Aliases for KCNJ14 Gene
External Ids for KCNJ14 Gene
Previous GeneCards Identifiers for KCNJ14 Gene
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]
GeneCards Summary for KCNJ14 Gene
KCNJ14 (Potassium Inwardly Rectifying Channel Subfamily J Member 14) is a Protein Coding gene. Diseases associated with KCNJ14 include Andersen Cardiodysrhythmic Periodic Paralysis. Among its related pathways are Cardiac conduction and Oxytocin signaling pathway. Gene Ontology (GO) annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ2.
UniProtKB/Swiss-Prot Summary for KCNJ14 Gene
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors.