)
- hsa-miR-548x-3p (MIRT687794)
- hsa-miR-548j-3p (MIRT687795)
- hsa-miR-548aq-3p (MIRT687796)
- hsa-miR-548am-3p (MIRT687797)
- hsa-miR-548aj-3p (MIRT687798)
- hsa-miR-548ah-3p (MIRT687799)
- hsa-miR-548ae-3p (MIRT687800)
- hsa-miR-548z (MIRT687801)
- hsa-miR-548h-3p (MIRT687802)
- hsa-miR-548d-3p (MIRT687803)
- hsa-miR-548bb-3p (MIRT687804)
- hsa-miR-548ac (MIRT687805)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KCNJ15
- Browse OriGene Inhibitory RNA Products For KCNJ15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNJ15
Clone Products
- Applied Biological Materials (abm): Clones for KCNJ15 - Select products 50% OFF >
- * KCNJ15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205834
- MG224600
- MR205834
- MR205834L3
- MR205834L4
- MR224600
- MR224600L3
- MR224600L4
- MR229569
- MR229570
- MR229571
- MR229572
- MR229573
- MR229712
- MR229713
- MR229714
- MR229715
- RC203125
- RC203125L1
- RC203125L2
- RC203125L3
- RC203125L4
- RC216787
- RC216787L3
- RC216787L4
- RC217854
- RC217854L3
- RC217854L4
- RC232608
- RC232609
- RC232610
- RC232611
- RC232612
- RG203125
- RG216787
- RG217854
- RG232608
- RG232609
- RG232610
- RG232611
- RG232612
- RR215192
- RR215192L3
- RR215192L4
- MR205834L3V
- MR205834L4V
- MR224600L3V
- MR224600L4V
- RC203125L1V
- RC203125L2V
- RC203125L3V
- RC203125L4V
- RC216787L3V
- RC216787L4V
- RC217854L3V
- RC217854L4V
- RR215192L3V
- RR215192L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KCNJ15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNJ15
Cell Line Products
-
Horizon Cell Lines for KCNJ15
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KCNJ15 Gene
Localization for KCNJ15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KCNJ15 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Cytosol (2)
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8995301 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for KCNJ15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Inwardly rectifying K+ channels | ||
| 2 | GABA receptor activation | ||
| 3 | Transmission across Chemical Synapses |
.62
|
|
| 4 | Salivary secretion | ||
| 5 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Dopamine-DARPP32 Feedback onto cAMP Pathway
-
|
|
Pathways by source for KCNJ15 Gene
11 Reactome pathways for KCNJ15 Gene
1 KEGG pathway for KCNJ15 Gene
1 Qiagen pathway for KCNJ15 Gene
- Dopamine-DARPP32 Feedback onto cAMP Pathway
Interacting Proteins for KCNJ15 Gene
Selected Interacting proteins:
Q99712-KCJ15_HUMAN
ENSP00000331698
for KCNJ15 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KCNJ15
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0006813 | potassium ion transport | TAS | 8995301 |
| GO:0034220 | ion transmembrane transport | IEA | -- |
| GO:0034765 | regulation of ion transmembrane transport | IBA | 21873635 |
| GO:0071805 | potassium ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for KCNJ15 Gene
Drugs & Compounds for KCNJ15 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Butamben | Approved, Withdrawn | Pharma | Target, antagonist | 0 | ||
| Yohimbine | Approved, Investigational, Vet_approved | Pharma | Antagonist, Target, inhibitor | 36 | ||
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| Glyburide | Approved | Pharma | Channel blocker, Inhibitor, Inhibition | Kir6 (KATP) channel blocker | 127 | |
| Minoxidil | Approved, Investigational | Pharma | Activator | Kir6 channel (KATP) opener | 46 |
(5) Tocris Compounds for KCNJ15 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Glibenclamide | Kir6 (KATP) channel blocker | 10238-21-8 |
| Minoxidil | Kir6 channel (KATP) opener | 38304-91-5 |
| Nicorandil | Kir6 (KATP) channel opener and NO donor | 65141-46-0 |
| P1075 | Potent Kir6 (KATP) channel opener | 60559-98-0 |
| ZM 226600 | Kir6 (KATP) channel opener | 147695-92-9 |
Transcripts for KCNJ15 Gene
mRNA/cDNA for KCNJ15 Gene
- 8 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000328656 8399 nts (view in UCSC)
- ENST00000398925 532 nts (view in UCSC)
- ENST00000398927 665 nts (view in UCSC)
- ENST00000398928 715 nts (view in UCSC)
- ENST00000398930 2914 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KCNJ15 - Select products 50% OFF >
- * KCNJ15 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KCNJ15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KCNJ15
-
Santa Cruz Biotechnology (SCBT) CRISPR for KCNJ15
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KCNJ15
- Browse OriGene Inhibitory RNA Products For KCNJ15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KCNJ15
Clone Products
- Applied Biological Materials (abm): Clones for KCNJ15 - Select products 50% OFF >
- * KCNJ15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205834
- MG224600
- MR205834
- MR205834L3
- MR205834L4
- MR224600
- MR224600L3
- MR224600L4
- MR229569
- MR229570
- MR229571
- MR229572
- MR229573
- MR229712
- MR229713
- MR229714
- MR229715
- RC203125
- RC203125L1
- RC203125L2
- RC203125L3
- RC203125L4
- RC216787
- RC216787L3
- RC216787L4
- RC217854
- RC217854L3
- RC217854L4
- RC232608
- RC232609
- RC232610
- RC232611
- RC232612
- RG203125
- RG216787
- RG217854
- RG232608
- RG232609
- RG232610
- RG232611
- RG232612
- RR215192
- RR215192L3
- RR215192L4
- MR205834L3V
- MR205834L4V
- MR224600L3V
- MR224600L4V
- RC203125L1V
- RC203125L2V
- RC203125L3V
- RC203125L4V
- RC216787L3V
- RC216787L4V
- RC217854L3V
- RC217854L4V
- RR215192L3V
- RR215192L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KCNJ15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KCNJ15
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||
| SP8: | - |
Relevant External Links for KCNJ15 Gene
- GeneLoc Exon Structure for
- KCNJ15
Expression for KCNJ15 Gene
mRNA differential expression in normal tissues according to GTEx for KCNJ15 Gene
This gene is overexpressed in Whole Blood (x26.9) and Kidney - Cortex (x7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KCNJ15 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KCNJ15
SOURCE GeneReport for Unigene cluster for KCNJ15 Gene:
Hs.411299Evidence on tissue expression from TISSUES for KCNJ15 Gene
- Kidney(4.7)
- Thyroid gland(2.5)
- Pancreas(2.4)
- Blood(2.4)
- Stomach(2.4)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for KCNJ15
-
OriGene qPCR primer pairs and template standards for KCNJ15
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KCNJ15 Gene
Orthologs for KCNJ15 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KCNJ15 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KCNJ15 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KCNJ15 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Kcnj15 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Kcnj15 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | KCNJ15 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | KCNJ15 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | KCNJ15 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | KCNJ15 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | kcnj15 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68935 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC572476 30 |
|
||
| KCNJ15 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Irk3 32 |
|
|
|
| Irk2 31 |
|
ManyToMany | |||
| Ir 31 |
|
ManyToMany |
- Species where no ortholog for KCNJ15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for KCNJ15 Gene
- ENSEMBL:
- Gene Tree for KCNJ15 (if available)
- TreeFam:
- Gene Tree for KCNJ15 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KCNJ15: view image
Paralogs for KCNJ15 Gene
Paralogs for KCNJ15 Gene
(16) SIMAP similar genes for KCNJ15 Gene using alignment to 9 proteins:
- IRK15_HUMAN
- A8MTZ5_HUMAN
- A8MVK1_HUMAN
- C9J0W5_HUMAN
- C9JTX1_HUMAN
- E7EPG3_HUMAN
- E7EWV2_HUMAN
- F8VW46_HUMAN
- F8VX74_HUMAN
Variants for KCNJ15 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KCNJ15 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 770817 | Benign: not provided | 38,299,277(+) | A/G | MISSENSE_VARIANT | |
| rs199857043 | A breast cancer sample | p.Ala71Thr | |||
| rs2230033 | - | p.Gly98Asp | |||
| rs3746875 | - | p.Met30Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv22065 | CNV | loss | 19812545 |
| esv2677092 | CNV | deletion | 23128226 |
| esv33823 | CNV | loss | 17666407 |
| esv3387523 | CNV | insertion | 20981092 |
| esv3389609 | CNV | insertion | 20981092 |
| esv3647000 | CNV | loss | 21293372 |
| nsv1058886 | CNV | gain | 25217958 |
| nsv3514 | CNV | insertion | 18451855 |
| nsv474591 | CNV | novel sequence insertion | 20440878 |
| nsv819873 | CNV | loss | 19587683 |
Residual Variation Intolerance Score:
47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.64;
65.67% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KCNJ15 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KCNJ15 Gene
Disorders for KCNJ15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypomagnesemia 4, renal |
|
|
| vitreoretinal degeneration, snowflake type |
|
|
Search KCNJ15 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KCNJ15
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KCNJ15 Gene
Publications for KCNJ15 Gene
- A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). (PMID: 9299242) Gosset P … Créau N (Genomics 1997) 2 3 4 23
- Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). (PMID: 8995301) Shuck ME … Bienkowski MJ (The Journal of biological chemistry 1997) 2 3 4
- Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. (PMID: 20085713) Okamoto K … Tokunaga K (American journal of human genetics 2010) 3 41
- International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (PMID: 16382105) Kubo Y … Vandenberg CA (Pharmacological reviews 2005) 2 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for KCNJ15 Gene
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- Invitrogen Antibodies for KCNJ15 (AFLGC-Kcnj15)
- VectorBuilder Custom and pre-made DNA vectors for KCNJ15 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for KCNJ15 (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 14 available KCNJ15 Antibodies ranked by validation data
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- Boster Bio Antibodies for KCNJ15
- Browse Boster Bio ELISA Kits
Sources for KCNJ15 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (110) Genetics Home Reference
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- (115) NCBI Bookshelf
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
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- (165) LNCipedia
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- (170) snOPY
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- (172) GENCODE
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB